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The map label for this gene is asnC

Identifier: 46445980

GI number: 46445980

Start: 470251

End: 471654

Strand: Direct

Name: asnC

Synonym: pc0346

Alternate gene names: 46445980

Gene position: 470251-471654 (Clockwise)

Preceding gene: 46445979

Following gene: 46445982

Centisome position: 19.48

GC content: 36.75

Gene sequence:

>1404_bases
ATGCGTACAAAAATTAAAAGCCTTAGAGGTACGACTCCAGAGGTTCGTGCTTTGATCGGACACGATATAACATTAAAAGG
ATGGGTGAGAACTGTTCGTAATCAAAAGACCTTTACTTTTATTGAAATCAATGATGGTTCTACTCTTTCTAATTTTCAAA
TTATAGCGACTCCAGATATAGCGGGTTATGATCAACTAATTAATCAACTTTCAACAGGAGTTTCTGTTTCAGCAATAGGT
ACAATTGTAGAAAGCCCAGGTAAAGAGCAAAATTTAGAAATGCAAGCAACAGCGATTACCATTATTGGAAAATGTGACCC
TGAAGTTTATCTCTTGCAAAAAAAACGGCATACTTTTGAATTTTTGCGATCAATTGCGCATCTTAGACCTCGCACTAATA
CGATTGGAGCTGTTACACGAGTTCGTAATGCATTAGCCTTTGCAACGCATCAGTTTTTTCAAAAACGCGGATTTCTATAT
ATCCATACTCCAATTATTACAGGGTCTGATTGTGAGGGGGCGGGTAAAATGTTTCAAGTGACAACGTTAGATCAAAACAA
TCCCGCTAGAACACCAGAAGGAAGAGTTGATTATACACAAGATTTTTTTGGCAAGCCTACTTATTTGACAGTTTCTGGGC
AGTTAAATGGAGAGATTTATGCTTGTGCGTTATCAGATGTTTATACATTTGGTCCAACATTTCGGGCAGAAAATTCCAAT
ACTTCCCGTCATTTAGCAGAATTTTGGATGATTGAACCCGAAATGGCTTTTGCAGATTTAAACGATAATATGGACTGTGC
GGAAGATTATCTTAAGTATATTTTAAAATATGTCTTAGACAATTGCCAAGAAGATATGGAGTTTTTCAACAAGCACGTTG
CGACAGATTTAATTTCTAGACTTGAGCATGTCATTAACACTTCATTTGAGAGAGCTTCTTATACTTATGCTGTAAGAATT
TTAGAGAAAGCGGATAAAAAATTTGAATATCCAGTTAAGTGGGGATTAGATTTGCAATCTGAGCATGAGCGTTTTTTGGC
AGAAGAATTTTTTGGTAAGCCAGTCATTTTGACAGATTATCCAAAAGACATTAAAGCATTTTATATGCGTACCAATGAAG
ATAATAAGACCGTGGCTGCGATGGATGTTCTCGTCCCAAAAGTGGGAGAAATTATCGGAGGTAGCCAACGGGAAGAAAGG
CTTAGTGTATTAGAGTCAAAATTAAAAGAATTCAATTTACCAGCAGAAGAATATTGGTGGTATTTAGAACTTCGTAAATT
CGGGAGTGTTCCTCACTCTGGTTTTGGTGCGGGTTTTGAACGTTTAGTTCAATTTACAACTGGAATGGAAAATATACGTG
ATGTCATTCCTTTCCCAAGGCACCCTGGAAAAGCTGATTTTTAA

Upstream 100 bases:

>100_bases
CAATTGGTAAATATTTTTAAAACTTCTTCAAATTTGAAGAAAAAAACCAGCAAAAAAATTCAAATTAATAATCGAATAAA
ATGTAGTGGGGTAAATTTGC

Downstream 100 bases:

>100_bases
TCAGATAAGTTATGAAAATTTGCAAGAAATCAAAAACTTGCAAATTTTTAACAAATAAATCCATTCGTGCTTATCGTTTA
GACAGTTTTTTTACCTCCCA

Product: asparaginyl-tRNA synthetase

Products: NA

Alternate protein names: Asparagine--tRNA ligase; AsnRS

Number of amino acids: Translated: 467; Mature: 467

Protein sequence:

>467_residues
MRTKIKSLRGTTPEVRALIGHDITLKGWVRTVRNQKTFTFIEINDGSTLSNFQIIATPDIAGYDQLINQLSTGVSVSAIG
TIVESPGKEQNLEMQATAITIIGKCDPEVYLLQKKRHTFEFLRSIAHLRPRTNTIGAVTRVRNALAFATHQFFQKRGFLY
IHTPIITGSDCEGAGKMFQVTTLDQNNPARTPEGRVDYTQDFFGKPTYLTVSGQLNGEIYACALSDVYTFGPTFRAENSN
TSRHLAEFWMIEPEMAFADLNDNMDCAEDYLKYILKYVLDNCQEDMEFFNKHVATDLISRLEHVINTSFERASYTYAVRI
LEKADKKFEYPVKWGLDLQSEHERFLAEEFFGKPVILTDYPKDIKAFYMRTNEDNKTVAAMDVLVPKVGEIIGGSQREER
LSVLESKLKEFNLPAEEYWWYLELRKFGSVPHSGFGAGFERLVQFTTGMENIRDVIPFPRHPGKADF

Sequences:

>Translated_467_residues
MRTKIKSLRGTTPEVRALIGHDITLKGWVRTVRNQKTFTFIEINDGSTLSNFQIIATPDIAGYDQLINQLSTGVSVSAIG
TIVESPGKEQNLEMQATAITIIGKCDPEVYLLQKKRHTFEFLRSIAHLRPRTNTIGAVTRVRNALAFATHQFFQKRGFLY
IHTPIITGSDCEGAGKMFQVTTLDQNNPARTPEGRVDYTQDFFGKPTYLTVSGQLNGEIYACALSDVYTFGPTFRAENSN
TSRHLAEFWMIEPEMAFADLNDNMDCAEDYLKYILKYVLDNCQEDMEFFNKHVATDLISRLEHVINTSFERASYTYAVRI
LEKADKKFEYPVKWGLDLQSEHERFLAEEFFGKPVILTDYPKDIKAFYMRTNEDNKTVAAMDVLVPKVGEIIGGSQREER
LSVLESKLKEFNLPAEEYWWYLELRKFGSVPHSGFGAGFERLVQFTTGMENIRDVIPFPRHPGKADF
>Mature_467_residues
MRTKIKSLRGTTPEVRALIGHDITLKGWVRTVRNQKTFTFIEINDGSTLSNFQIIATPDIAGYDQLINQLSTGVSVSAIG
TIVESPGKEQNLEMQATAITIIGKCDPEVYLLQKKRHTFEFLRSIAHLRPRTNTIGAVTRVRNALAFATHQFFQKRGFLY
IHTPIITGSDCEGAGKMFQVTTLDQNNPARTPEGRVDYTQDFFGKPTYLTVSGQLNGEIYACALSDVYTFGPTFRAENSN
TSRHLAEFWMIEPEMAFADLNDNMDCAEDYLKYILKYVLDNCQEDMEFFNKHVATDLISRLEHVINTSFERASYTYAVRI
LEKADKKFEYPVKWGLDLQSEHERFLAEEFFGKPVILTDYPKDIKAFYMRTNEDNKTVAAMDVLVPKVGEIIGGSQREER
LSVLESKLKEFNLPAEEYWWYLELRKFGSVPHSGFGAGFERLVQFTTGMENIRDVIPFPRHPGKADF

Specific function: Unknown

COG id: COG0017

COG function: function code J; Aspartyl/asparaginyl-tRNA synthetases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family

Homologues:

Organism=Homo sapiens, GI226491502, Length=447, Percent_Identity=46.7561521252796, Blast_Score=412, Evalue=1e-115,
Organism=Homo sapiens, GI4758762, Length=452, Percent_Identity=26.9911504424779, Blast_Score=161, Evalue=1e-39,
Organism=Homo sapiens, GI45439306, Length=342, Percent_Identity=27.7777777777778, Blast_Score=122, Evalue=1e-27,
Organism=Escherichia coli, GI1787161, Length=454, Percent_Identity=57.0484581497797, Blast_Score=555, Evalue=1e-159,
Organism=Caenorhabditis elegans, GI17556372, Length=427, Percent_Identity=31.615925058548, Blast_Score=203, Evalue=2e-52,
Organism=Caenorhabditis elegans, GI71984122, Length=478, Percent_Identity=29.7071129707113, Blast_Score=184, Evalue=6e-47,
Organism=Caenorhabditis elegans, GI17551876, Length=341, Percent_Identity=26.099706744868, Blast_Score=107, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6319872, Length=467, Percent_Identity=39.186295503212, Blast_Score=313, Evalue=3e-86,
Organism=Saccharomyces cerevisiae, GI6321807, Length=471, Percent_Identity=28.2377919320594, Blast_Score=189, Evalue=6e-49,
Organism=Saccharomyces cerevisiae, GI6323011, Length=479, Percent_Identity=25.0521920668058, Blast_Score=119, Evalue=1e-27,
Organism=Drosophila melanogaster, GI19922416, Length=450, Percent_Identity=35.3333333333333, Blast_Score=273, Evalue=3e-73,
Organism=Drosophila melanogaster, GI19921528, Length=455, Percent_Identity=28.7912087912088, Blast_Score=152, Evalue=7e-37,
Organism=Drosophila melanogaster, GI17136276, Length=340, Percent_Identity=26.7647058823529, Blast_Score=108, Evalue=6e-24,

Paralogues:

None

Copy number: 80 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): SYN_PARUW (Q6MEC9)

Other databases:

- EMBL:   BX908798
- RefSeq:   YP_007345.1
- ProteinModelPortal:   Q6MEC9
- SMR:   Q6MEC9
- STRING:   Q6MEC9
- GeneID:   2779793
- GenomeReviews:   BX908798_GR
- KEGG:   pcu:pc0346
- NMPDR:   fig|264201.1.peg.346
- eggNOG:   COG0017
- HOGENOM:   HBG745843
- OMA:   EPEMAFC
- PhylomeDB:   Q6MEC9
- ProtClustDB:   PRK03932
- BioCyc:   CPRO264201:PC0346-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00534
- InterPro:   IPR004364
- InterPro:   IPR018150
- InterPro:   IPR006195
- InterPro:   IPR004522
- InterPro:   IPR002312
- InterPro:   IPR012340
- InterPro:   IPR016027
- InterPro:   IPR004365
- Gene3D:   G3DSA:2.40.50.140
- PANTHER:   PTHR22594
- PRINTS:   PR01042
- TIGRFAMs:   TIGR00457

Pfam domain/function: PF00152 tRNA-synt_2; PF01336 tRNA_anti; SSF50249 Nucleic_acid_OB

EC number: =6.1.1.22

Molecular weight: Translated: 53285; Mature: 53285

Theoretical pI: Translated: 6.31; Mature: 6.31

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRTKIKSLRGTTPEVRALIGHDITLKGWVRTVRNQKTFTFIEINDGSTLSNFQIIATPDI
CCCCCCHHCCCCHHHHHHHCCCCCHHHHHHHHCCCCEEEEEEECCCCCCCCEEEEECCCC
AGYDQLINQLSTGVSVSAIGTIVESPGKEQNLEMQATAITIIGKCDPEVYLLQKKRHTFE
CCHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCEEEEEEEEEEECCCCCEEEEHHHHHHHH
FLRSIAHLRPRTNTIGAVTRVRNALAFATHQFFQKRGFLYIHTPIITGSDCEGAGKMFQV
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECEEECCCCCCCCCEEEE
TTLDQNNPARTPEGRVDYTQDFFGKPTYLTVSGQLNGEIYACALSDVYTFGPTFRAENSN
EEECCCCCCCCCCCCCCCCHHHCCCCEEEEEEECCCCCEEEEEEHHHHHCCCCEECCCCC
TSRHLAEFWMIEPEMAFADLNDNMDCAEDYLKYILKYVLDNCQEDMEFFNKHVATDLISR
CHHHHHHHHEECCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LEHVINTSFERASYTYAVRILEKADKKFEYPVKWGLDLQSEHERFLAEEFFGKPVILTDY
HHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCHHHHHHHHHHHCCCCEEEECC
PKDIKAFYMRTNEDNKTVAAMDVLVPKVGEIIGGSQREERLSVLESKLKEFNLPAEEYWW
CCCCEEEEEEECCCCCEEHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCHHHHEE
YLELRKFGSVPHSGFGAGFERLVQFTTGMENIRDVIPFPRHPGKADF
EEEHHHHCCCCCCCCHHHHHHHHHHHHCHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure
MRTKIKSLRGTTPEVRALIGHDITLKGWVRTVRNQKTFTFIEINDGSTLSNFQIIATPDI
CCCCCCHHCCCCHHHHHHHCCCCCHHHHHHHHCCCCEEEEEEECCCCCCCCEEEEECCCC
AGYDQLINQLSTGVSVSAIGTIVESPGKEQNLEMQATAITIIGKCDPEVYLLQKKRHTFE
CCHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCEEEEEEEEEEECCCCCEEEEHHHHHHHH
FLRSIAHLRPRTNTIGAVTRVRNALAFATHQFFQKRGFLYIHTPIITGSDCEGAGKMFQV
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECEEECCCCCCCCCEEEE
TTLDQNNPARTPEGRVDYTQDFFGKPTYLTVSGQLNGEIYACALSDVYTFGPTFRAENSN
EEECCCCCCCCCCCCCCCCHHHCCCCEEEEEEECCCCCEEEEEEHHHHHCCCCEECCCCC
TSRHLAEFWMIEPEMAFADLNDNMDCAEDYLKYILKYVLDNCQEDMEFFNKHVATDLISR
CHHHHHHHHEECCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LEHVINTSFERASYTYAVRILEKADKKFEYPVKWGLDLQSEHERFLAEEFFGKPVILTDY
HHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCHHHHHHHHHHHCCCCEEEECC
PKDIKAFYMRTNEDNKTVAAMDVLVPKVGEIIGGSQREERLSVLESKLKEFNLPAEEYWW
CCCCEEEEEEECCCCCEEHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCHHHHEE
YLELRKFGSVPHSGFGAGFERLVQFTTGMENIRDVIPFPRHPGKADF
EEEHHHHCCCCCCCCHHHHHHHHHHHHCHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA