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The map label for this gene is hemC [H]

Identifier: 46445906

GI number: 46445906

Start: 383591

End: 384292

Strand: Reverse

Name: hemC [H]

Synonym: pc0272

Alternate gene names: 46445906

Gene position: 384292-383591 (Counterclockwise)

Preceding gene: 46445907

Following gene: 46445905

Centisome position: 15.92

GC content: 40.17

Gene sequence:

>702_bases
TTGTTGAGGAAGCGATCGATGCTTTACTCAAATAATTCCCAACCCTATTCTATCTCTGTCGGGGCTCGTTCTTCACCACT
CTCACGTGCGCAAGTACAAGAGATTTTAAAAGCACTTAGATCTTTTTATCCTTCTATAGAATTTACCATTTCTTATTTCG
ACACAATAGGTGATCTGGATCAAAAAACTTCATTGCGAGACCTTGATAAAACCAATTTTTTTACCAAAGAAATTGATGAA
GCTATTCTTCAAAAAAAGTGTCAAATTGGCATCCATTCGGCAAAAGATCTCCCTGATCCAATTCCAGATGGCCTTCAACT
CATTTGTCTAACAAAAGGTGTCGACTGCAGTGATGTCTTGGTCTTGCGCGATGGAGAAACCTTACAAACTCTTCCTCCTC
ACTCGCGAATTGCGACTTCTTCTATAAGAAGAGAGAATATAGTCAAATTATTAAGAAACGATTTCATTTTTTTAGATTTG
AGAGGCACCATTCACCAAAGACTAGCTTTGCTTGAAAAAAAACAGGCAGACGGTGTTGTGGTGGCTGAAGCTGCACTAAT
CCGGCTGGGTTTAACGCATTTGAATCGTATTCGCCTACCAGGAACAACGGTAGAAGGGCAAGGCCAACTGGCCATTATCG
CACGAAAGGACGATGCAAAAATGCAAACTCTTTTTGCCTGCTTAGATGTGAGAAAAAATTGA

Upstream 100 bases:

>100_bases
GCCATTCATATGGGATTTAGACGTTGCATTATCCCTAAAAGAAACGCTAAAGGAATTGCTGAAGATATTCTTCGAAAGAT
TGTGGTACAAGGCGTAGAAT

Downstream 100 bases:

>100_bases
GAAAAATCTTATATACAGGTTTAAATCCCGCTCATTATCACTCCACTGACCAATTAACTCATTGTCCTTTAATCAAAATT
ATTCCTCGCCCTTTGACTGA

Product: porphobilinogen deaminase

Products: NA

Alternate protein names: PBG; Hydroxymethylbilane synthase; HMBS; Pre-uroporphyrinogen synthase [H]

Number of amino acids: Translated: 233; Mature: 233

Protein sequence:

>233_residues
MLRKRSMLYSNNSQPYSISVGARSSPLSRAQVQEILKALRSFYPSIEFTISYFDTIGDLDQKTSLRDLDKTNFFTKEIDE
AILQKKCQIGIHSAKDLPDPIPDGLQLICLTKGVDCSDVLVLRDGETLQTLPPHSRIATSSIRRENIVKLLRNDFIFLDL
RGTIHQRLALLEKKQADGVVVAEAALIRLGLTHLNRIRLPGTTVEGQGQLAIIARKDDAKMQTLFACLDVRKN

Sequences:

>Translated_233_residues
MLRKRSMLYSNNSQPYSISVGARSSPLSRAQVQEILKALRSFYPSIEFTISYFDTIGDLDQKTSLRDLDKTNFFTKEIDE
AILQKKCQIGIHSAKDLPDPIPDGLQLICLTKGVDCSDVLVLRDGETLQTLPPHSRIATSSIRRENIVKLLRNDFIFLDL
RGTIHQRLALLEKKQADGVVVAEAALIRLGLTHLNRIRLPGTTVEGQGQLAIIARKDDAKMQTLFACLDVRKN
>Mature_233_residues
MLRKRSMLYSNNSQPYSISVGARSSPLSRAQVQEILKALRSFYPSIEFTISYFDTIGDLDQKTSLRDLDKTNFFTKEIDE
AILQKKCQIGIHSAKDLPDPIPDGLQLICLTKGVDCSDVLVLRDGETLQTLPPHSRIATSSIRRENIVKLLRNDFIFLDL
RGTIHQRLALLEKKQADGVVVAEAALIRLGLTHLNRIRLPGTTVEGQGQLAIIARKDDAKMQTLFACLDVRKN

Specific function: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps [H]

COG id: COG0181

COG function: function code H; Porphobilinogen deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMBS family [H]

Homologues:

Organism=Homo sapiens, GI20149500, Length=225, Percent_Identity=30.6666666666667, Blast_Score=102, Evalue=3e-22,
Organism=Homo sapiens, GI66933009, Length=218, Percent_Identity=31.1926605504587, Blast_Score=102, Evalue=4e-22,
Organism=Escherichia coli, GI48994974, Length=215, Percent_Identity=32.093023255814, Blast_Score=111, Evalue=5e-26,
Organism=Saccharomyces cerevisiae, GI6319996, Length=225, Percent_Identity=32.4444444444444, Blast_Score=98, Evalue=1e-21,
Organism=Drosophila melanogaster, GI20130425, Length=231, Percent_Identity=31.1688311688312, Blast_Score=109, Evalue=1e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000860
- InterPro:   IPR022417 [H]

Pfam domain/function: PF01379 Porphobil_deam [H]

EC number: =2.5.1.61 [H]

Molecular weight: Translated: 26131; Mature: 26131

Theoretical pI: Translated: 9.49; Mature: 9.49

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLRKRSMLYSNNSQPYSISVGARSSPLSRAQVQEILKALRSFYPSIEFTISYFDTIGDLD
CCCCCCHHCCCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEEHHHHHCCCC
QKTSLRDLDKTNFFTKEIDEAILQKKCQIGIHSAKDLPDPIPDGLQLICLTKGVDCSDVL
HHCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEECCCCCCCEE
VLRDGETLQTLPPHSRIATSSIRRENIVKLLRNDFIFLDLRGTIHQRLALLEKKQADGVV
EEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCEEEEEECHHHHHHHHHHHHHCCCCEE
VAEAALIRLGLTHLNRIRLPGTTVEGQGQLAIIARKDDAKMQTLFACLDVRKN
EHHHHHHHHHHHHHHEEECCCCEECCCCCEEEEEECCCHHHHHHHHHHHHCCC
>Mature Secondary Structure
MLRKRSMLYSNNSQPYSISVGARSSPLSRAQVQEILKALRSFYPSIEFTISYFDTIGDLD
CCCCCCHHCCCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHCCCEEEEEEHHHHHCCCC
QKTSLRDLDKTNFFTKEIDEAILQKKCQIGIHSAKDLPDPIPDGLQLICLTKGVDCSDVL
HHCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEECCCCCCCEE
VLRDGETLQTLPPHSRIATSSIRRENIVKLLRNDFIFLDLRGTIHQRLALLEKKQADGVV
EEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCEEEEEECHHHHHHHHHHHHHCCCCEE
VAEAALIRLGLTHLNRIRLPGTTVEGQGQLAIIARKDDAKMQTLFACLDVRKN
EHHHHHHHHHHHHHHEEECCCCEECCCCCEEEEEECCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10192388; 10684935; 10871362 [H]