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The map label for this gene is dxr

Identifier: 46445894

GI number: 46445894

Start: 365941

End: 367095

Strand: Direct

Name: dxr

Synonym: pc0260

Alternate gene names: 46445894

Gene position: 365941-367095 (Clockwise)

Preceding gene: 46445893

Following gene: 46445895

Centisome position: 15.16

GC content: 38.27

Gene sequence:

>1155_bases
ATGAAACATATTGCCATTTTAGGTAGCACAGGCTCAATTGGAAAAAACACTTTGCAAGTGGCTCGCCATTTGAAAGAACG
GATTAAAGTCGTCGCGATTGCTGCTCGAGAAAATATTGATTTATTAGAGGCTCAATCGAAAGAATTTTGTCCTGATATTA
TTGCTGTTTTTAATAATGCTAAGGCTTATGAATTACAAAAGCGTTTGCCAGGAAAAACGGTATTGGCAGGGATGGAAGGT
CTATTAGCTGCTGCTTCTTATTCTGAGGCAGATCTTGTTATTTCCGCTATGACTGGGACAATGGGGCTTCAACCTACTAT
TGAAGCCATTAAAGCAGGAAAAGATGTTGGTTTAGCGAATAAAGAGGCTCTCGTCTCTGGCGGCGCAATAATCATGAAAT
TAGTAAAAGAGAAAAACATTAATCTTTTACCGATCGATAGCGAACATAGCGCCATTTTTCAATGTTTAAATGGAGAGGCT
CTTAAGTCAGTCCAGCGTATTATTTTGACCTCTTCTGGAGGACCTTTTAGAACTTGGACTCAAGAACAATTAGAAACTGT
AACAGTTGAGCAAGCTCTAAATCATCCAACTTGGAGTATGGGGCCTAAAGTCACAATTGATTCATCAACTTTAATGAACA
AGGGTTTAGAGGTTATTGAGGCATTTTGGTTATTTGATGTATCGCCAGAACAAATTGATGTTATTGTTCATCCCCAAAGT
ATTATTCATAGTCTTGTGGAATTTTGCGACGGTTCTATGTTGGCTCAAATGAGCGAGCCAAACATGATTGTTCCCATTCA
ATATTCGCTGACGTATCCTGACCGAGCTCCGGGTCTCTTTAAGCCATTTGATTTTATGAAAAATAGTAAATTAGAATTTT
TTGAGCCCAATAAAAAAACTTTCCGTTGTTTAGCTCTTGCTTATGAAGCATTGAAATGCGGAGGGACTCTTCCGTGTTAT
ATGAATGCTGCCAATGAAGTGCTCGTAGAGCGTTTTTTAAAAGGGGAATTGAGCTGGAAAAATATTGGAATTCAATTAGA
AAAACTTATGGATCAACATGCATCGATTTCGGTTGATTCTTTAGAAACGATTTTAGCAGTAGATGCTCTTGCTCGGGAAG
AGGCTGCAAGGTCTAAACTAATATCAACGAAATAG

Upstream 100 bases:

>100_bases
ATTCTGTTTCAGAGTAGTGTATTATCAAATAACAAGAGAGGTTCATTGACTTTTTCGTACAGCTTGCTATACTAGCAAAA
TATTAAAAAAAGAATCGAAG

Downstream 100 bases:

>100_bases
ATATTTTCGATTGATATAACCCGTTTTTAATATAAGGTTTGTATTATTATGGTTGTCAGTATTCTTTATGTGATCTTAGC
TATTCTAGGCTTAAGCTTTT

Product: 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Products: NA

Alternate protein names: DXP reductoisomerase; 1-deoxyxylulose-5-phosphate reductoisomerase; 2-C-methyl-D-erythritol 4-phosphate synthase

Number of amino acids: Translated: 384; Mature: 384

Protein sequence:

>384_residues
MKHIAILGSTGSIGKNTLQVARHLKERIKVVAIAARENIDLLEAQSKEFCPDIIAVFNNAKAYELQKRLPGKTVLAGMEG
LLAAASYSEADLVISAMTGTMGLQPTIEAIKAGKDVGLANKEALVSGGAIIMKLVKEKNINLLPIDSEHSAIFQCLNGEA
LKSVQRIILTSSGGPFRTWTQEQLETVTVEQALNHPTWSMGPKVTIDSSTLMNKGLEVIEAFWLFDVSPEQIDVIVHPQS
IIHSLVEFCDGSMLAQMSEPNMIVPIQYSLTYPDRAPGLFKPFDFMKNSKLEFFEPNKKTFRCLALAYEALKCGGTLPCY
MNAANEVLVERFLKGELSWKNIGIQLEKLMDQHASISVDSLETILAVDALAREEAARSKLISTK

Sequences:

>Translated_384_residues
MKHIAILGSTGSIGKNTLQVARHLKERIKVVAIAARENIDLLEAQSKEFCPDIIAVFNNAKAYELQKRLPGKTVLAGMEG
LLAAASYSEADLVISAMTGTMGLQPTIEAIKAGKDVGLANKEALVSGGAIIMKLVKEKNINLLPIDSEHSAIFQCLNGEA
LKSVQRIILTSSGGPFRTWTQEQLETVTVEQALNHPTWSMGPKVTIDSSTLMNKGLEVIEAFWLFDVSPEQIDVIVHPQS
IIHSLVEFCDGSMLAQMSEPNMIVPIQYSLTYPDRAPGLFKPFDFMKNSKLEFFEPNKKTFRCLALAYEALKCGGTLPCY
MNAANEVLVERFLKGELSWKNIGIQLEKLMDQHASISVDSLETILAVDALAREEAARSKLISTK
>Mature_384_residues
MKHIAILGSTGSIGKNTLQVARHLKERIKVVAIAARENIDLLEAQSKEFCPDIIAVFNNAKAYELQKRLPGKTVLAGMEG
LLAAASYSEADLVISAMTGTMGLQPTIEAIKAGKDVGLANKEALVSGGAIIMKLVKEKNINLLPIDSEHSAIFQCLNGEA
LKSVQRIILTSSGGPFRTWTQEQLETVTVEQALNHPTWSMGPKVTIDSSTLMNKGLEVIEAFWLFDVSPEQIDVIVHPQS
IIHSLVEFCDGSMLAQMSEPNMIVPIQYSLTYPDRAPGLFKPFDFMKNSKLEFFEPNKKTFRCLALAYEALKCGGTLPCY
MNAANEVLVERFLKGELSWKNIGIQLEKLMDQHASISVDSLETILAVDALAREEAARSKLISTK

Specific function: Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)

COG id: COG0743

COG function: function code I; 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DXR family

Homologues:

Organism=Escherichia coli, GI1786369, Length=395, Percent_Identity=43.7974683544304, Blast_Score=293, Evalue=2e-80,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DXR_PARUW (Q6MEL5)

Other databases:

- EMBL:   BX908798
- RefSeq:   YP_007259.1
- ProteinModelPortal:   Q6MEL5
- SMR:   Q6MEL5
- STRING:   Q6MEL5
- GeneID:   2779453
- GenomeReviews:   BX908798_GR
- KEGG:   pcu:pc0260
- NMPDR:   fig|264201.1.peg.260
- eggNOG:   COG0743
- HOGENOM:   HBG430762
- OMA:   IHSMVEY
- PhylomeDB:   Q6MEL5
- ProtClustDB:   PRK05447
- BioCyc:   CPRO264201:PC0260-MONOMER
- HAMAP:   MF_00183
- InterPro:   IPR003821
- InterPro:   IPR013644
- InterPro:   IPR013512
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- PIRSF:   PIRSF006205
- TIGRFAMs:   TIGR00243

Pfam domain/function: PF08436 DXP_redisom_C; PF02670 DXP_reductoisom

EC number: =1.1.1.267

Molecular weight: Translated: 42136; Mature: 42136

Theoretical pI: Translated: 6.19; Mature: 6.19

Prosite motif: NA

Important sites: BINDING 121-121 BINDING 148-148 BINDING 172-172 BINDING 195-195 BINDING 217-217

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKHIAILGSTGSIGKNTLQVARHLKERIKVVAIAARENIDLLEAQSKEFCPDIIAVFNNA
CCEEEEEECCCCCCHHHHHHHHHHHHHHHEEEEECCCCCHHHHHCCHHHCHHHHHHHCCC
KAYELQKRLPGKTVLAGMEGLLAAASYSEADLVISAMTGTMGLQPTIEAIKAGKDVGLAN
HHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCHHHHHHHCCCCCCCCC
KEALVSGGAIIMKLVKEKNINLLPIDSEHSAIFQCLNGEALKSVQRIILTSSGGPFRTWT
CHHHHCCCHHHHHHHHHCCCCEEEECCCHHHHHHHHCCHHHHHHHHHEEECCCCCCCCCC
QEQLETVTVEQALNHPTWSMGPKVTIDSSTLMNKGLEVIEAFWLFDVSPEQIDVIVHPQS
HHHHHHHHHHHHHCCCCCCCCCEEEECCHHHHHHHHHHHHHHHHCCCCCCCEEEEECCHH
IIHSLVEFCDGSMLAQMSEPNMIVPIQYSLTYPDRAPGLFKPFDFMKNSKLEFFEPNKKT
HHHHHHHHCCCHHEECCCCCCEEEEEEEEEECCCCCCCCCCCHHHHCCCCCEEECCCHHH
FRCLALAYEALKCGGTLPCYMNAANEVLVERFLKGELSWKNIGIQLEKLMDQHASISVDS
HHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCHHHCCEEHHHHHHHHCCCCHHH
LETILAVDALAREEAARSKLISTK
HHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MKHIAILGSTGSIGKNTLQVARHLKERIKVVAIAARENIDLLEAQSKEFCPDIIAVFNNA
CCEEEEEECCCCCCHHHHHHHHHHHHHHHEEEEECCCCCHHHHHCCHHHCHHHHHHHCCC
KAYELQKRLPGKTVLAGMEGLLAAASYSEADLVISAMTGTMGLQPTIEAIKAGKDVGLAN
HHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCHHHHHHHCCCCCCCCC
KEALVSGGAIIMKLVKEKNINLLPIDSEHSAIFQCLNGEALKSVQRIILTSSGGPFRTWT
CHHHHCCCHHHHHHHHHCCCCEEEECCCHHHHHHHHCCHHHHHHHHHEEECCCCCCCCCC
QEQLETVTVEQALNHPTWSMGPKVTIDSSTLMNKGLEVIEAFWLFDVSPEQIDVIVHPQS
HHHHHHHHHHHHHCCCCCCCCCEEEECCHHHHHHHHHHHHHHHHCCCCCCCEEEEECCHH
IIHSLVEFCDGSMLAQMSEPNMIVPIQYSLTYPDRAPGLFKPFDFMKNSKLEFFEPNKKT
HHHHHHHHCCCHHEECCCCCCEEEEEEEEEECCCCCCCCCCCHHHHCCCCCEEECCCHHH
FRCLALAYEALKCGGTLPCYMNAANEVLVERFLKGELSWKNIGIQLEKLMDQHASISVDS
HHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCHHHCCEEHHHHHHHHCCCCHHH
LETILAVDALAREEAARSKLISTK
HHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA