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The map label for this gene is tyrP_2 [H]

Identifier: 46445803

GI number: 46445803

Start: 248122

End: 249321

Strand: Direct

Name: tyrP_2 [H]

Synonym: pc0169

Alternate gene names: 46445803

Gene position: 248122-249321 (Clockwise)

Preceding gene: 46445802

Following gene: 46445804

Centisome position: 10.28

GC content: 37.25

Gene sequence:

>1200_bases
ATGACCAATGATAAATATCGTTTATTAGGCGGTATTCTCCTTGTTGCTGGAACGACAATAGGAGCAGGGATGCTCGCTCT
TCCAATTGTAACAGGATTTGCAGGGTTTATTCCTTCGATTGTTCTGTTTGTGATTTATTGGGTTTTTATGACTTTCACAG
CCCTTTTGATGTTAGAGGTTAACTTATGGATGGGAGAGCATACTAATCTGATTACGATGGCTAAAAAAACGCTTGGAAGA
GGTGGACAAGCGATTAGTTGGATGATTTACCTCTTCCTTTTATATACATTGACAACTGCGTATGTAGCGGGGGGAGGTCA
TATCATTGTTGATTTTGCAAGGCAAGTTACTGAATGGAATCTGCCAAGCTGGATAGGGCCTCTTCCTTTGTTGGGAATTT
TTGGTTTTTTTGTTTATAAAGGAGCTCGTTCAGTAGATTATGTTAATCGAATTTTGATGGGCGGATTAGTTTTGACTTAT
GTTTGCATGGTCTTCTTTTTATCATCTCATATACAACCGATTCTTTTAAAACATCAAAGGTGGGATGCGCTTTGGATTGC
AGTCCCTATTGTGTCAACCTCATTTGGTTTTCATATTATTATTCCTACCCTGACTGACTATTTGAAACGAGATGTCAAGC
AAATTAGAAATGTCATTTTAATCGGCGGTGCAATCCCGCTTTTGATTTACGTTAGCTGGGAATTGCTAACACTTGGAATT
ATTCCATTGCAGGGAGAAAATGGGTTGTTAATGGGATATGAAAAAGGTTTAGATGGGGCCACTTTAATGAGTCAATTACT
TGAACACTCTGAACTTTCTCTTTTAGCAAGGTTGTTTTCCCTTTTTGCCATTCTAACTTCATTTTTAGGGGTCTCATTGA
GTTTGCGAGATTTTTTATCTGACGGATTGAAAATTCAAAAATCAAATAAAGGAAGATTTGTTCTTTATTTACTGACATTT
ATTCCTCCTCTTCTTCTAACTTTAACAGATCCACGGGCGTTTTTAAATGCCTTAGAATACGCTGGGGCATTTGGAGTTGT
TACCTTACTTGGCTTGATTCCTATTTTAATGGTTTGGCGTGGACGTTATCATTTAAAATTGCCTTCAACTTTTAAAGCTC
CTGGAGGCAAAATAGCTTTAATCTTAGCATTACTTGTGTCATTAGGCGTGATTGGAATGGAAATTTTTAATAAAGTGTAG

Upstream 100 bases:

>100_bases
ATTGTTCCCGGAGGGAGGCCACTTTTAATTGGCGTCATTCTATTTTCTCTATGGATTATGGCCCTTCAACTTATTTAATA
AATACTCAGGATGTAGCGAA

Downstream 100 bases:

>100_bases
GATAAACGGAATATATCATATGACAGAAAAAAAACGGATTTTAACAGGAGACCGTCCAACAGGTCTTCTGCATTTGGGAC
ATTATGTCGGCTCCTTAAAA

Product: putative tyrosine/tryptophan transport protein

Products: Proton [Cytoplasm]; L-tyrosine [Cytoplasm] [C]

Alternate protein names: Tyrosine permease [H]

Number of amino acids: Translated: 399; Mature: 398

Protein sequence:

>399_residues
MTNDKYRLLGGILLVAGTTIGAGMLALPIVTGFAGFIPSIVLFVIYWVFMTFTALLMLEVNLWMGEHTNLITMAKKTLGR
GGQAISWMIYLFLLYTLTTAYVAGGGHIIVDFARQVTEWNLPSWIGPLPLLGIFGFFVYKGARSVDYVNRILMGGLVLTY
VCMVFFLSSHIQPILLKHQRWDALWIAVPIVSTSFGFHIIIPTLTDYLKRDVKQIRNVILIGGAIPLLIYVSWELLTLGI
IPLQGENGLLMGYEKGLDGATLMSQLLEHSELSLLARLFSLFAILTSFLGVSLSLRDFLSDGLKIQKSNKGRFVLYLLTF
IPPLLLTLTDPRAFLNALEYAGAFGVVTLLGLIPILMVWRGRYHLKLPSTFKAPGGKIALILALLVSLGVIGMEIFNKV

Sequences:

>Translated_399_residues
MTNDKYRLLGGILLVAGTTIGAGMLALPIVTGFAGFIPSIVLFVIYWVFMTFTALLMLEVNLWMGEHTNLITMAKKTLGR
GGQAISWMIYLFLLYTLTTAYVAGGGHIIVDFARQVTEWNLPSWIGPLPLLGIFGFFVYKGARSVDYVNRILMGGLVLTY
VCMVFFLSSHIQPILLKHQRWDALWIAVPIVSTSFGFHIIIPTLTDYLKRDVKQIRNVILIGGAIPLLIYVSWELLTLGI
IPLQGENGLLMGYEKGLDGATLMSQLLEHSELSLLARLFSLFAILTSFLGVSLSLRDFLSDGLKIQKSNKGRFVLYLLTF
IPPLLLTLTDPRAFLNALEYAGAFGVVTLLGLIPILMVWRGRYHLKLPSTFKAPGGKIALILALLVSLGVIGMEIFNKV
>Mature_398_residues
TNDKYRLLGGILLVAGTTIGAGMLALPIVTGFAGFIPSIVLFVIYWVFMTFTALLMLEVNLWMGEHTNLITMAKKTLGRG
GQAISWMIYLFLLYTLTTAYVAGGGHIIVDFARQVTEWNLPSWIGPLPLLGIFGFFVYKGARSVDYVNRILMGGLVLTYV
CMVFFLSSHIQPILLKHQRWDALWIAVPIVSTSFGFHIIIPTLTDYLKRDVKQIRNVILIGGAIPLLIYVSWELLTLGII
PLQGENGLLMGYEKGLDGATLMSQLLEHSELSLLARLFSLFAILTSFLGVSLSLRDFLSDGLKIQKSNKGRFVLYLLTFI
PPLLLTLTDPRAFLNALEYAGAFGVVTLLGLIPILMVWRGRYHLKLPSTFKAPGGKIALILALLVSLGVIGMEIFNKV

Specific function: Involved in transporting tyrosine across the cytoplasmic membrane [H]

COG id: COG0814

COG function: function code E; Amino acid permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid/polyamine transporter 2 family. Mtr/TnaB/TyrP permease subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788218, Length=398, Percent_Identity=36.9346733668342, Blast_Score=216, Evalue=2e-57,
Organism=Escherichia coli, GI1789552, Length=371, Percent_Identity=32.0754716981132, Blast_Score=140, Evalue=1e-34,
Organism=Escherichia coli, GI1790145, Length=407, Percent_Identity=28.7469287469287, Blast_Score=132, Evalue=4e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002091
- InterPro:   IPR013061
- InterPro:   IPR013059
- InterPro:   IPR018227 [H]

Pfam domain/function: PF03222 Trp_Tyr_perm [H]

EC number: NA

Molecular weight: Translated: 44145; Mature: 44014

Theoretical pI: Translated: 9.90; Mature: 9.90

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNDKYRLLGGILLVAGTTIGAGMLALPIVTGFAGFIPSIVLFVIYWVFMTFTALLMLEV
CCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NLWMGEHTNLITMAKKTLGRGGQAISWMIYLFLLYTLTTAYVAGGGHIIVDFARQVTEWN
HHHCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCC
LPSWIGPLPLLGIFGFFVYKGARSVDYVNRILMGGLVLTYVCMVFFLSSHIQPILLKHQR
CCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCC
WDALWIAVPIVSTSFGFHIIIPTLTDYLKRDVKQIRNVILIGGAIPLLIYVSWELLTLGI
CCEEEEEEEHHHCCCCCEEEHHHHHHHHHHHHHHHHHEEEECCHHHHHHHHHHHHHHEEE
IPLQGENGLLMGYEKGLDGATLMSQLLEHSELSLLARLFSLFAILTSFLGVSLSLRDFLS
EEEECCCCEEEEHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
DGLKIQKSNKGRFVLYLLTFIPPLLLTLTDPRAFLNALEYAGAFGVVTLLGLIPILMVWR
CCCEEEECCCCCEEEEHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GRYHLKLPSTFKAPGGKIALILALLVSLGVIGMEIFNKV
CCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TNDKYRLLGGILLVAGTTIGAGMLALPIVTGFAGFIPSIVLFVIYWVFMTFTALLMLEV
CCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NLWMGEHTNLITMAKKTLGRGGQAISWMIYLFLLYTLTTAYVAGGGHIIVDFARQVTEWN
HHHCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCC
LPSWIGPLPLLGIFGFFVYKGARSVDYVNRILMGGLVLTYVCMVFFLSSHIQPILLKHQR
CCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCC
WDALWIAVPIVSTSFGFHIIIPTLTDYLKRDVKQIRNVILIGGAIPLLIYVSWELLTLGI
CCEEEEEEEHHHCCCCCEEEHHHHHHHHHHHHHHHHHEEEECCHHHHHHHHHHHHHHEEE
IPLQGENGLLMGYEKGLDGATLMSQLLEHSELSLLARLFSLFAILTSFLGVSLSLRDFLS
EEEECCCCEEEEHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
DGLKIQKSNKGRFVLYLLTFIPPLLLTLTDPRAFLNALEYAGAFGVVTLLGLIPILMVWR
CCCEEEECCCCCEEEEHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GRYHLKLPSTFKAPGGKIALILALLVSLGVIGMEIFNKV
CCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; L-tyrosine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-tyrosine [Periplasm] = Proton [Cytoplasm] + L-tyrosine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3049553; 9097040; 9278503 [H]