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The map label for this gene is trpS [H]

Identifier: 46445804

GI number: 46445804

Start: 249341

End: 250402

Strand: Direct

Name: trpS [H]

Synonym: pc0170

Alternate gene names: 46445804

Gene position: 249341-250402 (Clockwise)

Preceding gene: 46445803

Following gene: 46445805

Centisome position: 10.33

GC content: 38.42

Gene sequence:

>1062_bases
ATGACAGAAAAAAAACGGATTTTAACAGGAGACCGTCCAACAGGTCTTCTGCATTTGGGACATTATGTCGGCTCCTTAAA
AAATAGAATTGCTTTACAAGATAGTTATGAATGTTATTTTATTATTGCTGATCTTCACACGTTGACGACAAAACCTTCTA
AAGAAGAAATTCTACAGGTTCGTGAAAATGTGCGGACAATGGTGATAGACTATTTGGCGTGTGGAATCGATCCCAAGAAG
TCGACGATTTATCTTCAGTCCGCTATTCCTGCCGTTTATGAGATGAATTTAATTTTTGAGATGCTCATTTCACTTAATCG
TTTAATAGGTTTGCCAAGTCTCAAAGAAATGGCTCGAAATGCTCATCTAGATAATGACAATATGCCATTTGGTCTTATTG
GTTACCCTATATTGCAAACAGCCGATATTTTAATGCCAAAGGCTCATTTAGTTCCCGTCGGGAAAGATAACGAAGCTCAC
ATTGAGCTTGCACGTGATATAGCGAGACGCTTTAATCAATTTTATGGAGATGTCTTTCCTTTACCTGAAGTGTTATTAAG
TCAAACTCCTACTCTTGTGGGAACAGATGGTAAAGGGAAAATGAGCAAATCGGCAGGAAATACAATTTTCCTGGCAGATG
ATGCAAAATCTGTTGAGAAAAAAGTTAAAGGAATGTTTACAGACCCGAATCGCATTCGCGCAGATATGCCAGGAACAGTA
GAAGGCAATCCAGTCTTTATTTACCATACGTTGTTTAACTGTCGGCAAGATGAAATTGAAGATCTTAAGAAACGGTATCG
GGAAGGGCGGGTAGGAGATGTAGAAGTAAAAGAAAAATTGATTATTGCGATTAATGAATTTTTAGATCCGATTCGCGAAA
AACGGAAAATTTTTGAAGAAGATAGGGGACTTGTTGAAGAAATTATTTATGAGGGAACAGAAAAGATGCATGACATTTCT
CAAGCGACAATCAAAGAAATGCGAAGCGCGATGGGGTTGATGGGTACTTGGAATAAAATCTCTCGCGTGGCCAGGGATCG
GAAAAAAAAGCTTCAAGGATAA

Upstream 100 bases:

>100_bases
CCTGGAGGCAAAATAGCTTTAATCTTAGCATTACTTGTGTCATTAGGCGTGATTGGAATGGAAATTTTTAATAAAGTGTA
GGATAAACGGAATATATCAT

Downstream 100 bases:

>100_bases
CTAAATAAAACTTAATAAATTATTAATTTGATTAATTATTTGTTAATAAATTAAATTTACTTGCTTATATCAATAATTCA
AGGGGCCTTATGCCAGCAGA

Product: tryptophanyl-tRNA synthetase

Products: NA

Alternate protein names: Tryptophan--tRNA ligase; TrpRS [H]

Number of amino acids: Translated: 353; Mature: 352

Protein sequence:

>353_residues
MTEKKRILTGDRPTGLLHLGHYVGSLKNRIALQDSYECYFIIADLHTLTTKPSKEEILQVRENVRTMVIDYLACGIDPKK
STIYLQSAIPAVYEMNLIFEMLISLNRLIGLPSLKEMARNAHLDNDNMPFGLIGYPILQTADILMPKAHLVPVGKDNEAH
IELARDIARRFNQFYGDVFPLPEVLLSQTPTLVGTDGKGKMSKSAGNTIFLADDAKSVEKKVKGMFTDPNRIRADMPGTV
EGNPVFIYHTLFNCRQDEIEDLKKRYREGRVGDVEVKEKLIIAINEFLDPIREKRKIFEEDRGLVEEIIYEGTEKMHDIS
QATIKEMRSAMGLMGTWNKISRVARDRKKKLQG

Sequences:

>Translated_353_residues
MTEKKRILTGDRPTGLLHLGHYVGSLKNRIALQDSYECYFIIADLHTLTTKPSKEEILQVRENVRTMVIDYLACGIDPKK
STIYLQSAIPAVYEMNLIFEMLISLNRLIGLPSLKEMARNAHLDNDNMPFGLIGYPILQTADILMPKAHLVPVGKDNEAH
IELARDIARRFNQFYGDVFPLPEVLLSQTPTLVGTDGKGKMSKSAGNTIFLADDAKSVEKKVKGMFTDPNRIRADMPGTV
EGNPVFIYHTLFNCRQDEIEDLKKRYREGRVGDVEVKEKLIIAINEFLDPIREKRKIFEEDRGLVEEIIYEGTEKMHDIS
QATIKEMRSAMGLMGTWNKISRVARDRKKKLQG
>Mature_352_residues
TEKKRILTGDRPTGLLHLGHYVGSLKNRIALQDSYECYFIIADLHTLTTKPSKEEILQVRENVRTMVIDYLACGIDPKKS
TIYLQSAIPAVYEMNLIFEMLISLNRLIGLPSLKEMARNAHLDNDNMPFGLIGYPILQTADILMPKAHLVPVGKDNEAHI
ELARDIARRFNQFYGDVFPLPEVLLSQTPTLVGTDGKGKMSKSAGNTIFLADDAKSVEKKVKGMFTDPNRIRADMPGTVE
GNPVFIYHTLFNCRQDEIEDLKKRYREGRVGDVEVKEKLIIAINEFLDPIREKRKIFEEDRGLVEEIIYEGTEKMHDISQ
ATIKEMRSAMGLMGTWNKISRVARDRKKKLQG

Specific function: Unknown

COG id: COG0180

COG function: function code J; Tryptophanyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI7710154, Length=339, Percent_Identity=30.3834808259587, Blast_Score=157, Evalue=2e-38,
Organism=Homo sapiens, GI41352700, Length=186, Percent_Identity=40.3225806451613, Blast_Score=142, Evalue=6e-34,
Organism=Escherichia coli, GI1789786, Length=338, Percent_Identity=31.6568047337278, Blast_Score=172, Evalue=2e-44,
Organism=Caenorhabditis elegans, GI71982800, Length=341, Percent_Identity=28.4457478005865, Blast_Score=142, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI71982793, Length=341, Percent_Identity=28.4457478005865, Blast_Score=141, Evalue=5e-34,
Organism=Saccharomyces cerevisiae, GI6320474, Length=237, Percent_Identity=37.5527426160338, Blast_Score=137, Evalue=2e-33,
Organism=Drosophila melanogaster, GI24666151, Length=344, Percent_Identity=34.3023255813954, Blast_Score=165, Evalue=4e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002305
- InterPro:   IPR014729
- InterPro:   IPR002306 [H]

Pfam domain/function: PF00579 tRNA-synt_1b [H]

EC number: =6.1.1.2 [H]

Molecular weight: Translated: 40153; Mature: 40022

Theoretical pI: Translated: 8.42; Mature: 8.42

Prosite motif: PS00178 AA_TRNA_LIGASE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEKKRILTGDRPTGLLHLGHYVGSLKNRIALQDSYECYFIIADLHTLTTKPSKEEILQV
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHEEEECCCCEEEEEEEHHHHCCCCCHHHHHHH
RENVRTMVIDYLACGIDPKKSTIYLQSAIPAVYEMNLIFEMLISLNRLIGLPSLKEMARN
HHHHHHHHHHHHHHCCCCCCCEEEEHHHCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
AHLDNDNMPFGLIGYPILQTADILMPKAHLVPVGKDNEAHIELARDIARRFNQFYGDVFP
CCCCCCCCCEEECCCHHHHHHHHHCCCHHEEECCCCCHHHHHHHHHHHHHHHHHHCCCCC
LPEVLLSQTPTLVGTDGKGKMSKSAGNTIFLADDAKSVEKKVKGMFTDPNRIRADMPGTV
HHHHHHCCCCCEEECCCCCCCCCCCCCEEEEECCHHHHHHHHCCCCCCCHHHCCCCCCCC
EGNPVFIYHTLFNCRQDEIEDLKKRYREGRVGDVEVKEKLIIAINEFLDPIREKRKIFEE
CCCEEEEEECHHCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
DRGLVEEIIYEGTEKMHDISQATIKEMRSAMGLMGTWNKISRVARDRKKKLQG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TEKKRILTGDRPTGLLHLGHYVGSLKNRIALQDSYECYFIIADLHTLTTKPSKEEILQV
CCCCCCCCCCCCCHHHHHHHHHHHHHHHEEEECCCCEEEEEEEHHHHCCCCCHHHHHHH
RENVRTMVIDYLACGIDPKKSTIYLQSAIPAVYEMNLIFEMLISLNRLIGLPSLKEMARN
HHHHHHHHHHHHHHCCCCCCCEEEEHHHCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
AHLDNDNMPFGLIGYPILQTADILMPKAHLVPVGKDNEAHIELARDIARRFNQFYGDVFP
CCCCCCCCCEEECCCHHHHHHHHHCCCHHEEECCCCCHHHHHHHHHHHHHHHHHHCCCCC
LPEVLLSQTPTLVGTDGKGKMSKSAGNTIFLADDAKSVEKKVKGMFTDPNRIRADMPGTV
HHHHHHCCCCCEEECCCCCCCCCCCCCEEEEECCHHHHHHHHCCCCCCCHHHCCCCCCCC
EGNPVFIYHTLFNCRQDEIEDLKKRYREGRVGDVEVKEKLIIAINEFLDPIREKRKIFEE
CCCEEEEEECHHCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
DRGLVEEIIYEGTEKMHDISQATIKEMRSAMGLMGTWNKISRVARDRKKKLQG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10684935 [H]