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The map label for this gene is tyrP_1 [H]

Identifier: 46445802

GI number: 46445802

Start: 246909

End: 248099

Strand: Direct

Name: tyrP_1 [H]

Synonym: pc0168

Alternate gene names: 46445802

Gene position: 246909-248099 (Clockwise)

Preceding gene: 46445801

Following gene: 46445803

Centisome position: 10.23

GC content: 36.94

Gene sequence:

>1191_bases
ATGAAAACTTATGCAACCCAAAAGGGAAGTCTCTTAGGAGGAATCTTATTAGTGGCTGGTTGTTGCATTGGAGCTGGAAT
GTTAGGCTTACCAGTGTTGAGCGCAATGGCTGGTTTTATCCCTAGTGTCGCCATGTTTATGACTTGTTGGGCTTTTATGG
TTTGCACAGGCCTTCTGTTGTTAGAAGTGAATTTATGGTTTGGCCAAGAAATTAGTATTATTACGATGGCAGAAAAAACT
TTGGGAGAAGTAGGAAAAGGTGTGAGTTGGTTTGTTTTTCTTTTTCTTTTTTATTCGCTAATGGTGGCTTATGTAGCGGC
AAGTGGATCTTTAGTTTCAGATTTAGTTGAACAAGGGTTCAATCACTCTTTTCCCCAAGGGTTAGGAAGTGTTTTGTTTT
GCTTACTTTTTGGAGTGCTCATTTATTTAGGTATTGGGGCTGTTGACTGGTTTAATCGATTTTTAATGTGTGGGTTAATT
TTGACTTATGTTTGTTTAATGATAACGGGAATTCCTTATATAGATGCTTCTCTTTTAAAACATCAAGATTGGAATGCCGC
GACTTTAGTTCTTCCAGCAGTTATTGTTTCGTTTGGGTTTCATAATTTGATCCCTAGTTTAACAACCTATCTTAACAGCG
ATCGAAAAACTCTTTTAAAGGCTATCTTGATTGGAAGCGCCATTCCTTTAGTGATTTATTTAGCTTGGGAATGGTTGATT
TTAGGATTGGTTCCTCTTGGAGAATTTAAAGAAGCTTTAGATAAAGGGGAAATAGCAACAGAAGCTTTAAAAGATGTGGT
AGGAATTTCTTGGATTCTCGATGTTGCACAAGGTTTTGCTTTTTTTGCAATAGTCACTTCTTTTTTAAGCGTAGCTATTA
GTTTTGTTGACTTTCTAGCAGATGGATTAAATATTCAAAAAACTGCCGGAGGTAAAATGTTTTTAGCAGGACTTGTACTA
GTTCCTCCACTTATTTGTTCTATAGTTTACCCTAGGATTTTTTTGTCGGCTTTAAATTATGCTGGAGGATTTGGAGCCGT
GATTCTTTTTGGTATCTTGCCGGCTCTCATGGTTTGGAAAGGTCGTTATACAAAAAAGATTAACTTACCTCAAATTGTTC
CCGGAGGGAGGCCACTTTTAATTGGCGTCATTCTATTTTCTCTATGGATTATGGCCCTTCAACTTATTTAA

Upstream 100 bases:

>100_bases
ACATTTTTTCCTTTCTTTTTCTTTGCTTGGCGTTAATGCCCATTCTTTTGCATTTCCCTCTTTTTTAAAGTGATCAATAA
AAAACATAAACAAGGTAGAT

Downstream 100 bases:

>100_bases
TAAATACTCAGGATGTAGCGAAATGACCAATGATAAATATCGTTTATTAGGCGGTATTCTCCTTGTTGCTGGAACGACAA
TAGGAGCAGGGATGCTCGCT

Product: putative tyrosine/tryptophan transport protein

Products: Proton [Cytoplasm]; L-tyrosine [Cytoplasm] [C]

Alternate protein names: Tyrosine permease [H]

Number of amino acids: Translated: 396; Mature: 396

Protein sequence:

>396_residues
MKTYATQKGSLLGGILLVAGCCIGAGMLGLPVLSAMAGFIPSVAMFMTCWAFMVCTGLLLLEVNLWFGQEISIITMAEKT
LGEVGKGVSWFVFLFLFYSLMVAYVAASGSLVSDLVEQGFNHSFPQGLGSVLFCLLFGVLIYLGIGAVDWFNRFLMCGLI
LTYVCLMITGIPYIDASLLKHQDWNAATLVLPAVIVSFGFHNLIPSLTTYLNSDRKTLLKAILIGSAIPLVIYLAWEWLI
LGLVPLGEFKEALDKGEIATEALKDVVGISWILDVAQGFAFFAIVTSFLSVAISFVDFLADGLNIQKTAGGKMFLAGLVL
VPPLICSIVYPRIFLSALNYAGGFGAVILFGILPALMVWKGRYTKKINLPQIVPGGRPLLIGVILFSLWIMALQLI

Sequences:

>Translated_396_residues
MKTYATQKGSLLGGILLVAGCCIGAGMLGLPVLSAMAGFIPSVAMFMTCWAFMVCTGLLLLEVNLWFGQEISIITMAEKT
LGEVGKGVSWFVFLFLFYSLMVAYVAASGSLVSDLVEQGFNHSFPQGLGSVLFCLLFGVLIYLGIGAVDWFNRFLMCGLI
LTYVCLMITGIPYIDASLLKHQDWNAATLVLPAVIVSFGFHNLIPSLTTYLNSDRKTLLKAILIGSAIPLVIYLAWEWLI
LGLVPLGEFKEALDKGEIATEALKDVVGISWILDVAQGFAFFAIVTSFLSVAISFVDFLADGLNIQKTAGGKMFLAGLVL
VPPLICSIVYPRIFLSALNYAGGFGAVILFGILPALMVWKGRYTKKINLPQIVPGGRPLLIGVILFSLWIMALQLI
>Mature_396_residues
MKTYATQKGSLLGGILLVAGCCIGAGMLGLPVLSAMAGFIPSVAMFMTCWAFMVCTGLLLLEVNLWFGQEISIITMAEKT
LGEVGKGVSWFVFLFLFYSLMVAYVAASGSLVSDLVEQGFNHSFPQGLGSVLFCLLFGVLIYLGIGAVDWFNRFLMCGLI
LTYVCLMITGIPYIDASLLKHQDWNAATLVLPAVIVSFGFHNLIPSLTTYLNSDRKTLLKAILIGSAIPLVIYLAWEWLI
LGLVPLGEFKEALDKGEIATEALKDVVGISWILDVAQGFAFFAIVTSFLSVAISFVDFLADGLNIQKTAGGKMFLAGLVL
VPPLICSIVYPRIFLSALNYAGGFGAVILFGILPALMVWKGRYTKKINLPQIVPGGRPLLIGVILFSLWIMALQLI

Specific function: Involved in transporting tyrosine across the cytoplasmic membrane [H]

COG id: COG0814

COG function: function code E; Amino acid permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid/polyamine transporter 2 family. Mtr/TnaB/TyrP permease subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788218, Length=397, Percent_Identity=34.0050377833753, Blast_Score=191, Evalue=9e-50,
Organism=Escherichia coli, GI1789552, Length=371, Percent_Identity=29.3800539083558, Blast_Score=136, Evalue=3e-33,
Organism=Escherichia coli, GI1790145, Length=403, Percent_Identity=28.7841191066998, Blast_Score=135, Evalue=5e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002091
- InterPro:   IPR013061
- InterPro:   IPR013059
- InterPro:   IPR018227 [H]

Pfam domain/function: PF03222 Trp_Tyr_perm [H]

EC number: NA

Molecular weight: Translated: 42810; Mature: 42810

Theoretical pI: Translated: 7.24; Mature: 7.24

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure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CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; L-tyrosine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-tyrosine [Periplasm] = Proton [Cytoplasm] + L-tyrosine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3049553; 9097040; 9278503 [H]