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The map label for this gene is argE [C]

Identifier: 45659304

GI number: 45659304

Start: 4266394

End: 4267842

Strand: Reverse

Name: argE [C]

Synonym: LIC13491

Alternate gene names: 45659304

Gene position: 4267842-4266394 (Counterclockwise)

Preceding gene: 45659306

Following gene: 45659303

Centisome position: 99.78

GC content: 36.37

Gene sequence:

>1449_bases
ATGAATTGGAAAAAAATCGTCTTCGGCTTTTTAGGAGCTTTGGTTTTATTTTTACTCTATACGATTTTTGTTACAGAAAA
AGGGATCCAGTCGATAAACCCCACCACAAAGTTTAAACGAGATTATGGAAAAATTGCCGAAGAAGCTTCGAAAGATTTAC
AAACGTATCTTAAAATTCAAACGGTTCGAGGAAATGAAAAACAGGCGGTTTTATTTTTAAAAAGTCTCTTTGATAAACGA
GGAATTAAAACCAGAATATTTGAAGTTCCTGGAAAACCGGAAAGAGCGAGTATCATGGCGGAGATCAAAGGAACAGATCC
AGAAGGTGGTTTGATACTTACAAATCATATCGATGTAGTAGAAGCCGATCCAAGTGAGTGGGATGAGGCGCCGTTTTCAG
GAGTAAGAAAAGGAGATAGAATTTACGGAAGAGGGGCCGTGGATATGAAAGGTCTGGGAATCATGGAGTTATATGCTTTC
TTTTTGATTCATGATTCTGGAATGAAACTTAAGAAAAATCTAATGTATCTTGCAGTTGCCGACGAAGAAAGTCGTTCCGA
ATTTGGGATGAGGTTTTTGATCGCAAATCATAAAGAAATTTTTAACGGTTATGAGTTTGTTCACAATGAGGGAGGAATCG
GAACCAAAGACGTAGTTGTAAAGGGAAGTAAAATCTTTAATATTCAACACGCAGAAAAAGGAATTATCTGGTTGGATCTG
AAATCAGAAGATATTTCCGGACACGGAAGTACTCCGCCAATACAATATGCAGCTTTGAATCTCATCGACTTTCTCAGTGA
GCTTAAGAAGATGAACGAAGTTGTTATTATCAAAGACGAGACCGCTTCGTTCTTTTATCAAATGGGAGAAGTAAGCCCTT
TCCCCAATTCATTTGTATTAAAAAGATCTCGGAATCCGTTATTAGGAATCGTTCTAAATGGAGTGATTCGATCAAACAAA
CATCTAAGAGCTATGACTAGTAATACCGTAAGTATAACCGGAATTGATACTCATCAAGCAGGTATAAACGTAATCACTTC
AAAAACAGAAGGAATGGTCGACATAAGAATCTTACCTGGTTTTAGTGAAAATGAGATCTTTGAAAAAATAAAAAAACTCG
CTGAAAAATATAGAGTGAAAGTCAGTGCGAGACATTTAGAACCTGGAACGATTTCGCCAGTGGATTCAAAATATTTTCAA
ATTTTATCTGGAGTTGTTCAACAAGTGGTTCCAGGTTCGATCGTAACTCCTTTTTTATCTCCTGGAACTACGGACTCATC
TTATTTAAGAATGGCCGGATTTAAATGTTACGGTTTGATTCCAGCGCTCATGACTTCGGAAGAAATAGATGGAATACATG
GTAAAAATGAAAGTACTACGATTGAACATTTAAAAACAGGAATTGAAATTCTACATAGAACGGTTTTAGAATTCAATAAT
GCTCCTTAA

Upstream 100 bases:

>100_bases
AAACGTGGAAACTTATACACGAACTCTCTAGTCACAAACGGAAATGCCTTGAAAGTAAAATAGGGCACAATATTTTCTTC
CGCACTTAGGAGAATTAAAG

Downstream 100 bases:

>100_bases
AGTTCTTTTAGAGTTACTTCAAGGTGAGAATTCATGCCTTGAAGTAACTGAGGATTGTCCCAAAACATTAGAAATGTAGA
AACCCCTACGAAATTCATTA

Product: metallopeptidase

Products: Acetate; Ornithine [C]

Alternate protein names: NA

Number of amino acids: Translated: 482; Mature: 482

Protein sequence:

>482_residues
MNWKKIVFGFLGALVLFLLYTIFVTEKGIQSINPTTKFKRDYGKIAEEASKDLQTYLKIQTVRGNEKQAVLFLKSLFDKR
GIKTRIFEVPGKPERASIMAEIKGTDPEGGLILTNHIDVVEADPSEWDEAPFSGVRKGDRIYGRGAVDMKGLGIMELYAF
FLIHDSGMKLKKNLMYLAVADEESRSEFGMRFLIANHKEIFNGYEFVHNEGGIGTKDVVVKGSKIFNIQHAEKGIIWLDL
KSEDISGHGSTPPIQYAALNLIDFLSELKKMNEVVIIKDETASFFYQMGEVSPFPNSFVLKRSRNPLLGIVLNGVIRSNK
HLRAMTSNTVSITGIDTHQAGINVITSKTEGMVDIRILPGFSENEIFEKIKKLAEKYRVKVSARHLEPGTISPVDSKYFQ
ILSGVVQQVVPGSIVTPFLSPGTTDSSYLRMAGFKCYGLIPALMTSEEIDGIHGKNESTTIEHLKTGIEILHRTVLEFNN
AP

Sequences:

>Translated_482_residues
MNWKKIVFGFLGALVLFLLYTIFVTEKGIQSINPTTKFKRDYGKIAEEASKDLQTYLKIQTVRGNEKQAVLFLKSLFDKR
GIKTRIFEVPGKPERASIMAEIKGTDPEGGLILTNHIDVVEADPSEWDEAPFSGVRKGDRIYGRGAVDMKGLGIMELYAF
FLIHDSGMKLKKNLMYLAVADEESRSEFGMRFLIANHKEIFNGYEFVHNEGGIGTKDVVVKGSKIFNIQHAEKGIIWLDL
KSEDISGHGSTPPIQYAALNLIDFLSELKKMNEVVIIKDETASFFYQMGEVSPFPNSFVLKRSRNPLLGIVLNGVIRSNK
HLRAMTSNTVSITGIDTHQAGINVITSKTEGMVDIRILPGFSENEIFEKIKKLAEKYRVKVSARHLEPGTISPVDSKYFQ
ILSGVVQQVVPGSIVTPFLSPGTTDSSYLRMAGFKCYGLIPALMTSEEIDGIHGKNESTTIEHLKTGIEILHRTVLEFNN
AP
>Mature_482_residues
MNWKKIVFGFLGALVLFLLYTIFVTEKGIQSINPTTKFKRDYGKIAEEASKDLQTYLKIQTVRGNEKQAVLFLKSLFDKR
GIKTRIFEVPGKPERASIMAEIKGTDPEGGLILTNHIDVVEADPSEWDEAPFSGVRKGDRIYGRGAVDMKGLGIMELYAF
FLIHDSGMKLKKNLMYLAVADEESRSEFGMRFLIANHKEIFNGYEFVHNEGGIGTKDVVVKGSKIFNIQHAEKGIIWLDL
KSEDISGHGSTPPIQYAALNLIDFLSELKKMNEVVIIKDETASFFYQMGEVSPFPNSFVLKRSRNPLLGIVLNGVIRSNK
HLRAMTSNTVSITGIDTHQAGINVITSKTEGMVDIRILPGFSENEIFEKIKKLAEKYRVKVSARHLEPGTISPVDSKYFQ
ILSGVVQQVVPGSIVTPFLSPGTTDSSYLRMAGFKCYGLIPALMTSEEIDGIHGKNESTTIEHLKTGIEILHRTVLEFNN
AP

Specific function: Displays A Broad Specificity And Can Also Deacylate Substrates Such As Acetylarginine, Acetylhistidine Or Acetylglutamate Semialdehyde. [C]

COG id: COG0624

COG function: function code E; Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M20A family [H]

Homologues:

Organism=Homo sapiens, GI269846968, Length=387, Percent_Identity=27.390180878553, Blast_Score=115, Evalue=8e-26,
Organism=Drosophila melanogaster, GI24649210, Length=444, Percent_Identity=24.7747747747748, Blast_Score=83, Evalue=4e-16,
Organism=Drosophila melanogaster, GI24649208, Length=445, Percent_Identity=26.0674157303371, Blast_Score=82, Evalue=8e-16,
Organism=Drosophila melanogaster, GI24649206, Length=400, Percent_Identity=24.75, Blast_Score=79, Evalue=6e-15,
Organism=Drosophila melanogaster, GI24649202, Length=409, Percent_Identity=25.9168704156479, Blast_Score=79, Evalue=7e-15,
Organism=Drosophila melanogaster, GI24649204, Length=409, Percent_Identity=25.9168704156479, Blast_Score=79, Evalue=7e-15,
Organism=Drosophila melanogaster, GI24649212, Length=233, Percent_Identity=29.1845493562232, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI21356353, Length=209, Percent_Identity=25.8373205741627, Blast_Score=74, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010182
- InterPro:   IPR002933
- InterPro:   IPR011650 [H]

Pfam domain/function: PF07687 M20_dimer; PF01546 Peptidase_M20 [H]

EC number: 3.5.1.16 [C]

Molecular weight: Translated: 53759; Mature: 53759

Theoretical pI: Translated: 8.73; Mature: 8.73

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNWKKIVFGFLGALVLFLLYTIFVTEKGIQSINPTTKFKRDYGKIAEEASKDLQTYLKIQ
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHEEE
TVRGNEKQAVLFLKSLFDKRGIKTRIFEVPGKPERASIMAEIKGTDPEGGLILTNHIDVV
EECCCCCHHHHHHHHHHHHCCCEEEEEECCCCCCCCEEEEEEECCCCCCCEEEECCEEEE
EADPSEWDEAPFSGVRKGDRIYGRGAVDMKGLGIMELYAFFLIHDSGMKLKKNLMYLAVA
ECCCCCCCCCCCHHCCCCCEEECCCCCCCCCCCHHHHHHHHHHCCCCCCEECCEEEEEEE
DEESRSEFGMRFLIANHKEIFNGYEFVHNEGGIGTKDVVVKGSKIFNIQHAEKGIIWLDL
CCCCHHHHCEEEEEECCHHHHCCHHHEECCCCCCCCCEEEECCEEEEEEECCCCEEEEEE
KSEDISGHGSTPPIQYAALNLIDFLSELKKMNEVVIIKDETASFFYQMGEVSPFPNSFVL
ECCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEECHHHHHHHHCCCCCCCCCCEE
KRSRNPLLGIVLNGVIRSNKHLRAMTSNTVSITGIDTHQAGINVITSKTEGMVDIRILPG
ECCCCCEEEHEEHHHHHCCCCEEEEECCEEEEEECCCCCCCCEEEEECCCCEEEEEEECC
FSENEIFEKIKKLAEKYRVKVSARHLEPGTISPVDSKYFQILSGVVQQVVPGSIVTPFLS
CCHHHHHHHHHHHHHHHEEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCC
PGTTDSSYLRMAGFKCYGLIPALMTSEEIDGIHGKNESTTIEHLKTGIEILHRTVLEFNN
CCCCCCHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCC
AP
CC
>Mature Secondary Structure
MNWKKIVFGFLGALVLFLLYTIFVTEKGIQSINPTTKFKRDYGKIAEEASKDLQTYLKIQ
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHEEE
TVRGNEKQAVLFLKSLFDKRGIKTRIFEVPGKPERASIMAEIKGTDPEGGLILTNHIDVV
EECCCCCHHHHHHHHHHHHCCCEEEEEECCCCCCCCEEEEEEECCCCCCCEEEECCEEEE
EADPSEWDEAPFSGVRKGDRIYGRGAVDMKGLGIMELYAFFLIHDSGMKLKKNLMYLAVA
ECCCCCCCCCCCHHCCCCCEEECCCCCCCCCCCHHHHHHHHHHCCCCCCEECCEEEEEEE
DEESRSEFGMRFLIANHKEIFNGYEFVHNEGGIGTKDVVVKGSKIFNIQHAEKGIIWLDL
CCCCHHHHCEEEEEECCHHHHCCHHHEECCCCCCCCCEEEECCEEEEEEECCCCEEEEEE
KSEDISGHGSTPPIQYAALNLIDFLSELKKMNEVVIIKDETASFFYQMGEVSPFPNSFVL
ECCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEECHHHHHHHHCCCCCCCCCCEE
KRSRNPLLGIVLNGVIRSNKHLRAMTSNTVSITGIDTHQAGINVITSKTEGMVDIRILPG
ECCCCCEEEHEEHHHHHCCCCEEEEECCEEEEEECCCCCCCCEEEEECCCCEEEEEEECC
FSENEIFEKIKKLAEKYRVKVSARHLEPGTISPVDSKYFQILSGVVQQVVPGSIVTPFLS
CCHHHHHHHHHHHHHHHEEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCC
PGTTDSSYLRMAGFKCYGLIPALMTSEEIDGIHGKNESTTIEHLKTGIEILHRTVLEFNN
CCCCCCHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCC
AP
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: Glutathione. [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: N2-Acetyl-L-ornithine; H2O [C]

Specific reaction: N2-Acetyl-L-ornithine + H2O --> Acetate + Ornithine [C]

General reaction: Carboxylic acid amide hydrolysis [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]