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The map label for this gene is coaBC [H]

Identifier: 45658964

GI number: 45658964

Start: 3852096

End: 3852638

Strand: Reverse

Name: coaBC [H]

Synonym: LIC13142

Alternate gene names: 45658964

Gene position: 3852638-3852096 (Counterclockwise)

Preceding gene: 45658965

Following gene: 45658963

Centisome position: 90.07

GC content: 41.62

Gene sequence:

>543_bases
ATGTCTAATCTTAAAAAAGAAATACTCGTTGCTGTTTCGGGAAGTATTGCCGCATACAAGACGTGTGAACTTGTAAGAAA
TCTTACTAAGGAAGGTTATCCAGTAAGCGTAATTATGACGGCGAACGCGACTAAGTTTGTGGGCCCGATTACGTTTGAAG
CTTTAACCGGTAAAAAAGTGCGTGTGGATGAATATGAACAAGGAATGGCTCATATAGACGCAAAAAATTCCGCGTCCGTC
ATTGCGATTGTTCCCGCCACAGCAAACATAATCGGTAAAATGGCGAACGGAATTGCGGATGATCTTGTCACTTCTACTTA
TCTTGCGGCGAATTGTCCTGTGGTTATCGCGCCTGCTATGAATCCTTTTATGTATGCTCATCCTTCAGTTCAAAGAAACC
TAAAACGATTGATCGAAGACGGTGTGACGCTTGCGGATCCTTCTGAGGGGGTAGTTGTCTGTGGGGACGAAGGATATGGA
AAGTTAGCCGAAATTTCTATAATACAAAAAATGATCTTAGATTTATACCAGAGAAATTTTTAG

Upstream 100 bases:

>100_bases
CGTTGAGAAAATGGAAGGTAATAAAATTCTTTCGGTTCGTTTTACAAGAGTTAGCTTAAATAATCGAGCTCAGTCTAAAA
AATGAGAATCGGAAACGTTT

Downstream 100 bases:

>100_bases
ATTCAGAGAAATTAAAGTGAGATTTTCCAAAGCAATCATTACGTCTGGACCGACCATTGAATGGATCGATCCTGTGCGAT
ATATTTCGAACGCTTCTTCG

Product: phosphopantothenoylcysteine decarboxylase

Products: NA

Alternate protein names: DNA/pantothenate metabolism flavoprotein; Phosphopantothenoylcysteine decarboxylase; PPCDC; CoaC; Phosphopantothenate--cysteine ligase; CoaB; PPC synthetase; PPCS; Phosphopantothenoylcysteine synthase [H]

Number of amino acids: Translated: 180; Mature: 179

Protein sequence:

>180_residues
MSNLKKEILVAVSGSIAAYKTCELVRNLTKEGYPVSVIMTANATKFVGPITFEALTGKKVRVDEYEQGMAHIDAKNSASV
IAIVPATANIIGKMANGIADDLVTSTYLAANCPVVIAPAMNPFMYAHPSVQRNLKRLIEDGVTLADPSEGVVVCGDEGYG
KLAEISIIQKMILDLYQRNF

Sequences:

>Translated_180_residues
MSNLKKEILVAVSGSIAAYKTCELVRNLTKEGYPVSVIMTANATKFVGPITFEALTGKKVRVDEYEQGMAHIDAKNSASV
IAIVPATANIIGKMANGIADDLVTSTYLAANCPVVIAPAMNPFMYAHPSVQRNLKRLIEDGVTLADPSEGVVVCGDEGYG
KLAEISIIQKMILDLYQRNF
>Mature_179_residues
SNLKKEILVAVSGSIAAYKTCELVRNLTKEGYPVSVIMTANATKFVGPITFEALTGKKVRVDEYEQGMAHIDAKNSASVI
AIVPATANIIGKMANGIADDLVTSTYLAANCPVVIAPAMNPFMYAHPSVQRNLKRLIEDGVTLADPSEGVVVCGDEGYGK
LAEISIIQKMILDLYQRNF

Specific function: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine [H]

COG id: COG0452

COG function: function code H; Phosphopantothenoylcysteine synthetase/decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PPC synthetase family [H]

Homologues:

Organism=Homo sapiens, GI71725351, Length=185, Percent_Identity=32.972972972973, Blast_Score=86, Evalue=2e-17,
Organism=Escherichia coli, GI87082301, Length=175, Percent_Identity=40, Blast_Score=119, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI17560194, Length=184, Percent_Identity=29.3478260869565, Blast_Score=72, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6322762, Length=191, Percent_Identity=28.7958115183246, Blast_Score=77, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24657262, Length=185, Percent_Identity=29.1891891891892, Blast_Score=86, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005252
- InterPro:   IPR007085
- InterPro:   IPR003382 [H]

Pfam domain/function: PF04127 DFP; PF02441 Flavoprotein [H]

EC number: =4.1.1.36; =6.3.2.5 [H]

Molecular weight: Translated: 19338; Mature: 19207

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNLKKEILVAVSGSIAAYKTCELVRNLTKEGYPVSVIMTANATKFVGPITFEALTGKKV
CCCCHHEEEEEECCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCEEEEECCCCEE
RVDEYEQGMAHIDAKNSASVIAIVPATANIIGKMANGIADDLVTSTYLAANCPVVIAPAM
ECCHHHCCHHEECCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCC
NPFMYAHPSVQRNLKRLIEDGVTLADPSEGVVVCGDEGYGKLAEISIIQKMILDLYQRNF
CCEEEECCHHHHHHHHHHHCCCEEECCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SNLKKEILVAVSGSIAAYKTCELVRNLTKEGYPVSVIMTANATKFVGPITFEALTGKKV
CCCHHEEEEEECCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCEEEEECCCCEE
RVDEYEQGMAHIDAKNSASVIAIVPATANIIGKMANGIADDLVTSTYLAANCPVVIAPAM
ECCHHHCCHHEECCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCC
NPFMYAHPSVQRNLKRLIEDGVTLADPSEGVVVCGDEGYGKLAEISIIQKMILDLYQRNF
CCEEEECCHHHHHHHHHHHCCCEEECCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9534248; 9384377 [H]