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The map label for this gene is tlyC

Identifier: 45658965

GI number: 45658965

Start: 3852654

End: 3853988

Strand: Reverse

Name: tlyC

Synonym: LIC13143

Alternate gene names: 45658965

Gene position: 3853988-3852654 (Counterclockwise)

Preceding gene: 45658966

Following gene: 45658964

Centisome position: 90.11

GC content: 36.63

Gene sequence:

>1335_bases
ATGGAATTAATCGGCTTTTTTATAATCGTTTTACTTATATTTGCGAACGGATTTTTCGTTTCCGCAGAGTTTGCTTTGGT
TTCGATTCGTCCTTCTCGTTTAGAGGAATTGATCAAGGAAAATAAACCTCTTGCATTTATTACCAAACGCGCGGCTCAAA
AACTCAATGACATGTTATCCGTATGTCAGGTAGGAATTACCATCGCCAGTCTTTTGTTAGGTTGGGTGGGGGAAGGTTAC
GTTTCTAGATGGCTTATTTTTCTTTTGGAAATGTTTGGCTATTCCGCAAACGAAGCAACTGTTCACGGTTTGGCGATTAC
TATTTCGTTTACGATTATTACGTTTCTACATATACTTTTAGGAGAACTTCTTCCTAAGACAGTAGCAATTCAGAACACGG
AAACGATTGCACTTTTTATTAGCATTCCTTTATTCTTCTTTTATTATCTATTTTATCCAATTACTTTCTTCTTAAATGAA
ATGACATCTTTTCTTTTGAAGCTGATTGGAATCGAAGCAAACAAAAGCAGAATGATGCATTCTCCTGAAGAATTGATGAT
CATCATAGAAGAGCAAAACAAACAAGGTAAGATCGATCAGGAAGAATTTCAAATCATTCAGAATACGTTTCAGTTTTCAG
AACATCAAGCAAAGGATGTGATGACTCATCGTTTGAGTATCATTGGGATTCCGCATGATACTTCTATGGATTCTTTGATT
TCTATCATTGCAGAACACCATTTTTCTAGATATCCTATTTATGAAGGCAGTACAGATAAAATTATTGGAATCATTCACGT
TCAGACGTATCTTACTTGGTTGTCTAATTCTAAAAAAGGTAGAAAAGAAAAAGTTACCGCAATTATGCAACCTCCGATTT
TTGTTCCCGAAGGTCTTTCGATAGAAAAGGTGATGCAAAAACTCCGAGAAAACAAACAACACATGGCGATCGTTATAGAT
GAGTACGGTGGAGTTGCGGGTCTTCTTACATTAGAGGATATTATCGAAGAAATTTTTGGACAGATCCGAGATGAAACGGA
CGATCATGAGACGGATCCGTTCCCTACTCAACATTCAGACAGTTTTACGATCGACGGCGAAGCGGAGTTAGACGATCTAA
AAGAAATTCTTGTAGGAGTCCAAGAAGAAGAGATCAAAGATATTCGTACGATTGCAGGTTTTATCTTAGGTCGTTTAGAA
GATATGCCGGAAGAAGGTTCTACAATTTCTCTTCAAACAGGAACTCTTACCGTTGAGAAAATGGAAGGTAATAAAATTCT
TTCGGTTCGTTTTACAAGAGTTAGCTTAAATAATCGAGCTCAGTCTAAAAAATGA

Upstream 100 bases:

>100_bases
GTCAGTTCTACATTCCAGCGATACTGAATTTCCGCTTTCTAAACTCAAAGGTTGTCCTAAACCCACATATTCTTAGATCC
AATTTGATCTTTCTCCTACA

Downstream 100 bases:

>100_bases
GAATCGGAAACGTTTATGTCTAATCTTAAAAAAGAAATACTCGTTGCTGTTTCGGGAAGTATTGCCGCATACAAGACGTG
TGAACTTGTAAGAAATCTTA

Product: hemolysin

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 444; Mature: 444

Protein sequence:

>444_residues
MELIGFFIIVLLIFANGFFVSAEFALVSIRPSRLEELIKENKPLAFITKRAAQKLNDMLSVCQVGITIASLLLGWVGEGY
VSRWLIFLLEMFGYSANEATVHGLAITISFTIITFLHILLGELLPKTVAIQNTETIALFISIPLFFFYYLFYPITFFLNE
MTSFLLKLIGIEANKSRMMHSPEELMIIIEEQNKQGKIDQEEFQIIQNTFQFSEHQAKDVMTHRLSIIGIPHDTSMDSLI
SIIAEHHFSRYPIYEGSTDKIIGIIHVQTYLTWLSNSKKGRKEKVTAIMQPPIFVPEGLSIEKVMQKLRENKQHMAIVID
EYGGVAGLLTLEDIIEEIFGQIRDETDDHETDPFPTQHSDSFTIDGEAELDDLKEILVGVQEEEIKDIRTIAGFILGRLE
DMPEEGSTISLQTGTLTVEKMEGNKILSVRFTRVSLNNRAQSKK

Sequences:

>Translated_444_residues
MELIGFFIIVLLIFANGFFVSAEFALVSIRPSRLEELIKENKPLAFITKRAAQKLNDMLSVCQVGITIASLLLGWVGEGY
VSRWLIFLLEMFGYSANEATVHGLAITISFTIITFLHILLGELLPKTVAIQNTETIALFISIPLFFFYYLFYPITFFLNE
MTSFLLKLIGIEANKSRMMHSPEELMIIIEEQNKQGKIDQEEFQIIQNTFQFSEHQAKDVMTHRLSIIGIPHDTSMDSLI
SIIAEHHFSRYPIYEGSTDKIIGIIHVQTYLTWLSNSKKGRKEKVTAIMQPPIFVPEGLSIEKVMQKLRENKQHMAIVID
EYGGVAGLLTLEDIIEEIFGQIRDETDDHETDPFPTQHSDSFTIDGEAELDDLKEILVGVQEEEIKDIRTIAGFILGRLE
DMPEEGSTISLQTGTLTVEKMEGNKILSVRFTRVSLNNRAQSKK
>Mature_444_residues
MELIGFFIIVLLIFANGFFVSAEFALVSIRPSRLEELIKENKPLAFITKRAAQKLNDMLSVCQVGITIASLLLGWVGEGY
VSRWLIFLLEMFGYSANEATVHGLAITISFTIITFLHILLGELLPKTVAIQNTETIALFISIPLFFFYYLFYPITFFLNE
MTSFLLKLIGIEANKSRMMHSPEELMIIIEEQNKQGKIDQEEFQIIQNTFQFSEHQAKDVMTHRLSIIGIPHDTSMDSLI
SIIAEHHFSRYPIYEGSTDKIIGIIHVQTYLTWLSNSKKGRKEKVTAIMQPPIFVPEGLSIEKVMQKLRENKQHMAIVID
EYGGVAGLLTLEDIIEEIFGQIRDETDDHETDPFPTQHSDSFTIDGEAELDDLKEILVGVQEEEIKDIRTIAGFILGRLE
DMPEEGSTISLQTGTLTVEKMEGNKILSVRFTRVSLNNRAQSKK

Specific function: Unknown

COG id: COG1253

COG function: function code R; Hemolysins and related proteins containing CBS domains

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI310128564, Length=378, Percent_Identity=37.3015873015873, Blast_Score=258, Evalue=1e-68,
Organism=Homo sapiens, GI94681046, Length=291, Percent_Identity=26.1168384879725, Blast_Score=80, Evalue=5e-15,
Organism=Homo sapiens, GI40068055, Length=351, Percent_Identity=24.2165242165242, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI40068053, Length=351, Percent_Identity=24.2165242165242, Blast_Score=72, Evalue=1e-12,
Organism=Escherichia coli, GI145693175, Length=415, Percent_Identity=24.578313253012, Blast_Score=136, Evalue=3e-33,
Organism=Escherichia coli, GI1790664, Length=439, Percent_Identity=22.0956719817768, Blast_Score=127, Evalue=2e-30,
Organism=Escherichia coli, GI1786879, Length=248, Percent_Identity=26.2096774193548, Blast_Score=104, Evalue=1e-23,
Organism=Escherichia coli, GI87082033, Length=306, Percent_Identity=22.2222222222222, Blast_Score=92, Evalue=1e-19,
Organism=Escherichia coli, GI1788119, Length=232, Percent_Identity=27.1551724137931, Blast_Score=71, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI71980512, Length=371, Percent_Identity=25.3369272237197, Blast_Score=68, Evalue=8e-12,
Organism=Saccharomyces cerevisiae, GI6324512, Length=246, Percent_Identity=23.9837398373984, Blast_Score=67, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016169
- InterPro:   IPR000644
- InterPro:   IPR002550
- InterPro:   IPR005170 [H]

Pfam domain/function: PF00571 CBS; PF03471 CorC_HlyC; PF01595 DUF21 [H]

EC number: NA

Molecular weight: Translated: 50432; Mature: 50432

Theoretical pI: Translated: 4.79; Mature: 4.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELIGFFIIVLLIFANGFFVSAEFALVSIRPSRLEELIKENKPLAFITKRAAQKLNDMLS
CHHHHHHHHHHHHHHCCCEEEEEEEEEEECHHHHHHHHHCCCCEEHHHHHHHHHHHHHHH
VCQVGITIASLLLGWVGEGYVSRWLIFLLEMFGYSANEATVHGLAITISFTIITFLHILL
HHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCEEEEEEEHHHHHHHHHHHHHH
GELLPKTVAIQNTETIALFISIPLFFFYYLFYPITFFLNEMTSFLLKLIGIEANKSRMMH
HHHCCCCEEECCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCC
SPEELMIIIEEQNKQGKIDQEEFQIIQNTFQFSEHQAKDVMTHRLSIIGIPHDTSMDSLI
CCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCHHHHH
SIIAEHHFSRYPIYEGSTDKIIGIIHVQTYLTWLSNSKKGRKEKVTAIMQPPIFVPEGLS
HHHHHHCCCCCCCCCCCCCCEEEEEEHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCCCCC
IEKVMQKLRENKQHMAIVIDEYGGVAGLLTLEDIIEEIFGQIRDETDDHETDPFPTQHSD
HHHHHHHHHCCCCEEEEEEECCCCEEHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
SFTIDGEAELDDLKEILVGVQEEEIKDIRTIAGFILGRLEDMPEEGSTISLQTGTLTVEK
CEEECCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECEEEEEE
MEGNKILSVRFTRVSLNNRAQSKK
ECCCEEEEEEEEEEECCCCCCCCC
>Mature Secondary Structure
MELIGFFIIVLLIFANGFFVSAEFALVSIRPSRLEELIKENKPLAFITKRAAQKLNDMLS
CHHHHHHHHHHHHHHCCCEEEEEEEEEEECHHHHHHHHHCCCCEEHHHHHHHHHHHHHHH
VCQVGITIASLLLGWVGEGYVSRWLIFLLEMFGYSANEATVHGLAITISFTIITFLHILL
HHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCEEEEEEEHHHHHHHHHHHHHH
GELLPKTVAIQNTETIALFISIPLFFFYYLFYPITFFLNEMTSFLLKLIGIEANKSRMMH
HHHCCCCEEECCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCC
SPEELMIIIEEQNKQGKIDQEEFQIIQNTFQFSEHQAKDVMTHRLSIIGIPHDTSMDSLI
CCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCHHHHH
SIIAEHHFSRYPIYEGSTDKIIGIIHVQTYLTWLSNSKKGRKEKVTAIMQPPIFVPEGLS
HHHHHHCCCCCCCCCCCCCCEEEEEEHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCCCCC
IEKVMQKLRENKQHMAIVIDEYGGVAGLLTLEDIIEEIFGQIRDETDDHETDPFPTQHSD
HHHHHHHHHCCCCEEEEEEECCCCEEHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
SFTIDGEAELDDLKEILVGVQEEEIKDIRTIAGFILGRLEDMPEEGSTISLQTGTLTVEK
CEEECCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECEEEEEE
MEGNKILSVRFTRVSLNNRAQSKK
ECCCEEEEEEEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377 [H]