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The map label for this gene is dfp

Identifier: 45658963

GI number: 45658963

Start: 3851393

End: 3852079

Strand: Reverse

Name: dfp

Synonym: LIC13141

Alternate gene names: 45658963

Gene position: 3852079-3851393 (Counterclockwise)

Preceding gene: 45658964

Following gene: 45658961

Centisome position: 90.06

GC content: 35.95

Gene sequence:

>687_bases
GTGAGATTTTCCAAAGCAATCATTACGTCTGGACCGACCATTGAATGGATCGATCCTGTGCGATATATTTCGAACGCTTC
TTCGGGTAAGATGGGTTTTCATATCGCCGAATCTGTTTCTAAATGGGTTTCTGAAGTCGTTTACATACACGGTCAAGTAT
TAGAAAATTATAAAAATCCTAAGGGTTCTAAAAGTATTGCTGTAGAAACCACATCCGATCTTTGCAACTCGGTTCTTGCG
GAGATTCAAACGGATACGATCCTAATTATGGCGGCGGCTCCTGTAGATTTTAGGCCTGCAAAAAGTGAAAAATCTAAAAT
TAAAAAAGAAGAAGGAAACGAAACTTTTGTTTTGGAACTAGTTAAAAATCCAGATATCTTAAAAACGGTAAGTTCTAAAA
TTGCTAAAGAAGAGATTTCCGGTTGTTGTTTGGTTGGGTTTGCTGCTGAAACGGATTTTTTAGAAGAATACGCTCAAAAC
AAACTGAAAAATAAAAATTTAGATTATATCATTGGTAACTACGTGGGCAAGAATGAAAAAGGTTTTGGCGAAGTCGATAC
TACGGTTTTTATTTATTCCGCTTTTGGGAAAGTCGCTCAAATTGGTCCTTTTTCTAAGGAAGTAATTTCCGATAAGATTG
TAGAGTTTTTAAAGATGGAAACTTCCAAACCTTTCGTAAAGTTTTAG

Upstream 100 bases:

>100_bases
TGTGGGGACGAAGGATATGGAAAGTTAGCCGAAATTTCTATAATACAAAAAATGATCTTAGATTTATACCAGAGAAATTT
TTAGATTCAGAGAAATTAAA

Downstream 100 bases:

>100_bases
TTGGGTGGAGTTTTCAATGATGTTTATTTATAATAATATTCTAATATATATTTGACTAAAATATTTATTAGAGCTATTGA
AGGATTTAACGTTCTTCTGT

Product: panthotenate metabolism flavoprotein

Products: NA

Alternate protein names: DNA/pantothenate metabolism flavoprotein; Phosphopantothenoylcysteine decarboxylase; PPCDC; CoaC; Phosphopantothenate--cysteine ligase; CoaB; PPC synthetase; PPCS; Phosphopantothenoylcysteine synthase [H]

Number of amino acids: Translated: 228; Mature: 228

Protein sequence:

>228_residues
MRFSKAIITSGPTIEWIDPVRYISNASSGKMGFHIAESVSKWVSEVVYIHGQVLENYKNPKGSKSIAVETTSDLCNSVLA
EIQTDTILIMAAAPVDFRPAKSEKSKIKKEEGNETFVLELVKNPDILKTVSSKIAKEEISGCCLVGFAAETDFLEEYAQN
KLKNKNLDYIIGNYVGKNEKGFGEVDTTVFIYSAFGKVAQIGPFSKEVISDKIVEFLKMETSKPFVKF

Sequences:

>Translated_228_residues
MRFSKAIITSGPTIEWIDPVRYISNASSGKMGFHIAESVSKWVSEVVYIHGQVLENYKNPKGSKSIAVETTSDLCNSVLA
EIQTDTILIMAAAPVDFRPAKSEKSKIKKEEGNETFVLELVKNPDILKTVSSKIAKEEISGCCLVGFAAETDFLEEYAQN
KLKNKNLDYIIGNYVGKNEKGFGEVDTTVFIYSAFGKVAQIGPFSKEVISDKIVEFLKMETSKPFVKF
>Mature_228_residues
MRFSKAIITSGPTIEWIDPVRYISNASSGKMGFHIAESVSKWVSEVVYIHGQVLENYKNPKGSKSIAVETTSDLCNSVLA
EIQTDTILIMAAAPVDFRPAKSEKSKIKKEEGNETFVLELVKNPDILKTVSSKIAKEEISGCCLVGFAAETDFLEEYAQN
KLKNKNLDYIIGNYVGKNEKGFGEVDTTVFIYSAFGKVAQIGPFSKEVISDKIVEFLKMETSKPFVKF

Specific function: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine [H]

COG id: COG0452

COG function: function code H; Phosphopantothenoylcysteine synthetase/decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PPC synthetase family [H]

Homologues:

Organism=Escherichia coli, GI87082301, Length=188, Percent_Identity=39.3617021276596, Blast_Score=112, Evalue=2e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005252
- InterPro:   IPR007085
- InterPro:   IPR003382 [H]

Pfam domain/function: PF04127 DFP; PF02441 Flavoprotein [H]

EC number: =4.1.1.36; =6.3.2.5 [H]

Molecular weight: Translated: 25271; Mature: 25271

Theoretical pI: Translated: 6.55; Mature: 6.55

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRFSKAIITSGPTIEWIDPVRYISNASSGKMGFHIAESVSKWVSEVVYIHGQVLENYKNP
CCCCCCEECCCCCEEHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
KGSKSIAVETTSDLCNSVLAEIQTDTILIMAAAPVDFRPAKSEKSKIKKEEGNETFVLEL
CCCCEEEEECHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCHHHHHHHHCCCCEEEEEE
VKNPDILKTVSSKIAKEEISGCCLVGFAAETDFLEEYAQNKLKNKNLDYIIGNYVGKNEK
ECCCHHHHHHHHHHHHHHHCCEEEEEECCCHHHHHHHHHHHHCCCCCCEEECCCCCCCCC
GFGEVDTTVFIYSAFGKVAQIGPFSKEVISDKIVEFLKMETSKPFVKF
CCCCCCHHEEEEHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MRFSKAIITSGPTIEWIDPVRYISNASSGKMGFHIAESVSKWVSEVVYIHGQVLENYKNP
CCCCCCEECCCCCEEHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
KGSKSIAVETTSDLCNSVLAEIQTDTILIMAAAPVDFRPAKSEKSKIKKEEGNETFVLEL
CCCCEEEEECHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCHHHHHHHHCCCCEEEEEE
VKNPDILKTVSSKIAKEEISGCCLVGFAAETDFLEEYAQNKLKNKNLDYIIGNYVGKNEK
ECCCHHHHHHHHHHHHHHHCCEEEEEECCCHHHHHHHHHHHHCCCCCCEEECCCCCCCCC
GFGEVDTTVFIYSAFGKVAQIGPFSKEVISDKIVEFLKMETSKPFVKF
CCCCCCHHEEEEHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]