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The map label for this gene is mvaB [H]

Identifier: 45658613

GI number: 45658613

Start: 3385822

End: 3386718

Strand: Reverse

Name: mvaB [H]

Synonym: LIC12782

Alternate gene names: 45658613

Gene position: 3386718-3385822 (Counterclockwise)

Preceding gene: 45658614

Following gene: 45658612

Centisome position: 79.18

GC content: 36.9

Gene sequence:

>897_bases
ATGGAAATAAAAATTACAGAAGTGGGGCCGCGTGATGGGCTACAAAATGAAAAATCTCCAGTTTCTACAGAGGTCAAAGC
GGAATTTATTCAACGTTTGGTTCGTGCTGGTTTAAAAAATATAGAAGCGACATCTTTTGTTAAAAAAGATTCGATTCCTC
AATTAGCGGATGCTACCGAACTCTCCGCCTTTCTGGATTTAAACGGTTCCGTTTCTTTTTCTGCTCTGACACCAAATCTT
AAAGGTTACGAAGCCGCAAAGAGTGCAGGTTACAAAGAAGTTGCGGTTTTTACAGCCGCTTCCGAATCGTTTACTAAAAA
AAACATCAATCGGACAATTTCTGAATCTATAGAAGGGTTTAAAGATATATTCAATTTTTCTAAAATAGATGGAATTCAAG
TAAGAGGTTATGTTTCTACTGTGATCGATTGTCCTTACGAAGGTAAGATGAATCCAAAGAAAGTATTAGAAGTTTCTAAA
ATTCTTTTGGATTTAGGTGCGTATGAAATTTCTCTGGGAGAAACTATAGGCACTGGAGTTCCTACAGAAGTAGAAAAACT
TTTAGAAGTCCTTTTGAAAGAAATTCCTGCCAATAAACTAGCAGGTCATTTTCATGATACATACGGAATGGCGATTGCAA
ATGTGGAAAAGGCCTATTCTATGGGTCTTCGTTCTTTTGATTCTTCTGCGGGTGGTTTAGGTGGATGTCCTTACGCAAAA
GGTGCTGCGGGAAATTTAGCCACAGATGATCTTGTATATTTTTTAGAAAAGTCTGGTATTTCTACTGGAATTGATCCAAA
CCTTTTGTGGGAAGCGTCTTTATTTATGGAAAAGTCTCTTTCGAGAGAATTACAATCTAGAACTTTTTTAGCGACTAAAA
AGAAAAGAGAGTCTTGA

Upstream 100 bases:

>100_bases
ATATACTCTTTTATAGCCCTGAGTAAAATAGCATTTTCGTAATCACCTCAGTTGTTATTTGACTTGCAGGTTTTTAGTAT
AAAGGTTGAATAAGAAGTAA

Downstream 100 bases:

>100_bases
ATCGATCTTCTCAAAAAATCAAAAGAGTATTAGAAAATTTATTTTTAGAATACCAAACATCGGATTATCTCAGATCTGAT
CCGGTTGAGTTTCCACATTT

Product: hydroxymethylglutaryl-CoA lyase

Products: NA

Alternate protein names: HL; HMG-CoA lyase; 3-hydroxy-3-methylglutarate-CoA lyase [H]

Number of amino acids: Translated: 298; Mature: 298

Protein sequence:

>298_residues
MEIKITEVGPRDGLQNEKSPVSTEVKAEFIQRLVRAGLKNIEATSFVKKDSIPQLADATELSAFLDLNGSVSFSALTPNL
KGYEAAKSAGYKEVAVFTAASESFTKKNINRTISESIEGFKDIFNFSKIDGIQVRGYVSTVIDCPYEGKMNPKKVLEVSK
ILLDLGAYEISLGETIGTGVPTEVEKLLEVLLKEIPANKLAGHFHDTYGMAIANVEKAYSMGLRSFDSSAGGLGGCPYAK
GAAGNLATDDLVYFLEKSGISTGIDPNLLWEASLFMEKSLSRELQSRTFLATKKKRES

Sequences:

>Translated_298_residues
MEIKITEVGPRDGLQNEKSPVSTEVKAEFIQRLVRAGLKNIEATSFVKKDSIPQLADATELSAFLDLNGSVSFSALTPNL
KGYEAAKSAGYKEVAVFTAASESFTKKNINRTISESIEGFKDIFNFSKIDGIQVRGYVSTVIDCPYEGKMNPKKVLEVSK
ILLDLGAYEISLGETIGTGVPTEVEKLLEVLLKEIPANKLAGHFHDTYGMAIANVEKAYSMGLRSFDSSAGGLGGCPYAK
GAAGNLATDDLVYFLEKSGISTGIDPNLLWEASLFMEKSLSRELQSRTFLATKKKRES
>Mature_298_residues
MEIKITEVGPRDGLQNEKSPVSTEVKAEFIQRLVRAGLKNIEATSFVKKDSIPQLADATELSAFLDLNGSVSFSALTPNL
KGYEAAKSAGYKEVAVFTAASESFTKKNINRTISESIEGFKDIFNFSKIDGIQVRGYVSTVIDCPYEGKMNPKKVLEVSK
ILLDLGAYEISLGETIGTGVPTEVEKLLEVLLKEIPANKLAGHFHDTYGMAIANVEKAYSMGLRSFDSSAGGLGGCPYAK
GAAGNLATDDLVYFLEKSGISTGIDPNLLWEASLFMEKSLSRELQSRTFLATKKKRES

Specific function: Involved in the catabolism of branched amino acids such as leucine (Probable) [H]

COG id: COG0119

COG function: function code E; Isopropylmalate/homocitrate/citramalate synthases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMG-CoA lyase family [H]

Homologues:

Organism=Homo sapiens, GI62198232, Length=293, Percent_Identity=52.2184300341297, Blast_Score=301, Evalue=5e-82,
Organism=Homo sapiens, GI109150427, Length=290, Percent_Identity=50, Blast_Score=296, Evalue=1e-80,
Organism=Homo sapiens, GI109150422, Length=290, Percent_Identity=50, Blast_Score=296, Evalue=1e-80,
Organism=Homo sapiens, GI260654708, Length=137, Percent_Identity=50.3649635036496, Blast_Score=140, Evalue=1e-33,
Organism=Caenorhabditis elegans, GI17510563, Length=294, Percent_Identity=45.2380952380952, Blast_Score=261, Evalue=4e-70,
Organism=Drosophila melanogaster, GI24582381, Length=292, Percent_Identity=46.5753424657534, Blast_Score=280, Evalue=8e-76,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000138
- InterPro:   IPR000891 [H]

Pfam domain/function: PF00682 HMGL-like [H]

EC number: =4.1.3.4 [H]

Molecular weight: Translated: 32331; Mature: 32331

Theoretical pI: Translated: 5.55; Mature: 5.55

Prosite motif: PS50991 PYR_CT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEIKITEVGPRDGLQNEKSPVSTEVKAEFIQRLVRAGLKNIEATSFVKKDSIPQLADATE
CEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCHHHHHH
LSAFLDLNGSVSFSALTPNLKGYEAAKSAGYKEVAVFTAASESFTKKNINRTISESIEGF
HHHHEECCCCEEEEEECCCCCCHHHHHHCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHH
KDIFNFSKIDGIQVRGYVSTVIDCPYEGKMNPKKVLEVSKILLDLGAYEISLGETIGTGV
HHHHHHHHCCCEEEHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCEEECCCHHCCCC
PTEVEKLLEVLLKEIPANKLAGHFHDTYGMAIANVEKAYSMGLRSFDSSAGGLGGCPYAK
CHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
GAAGNLATDDLVYFLEKSGISTGIDPNLLWEASLFMEKSLSRELQSRTFLATKKKRES
CCCCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MEIKITEVGPRDGLQNEKSPVSTEVKAEFIQRLVRAGLKNIEATSFVKKDSIPQLADATE
CEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCHHHHHH
LSAFLDLNGSVSFSALTPNLKGYEAAKSAGYKEVAVFTAASESFTKKNINRTISESIEGF
HHHHEECCCCEEEEEECCCCCCHHHHHHCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHH
KDIFNFSKIDGIQVRGYVSTVIDCPYEGKMNPKKVLEVSKILLDLGAYEISLGETIGTGV
HHHHHHHHCCCEEEHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCEEECCCHHCCCC
PTEVEKLLEVLLKEIPANKLAGHFHDTYGMAIANVEKAYSMGLRSFDSSAGGLGGCPYAK
CHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
GAAGNLATDDLVYFLEKSGISTGIDPNLLWEASLFMEKSLSRELQSRTFLATKKKRES
CCCCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2687236; 2656635; 1637819 [H]