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The map label for this gene is pgsA

Identifier: 45658384

GI number: 45658384

Start: 3080758

End: 3081510

Strand: Reverse

Name: pgsA

Synonym: LIC12542

Alternate gene names: 45658384

Gene position: 3081510-3080758 (Counterclockwise)

Preceding gene: 45658385

Following gene: 45658383

Centisome position: 72.05

GC content: 37.45

Gene sequence:

>753_bases
TTGGGTATGAACAAGGTTATTTTCAATATTCCTAATATTCTTACTATGTTAAGAGTTGCTGCGGTGCCTTTTTTCGTATG
GTTTTTATTTCAAAAGGAATTGGAATATCATATCGCGGCTCTGATCCTTTTTTCAGTGGCTTCTTTAACTGATTTGATAG
ACGGTTATCTGGCTCGAAAGTGGAACCAGGAAACGGAGTTCGGTAAATTTTTAGATCCTCTTGCGGATAAGATCATCGTT
ACTGGTTGTTTTATTACGTTTATATTTTTACAAGAACAGATCGAATTTTGGATGGTTTGTTTAATTATTGGAAGAGATAT
GCTGATCACTTCTCTTCGTTATCTTGCGATTCGCCAAGGACAGTCGATCCGTACTACGATGCTTGGAAAGGTAAAGACTG
TCTTTCAAATGGGGGCCATCGTTTTGATCCTTGTATTTTTTATTTTGATTTCTAGCAAAAAGAGGATTTTGATCAACCAA
GCATACGCAACCGGAAAAGCGAATGGTCTCACCGTATTTGAATTTGCGACCAATAACGCAATTCAGTTTTTCCGAAATTT
GGACCAAAATAACGGACTAGGAGACGTGGTTTTTGGTTTAGGAACGTTTGTCCCTTATTGGGGAATGTTGGTCACTACCA
CAATTACTGTGATTTCCGGAATCCGTTATTTAGTTTCCAATAGTAAAGTTCTTTATCCTTCTAATCTCAAAGGGATGTTT
CAAAAAAATGGAACCAAGAGCAGCCGTTCTTAA

Upstream 100 bases:

>100_bases
AAATGGATGAAGTAGTCTACGTGGACGATGTTTCTCTCCTTCCGGGTAGGATCGGAAAAGTGCGGATCGATTCCTTTTAC
GAATACGACATGAATGGAAC

Downstream 100 bases:

>100_bases
ACTCATCGAACATAAACATTTAACCGCTTTAGAAGCGGAATCTTTTATGAACCATGTAATGAAAGGAGAGGTTTCTGAAA
TTTTACTTTCTTCTTTTTTG

Product: phosphatidylglycerophosphate synthase

Products: NA

Alternate protein names: Phosphatidylglycerophosphate synthase; PGP synthase [H]

Number of amino acids: Translated: 250; Mature: 249

Protein sequence:

>250_residues
MGMNKVIFNIPNILTMLRVAAVPFFVWFLFQKELEYHIAALILFSVASLTDLIDGYLARKWNQETEFGKFLDPLADKIIV
TGCFITFIFLQEQIEFWMVCLIIGRDMLITSLRYLAIRQGQSIRTTMLGKVKTVFQMGAIVLILVFFILISSKKRILINQ
AYATGKANGLTVFEFATNNAIQFFRNLDQNNGLGDVVFGLGTFVPYWGMLVTTTITVISGIRYLVSNSKVLYPSNLKGMF
QKNGTKSSRS

Sequences:

>Translated_250_residues
MGMNKVIFNIPNILTMLRVAAVPFFVWFLFQKELEYHIAALILFSVASLTDLIDGYLARKWNQETEFGKFLDPLADKIIV
TGCFITFIFLQEQIEFWMVCLIIGRDMLITSLRYLAIRQGQSIRTTMLGKVKTVFQMGAIVLILVFFILISSKKRILINQ
AYATGKANGLTVFEFATNNAIQFFRNLDQNNGLGDVVFGLGTFVPYWGMLVTTTITVISGIRYLVSNSKVLYPSNLKGMF
QKNGTKSSRS
>Mature_249_residues
GMNKVIFNIPNILTMLRVAAVPFFVWFLFQKELEYHIAALILFSVASLTDLIDGYLARKWNQETEFGKFLDPLADKIIVT
GCFITFIFLQEQIEFWMVCLIIGRDMLITSLRYLAIRQGQSIRTTMLGKVKTVFQMGAIVLILVFFILISSKKRILINQA
YATGKANGLTVFEFATNNAIQFFRNLDQNNGLGDVVFGLGTFVPYWGMLVTTTITVISGIRYLVSNSKVLYPSNLKGMFQ
KNGTKSSRS

Specific function: This protein catalyzes the committed step to the synthesis of the acidic phospholipids [H]

COG id: COG0558

COG function: function code I; Phosphatidylglycerophosphate synthase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CDP-alcohol phosphatidyltransferase class-I family [H]

Homologues:

Organism=Homo sapiens, GI188536108, Length=120, Percent_Identity=35.8333333333333, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI10092647, Length=120, Percent_Identity=35.8333333333333, Blast_Score=76, Evalue=3e-14,
Organism=Escherichia coli, GI1788220, Length=143, Percent_Identity=41.2587412587413, Blast_Score=108, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI71984838, Length=195, Percent_Identity=27.1794871794872, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI71984834, Length=195, Percent_Identity=27.1794871794872, Blast_Score=68, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6320059, Length=167, Percent_Identity=34.1317365269461, Blast_Score=76, Evalue=6e-15,
Organism=Drosophila melanogaster, GI24650130, Length=195, Percent_Identity=26.1538461538462, Blast_Score=72, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24650126, Length=195, Percent_Identity=26.1538461538462, Blast_Score=72, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24650128, Length=195, Percent_Identity=26.1538461538462, Blast_Score=72, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000462
- InterPro:   IPR004570 [H]

Pfam domain/function: PF01066 CDP-OH_P_transf [H]

EC number: =2.7.8.5 [H]

Molecular weight: Translated: 28307; Mature: 28176

Theoretical pI: Translated: 10.23; Mature: 10.23

Prosite motif: PS00379 CDP_ALCOHOL_P_TRANSF

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HCCCCCCCCC
>Mature Secondary Structure 
GMNKVIFNIPNILTMLRVAAVPFFVWFLFQKELEYHIAALILFSVASLTDLIDGYLARK
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
WNQETEFGKFLDPLADKIIVTGCFITFIFLQEQIEFWMVCLIIGRDMLITSLRYLAIRQG
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
QSIRTTMLGKVKTVFQMGAIVLILVFFILISSKKRILINQAYATGKANGLTVFEFATNNA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEHHHHCCCCCCEEEEEECCCHH
IQFFRNLDQNNGLGDVVFGLGTFVPYWGMLVTTTITVISGIRYLVSNSKVLYPSNLKGMF
HHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCHHHH
QKNGTKSSRS
HCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]