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The map label for this gene is mutL

Identifier: 45658356

GI number: 45658356

Start: 3041807

End: 3043600

Strand: Reverse

Name: mutL

Synonym: LIC12514

Alternate gene names: 45658356

Gene position: 3043600-3041807 (Counterclockwise)

Preceding gene: 45658357

Following gene: 45658355

Centisome position: 71.16

GC content: 37.96

Gene sequence:

>1794_bases
TTGGAAACATCCATGGGAAAAATTCAAGAACTGAGCCCGGAACTAATCAATCAAATTGCGGCCGGAGAAGTCATAGAATC
TGCTCATTCTGTAGTCAAAGAACTAATGGAAAATTCTATGGATGCGAGTGCCACTCAGGTGGATGTAGAGTCCAAGGACG
GAGGACTTTCGCTTTTAAGAATTACAGATAACGGAACCGGAATTGAACCAGAAGATTTAGAGCCCGCTCTAAAAAGACAT
GCTACGAGTAAGATTCAAGATTATAAAGACCTAGAAAGTGTATTGAGTTATGGATTTAGAGGAGAAGCCTTAGCTTCGAT
CGCTTCGGTATCTCGACTAACGTTAGAGAGCGGCACAAAGGAACAGAAAACAGCCTGGAAGACTCGTTCTGTTGCTGGAA
AGATCTCCGAAAAAGAAGAAATCCCTGGATTTATCGGAACTAAAATACTTGTAGAAGAATTATTCTTTAATACTCCCGTT
CGAAGAAAATTTTTAAAATCCATTCGCTCCGAAGATAAAAAGATCAGAGACCGAGTTACCACCCAAGCGCTTGCAAGAGA
GGACGTTCGTTTTCGACTTTTTCAAGATGGAAAAGAAGTATTTGTTCTTCCAACTAGAGAAAATAAAAAAGAAAGAATTA
TAGATTTATTCGGTGAGAATTTTAGAGATCATCTATTAGAAGTAAGTCTAGAACGGGGAGGAATCCAAGCCACGGGTTAT
ATTAGTGATCCTGACTTCTACAAGTCTAATCGAACCGGACAATTTATATTTATCAATGGAAGGCCGATTGAGATCAAATA
TAGTTCTGTTCTATTAAAAAAAGCTTATGATGAATTATTACCTCCAAACGGACATCCCTATTGTTTTTTATTTTTTGAAA
TTGATCCGTCCAGAGTAGATGTAAACGTACATCCCGCAAAAAGAGAAATTCGTTTTTTAGATGAGGATGGATTTAACGGA
TTTTTTCTCGCACTGATTCAAAAGGAACTTAGATCTAGCACTCCGGTCAGTTTTTTAGAGTTGAAAAAACGACTCTTAAA
ACCGGCTCCTGAAACTCATTCTACTACTTCTTTTTACCAAGCTCGTTCTTCTGGAAAAAATCCTTTGTTAGGTCGTGAAC
TCTTTTCCGGAGTTTCCAAACAGGAGGGATTTGAATTGGATCGAATGGGGCCAGGAGTTTCTTTATCTGAACTGACGGAT
GAGAGGGTAAAACATTCTTCCTTTGTACCTAAAAAACATTTCGGAGTATTGTTTGAAACGTTTATACTTGCAGAAGCCGA
GGACGGATTTTATATTATAGATCAACATACCGCACACGAAAGAATACGATACGAAGAAGTTTTAAGAAAACTAGAAAAAA
GAAATTACGGAATTCAACCATTATTGACTCCAATTCGGATCGACGTATCTAAACAGGAACAAGAAGACATTTTAAATCGA
AAAAAAGAATATGAGGAAGTTGGAATATTCTTAGATCCTTTAGGAGAAGACAGTATAGTTTTAAGAGAAATTCCTGCTTA
TATGGAGCCAGGACAAGAAAAAGAAATTGTACTTGACTTTTTAAATAGAACCGAAGGAAAAGAAACCAGCGAACCGGAAT
TATACGACCTTATGGCCAAATGTGTGGCTTGTAGATCCGCGATTAAAAAAGGGGATCAACTTTCCGATCCTATCTTGGCG
GAAATTTTAAATAGACTGAGTTATTGCGAAAATCCATCCCGTTGTCCACACGGAAGGCCTACCCTAGTAAAGTTGAGCAG
AGATGACCTCGAAAGAATGTTCCACAGAAAATGA

Upstream 100 bases:

>100_bases
TTTTGTTTTGAACCTGTTACTGATTGATCAAGTTGAAACAATTTTATTTTAATAGAATTGATAGATCCCGTTCTTGACAG
GTTTGAGAATAGTTCCGACA

Downstream 100 bases:

>100_bases
AGAAGTTACCGGAAAAGAACCGGATAGAGTTGTAAGAAAATTATTTCGACAAACGTTAGTCGGAATTGTGATTCTCGTAT
TAGGAGTAGTTTTTCTTGCA

Product: DNA mismatch repair protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 597; Mature: 597

Protein sequence:

>597_residues
METSMGKIQELSPELINQIAAGEVIESAHSVVKELMENSMDASATQVDVESKDGGLSLLRITDNGTGIEPEDLEPALKRH
ATSKIQDYKDLESVLSYGFRGEALASIASVSRLTLESGTKEQKTAWKTRSVAGKISEKEEIPGFIGTKILVEELFFNTPV
RRKFLKSIRSEDKKIRDRVTTQALAREDVRFRLFQDGKEVFVLPTRENKKERIIDLFGENFRDHLLEVSLERGGIQATGY
ISDPDFYKSNRTGQFIFINGRPIEIKYSSVLLKKAYDELLPPNGHPYCFLFFEIDPSRVDVNVHPAKREIRFLDEDGFNG
FFLALIQKELRSSTPVSFLELKKRLLKPAPETHSTTSFYQARSSGKNPLLGRELFSGVSKQEGFELDRMGPGVSLSELTD
ERVKHSSFVPKKHFGVLFETFILAEAEDGFYIIDQHTAHERIRYEEVLRKLEKRNYGIQPLLTPIRIDVSKQEQEDILNR
KKEYEEVGIFLDPLGEDSIVLREIPAYMEPGQEKEIVLDFLNRTEGKETSEPELYDLMAKCVACRSAIKKGDQLSDPILA
EILNRLSYCENPSRCPHGRPTLVKLSRDDLERMFHRK

Sequences:

>Translated_597_residues
METSMGKIQELSPELINQIAAGEVIESAHSVVKELMENSMDASATQVDVESKDGGLSLLRITDNGTGIEPEDLEPALKRH
ATSKIQDYKDLESVLSYGFRGEALASIASVSRLTLESGTKEQKTAWKTRSVAGKISEKEEIPGFIGTKILVEELFFNTPV
RRKFLKSIRSEDKKIRDRVTTQALAREDVRFRLFQDGKEVFVLPTRENKKERIIDLFGENFRDHLLEVSLERGGIQATGY
ISDPDFYKSNRTGQFIFINGRPIEIKYSSVLLKKAYDELLPPNGHPYCFLFFEIDPSRVDVNVHPAKREIRFLDEDGFNG
FFLALIQKELRSSTPVSFLELKKRLLKPAPETHSTTSFYQARSSGKNPLLGRELFSGVSKQEGFELDRMGPGVSLSELTD
ERVKHSSFVPKKHFGVLFETFILAEAEDGFYIIDQHTAHERIRYEEVLRKLEKRNYGIQPLLTPIRIDVSKQEQEDILNR
KKEYEEVGIFLDPLGEDSIVLREIPAYMEPGQEKEIVLDFLNRTEGKETSEPELYDLMAKCVACRSAIKKGDQLSDPILA
EILNRLSYCENPSRCPHGRPTLVKLSRDDLERMFHRK
>Mature_597_residues
METSMGKIQELSPELINQIAAGEVIESAHSVVKELMENSMDASATQVDVESKDGGLSLLRITDNGTGIEPEDLEPALKRH
ATSKIQDYKDLESVLSYGFRGEALASIASVSRLTLESGTKEQKTAWKTRSVAGKISEKEEIPGFIGTKILVEELFFNTPV
RRKFLKSIRSEDKKIRDRVTTQALAREDVRFRLFQDGKEVFVLPTRENKKERIIDLFGENFRDHLLEVSLERGGIQATGY
ISDPDFYKSNRTGQFIFINGRPIEIKYSSVLLKKAYDELLPPNGHPYCFLFFEIDPSRVDVNVHPAKREIRFLDEDGFNG
FFLALIQKELRSSTPVSFLELKKRLLKPAPETHSTTSFYQARSSGKNPLLGRELFSGVSKQEGFELDRMGPGVSLSELTD
ERVKHSSFVPKKHFGVLFETFILAEAEDGFYIIDQHTAHERIRYEEVLRKLEKRNYGIQPLLTPIRIDVSKQEQEDILNR
KKEYEEVGIFLDPLGEDSIVLREIPAYMEPGQEKEIVLDFLNRTEGKETSEPELYDLMAKCVACRSAIKKGDQLSDPILA
EILNRLSYCENPSRCPHGRPTLVKLSRDDLERMFHRK

Specific function: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-bindi

COG id: COG0323

COG function: function code L; DNA mismatch repair enzyme (predicted ATPase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA mismatch repair mutL/hexB family [H]

Homologues:

Organism=Homo sapiens, GI4557757, Length=323, Percent_Identity=37.7708978328173, Blast_Score=211, Evalue=1e-54,
Organism=Homo sapiens, GI4505913, Length=342, Percent_Identity=31.2865497076023, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI310128478, Length=342, Percent_Identity=31.2865497076023, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI4505911, Length=319, Percent_Identity=30.7210031347962, Blast_Score=129, Evalue=5e-30,
Organism=Homo sapiens, GI189458898, Length=319, Percent_Identity=30.7210031347962, Blast_Score=129, Evalue=7e-30,
Organism=Homo sapiens, GI189458896, Length=311, Percent_Identity=30.2250803858521, Blast_Score=116, Evalue=6e-26,
Organism=Homo sapiens, GI263191589, Length=222, Percent_Identity=33.3333333333333, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI91992162, Length=264, Percent_Identity=33.3333333333333, Blast_Score=114, Evalue=3e-25,
Organism=Homo sapiens, GI91992160, Length=264, Percent_Identity=33.3333333333333, Blast_Score=114, Evalue=4e-25,
Organism=Homo sapiens, GI310128480, Length=306, Percent_Identity=29.4117647058824, Blast_Score=112, Evalue=1e-24,
Organism=Escherichia coli, GI1790612, Length=513, Percent_Identity=33.3333333333333, Blast_Score=249, Evalue=3e-67,
Organism=Caenorhabditis elegans, GI71991825, Length=323, Percent_Identity=36.8421052631579, Blast_Score=196, Evalue=3e-50,
Organism=Caenorhabditis elegans, GI17562796, Length=403, Percent_Identity=26.0545905707196, Blast_Score=129, Evalue=3e-30,
Organism=Saccharomyces cerevisiae, GI6323819, Length=317, Percent_Identity=38.1703470031546, Blast_Score=217, Evalue=5e-57,
Organism=Saccharomyces cerevisiae, GI6324247, Length=408, Percent_Identity=30.1470588235294, Blast_Score=152, Evalue=1e-37,
Organism=Saccharomyces cerevisiae, GI6325093, Length=724, Percent_Identity=23.4806629834254, Blast_Score=115, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6323063, Length=200, Percent_Identity=29, Blast_Score=68, Evalue=5e-12,
Organism=Drosophila melanogaster, GI17136968, Length=316, Percent_Identity=35.126582278481, Blast_Score=194, Evalue=1e-49,
Organism=Drosophila melanogaster, GI17136970, Length=357, Percent_Identity=28.5714285714286, Blast_Score=130, Evalue=2e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR002099
- InterPro:   IPR013507
- InterPro:   IPR014762
- InterPro:   IPR020667
- InterPro:   IPR014763
- InterPro:   IPR014790
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF01119 DNA_mis_repair; PF02518 HATPase_c; PF08676 MutL_C [H]

EC number: NA

Molecular weight: Translated: 68089; Mature: 68089

Theoretical pI: Translated: 5.89; Mature: 5.89

Prosite motif: PS00058 DNA_MISMATCH_REPAIR_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
METSMGKIQELSPELINQIAAGEVIESAHSVVKELMENSMDASATQVDVESKDGGLSLLR
CCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCEEEEE
ITDNGTGIEPEDLEPALKRHATSKIQDYKDLESVLSYGFRGEALASIASVSRLTLESGTK
EECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCC
EQKTAWKTRSVAGKISEKEEIPGFIGTKILVEELFFNTPVRRKFLKSIRSEDKKIRDRVT
HHHHHHHHHHHHHCCCCHHHCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
TQALAREDVRFRLFQDGKEVFVLPTRENKKERIIDLFGENFRDHLLEVSLERGGIQATGY
HHHHHHHHHHHHEEECCCEEEEEECCCCHHHHHHHHHCCHHHHHHHHHHHHCCCEEEEEE
ISDPDFYKSNRTGQFIFINGRPIEIKYSSVLLKKAYDELLPPNGHPYCFLFFEIDPSRVD
CCCCCHHCCCCCCEEEEECCEEEEEEHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCEEE
VNVHPAKREIRFLDEDGFNGFFLALIQKELRSSTPVSFLELKKRLLKPAPETHSTTSFYQ
EEECCCHHHHEEECCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCHHHHHH
ARSSGKNPLLGRELFSGVSKQEGFELDRMGPGVSLSELTDERVKHSSFVPKKHFGVLFET
HHHCCCCCCCHHHHHCCCCHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHH
FILAEAEDGFYIIDQHTAHERIRYEEVLRKLEKRNYGIQPLLTPIRIDVSKQEQEDILNR
HHHEECCCCEEEEECCCHHHHHHHHHHHHHHHHCCCCCCCCCCCEEECCCCHHHHHHHHH
KKEYEEVGIFLDPLGEDSIVLREIPAYMEPGQEKEIVLDFLNRTEGKETSEPELYDLMAK
HHHHHHCCEEECCCCCCCCHHHHCCHHHCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHH
CVACRSAIKKGDQLSDPILAEILNRLSYCENPSRCPHGRPTLVKLSRDDLERMFHRK
HHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCEEEECHHHHHHHHCCC
>Mature Secondary Structure
METSMGKIQELSPELINQIAAGEVIESAHSVVKELMENSMDASATQVDVESKDGGLSLLR
CCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCEEEEE
ITDNGTGIEPEDLEPALKRHATSKIQDYKDLESVLSYGFRGEALASIASVSRLTLESGTK
EECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCC
EQKTAWKTRSVAGKISEKEEIPGFIGTKILVEELFFNTPVRRKFLKSIRSEDKKIRDRVT
HHHHHHHHHHHHHCCCCHHHCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
TQALAREDVRFRLFQDGKEVFVLPTRENKKERIIDLFGENFRDHLLEVSLERGGIQATGY
HHHHHHHHHHHHEEECCCEEEEEECCCCHHHHHHHHHCCHHHHHHHHHHHHCCCEEEEEE
ISDPDFYKSNRTGQFIFINGRPIEIKYSSVLLKKAYDELLPPNGHPYCFLFFEIDPSRVD
CCCCCHHCCCCCCEEEEECCEEEEEEHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCEEE
VNVHPAKREIRFLDEDGFNGFFLALIQKELRSSTPVSFLELKKRLLKPAPETHSTTSFYQ
EEECCCHHHHEEECCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCHHHHHH
ARSSGKNPLLGRELFSGVSKQEGFELDRMGPGVSLSELTDERVKHSSFVPKKHFGVLFET
HHHCCCCCCCHHHHHCCCCHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHH
FILAEAEDGFYIIDQHTAHERIRYEEVLRKLEKRNYGIQPLLTPIRIDVSKQEQEDILNR
HHHEECCCCEEEEECCCHHHHHHHHHHHHHHHHCCCCCCCCCCCEEECCCCHHHHHHHHH
KKEYEEVGIFLDPLGEDSIVLREIPAYMEPGQEKEIVLDFLNRTEGKETSEPELYDLMAK
HHHHHHCCEEECCCCCCCCHHHHCCHHHCCCCCHHHHHHHHHCCCCCCCCCCHHHHHHHH
CVACRSAIKKGDQLSDPILAEILNRLSYCENPSRCPHGRPTLVKLSRDDLERMFHRK
HHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCEEEECHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA