| Definition | Leptospira interrogans serovar Copenhageni str. Fiocruz L1-130 chromosome chromosome I, complete sequence. |
|---|---|
| Accession | NC_005823 |
| Length | 4,277,185 |
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The map label for this gene is pbp1a
Identifier: 45658319
GI number: 45658319
Start: 3000626
End: 3003064
Strand: Reverse
Name: pbp1a
Synonym: LIC12477
Alternate gene names: 45658319
Gene position: 3003064-3000626 (Counterclockwise)
Preceding gene: 45658320
Following gene: 45658318
Centisome position: 70.21
GC content: 41.57
Gene sequence:
>2439_bases ATGAAAAGTATCGGACTTCATAGAACTTCTAAAACCTTGCTCGTTATAGCCCTCTTAGGAGGACTTTTTTTTGGTTATAT TCTTTCGGAGGTAGACGAAGGAGGAGAATTAGCGATGCTTGCTTCTTACCAACCCACAACTCCTACTAGACTCTACGACA TCAATGGAGTTGTATTCGCAGAACTTTATAAACACAAACAACAACTACTGAAATACCAAGACATTCCACCTCACGTTGTG CAGGCGTTTTTATCTGTGGAAGATAATAACTTTTTCAATCACTTCGGGATCGATTTTATGGCGATACTTAGAGCTGGGAT TGTAAATGTAATTTCGGGTAGAATCAAACAAGGGGGGTCCACCCTTACGCAGCAGCTCGCCAAAACGGTTTTACAAAATA GAAAACGATCCTTTGCGAGAAAATTTATAGAAGCGTTATTTACGCTTCAGATAGAACAAGAATATTCAAAAGAAGAAATA TTAGAAATTTATTTTAATCTTATTTATTTAGGACACGGGACCACGGGACTGGCTTCTGCCGCGGATGTATATTTTCAAAA AGACGTAAGCGACTTAGACGTAGCCGAAGCGGCGCTTCTTGCTAGATTGCCTAAGGCTCCTGTAAAATATTCTCCCTTTA AAAACCCAGCCATTTCTAAGGGGGCACATTTAAGTGTTTTAAGGCTTATGGCGGAACAAGGTTATATCCCTACGGATAGG ATTCAAACCATTCACGACGATTTTTGGAATAAATATTGGCCTGTTGTCATCACTCAATCTCCTTCTCAATCCACTTGGGG AAATCGTCTGAATAAGGCCCCTCATTTTACGGAGTATGTTCGCCAGAAACTAGAAAAGGAGCTCGGAGAAGATAAGGTTT ATACAGGTGGATTGAAAGTATATACTACTCTTGACGCTCGCAAACAAGAGATCGCTCAGGATGAATTATCCAAAGCGATT AAAAAACACGATGACCTCGTTTCTGGGATTACCGTCAATTATTCCGGTGGAGCCGATAGGGGTCTTGTAGGTCTTTATTA TCTGATGGGTTCTGTGTTTCCGATCGGAATGCCTTTTATTAGTAAGTTAGACGACAAAGCGAACTATAGGGTGGCTTTAG AACGTGAACTTATAGACGCAGTAGACATTCTTACCATTTTAACTCCTGGAGAAAACGAGTCGGCTGCGATTTCGGAATTT CAAAAACAAACCGCGATCTTCGGAAAAAATCTACACGTAGAAGGAGCAGCGATTACGATCGAACCTTCTACTGGTTATAT TCAAACCATGGTAGGAGGATACGAATTCACTCCAAAGAACCAGTTCAATCGAGCTACGATGGCAAGACGTCAAACTGGTT CCGCATTTAAACCATTTGTTTATGGAGCTGCAATTCAAGAAAGAGTCGTAGGAAGTGGGACTGGAATTATGGACGCACCT CTTACCACTTTAACGGAAGAAGGAGAAGGTTGGTCACCTCAGGATTTTGACGGAGACTTTTTAGGAATGGTTCCTTTGTC CAGGGCTCTATCTTTATCGCTTAACATCGTTTCGGTGCAGGTTTTCTTACGAACTGGTCCCGATGCGGTCATCGATTTTT CTTCCAGACTTTTAGGAGTCAATCCGAATCGTTTTCCGCCTAGCCCTGCTTTGGCGCTTGGAATTGCAGAGTTGACACCT TTGGAAATGGCTCTTGGATATGCTACTATCGCTAATAATGGTAGAAGGGTAATTCCGTTTTCTGTTCGTTATGTGATCGA TCAGAGTGGAAATATAATTTATAACGAAGAAGTAAAGATACAAGAAGAGTTACAAAGGCAAGCAAAGGATGGAAGTATCC AAGTAATTTCGGAAGGGACCGCCTACATTCTAAAAAAAATGTTAACCAATGTAGCGATGGCCGGAACTGCAGCAATGGGA CTTAGAGATCCGGAAAAAGGAAATTATAGAGGAATCGCCGCAGGAAAAACGGGTTCCACTTCTTCTTTTACAAACGCTTG GTATTGTGGGTTTGATCCAAATTATACGACCGTAATTTGGTTGGGGTTTGATAAAAGTTCTATTTCCCTCGGAAGAGGAC AGGCCGCTTCTGTGCTTGCGGTTCCGATTTGGGGAAGAATGTACAATCGATTTTATGGAGGACAAAACTATCCTTCTTTT GGGGAAGATGTAATACCGGAAGAAGTACAAGGAGGAGGTACTTGTGCTTACAACGGACTTTCACCAAAACCGGGAGTATG TCCCGTAACTCAGAATCTGACTCTCAAACCGATCACAGTAGCAGGAGTGACCAAGGCTGTGATGGGCAATCGTCAGTGTG ATGGAGAAAGAGATCATCATAAGTCTATGGATTTTAGAGAATTCTTACAAAAAGAATATCAGATTAGCGATGAAGAATTA GGAAAAACGGATCGAAAATTCAAACCCAGAACAGAATAA
Upstream 100 bases:
>100_bases TGGATCTCATTCTTGAGGAAGCTAGGGCGCACTCGGTTTCGCTCGGCAATTCTTCCATGAAAATAGAACTCGCCGTCGAA GGAAACGTATATAAACTAAC
Downstream 100 bases:
>100_bases TTTCGTTTTGGAGAATTTCGTTTACAGAATTTTTTCATTTAGAAGGATTGAAACCGAGATGGCGTTGTCTCTCGAAAGGA ATCATTCATGTCTGTAGAAA
Product: Pbp1A
Products: NA
Alternate protein names: PBP-1a; PBP1a; Penicillin-insensitive transglycosylase; Peptidoglycan TGase; Penicillin-sensitive transpeptidase; DD-transpeptidase [H]
Number of amino acids: Translated: 812; Mature: 812
Protein sequence:
>812_residues MKSIGLHRTSKTLLVIALLGGLFFGYILSEVDEGGELAMLASYQPTTPTRLYDINGVVFAELYKHKQQLLKYQDIPPHVV QAFLSVEDNNFFNHFGIDFMAILRAGIVNVISGRIKQGGSTLTQQLAKTVLQNRKRSFARKFIEALFTLQIEQEYSKEEI LEIYFNLIYLGHGTTGLASAADVYFQKDVSDLDVAEAALLARLPKAPVKYSPFKNPAISKGAHLSVLRLMAEQGYIPTDR IQTIHDDFWNKYWPVVITQSPSQSTWGNRLNKAPHFTEYVRQKLEKELGEDKVYTGGLKVYTTLDARKQEIAQDELSKAI KKHDDLVSGITVNYSGGADRGLVGLYYLMGSVFPIGMPFISKLDDKANYRVALERELIDAVDILTILTPGENESAAISEF QKQTAIFGKNLHVEGAAITIEPSTGYIQTMVGGYEFTPKNQFNRATMARRQTGSAFKPFVYGAAIQERVVGSGTGIMDAP LTTLTEEGEGWSPQDFDGDFLGMVPLSRALSLSLNIVSVQVFLRTGPDAVIDFSSRLLGVNPNRFPPSPALALGIAELTP LEMALGYATIANNGRRVIPFSVRYVIDQSGNIIYNEEVKIQEELQRQAKDGSIQVISEGTAYILKKMLTNVAMAGTAAMG LRDPEKGNYRGIAAGKTGSTSSFTNAWYCGFDPNYTTVIWLGFDKSSISLGRGQAASVLAVPIWGRMYNRFYGGQNYPSF GEDVIPEEVQGGGTCAYNGLSPKPGVCPVTQNLTLKPITVAGVTKAVMGNRQCDGERDHHKSMDFREFLQKEYQISDEEL GKTDRKFKPRTE
Sequences:
>Translated_812_residues MKSIGLHRTSKTLLVIALLGGLFFGYILSEVDEGGELAMLASYQPTTPTRLYDINGVVFAELYKHKQQLLKYQDIPPHVV QAFLSVEDNNFFNHFGIDFMAILRAGIVNVISGRIKQGGSTLTQQLAKTVLQNRKRSFARKFIEALFTLQIEQEYSKEEI LEIYFNLIYLGHGTTGLASAADVYFQKDVSDLDVAEAALLARLPKAPVKYSPFKNPAISKGAHLSVLRLMAEQGYIPTDR IQTIHDDFWNKYWPVVITQSPSQSTWGNRLNKAPHFTEYVRQKLEKELGEDKVYTGGLKVYTTLDARKQEIAQDELSKAI KKHDDLVSGITVNYSGGADRGLVGLYYLMGSVFPIGMPFISKLDDKANYRVALERELIDAVDILTILTPGENESAAISEF QKQTAIFGKNLHVEGAAITIEPSTGYIQTMVGGYEFTPKNQFNRATMARRQTGSAFKPFVYGAAIQERVVGSGTGIMDAP LTTLTEEGEGWSPQDFDGDFLGMVPLSRALSLSLNIVSVQVFLRTGPDAVIDFSSRLLGVNPNRFPPSPALALGIAELTP LEMALGYATIANNGRRVIPFSVRYVIDQSGNIIYNEEVKIQEELQRQAKDGSIQVISEGTAYILKKMLTNVAMAGTAAMG LRDPEKGNYRGIAAGKTGSTSSFTNAWYCGFDPNYTTVIWLGFDKSSISLGRGQAASVLAVPIWGRMYNRFYGGQNYPSF GEDVIPEEVQGGGTCAYNGLSPKPGVCPVTQNLTLKPITVAGVTKAVMGNRQCDGERDHHKSMDFREFLQKEYQISDEEL GKTDRKFKPRTE >Mature_812_residues MKSIGLHRTSKTLLVIALLGGLFFGYILSEVDEGGELAMLASYQPTTPTRLYDINGVVFAELYKHKQQLLKYQDIPPHVV QAFLSVEDNNFFNHFGIDFMAILRAGIVNVISGRIKQGGSTLTQQLAKTVLQNRKRSFARKFIEALFTLQIEQEYSKEEI LEIYFNLIYLGHGTTGLASAADVYFQKDVSDLDVAEAALLARLPKAPVKYSPFKNPAISKGAHLSVLRLMAEQGYIPTDR IQTIHDDFWNKYWPVVITQSPSQSTWGNRLNKAPHFTEYVRQKLEKELGEDKVYTGGLKVYTTLDARKQEIAQDELSKAI KKHDDLVSGITVNYSGGADRGLVGLYYLMGSVFPIGMPFISKLDDKANYRVALERELIDAVDILTILTPGENESAAISEF QKQTAIFGKNLHVEGAAITIEPSTGYIQTMVGGYEFTPKNQFNRATMARRQTGSAFKPFVYGAAIQERVVGSGTGIMDAP LTTLTEEGEGWSPQDFDGDFLGMVPLSRALSLSLNIVSVQVFLRTGPDAVIDFSSRLLGVNPNRFPPSPALALGIAELTP LEMALGYATIANNGRRVIPFSVRYVIDQSGNIIYNEEVKIQEELQRQAKDGSIQVISEGTAYILKKMLTNVAMAGTAAMG LRDPEKGNYRGIAAGKTGSTSSFTNAWYCGFDPNYTTVIWLGFDKSSISLGRGQAASVLAVPIWGRMYNRFYGGQNYPSF GEDVIPEEVQGGGTCAYNGLSPKPGVCPVTQNLTLKPITVAGVTKAVMGNRQCDGERDHHKSMDFREFLQKEYQISDEEL GKTDRKFKPRTE
Specific function: Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal
COG id: COG5009
COG function: function code M; Membrane carboxypeptidase/penicillin-binding protein
Gene ontology:
Cell location: Cell inner membrane; Single-pass type II membrane protein [H]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: In the C-terminal section; belongs to the transpeptidase family [H]
Homologues:
Organism=Escherichia coli, GI87082258, Length=289, Percent_Identity=32.5259515570934, Blast_Score=165, Evalue=1e-41, Organism=Escherichia coli, GI1786343, Length=281, Percent_Identity=31.3167259786477, Blast_Score=122, Evalue=1e-28, Organism=Escherichia coli, GI1788867, Length=276, Percent_Identity=30.0724637681159, Blast_Score=114, Evalue=3e-26, Organism=Escherichia coli, GI1789601, Length=164, Percent_Identity=34.7560975609756, Blast_Score=89, Evalue=8e-19,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR012338 - InterPro: IPR001264 - InterPro: IPR011816 - InterPro: IPR001460 [H]
Pfam domain/function: PF00912 Transgly; PF00905 Transpeptidase [H]
EC number: 3.4.-.-; 2.4.2.-
Molecular weight: Translated: 89670; Mature: 89670
Theoretical pI: Translated: 6.96; Mature: 6.96
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.5 %Cys (Translated Protein) 2.1 %Met (Translated Protein) 2.6 %Cys+Met (Translated Protein) 0.5 %Cys (Mature Protein) 2.1 %Met (Mature Protein) 2.6 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MKSIGLHRTSKTLLVIALLGGLFFGYILSEVDEGGELAMLASYQPTTPTRLYDINGVVFA CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCEEEECCCHHHH ELYKHKQQLLKYQDIPPHVVQAFLSVEDNNFFNHFGIDFMAILRAGIVNVISGRIKQGGS HHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCHHCCHHHHHHHHHHHHHHHHHHHHCCCH TLTQQLAKTVLQNRKRSFARKFIEALFTLQIEQEYSKEEILEIYFNLIYLGHGTTGLASA HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHEECCCCCCHHHH ADVYFQKDVSDLDVAEAALLARLPKAPVKYSPFKNPAISKGAHLSVLRLMAEQGYIPTDR HHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCHHH IQTIHDDFWNKYWPVVITQSPSQSTWGNRLNKAPHFTEYVRQKLEKELGEDKVYTGGLKV HHHHHHHHCCCCCCEEEECCCCCCHHHHHCCCCCCHHHHHHHHHHHHHCCCCEEECCEEE YTTLDARKQEIAQDELSKAIKKHDDLVSGITVNYSGGADRGLVGLYYLMGSVFPIGMPFI EEECCHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCHHHHHHHHHHHHHCCCCHHH SKLDDKANYRVALERELIDAVDILTILTPGENESAAISEFQKQTAIFGKNLHVEGAAITI HHCCCCCCEEEEEHHHHHHHHHHHEEECCCCCCHHHHHHHHHHHHHHCCCEEECCEEEEE EPSTGYIQTMVGGYEFTPKNQFNRATMARRQTGSAFKPFVYGAAIQERVVGSGTGIMDAP ECCCCCHHHHHCCEEECCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCCC LTTLTEEGEGWSPQDFDGDFLGMVPLSRALSLSLNIVSVQVFLRTGPDAVIDFSSRLLGV HHHHHCCCCCCCCCCCCCCEEEHHHHHHHHEEEEEEEEEEEEEECCCCCEEECCCCEECC NPNRFPPSPALALGIAELTPLEMALGYATIANNGRRVIPFSVRYVIDQSGNIIYNEEVKI CCCCCCCCHHHHHHHHHCCHHHHHHHHHEECCCCCEEEEEEEEEEEECCCCEEECCCCCH QEELQRQAKDGSIQVISEGTAYILKKMLTNVAMAGTAAMGLRDPEKGNYRGIAAGKTGST HHHHHHHCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCC SSFTNAWYCGFDPNYTTVIWLGFDKSSISLGRGQAASVLAVPIWGRMYNRFYGGQNYPSF CCCCCCEEECCCCCCEEEEEEECCCCCCCCCCCCCCEEEEEHHHHHHHHHHCCCCCCCCC GEDVIPEEVQGGGTCAYNGLSPKPGVCPVTQNLTLKPITVAGVTKAVMGNRQCDGERDHH CCCCCCHHHCCCCEEEECCCCCCCCCCCCCCCCEECEEEHHHHHHHHHCCCCCCCCCHHH KSMDFREFLQKEYQISDEELGKTDRKFKPRTE CCCCHHHHHHHHHCCCHHHCCCCCCCCCCCCC >Mature Secondary Structure MKSIGLHRTSKTLLVIALLGGLFFGYILSEVDEGGELAMLASYQPTTPTRLYDINGVVFA CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCEEEECCCHHHH ELYKHKQQLLKYQDIPPHVVQAFLSVEDNNFFNHFGIDFMAILRAGIVNVISGRIKQGGS HHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCHHCCHHHHHHHHHHHHHHHHHHHHCCCH TLTQQLAKTVLQNRKRSFARKFIEALFTLQIEQEYSKEEILEIYFNLIYLGHGTTGLASA HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHEECCCCCCHHHH ADVYFQKDVSDLDVAEAALLARLPKAPVKYSPFKNPAISKGAHLSVLRLMAEQGYIPTDR HHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCHHH IQTIHDDFWNKYWPVVITQSPSQSTWGNRLNKAPHFTEYVRQKLEKELGEDKVYTGGLKV HHHHHHHHCCCCCCEEEECCCCCCHHHHHCCCCCCHHHHHHHHHHHHHCCCCEEECCEEE YTTLDARKQEIAQDELSKAIKKHDDLVSGITVNYSGGADRGLVGLYYLMGSVFPIGMPFI EEECCHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCHHHHHHHHHHHHHCCCCHHH SKLDDKANYRVALERELIDAVDILTILTPGENESAAISEFQKQTAIFGKNLHVEGAAITI HHCCCCCCEEEEEHHHHHHHHHHHEEECCCCCCHHHHHHHHHHHHHHCCCEEECCEEEEE EPSTGYIQTMVGGYEFTPKNQFNRATMARRQTGSAFKPFVYGAAIQERVVGSGTGIMDAP ECCCCCHHHHHCCEEECCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCCC LTTLTEEGEGWSPQDFDGDFLGMVPLSRALSLSLNIVSVQVFLRTGPDAVIDFSSRLLGV HHHHHCCCCCCCCCCCCCCEEEHHHHHHHHEEEEEEEEEEEEEECCCCCEEECCCCEECC NPNRFPPSPALALGIAELTPLEMALGYATIANNGRRVIPFSVRYVIDQSGNIIYNEEVKI CCCCCCCCHHHHHHHHHCCHHHHHHHHHEECCCCCEEEEEEEEEEEECCCCEEECCCCCH QEELQRQAKDGSIQVISEGTAYILKKMLTNVAMAGTAAMGLRDPEKGNYRGIAAGKTGST HHHHHHHCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCC SSFTNAWYCGFDPNYTTVIWLGFDKSSISLGRGQAASVLAVPIWGRMYNRFYGGQNYPSF CCCCCCEEECCCCCCEEEEEEECCCCCCCCCCCCCCEEEEEHHHHHHHHHHCCCCCCCCC GEDVIPEEVQGGGTCAYNGLSPKPGVCPVTQNLTLKPITVAGVTKAVMGNRQCDGERDHH CCCCCCHHHCCCCEEEECCCCCCCCCCCCCCCCEECEEEHHHHHHHHHCCCCCCCCCHHH KSMDFREFLQKEYQISDEELGKTDRKFKPRTE CCCCHHHHHHHHHCCCHHHCCCCCCCCCCCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 6.0
TargetDB status: NA
Availability: NA
References: NA