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The map label for this gene is ugd

Identifier: 45658142

GI number: 45658142

Start: 2768357

End: 2769667

Strand: Reverse

Name: ugd

Synonym: LIC12294

Alternate gene names: 45658142

Gene position: 2769667-2768357 (Counterclockwise)

Preceding gene: 45658143

Following gene: 45658138

Centisome position: 64.75

GC content: 39.21

Gene sequence:

>1311_bases
ATGAAAGTTTGTGTGATTGGAAGCGGTTATGTAGGTCTTGTCGCGGGTGCTTGTTTTGCGGAATATGGAAATCATGTAAT
TTGCGTAGATAAGGATGAAACTAAAATTGCAAATCTTAAAAAAGGAATCATTCCTATTTATGAGCCGGGGCTTTCTGAAC
TCGTTTTGAACAACTGGAAAGAAAAAAGATTAGAGTTTACAGTTTCTCTCAAAGAAGGGGTGGAAAAGTCGGATATTATT
TTTATTGCTGTGGGAACTCCCACTCTACCGGACGGTTCTTCTGATCTTTCTGCTGTTTTTGCAGTAGCAAAGGAAATCGG
TAAGTCCATCAACGGATACAAGGTAATCGTTGATAAGTCTACAGTTCCGGTCGGAACTGCGGCCAAAGTTAAAACCATCA
TCGCAAACGAAACTAAAGAAGAATTCGACGTGGTTTCCAATCCAGAATTTTTAAAGGAAGGCGCAGCGATTGAAGACTTT
ATGCGTCCCGAAAGAGTAGTGATCGGTTCTGAAACTCAAAAAGCAGGGGATTTAATTGCACAACTGTATGCTCCTTTTGT
TCTAAACGGAAATCCTATTTTGAGAATGGGAGTGGTTTCAGCCGAGCTTACGAAATACGCCTGTAACGCGTTTCTTGCGA
CTAAAATTTCTTTTGCAAATGAAATCGCTAATCTTTGTGAAGCCGTAGGTGGAAATTACGAAGACGTTCGTAAGGGAATG
GGAACCGATTCCAGAATCGGTAGGCAGTTTTTATACGCAGGAATTGGATACGGAGGTTCCTGTTTTCCCAAGGACGTTCG
AGCTTTGATCAAAACTTCTGAAGATGAAGGAGCTCCTCTTCAGATCATTCGTAAAGTGGAAGAGGTCAATGAATCTCAAA
AACTTAGACTCTATGAGAAAATTATAAAGTTCTATGGAGAATCTGGTCTTTCTGGAAAGACGTTTGCGGTTTGGGGGCTT
TCTTTTAAACCAGGAACGGACGACATGAGGGAGGCTCCTTCAATTCCTTTACTTTTAAAATTACATGATAAAAATGTAAA
GTTACGGGTTTATGATCCGGTTTCTAAAGAAACGTCTTCTATTTATTTTGAAGGGAAAGTAGAATATTCTGTGGACGCCT
ATTCTGCTTTGAAAGGTGCGGATGCTCTTTTACTTTTAACCGAGTGGAGAGAATTTAGAGAGCCCGATTTTTTAAAGATC
AAAGGGCTATTAAAAAATAAGGTTATCTTTGACGGTAGAAATCAATATTCTCCTGATCTGATGAAAAAAGAAGGCTTTCA
ATATTTCTCTATTGGTAAACCTAATGTTTGA

Upstream 100 bases:

>100_bases
GGTTGCTTGGCTTCCGGTGCAAAGTAAACTTCAAAAAGACGTTTCTGATTGATTTATTTTTCTTTCTCAGTCCGGAAAGT
TCGGAATCCTGGTTCTCAAT

Downstream 100 bases:

>100_bases
TTTTTTTTAGGTGCTTCTATAAAATTTAAAGATAGTTGTCTTCAAATTTACGAATTGTTCTGATTTCGGGTTTGTGGTTT
TTTCGTTCAAGTCCGGAAAT

Product: UDP-glucose dehydrogenase

Products: NA

Alternate protein names: UDP-Glc dehydrogenase; UDP-GlcDH; UDPGDH [H]

Number of amino acids: Translated: 436; Mature: 436

Protein sequence:

>436_residues
MKVCVIGSGYVGLVAGACFAEYGNHVICVDKDETKIANLKKGIIPIYEPGLSELVLNNWKEKRLEFTVSLKEGVEKSDII
FIAVGTPTLPDGSSDLSAVFAVAKEIGKSINGYKVIVDKSTVPVGTAAKVKTIIANETKEEFDVVSNPEFLKEGAAIEDF
MRPERVVIGSETQKAGDLIAQLYAPFVLNGNPILRMGVVSAELTKYACNAFLATKISFANEIANLCEAVGGNYEDVRKGM
GTDSRIGRQFLYAGIGYGGSCFPKDVRALIKTSEDEGAPLQIIRKVEEVNESQKLRLYEKIIKFYGESGLSGKTFAVWGL
SFKPGTDDMREAPSIPLLLKLHDKNVKLRVYDPVSKETSSIYFEGKVEYSVDAYSALKGADALLLLTEWREFREPDFLKI
KGLLKNKVIFDGRNQYSPDLMKKEGFQYFSIGKPNV

Sequences:

>Translated_436_residues
MKVCVIGSGYVGLVAGACFAEYGNHVICVDKDETKIANLKKGIIPIYEPGLSELVLNNWKEKRLEFTVSLKEGVEKSDII
FIAVGTPTLPDGSSDLSAVFAVAKEIGKSINGYKVIVDKSTVPVGTAAKVKTIIANETKEEFDVVSNPEFLKEGAAIEDF
MRPERVVIGSETQKAGDLIAQLYAPFVLNGNPILRMGVVSAELTKYACNAFLATKISFANEIANLCEAVGGNYEDVRKGM
GTDSRIGRQFLYAGIGYGGSCFPKDVRALIKTSEDEGAPLQIIRKVEEVNESQKLRLYEKIIKFYGESGLSGKTFAVWGL
SFKPGTDDMREAPSIPLLLKLHDKNVKLRVYDPVSKETSSIYFEGKVEYSVDAYSALKGADALLLLTEWREFREPDFLKI
KGLLKNKVIFDGRNQYSPDLMKKEGFQYFSIGKPNV
>Mature_436_residues
MKVCVIGSGYVGLVAGACFAEYGNHVICVDKDETKIANLKKGIIPIYEPGLSELVLNNWKEKRLEFTVSLKEGVEKSDII
FIAVGTPTLPDGSSDLSAVFAVAKEIGKSINGYKVIVDKSTVPVGTAAKVKTIIANETKEEFDVVSNPEFLKEGAAIEDF
MRPERVVIGSETQKAGDLIAQLYAPFVLNGNPILRMGVVSAELTKYACNAFLATKISFANEIANLCEAVGGNYEDVRKGM
GTDSRIGRQFLYAGIGYGGSCFPKDVRALIKTSEDEGAPLQIIRKVEEVNESQKLRLYEKIIKFYGESGLSGKTFAVWGL
SFKPGTDDMREAPSIPLLLKLHDKNVKLRVYDPVSKETSSIYFEGKVEYSVDAYSALKGADALLLLTEWREFREPDFLKI
KGLLKNKVIFDGRNQYSPDLMKKEGFQYFSIGKPNV

Specific function: Unknown

COG id: COG1004

COG function: function code M; Predicted UDP-glucose 6-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4507813, Length=462, Percent_Identity=37.2294372294372, Blast_Score=263, Evalue=4e-70,
Organism=Homo sapiens, GI296040438, Length=364, Percent_Identity=37.9120879120879, Blast_Score=211, Evalue=1e-54,
Organism=Homo sapiens, GI296040443, Length=311, Percent_Identity=38.2636655948553, Blast_Score=179, Evalue=3e-45,
Organism=Escherichia coli, GI1788340, Length=374, Percent_Identity=29.4117647058824, Blast_Score=162, Evalue=4e-41,
Organism=Escherichia coli, GI48994968, Length=415, Percent_Identity=25.7831325301205, Blast_Score=112, Evalue=6e-26,
Organism=Caenorhabditis elegans, GI17560350, Length=460, Percent_Identity=36.0869565217391, Blast_Score=258, Evalue=5e-69,
Organism=Drosophila melanogaster, GI17136908, Length=462, Percent_Identity=36.1471861471861, Blast_Score=262, Evalue=3e-70,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR021157
- InterPro:   IPR016040
- InterPro:   IPR017476
- InterPro:   IPR014027
- InterPro:   IPR014026
- InterPro:   IPR014028
- InterPro:   IPR001732 [H]

Pfam domain/function: PF00984 UDPG_MGDP_dh; PF03720 UDPG_MGDP_dh_C; PF03721 UDPG_MGDP_dh_N [H]

EC number: =1.1.1.22 [H]

Molecular weight: Translated: 47973; Mature: 47973

Theoretical pI: Translated: 6.57; Mature: 6.57

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVCVIGSGYVGLVAGACFAEYGNHVICVDKDETKIANLKKGIIPIYEPGLSELVLNNWK
CEEEEEECCHHHHHHHHHHHHHCCEEEEEECCCHHHHHHHHCCCCCCCCCHHHHHHCCCH
EKRLEFTVSLKEGVEKSDIIFIAVGTPTLPDGSSDLSAVFAVAKEIGKSINGYKVIVDKS
HHHEEEEEEHHHCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHCCCCCCEEEEEECC
TVPVGTAAKVKTIIANETKEEFDVVSNPEFLKEGAAIEDFMRPERVVIGSETQKAGDLIA
CCCCCCHHHHHHHHHCCCHHHHCCCCCHHHHHCCCHHHHHCCCCEEEECCCCHHHHHHHH
QLYAPFVLNGNPILRMGVVSAELTKYACNAFLATKISFANEIANLCEAVGGNYEDVRKGM
HHHCCEEECCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCC
GTDSRIGRQFLYAGIGYGGSCFPKDVRALIKTSEDEGAPLQIIRKVEEVNESQKLRLYEK
CCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHCCCHHHHHHHHH
IIKFYGESGLSGKTFAVWGLSFKPGTDDMREAPSIPLLLKLHDKNVKLRVYDPVSKETSS
HHHHHCCCCCCCCEEEEEEEEECCCCCHHHHCCCCCEEEEEECCCEEEEEECCCCCCCCE
IYFEGKVEYSVDAYSALKGADALLLLTEWREFREPDFLKIKGLLKNKVIFDGRNQYSPDL
EEEEEEEEEECHHHHHHCCCCEEEEEEHHHHHCCCCEEEEHHHHCCCEEECCCCCCCCHH
MKKEGFQYFSIGKPNV
HHHCCCEEEECCCCCC
>Mature Secondary Structure
MKVCVIGSGYVGLVAGACFAEYGNHVICVDKDETKIANLKKGIIPIYEPGLSELVLNNWK
CEEEEEECCHHHHHHHHHHHHHCCEEEEEECCCHHHHHHHHCCCCCCCCCHHHHHHCCCH
EKRLEFTVSLKEGVEKSDIIFIAVGTPTLPDGSSDLSAVFAVAKEIGKSINGYKVIVDKS
HHHEEEEEEHHHCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHCCCCCCEEEEEECC
TVPVGTAAKVKTIIANETKEEFDVVSNPEFLKEGAAIEDFMRPERVVIGSETQKAGDLIA
CCCCCCHHHHHHHHHCCCHHHHCCCCCHHHHHCCCHHHHHCCCCEEEECCCCHHHHHHHH
QLYAPFVLNGNPILRMGVVSAELTKYACNAFLATKISFANEIANLCEAVGGNYEDVRKGM
HHHCCEEECCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCC
GTDSRIGRQFLYAGIGYGGSCFPKDVRALIKTSEDEGAPLQIIRKVEEVNESQKLRLYEK
CCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHCCCHHHHHHHHH
IIKFYGESGLSGKTFAVWGLSFKPGTDDMREAPSIPLLLKLHDKNVKLRVYDPVSKETSS
HHHHHCCCCCCCCEEEEEEEEECCCCCHHHHCCCCCEEEEEECCCEEEEEECCCCCCCCE
IYFEGKVEYSVDAYSALKGADALLLLTEWREFREPDFLKIKGLLKNKVIFDGRNQYSPDL
EEEEEEEEEECHHHHHHCCCCEEEEEEHHHHHCCCCEEEEHHHHCCCEEECCCCCCCCHH
MKKEGFQYFSIGKPNV
HHHCCCEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]