BacMap

Definition	Leptospira interrogans serovar Copenhageni str. Fiocruz L1-130 chromosome chromosome I, complete sequence.
Accession	NC_005823
Length	4,277,185

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The map label for this gene is abcA [H]

Identifier: 45658143

GI number: 45658143

Start: 2769716

End: 2771014

Strand: Reverse

Name: abcA [H]

Synonym: LIC12295

Alternate gene names: 45658143

Gene position: 2771014-2769716 (Counterclockwise)

Preceding gene: 45658144

Following gene: 45658142

Centisome position: 64.79

GC content: 36.1

Gene sequence:

>1299_bases
TTGAGTTTAAAAGTAGAAAATTTAAGTAAGGTTTACTTTGGATTTAGCGGACCTTTACAAAGAATTTTGAATGTTTTATC
TCTTGGCTTTTTGGGAAATGACGTTAAATACGACGCTCTTAAAAACGTAAATTTTGAAGTTTCTTCGGGTGAGATTGTTG
GTTTGATCGGCAGAAATGGTGCCGGAAAATCTACACTTTTAAAAGTTCTCACTGGAGTTTCCTCTTATTCATCTGGAAAA
ATCTTAAAAACTGGTTCTATTCGTTCCATTTTAGAATTAGGAGTTGGTTTTAACCCGGAACTTTCCGGAGAAGAAAATTT
ATACTACAACGGACTTGTCTGGGGGCTTAGTCCAAACGAGATTCGGTTTTCTATGGCCGAAATTTTTGAATTTTCCGGTC
TAACAGAATTTAAGAATATTCCAATTAAACAATATTCTTCCGGAATGGTGATGCGTTTGGGTTTTGCACTTGCTACTTTT
TCAAGGCCCGACATTCTCATCGTGGATGAGGCTTTGGCGGTAGGGGACGCAAGTTTTCAACAAAAATGTCTGAGACGTTT
TCGTTCTTTCCAAGAACAAGGAACCATAACTTTAATTGTAAGTCATGATCTTGAACTTTTAAAATCTGTATGTTCTAGAG
TTTTGATTTTAGAAAAAGGAAGACTGGTTTTTGACGGCGATCCTGTAAAAGGTTTTAGAGAGTATATGCAAATAATTGCA
AGTTCTACAAGTGAACAAGAGACAATTTTTCCGGTTCAAAAAGATTCGGTTGTGAAAAGTCTTTCCGTGGATTTAGATCT
TGTAGGACCTTATTTAAAAAATTCACCGTTACAAGATATACAACAATTTCCAGTCAGAATCAATCGAAGTAGTGCAGAAG
AGGATTTTAAATATAAGGATCGTACAAATTTAAAATTTTTTTCAGTAGGTTGCGAAGTAGAAATTTCAATTCATGTAATA
TTCAAAAATGAGATTCCAGATCTTACGGTAGGTTTTCATATAGACGATTCTCGTGGAATTCGCGTTTTTGGAACAAACAC
GTTTCATCTCGGAAATTCTCTAAAAAACGTTCGAGCGGGGGAATCCGTTACGGCGAAATTCCGACTTCCTTTGAATTTTT
CTGCCGGTAAATATTCTTTGGGGATTGCGTTACACGAAGGTGATAATCACGTAGGAAATAATTATCTTTGGAAAGATGGG
ATTCTTTCCTTTGAACTGGAACGTTTAGATCTGCCTAAATTTGAAGGGGTTGCTTGGCTTCCGGTGCAAAGTAAACTTCA
AAAAGACGTTTCTGATTGA

Upstream 100 bases:

>100_bases
CAGTTTTTCATTGGAAAGAATTTATTCCTTCCTTGATTGTATTTCCTTTGATTGGAGTTTTAAGTCGTTCTAAATTTCAT
TCTGTTATTTTGGATCATCT

Downstream 100 bases:

>100_bases
TTTATTTTTCTTTCTCAGTCCGGAAAGTTCGGAATCCTGGTTCTCAATATGAAAGTTTGTGTGATTGGAAGCGGTTATGT
AGGTCTTGTCGCGGGTGCTT

Product: ABC transporter ATP-binding protein

Products: ADP; phosphate; L-glutamine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 432; Mature: 431

Protein sequence:

>432_residues
MSLKVENLSKVYFGFSGPLQRILNVLSLGFLGNDVKYDALKNVNFEVSSGEIVGLIGRNGAGKSTLLKVLTGVSSYSSGK
ILKTGSIRSILELGVGFNPELSGEENLYYNGLVWGLSPNEIRFSMAEIFEFSGLTEFKNIPIKQYSSGMVMRLGFALATF
SRPDILIVDEALAVGDASFQQKCLRRFRSFQEQGTITLIVSHDLELLKSVCSRVLILEKGRLVFDGDPVKGFREYMQIIA
SSTSEQETIFPVQKDSVVKSLSVDLDLVGPYLKNSPLQDIQQFPVRINRSSAEEDFKYKDRTNLKFFSVGCEVEISIHVI
FKNEIPDLTVGFHIDDSRGIRVFGTNTFHLGNSLKNVRAGESVTAKFRLPLNFSAGKYSLGIALHEGDNHVGNNYLWKDG
ILSFELERLDLPKFEGVAWLPVQSKLQKDVSD

Sequences:

>Translated_432_residues
MSLKVENLSKVYFGFSGPLQRILNVLSLGFLGNDVKYDALKNVNFEVSSGEIVGLIGRNGAGKSTLLKVLTGVSSYSSGK
ILKTGSIRSILELGVGFNPELSGEENLYYNGLVWGLSPNEIRFSMAEIFEFSGLTEFKNIPIKQYSSGMVMRLGFALATF
SRPDILIVDEALAVGDASFQQKCLRRFRSFQEQGTITLIVSHDLELLKSVCSRVLILEKGRLVFDGDPVKGFREYMQIIA
SSTSEQETIFPVQKDSVVKSLSVDLDLVGPYLKNSPLQDIQQFPVRINRSSAEEDFKYKDRTNLKFFSVGCEVEISIHVI
FKNEIPDLTVGFHIDDSRGIRVFGTNTFHLGNSLKNVRAGESVTAKFRLPLNFSAGKYSLGIALHEGDNHVGNNYLWKDG
ILSFELERLDLPKFEGVAWLPVQSKLQKDVSD
>Mature_431_residues
SLKVENLSKVYFGFSGPLQRILNVLSLGFLGNDVKYDALKNVNFEVSSGEIVGLIGRNGAGKSTLLKVLTGVSSYSSGKI
LKTGSIRSILELGVGFNPELSGEENLYYNGLVWGLSPNEIRFSMAEIFEFSGLTEFKNIPIKQYSSGMVMRLGFALATFS
RPDILIVDEALAVGDASFQQKCLRRFRSFQEQGTITLIVSHDLELLKSVCSRVLILEKGRLVFDGDPVKGFREYMQIIAS
STSEQETIFPVQKDSVVKSLSVDLDLVGPYLKNSPLQDIQQFPVRINRSSAEEDFKYKDRTNLKFFSVGCEVEISIHVIF
KNEIPDLTVGFHIDDSRGIRVFGTNTFHLGNSLKNVRAGESVTAKFRLPLNFSAGKYSLGIALHEGDNHVGNNYLWKDGI
LSFELERLDLPKFEGVAWLPVQSKLQKDVSD

Specific function: Influences the expression of the surface array protein gene (vapA). May have both regulatory and transport activities [H]

COG id: COG1134

COG function: function code GM; ABC-type polysaccharide/polyol phosphate transport system, ATPase component

Gene ontology:

Cell location: Inner Membrane-Associated [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transporter domain [H]

Homologues:

Organism=Homo sapiens, GI27436953, Length=192, Percent_Identity=29.1666666666667, Blast_Score=91, Evalue=3e-18,
Organism=Homo sapiens, GI153792144, Length=200, Percent_Identity=30, Blast_Score=90, Evalue=3e-18,
Organism=Homo sapiens, GI6005701, Length=192, Percent_Identity=30.2083333333333, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI30795238, Length=195, Percent_Identity=29.7435897435897, Blast_Score=88, Evalue=2e-17,
Organism=Homo sapiens, GI27881501, Length=195, Percent_Identity=29.7435897435897, Blast_Score=88, Evalue=2e-17,
Organism=Homo sapiens, GI27477115, Length=192, Percent_Identity=29.1666666666667, Blast_Score=87, Evalue=3e-17,
Organism=Homo sapiens, GI27262624, Length=207, Percent_Identity=28.9855072463768, Blast_Score=86, Evalue=9e-17,
Organism=Homo sapiens, GI27262626, Length=207, Percent_Identity=28.9855072463768, Blast_Score=86, Evalue=9e-17,
Organism=Homo sapiens, GI31657092, Length=205, Percent_Identity=27.3170731707317, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI105990541, Length=231, Percent_Identity=27.2727272727273, Blast_Score=81, Evalue=2e-15,
Organism=Homo sapiens, GI45446740, Length=237, Percent_Identity=27.4261603375527, Blast_Score=76, Evalue=8e-14,
Organism=Homo sapiens, GI47078218, Length=237, Percent_Identity=27.4261603375527, Blast_Score=75, Evalue=9e-14,
Organism=Homo sapiens, GI150417984, Length=237, Percent_Identity=26.5822784810127, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI116734710, Length=202, Percent_Identity=26.2376237623762, Blast_Score=71, Evalue=3e-12,
Organism=Homo sapiens, GI21536376, Length=216, Percent_Identity=25, Blast_Score=68, Evalue=2e-11,
Organism=Escherichia coli, GI1787029, Length=206, Percent_Identity=28.1553398058252, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI87081709, Length=224, Percent_Identity=27.6785714285714, Blast_Score=90, Evalue=3e-19,
Organism=Escherichia coli, GI1789873, Length=200, Percent_Identity=32.5, Blast_Score=89, Evalue=6e-19,
Organism=Escherichia coli, GI87081834, Length=208, Percent_Identity=30.2884615384615, Blast_Score=82, Evalue=7e-17,
Organism=Escherichia coli, GI48994943, Length=242, Percent_Identity=26.4462809917355, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI1787547, Length=241, Percent_Identity=27.8008298755187, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1788761, Length=214, Percent_Identity=26.1682242990654, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI87081782, Length=206, Percent_Identity=30.0970873786408, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI1787758, Length=207, Percent_Identity=26.0869565217391, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI87081791, Length=201, Percent_Identity=26.865671641791, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI1787370, Length=209, Percent_Identity=22.9665071770335, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1787089, Length=210, Percent_Identity=28.0952380952381, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1788506, Length=226, Percent_Identity=26.9911504424779, Blast_Score=76, Evalue=5e-15,
Organism=Escherichia coli, GI1786703, Length=200, Percent_Identity=33, Blast_Score=75, Evalue=7e-15,
Organism=Escherichia coli, GI1786398, Length=206, Percent_Identity=25.7281553398058, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI1786319, Length=196, Percent_Identity=25, Blast_Score=72, Evalue=9e-14,
Organism=Escherichia coli, GI1790467, Length=201, Percent_Identity=25.3731343283582, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1789672, Length=208, Percent_Identity=24.5192307692308, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1788165, Length=220, Percent_Identity=27.7272727272727, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI48995001, Length=204, Percent_Identity=29.4117647058824, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1788897, Length=206, Percent_Identity=25.2427184466019, Blast_Score=70, Evalue=4e-13,
Organism=Escherichia coli, GI1788225, Length=208, Percent_Identity=25, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI48994883, Length=236, Percent_Identity=26.271186440678, Blast_Score=69, Evalue=6e-13,
Organism=Escherichia coli, GI1789032, Length=206, Percent_Identity=23.7864077669903, Blast_Score=69, Evalue=8e-13,
Organism=Escherichia coli, GI1786563, Length=191, Percent_Identity=26.7015706806283, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI87082267, Length=230, Percent_Identity=25.2173913043478, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1788210, Length=206, Percent_Identity=24.7572815533981, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1789593, Length=208, Percent_Identity=26.4423076923077, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1789864, Length=222, Percent_Identity=28.3783783783784, Blast_Score=65, Evalue=8e-12,
Organism=Escherichia coli, GI1787712, Length=196, Percent_Identity=27.5510204081633, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17565586, Length=220, Percent_Identity=28.6363636363636, Blast_Score=92, Evalue=8e-19,
Organism=Caenorhabditis elegans, GI115533608, Length=198, Percent_Identity=29.2929292929293, Blast_Score=89, Evalue=6e-18,
Organism=Caenorhabditis elegans, GI71983510, Length=253, Percent_Identity=25.6916996047431, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI71983523, Length=253, Percent_Identity=25.6916996047431, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI71983516, Length=253, Percent_Identity=25.6916996047431, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI71988343, Length=217, Percent_Identity=30.4147465437788, Blast_Score=69, Evalue=5e-12,
Organism=Saccharomyces cerevisiae, GI6322640, Length=223, Percent_Identity=27.3542600896861, Blast_Score=69, Evalue=1e-12,
Organism=Drosophila melanogaster, GI221500365, Length=199, Percent_Identity=28.643216080402, Blast_Score=77, Evalue=3e-14,
Organism=Drosophila melanogaster, GI116007184, Length=199, Percent_Identity=28.643216080402, Blast_Score=77, Evalue=3e-14,
Organism=Drosophila melanogaster, GI28574150, Length=202, Percent_Identity=25.7425742574257, Blast_Score=75, Evalue=9e-14,
Organism=Drosophila melanogaster, GI28573571, Length=199, Percent_Identity=27.1356783919598, Blast_Score=75, Evalue=9e-14,
Organism=Drosophila melanogaster, GI28573573, Length=199, Percent_Identity=27.1356783919598, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI116007328, Length=202, Percent_Identity=25.7425742574257, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24648314, Length=194, Percent_Identity=29.3814432989691, Blast_Score=73, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24666092, Length=281, Percent_Identity=24.5551601423488, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24650853, Length=202, Percent_Identity=27.7227722772277, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24643674, Length=197, Percent_Identity=25.3807106598985, Blast_Score=70, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24650855, Length=202, Percent_Identity=27.7227722772277, Blast_Score=70, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24582014, Length=155, Percent_Identity=31.6129032258064, Blast_Score=69, Evalue=8e-12,
Organism=Drosophila melanogaster, GI24582012, Length=155, Percent_Identity=31.6129032258064, Blast_Score=69, Evalue=8e-12,
Organism=Drosophila melanogaster, GI281362751, Length=202, Percent_Identity=27.7227722772277, Blast_Score=69, Evalue=8e-12,
Organism=Drosophila melanogaster, GI221512771, Length=194, Percent_Identity=26.2886597938144, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003439
- InterPro:   IPR017871
- InterPro:   IPR003593 [H]

Pfam domain/function: PF00005 ABC_tran [H]

EC number: NA

Molecular weight: Translated: 48055; Mature: 47923

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: PS50893 ABC_TRANSPORTER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLKVENLSKVYFGFSGPLQRILNVLSLGFLGNDVKYDALKNVNFEVSSGEIVGLIGRNG
CCCCCCCCCEEEECCCHHHHHHHHHHHHHHCCCCCEEHHHCCCCEEECCCCEEEEEECCC
AGKSTLLKVLTGVSSYSSGKILKTGSIRSILELGVGFNPELSGEENLYYNGLVWGLSPNE
CCHHHHHHHHHCCCCCCCCCEEECCCHHHHHHHCCCCCCCCCCCCCEEEEEEEECCCCCH
IRFSMAEIFEFSGLTEFKNIPIKQYSSGMVMRLGFALATFSRPDILIVDEALAVGDASFQ
HHHHHHHHHHHCCCHHHHCCCHHHCCCCEEEEHHHHHHHCCCCCEEEEECHHHCCCHHHH
QKCLRRFRSFQEQGTITLIVSHDLELLKSVCSRVLILEKGRLVFDGDPVKGFREYMQIIA
HHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHEEEEECCCEEECCCCCHHHHHHHHHHH
SSTSEQETIFPVQKDSVVKSLSVDLDLVGPYLKNSPLQDIQQFPVRINRSSAEEDFKYKD
CCCCCCCEEECCCHHHHHHHHCCCCEEECHHHCCCCHHHHHHCCEEECCCCCCCCCCCCC
RTNLKFFSVGCEVEISIHVIFKNEIPDLTVGFHIDDSRGIRVFGTNTFHLGNSLKNVRAG
CCCEEEEEECEEEEEEEEEEEECCCCCEEEEEEECCCCCEEEEECCEEECCCCHHHCCCC
ESVTAKFRLPLNFSAGKYSLGIALHEGDNHVGNNYLWKDGILSFELERLDLPKFEGVAWL
CCEEEEEEEEEECCCCCEEEEEEEECCCCCCCCCEEECCCCEEEEEHHCCCCCCCCEEEE
PVQSKLQKDVSD
CCHHHHHHCCCC
>Mature Secondary Structure 
SLKVENLSKVYFGFSGPLQRILNVLSLGFLGNDVKYDALKNVNFEVSSGEIVGLIGRNG
CCCCCCCCEEEECCCHHHHHHHHHHHHHHCCCCCEEHHHCCCCEEECCCCEEEEEECCC
AGKSTLLKVLTGVSSYSSGKILKTGSIRSILELGVGFNPELSGEENLYYNGLVWGLSPNE
CCHHHHHHHHHCCCCCCCCCEEECCCHHHHHHHCCCCCCCCCCCCCEEEEEEEECCCCCH
IRFSMAEIFEFSGLTEFKNIPIKQYSSGMVMRLGFALATFSRPDILIVDEALAVGDASFQ
HHHHHHHHHHHCCCHHHHCCCHHHCCCCEEEEHHHHHHHCCCCCEEEEECHHHCCCHHHH
QKCLRRFRSFQEQGTITLIVSHDLELLKSVCSRVLILEKGRLVFDGDPVKGFREYMQIIA
HHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHEEEEECCCEEECCCCCHHHHHHHHHHH
SSTSEQETIFPVQKDSVVKSLSVDLDLVGPYLKNSPLQDIQQFPVRINRSSAEEDFKYKD
CCCCCCCEEECCCHHHHHHHHCCCCEEECHHHCCCCHHHHHHCCEEECCCCCCCCCCCCC
RTNLKFFSVGCEVEISIHVIFKNEIPDLTVGFHIDDSRGIRVFGTNTFHLGNSLKNVRAG
CCCEEEEEECEEEEEEEEEEEECCCCCEEEEEEECCCCCEEEEECCEEECCCCHHHCCCC
ESVTAKFRLPLNFSAGKYSLGIALHEGDNHVGNNYLWKDGILSFELERLDLPKFEGVAWL
CCEEEEEEEEEECCCCCEEEEEEEECCCCCCCCCEEECCCCEEEEEHHCCCCCCCCEEEE
PVQSKLQKDVSD
CCHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-glutamine [Periplasm]; H2O [C]

Specific reaction: ATP + L-glutamine [Periplasm] + H2O = ADP + phosphate + L-glutamine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8491726 [H]