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The map label for this gene is malL

Identifier: 45658138

GI number: 45658138

Start: 2761992

End: 2763626

Strand: Reverse

Name: malL

Synonym: LIC12290

Alternate gene names: 45658138

Gene position: 2763626-2761992 (Counterclockwise)

Preceding gene: 45658142

Following gene: 45658133

Centisome position: 64.61

GC content: 36.76

Gene sequence:

>1635_bases
TTGGATAAGTGGTGGCAAAAAACAACGATTTACCAGATTTATCCCCGCTCTTTTGCAGATAGTAATCGGGATGGTGTTGG
AGACATTCCAGGGATCATTTCTAAATTGGATTATCTTCAAGATCTTGGGTTTGAAACAATTTGGATATCTCCTTTGTATA
AAAGTCCACAAATGGATCACGGTTACGATGTAAGTGATTATTACTCGATCGCTCCAGAATATGGAACTATAAAAGATGCA
GAAAAGTTAATAAAGGAAGTTCATAAGCGCGGGATGAAAATCGTTTTTGATATGGTGATGAATCATACTTCTATTGAACA
CGATTGGTTTATACAATCCCGTTCTAGTCGAGATAATCCTAAAAGAGATTGGTATATTTGGAAAGACGGAAGAGGAAAAA
ATAAACCTCCTAATAATTGGAGTTCGTTTGTGACACCCAAGGCCTGGCATTATGATTCCAATACGGATCAATGGTATCTT
GCGAGTTTTCTAGATTTTCAACCAGACTTAAATTATTACAATCCAGAAGTCAAAAAGGCAATGTTCGACGTTTTGCGTTT
TTGGCTTAAGAAGGGAGTAGATGGTTTCCGTTTGGATATTTTTCACGCGATTTATAAGGATAAATATTTCAGAGACAATC
CGTTTCGATTTAAATATATCGTTTCGGAAAATGATCACGATGGTTATTTTCAGAGTAGGGTTCATACTGTAAACCATCCA
AATAACTTTGCTTTTGCGAAAGAGCTAAGATCCGTTTTAGATGAGTTTGATGGAGATCGTTTTGCGGTAGGAGAGGTGGC
CGGAGATGATCATATCATCAAACGCTACTTAGGCGAAAAAAAAGATGGCCTGAATCTAATCTTTTTATTCGAAACTTTGT
TGTTAAAGTTCAAGACTAGTTTTTTTAAGGGAATCGTAAAAAAAATGGAACAAGTATATCCGTATCCAAACGTTCCCACA
TACGTTTTTGGAAACCATGACCAAAGACGTTACATGATGAAAATCAATAATAATCTCGAAAAAGGAAAATTGATTGCTCT
GTTTCAGTTTACCGCGAGGGGGGTTCCAGTCACTTATTACGGAGAAGAAATTGGAATGACCAATGAGACGATCAAATTAA
CTGAGGCACAGGATCCGCTTGCAAGAATCTATCGCTGGTTAGGTGATTCGCTTTCCGAATTGTTGGGACTCGCAGACGTT
ATCATTCGGGATCGAGCAAGGTCGCCGATGCAATGGGACGACTCGCCAAACGCAGGTTTTACGGTTCAAGAAGCAAAACC
ATGGATTCGGGTTCACGGAAATTATAGAGAACGTAACGTTTTGATCGAGTCCGAAGATTCGGATTCTCTTTTAAATACTT
ATAAAAGTGTTCTTCGCATTCGAAATGGAAGTTTTGCTCTTAAAGAGGGTTCTTTGAGATTAATTGAAGAAAACGTTCCA
AAAGATATGTTAGTTTATTTAAGGGAATTTGGTAAGGAACGTAAACTGATCGTTTTTAATTTTGGTAAAAAAACCAAATT
TTTTTCTAATCCTACCGATTGTAGAAAATATTTTTTCTCTACGGTTTCTTTCGATCATAACGAATTTGATCAATTTAAAA
TACCTCCTTGTTCTGGAGTTATATTAGGTAATTAG

Upstream 100 bases:

>100_bases
CAGCCTTGACAGTCTTCATTCTTATATTTTTGATTCCATTAAAGCTCGAGTAAATATGACTTCTAAAAAATCAACTTCCA
AAAAAAAATCACCCAATCAA

Downstream 100 bases:

>100_bases
TATATTTTAAAAAATGTGTATTCTACAAAAAAAGATTTGTTTTGGACAAATCTATTGTTTGAAACAGAATTTTTGCGTCT
ATAATATGGGCGAAGTATTC

Product: oligo-1,6- glucosidase

Products: NA

Alternate protein names: Dextrin 6-alpha-D-glucanohydrolase; Oligosaccharide alpha-1,6-glucosidase; Sucrase-isomaltase; Isomaltase [H]

Number of amino acids: Translated: 544; Mature: 544

Protein sequence:

>544_residues
MDKWWQKTTIYQIYPRSFADSNRDGVGDIPGIISKLDYLQDLGFETIWISPLYKSPQMDHGYDVSDYYSIAPEYGTIKDA
EKLIKEVHKRGMKIVFDMVMNHTSIEHDWFIQSRSSRDNPKRDWYIWKDGRGKNKPPNNWSSFVTPKAWHYDSNTDQWYL
ASFLDFQPDLNYYNPEVKKAMFDVLRFWLKKGVDGFRLDIFHAIYKDKYFRDNPFRFKYIVSENDHDGYFQSRVHTVNHP
NNFAFAKELRSVLDEFDGDRFAVGEVAGDDHIIKRYLGEKKDGLNLIFLFETLLLKFKTSFFKGIVKKMEQVYPYPNVPT
YVFGNHDQRRYMMKINNNLEKGKLIALFQFTARGVPVTYYGEEIGMTNETIKLTEAQDPLARIYRWLGDSLSELLGLADV
IIRDRARSPMQWDDSPNAGFTVQEAKPWIRVHGNYRERNVLIESEDSDSLLNTYKSVLRIRNGSFALKEGSLRLIEENVP
KDMLVYLREFGKERKLIVFNFGKKTKFFSNPTDCRKYFFSTVSFDHNEFDQFKIPPCSGVILGN

Sequences:

>Translated_544_residues
MDKWWQKTTIYQIYPRSFADSNRDGVGDIPGIISKLDYLQDLGFETIWISPLYKSPQMDHGYDVSDYYSIAPEYGTIKDA
EKLIKEVHKRGMKIVFDMVMNHTSIEHDWFIQSRSSRDNPKRDWYIWKDGRGKNKPPNNWSSFVTPKAWHYDSNTDQWYL
ASFLDFQPDLNYYNPEVKKAMFDVLRFWLKKGVDGFRLDIFHAIYKDKYFRDNPFRFKYIVSENDHDGYFQSRVHTVNHP
NNFAFAKELRSVLDEFDGDRFAVGEVAGDDHIIKRYLGEKKDGLNLIFLFETLLLKFKTSFFKGIVKKMEQVYPYPNVPT
YVFGNHDQRRYMMKINNNLEKGKLIALFQFTARGVPVTYYGEEIGMTNETIKLTEAQDPLARIYRWLGDSLSELLGLADV
IIRDRARSPMQWDDSPNAGFTVQEAKPWIRVHGNYRERNVLIESEDSDSLLNTYKSVLRIRNGSFALKEGSLRLIEENVP
KDMLVYLREFGKERKLIVFNFGKKTKFFSNPTDCRKYFFSTVSFDHNEFDQFKIPPCSGVILGN
>Mature_544_residues
MDKWWQKTTIYQIYPRSFADSNRDGVGDIPGIISKLDYLQDLGFETIWISPLYKSPQMDHGYDVSDYYSIAPEYGTIKDA
EKLIKEVHKRGMKIVFDMVMNHTSIEHDWFIQSRSSRDNPKRDWYIWKDGRGKNKPPNNWSSFVTPKAWHYDSNTDQWYL
ASFLDFQPDLNYYNPEVKKAMFDVLRFWLKKGVDGFRLDIFHAIYKDKYFRDNPFRFKYIVSENDHDGYFQSRVHTVNHP
NNFAFAKELRSVLDEFDGDRFAVGEVAGDDHIIKRYLGEKKDGLNLIFLFETLLLKFKTSFFKGIVKKMEQVYPYPNVPT
YVFGNHDQRRYMMKINNNLEKGKLIALFQFTARGVPVTYYGEEIGMTNETIKLTEAQDPLARIYRWLGDSLSELLGLADV
IIRDRARSPMQWDDSPNAGFTVQEAKPWIRVHGNYRERNVLIESEDSDSLLNTYKSVLRIRNGSFALKEGSLRLIEENVP
KDMLVYLREFGKERKLIVFNFGKKTKFFSNPTDCRKYFFSTVSFDHNEFDQFKIPPCSGVILGN

Specific function: Unknown

COG id: COG0366

COG function: function code G; Glycosidases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glycosyl hydrolase 13 family [H]

Homologues:

Organism=Homo sapiens, GI187423904, Length=524, Percent_Identity=33.587786259542, Blast_Score=261, Evalue=8e-70,
Organism=Escherichia coli, GI1790687, Length=527, Percent_Identity=33.5863377609108, Blast_Score=282, Evalue=4e-77,
Organism=Escherichia coli, GI1786604, Length=499, Percent_Identity=21.4428857715431, Blast_Score=96, Evalue=6e-21,
Organism=Escherichia coli, GI87081873, Length=177, Percent_Identity=30.5084745762712, Blast_Score=66, Evalue=4e-12,
Organism=Escherichia coli, GI1789995, Length=92, Percent_Identity=35.8695652173913, Blast_Score=64, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI25147709, Length=497, Percent_Identity=24.5472837022133, Blast_Score=114, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI32565753, Length=376, Percent_Identity=26.3297872340426, Blast_Score=100, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6322245, Length=577, Percent_Identity=32.7556325823224, Blast_Score=292, Evalue=9e-80,
Organism=Saccharomyces cerevisiae, GI6321726, Length=575, Percent_Identity=34.2608695652174, Blast_Score=291, Evalue=1e-79,
Organism=Saccharomyces cerevisiae, GI6324416, Length=575, Percent_Identity=34.0869565217391, Blast_Score=291, Evalue=2e-79,
Organism=Saccharomyces cerevisiae, GI6322241, Length=575, Percent_Identity=34.0869565217391, Blast_Score=290, Evalue=3e-79,
Organism=Saccharomyces cerevisiae, GI6322021, Length=575, Percent_Identity=34.0869565217391, Blast_Score=290, Evalue=3e-79,
Organism=Saccharomyces cerevisiae, GI6319776, Length=580, Percent_Identity=33.9655172413793, Blast_Score=288, Evalue=1e-78,
Organism=Saccharomyces cerevisiae, GI6321731, Length=580, Percent_Identity=33.7931034482759, Blast_Score=288, Evalue=1e-78,
Organism=Drosophila melanogaster, GI24586599, Length=522, Percent_Identity=34.4827586206897, Blast_Score=292, Evalue=4e-79,
Organism=Drosophila melanogaster, GI24583745, Length=523, Percent_Identity=34.4168260038241, Blast_Score=291, Evalue=9e-79,
Organism=Drosophila melanogaster, GI45549022, Length=539, Percent_Identity=35.2504638218924, Blast_Score=291, Evalue=1e-78,
Organism=Drosophila melanogaster, GI221330053, Length=523, Percent_Identity=34.6080305927342, Blast_Score=287, Evalue=1e-77,
Organism=Drosophila melanogaster, GI24586593, Length=486, Percent_Identity=36.6255144032922, Blast_Score=287, Evalue=2e-77,
Organism=Drosophila melanogaster, GI24583747, Length=545, Percent_Identity=35.4128440366973, Blast_Score=283, Evalue=2e-76,
Organism=Drosophila melanogaster, GI24583749, Length=545, Percent_Identity=35.4128440366973, Blast_Score=283, Evalue=3e-76,
Organism=Drosophila melanogaster, GI24586597, Length=523, Percent_Identity=33.8432122370937, Blast_Score=281, Evalue=7e-76,
Organism=Drosophila melanogaster, GI24586591, Length=493, Percent_Identity=34.2799188640974, Blast_Score=271, Evalue=7e-73,
Organism=Drosophila melanogaster, GI24586589, Length=515, Percent_Identity=34.7572815533981, Blast_Score=269, Evalue=5e-72,
Organism=Drosophila melanogaster, GI24586587, Length=529, Percent_Identity=33.0812854442344, Blast_Score=261, Evalue=8e-70,
Organism=Drosophila melanogaster, GI281360393, Length=429, Percent_Identity=34.032634032634, Blast_Score=215, Evalue=8e-56,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013780
- InterPro:   IPR006047
- InterPro:   IPR006589
- InterPro:   IPR017853
- InterPro:   IPR013781 [H]

Pfam domain/function: PF00128 Alpha-amylase [H]

EC number: =3.2.1.10 [H]

Molecular weight: Translated: 64025; Mature: 64025

Theoretical pI: Translated: 8.67; Mature: 8.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDKWWQKTTIYQIYPRSFADSNRDGVGDIPGIISKLDYLQDLGFETIWISPLYKSPQMDH
CCCHHCCCEEEEECCCHHCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCC
GYDVSDYYSIAPEYGTIKDAEKLIKEVHKRGMKIVFDMVMNHTSIEHDWFIQSRSSRDNP
CCCCHHHHCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCEEECCCCCCCC
KRDWYIWKDGRGKNKPPNNWSSFVTPKAWHYDSNTDQWYLASFLDFQPDLNYYNPEVKKA
CCCEEEEECCCCCCCCCCCCHHCCCCCEEECCCCCCCCHHHHHHCCCCCCCCCCHHHHHH
MFDVLRFWLKKGVDGFRLDIFHAIYKDKYFRDNPFRFKYIVSENDHDGYFQSRVHTVNHP
HHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCEEEEEEEECCCCCCHHHHCEEECCCC
NNFAFAKELRSVLDEFDGDRFAVGEVAGDDHIIKRYLGEKKDGLNLIFLFETLLLKFKTS
CCHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHCCCCCCCEEHHHHHHHHHHHHHH
FFKGIVKKMEQVYPYPNVPTYVFGNHDQRRYMMKINNNLEKGKLIALFQFTARGVPVTYY
HHHHHHHHHHHHCCCCCCCEEEECCCCCEEEEEEECCCCCCCCEEEEEEECCCCCEEEEE
GEEIGMTNETIKLTEAQDPLARIYRWLGDSLSELLGLADVIIRDRARSPMQWDDSPNAGF
CHHHCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCE
TVQEAKPWIRVHGNYRERNVLIESEDSDSLLNTYKSVLRIRNGSFALKEGSLRLIEENVP
EEECCCCEEEEECCCCCCEEEEECCCCHHHHHHHHHHHHCCCCCEEEECCCEEEEHHCCC
KDMLVYLREFGKERKLIVFNFGKKTKFFSNPTDCRKYFFSTVSFDHNEFDQFKIPPCSGV
HHHHHHHHHHCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCE
ILGN
EECC
>Mature Secondary Structure
MDKWWQKTTIYQIYPRSFADSNRDGVGDIPGIISKLDYLQDLGFETIWISPLYKSPQMDH
CCCHHCCCEEEEECCCHHCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCC
GYDVSDYYSIAPEYGTIKDAEKLIKEVHKRGMKIVFDMVMNHTSIEHDWFIQSRSSRDNP
CCCCHHHHCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCCEEECCCCCCCC
KRDWYIWKDGRGKNKPPNNWSSFVTPKAWHYDSNTDQWYLASFLDFQPDLNYYNPEVKKA
CCCEEEEECCCCCCCCCCCCHHCCCCCEEECCCCCCCCHHHHHHCCCCCCCCCCHHHHHH
MFDVLRFWLKKGVDGFRLDIFHAIYKDKYFRDNPFRFKYIVSENDHDGYFQSRVHTVNHP
HHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCEEEEEEEECCCCCCHHHHCEEECCCC
NNFAFAKELRSVLDEFDGDRFAVGEVAGDDHIIKRYLGEKKDGLNLIFLFETLLLKFKTS
CCHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHCCCCCCCEEHHHHHHHHHHHHHH
FFKGIVKKMEQVYPYPNVPTYVFGNHDQRRYMMKINNNLEKGKLIALFQFTARGVPVTYY
HHHHHHHHHHHHCCCCCCCEEEECCCCCEEEEEEECCCCCCCCEEEEEEECCCCCEEEEE
GEEIGMTNETIKLTEAQDPLARIYRWLGDSLSELLGLADVIIRDRARSPMQWDDSPNAGF
CHHHCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCE
TVQEAKPWIRVHGNYRERNVLIESEDSDSLLNTYKSVLRIRNGSFALKEGSLRLIEENVP
EEECCCCEEEEECCCCCCEEEEECCCCHHHHHHHHHHHHCCCCCEEEECCCEEEEHHCCC
KDMLVYLREFGKERKLIVFNFGKKTKFFSNPTDCRKYFFSTVSFDHNEFDQFKIPPCSGV
HHHHHHHHHHCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCE
ILGN
EECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2120057; 8370659; 9193006 [H]