Click here to switch to the map view.

The map label for this gene is hppA

Identifier: 45658133

GI number: 45658133

Start: 2755852

End: 2757966

Strand: Reverse

Name: hppA

Synonym: LIC12285

Alternate gene names: 45658133

Gene position: 2757966-2755852 (Counterclockwise)

Preceding gene: 45658138

Following gene: 45658130

Centisome position: 64.48

GC content: 43.12

Gene sequence:

>2115_bases
ATGAATTCAGTTACGATAATTATCGCCATGTCTATTTTGGCGATCGTCACTGCTGTGGTCTATACCTTAAAAGTCACCTC
CATCAAAGTAGGTACCTTAGGCGGTAACGAAAAAGAAACGAAAAAGCTTTTAGAAATTTCATCCGCTATCTCCGAAGGAG
CTATGGCCTTTCTCGTAAGGGAATATAAAGTCATTTCCCTGTTTATTGCCTTTATGGCAGTATTGATCGTTCTATTGTTA
GACAATCCTGGATCGGAAGGATTTAACGACGGAATTTATACTGCAATTGCTTTTGTATCGGGAGCTTTGATTTCCTGTAT
TTCCGGTTTTATCGGAATGAAAATTGCAACTGCAGGAAACGTAAGAACCGCAGAGGCCGCTAAATCTTCTATGGCAAAGG
CTTTTCGGGTAGCATTTGATTCTGGAGCCGTGATGGGGTTCGGACTCGTAGGGCTTGCAATTTTAGGAATGATCGTGCTT
TTTCTTGTTTTTACTGGAATGTATCCAGGTGTAGAAAAACATTTTCTTATGGAATCCTTGGCTGGTTTTGGATTAGGGGG
GTCTGCTGTAGCACTTTTTGGAAGAGTGGGCGGCGGAATTTATACAAAAGCAGCAGACGTAGGAGCGGATCTAGTCGGAA
AGGTGGAAAAAGGAATTCCTGAAGACGATCCTAGAAACCCGGCAACGATTGCGGATAACGTAGGAGATAATGTGGGCGAT
GTGGCAGGAATGGGAGCAGATTTATTTGGTTCCTGTGCGGAAGCTACTTGTGCGGCTCTTGTAATTGGTGCTACTGCCTC
CGCTCTTTCTGGATCTGTAGACGCTCTATTATACCCGCTTTTGATTTCTGCATTTGGAATCCCAGCTTCTATTTTAACCA
GCTTTCTTGCAAGAGTCAAAGAAGATGGAAATGTGGAATCCGCTCTTAAAGTTCAACTTTGGGTTTCTACACTTCTAGTC
GCGGGAATCATGTATTTTGTAACAAAAACTTTCATGGTGGATTCTTTTGAAATTGCGGGGAAAACAATCACAAAATGGGA
CGTTTACATTTCGATGGTGGTTGGACTTTTTTCTGGAATGTTTATAGGGATTGTAACTGAATATTATACTTCACATTCTT
ATAAACCTGTAAGAGAAGTGGCAGAAGCGTCTAACACAGGAGCGGCGACAAATATCATCTACGGATTGTCTCTTGGTTAT
CATTCTTCCGTAATTCCAGTGATTTTACTTGTGATTACAATTGTAACGGCAAACCTACTTGCGGGAATGTATGGAATCGC
GATTGCGGCTCTGGGCATGATTTCCACGATCGCGATTGGATTGACCATAGACGCTTACGGTCCTGTTTCGGATAACGCGG
GCGGGATCGCGGAAATGGCGGAACTCGGAAAAGAAGTTCGTGATAGAACCGATACTCTGGACGCGGCTGGAAATACAACT
GCGGCGATCGGCAAGGGATTTGCGATTGGAAGCGCCGCTTTGACTTCTCTTGCGTTATTTGCGGCTTTCATCACAAGAAC
TCATACCACGAGTCTTGAGGTTTTAAATGCGGAAGTGTTTGGAGGATTGATGTTTGGAGCGATGCTTCCTTTTTTATTCA
CCGCAATGACGATGAAGTCTGTAGGAAAAGCCGCAGTGGATATGGTGGAAGAGGTTCGCAAACAATTCAAAGAGATTCCA
GGAATTATGGAAGGGAAAAATAAACCGGACTACAAACGTTGTGTGGATATATCTACGAGCGCTGCTTTGAGGGAAATGAT
TCTTCCGGGGCTTCTCGTTTTATTAACTCCGATCTTAGTAGGTTATCTTTTTGGAGTCAAAACTCTTGCCGGAGTACTTG
CGGGGGCATTGGTTGCGGGTGTGGTGCTTGCAATTTCTGCCGCAAATTCCGGAGGAGGTTGGGACAACGCAAAGAAATAC
ATTGAGAAAAAAGCGGGCGGAAAAGGATCGGATCAACACAAAGCCGCGGTTGTAGGTGATACTGTAGGAGATCCGTTTAA
AGATACTTCTGGACCATCTATCAATATTCTAATCAAATTGATGGCGATTACAAGTTTAGTTTTTGCTGAATTTTTTGTCC
AACAAGGTGGATTGATATTTAAAATATTTCATTAA

Upstream 100 bases:

>100_bases
GAGCCAAGTGGATAGCAGTCTCCCAGCCAGTCTGTTCGGTAGAATTCTTCCCATCTTTTTAAACATCGGAACATTAAAAA
AAAACAAGAGGTTTCACTGA

Downstream 100 bases:

>100_bases
AAAATTCTAAATTAGAATTTTATGAAGCTACAAAGCCCTTTTTGCAAAAAGCAAGAAGGGCTTTTTTTGTGGATTTGTTT
TGAAGATTAAATTTTTTGAA

Product: membrane-bound proton-translocating pyrophosphatase

Products: NA

Alternate protein names: Membrane-bound sodium-translocating pyrophosphatase; Pyrophosphate-energized inorganic pyrophosphatase; Na(+)-PPase

Number of amino acids: Translated: 704; Mature: 704

Protein sequence:

>704_residues
MNSVTIIIAMSILAIVTAVVYTLKVTSIKVGTLGGNEKETKKLLEISSAISEGAMAFLVREYKVISLFIAFMAVLIVLLL
DNPGSEGFNDGIYTAIAFVSGALISCISGFIGMKIATAGNVRTAEAAKSSMAKAFRVAFDSGAVMGFGLVGLAILGMIVL
FLVFTGMYPGVEKHFLMESLAGFGLGGSAVALFGRVGGGIYTKAADVGADLVGKVEKGIPEDDPRNPATIADNVGDNVGD
VAGMGADLFGSCAEATCAALVIGATASALSGSVDALLYPLLISAFGIPASILTSFLARVKEDGNVESALKVQLWVSTLLV
AGIMYFVTKTFMVDSFEIAGKTITKWDVYISMVVGLFSGMFIGIVTEYYTSHSYKPVREVAEASNTGAATNIIYGLSLGY
HSSVIPVILLVITIVTANLLAGMYGIAIAALGMISTIAIGLTIDAYGPVSDNAGGIAEMAELGKEVRDRTDTLDAAGNTT
AAIGKGFAIGSAALTSLALFAAFITRTHTTSLEVLNAEVFGGLMFGAMLPFLFTAMTMKSVGKAAVDMVEEVRKQFKEIP
GIMEGKNKPDYKRCVDISTSAALREMILPGLLVLLTPILVGYLFGVKTLAGVLAGALVAGVVLAISAANSGGGWDNAKKY
IEKKAGGKGSDQHKAAVVGDTVGDPFKDTSGPSINILIKLMAITSLVFAEFFVQQGGLIFKIFH

Sequences:

>Translated_704_residues
MNSVTIIIAMSILAIVTAVVYTLKVTSIKVGTLGGNEKETKKLLEISSAISEGAMAFLVREYKVISLFIAFMAVLIVLLL
DNPGSEGFNDGIYTAIAFVSGALISCISGFIGMKIATAGNVRTAEAAKSSMAKAFRVAFDSGAVMGFGLVGLAILGMIVL
FLVFTGMYPGVEKHFLMESLAGFGLGGSAVALFGRVGGGIYTKAADVGADLVGKVEKGIPEDDPRNPATIADNVGDNVGD
VAGMGADLFGSCAEATCAALVIGATASALSGSVDALLYPLLISAFGIPASILTSFLARVKEDGNVESALKVQLWVSTLLV
AGIMYFVTKTFMVDSFEIAGKTITKWDVYISMVVGLFSGMFIGIVTEYYTSHSYKPVREVAEASNTGAATNIIYGLSLGY
HSSVIPVILLVITIVTANLLAGMYGIAIAALGMISTIAIGLTIDAYGPVSDNAGGIAEMAELGKEVRDRTDTLDAAGNTT
AAIGKGFAIGSAALTSLALFAAFITRTHTTSLEVLNAEVFGGLMFGAMLPFLFTAMTMKSVGKAAVDMVEEVRKQFKEIP
GIMEGKNKPDYKRCVDISTSAALREMILPGLLVLLTPILVGYLFGVKTLAGVLAGALVAGVVLAISAANSGGGWDNAKKY
IEKKAGGKGSDQHKAAVVGDTVGDPFKDTSGPSINILIKLMAITSLVFAEFFVQQGGLIFKIFH
>Mature_704_residues
MNSVTIIIAMSILAIVTAVVYTLKVTSIKVGTLGGNEKETKKLLEISSAISEGAMAFLVREYKVISLFIAFMAVLIVLLL
DNPGSEGFNDGIYTAIAFVSGALISCISGFIGMKIATAGNVRTAEAAKSSMAKAFRVAFDSGAVMGFGLVGLAILGMIVL
FLVFTGMYPGVEKHFLMESLAGFGLGGSAVALFGRVGGGIYTKAADVGADLVGKVEKGIPEDDPRNPATIADNVGDNVGD
VAGMGADLFGSCAEATCAALVIGATASALSGSVDALLYPLLISAFGIPASILTSFLARVKEDGNVESALKVQLWVSTLLV
AGIMYFVTKTFMVDSFEIAGKTITKWDVYISMVVGLFSGMFIGIVTEYYTSHSYKPVREVAEASNTGAATNIIYGLSLGY
HSSVIPVILLVITIVTANLLAGMYGIAIAALGMISTIAIGLTIDAYGPVSDNAGGIAEMAELGKEVRDRTDTLDAAGNTT
AAIGKGFAIGSAALTSLALFAAFITRTHTTSLEVLNAEVFGGLMFGAMLPFLFTAMTMKSVGKAAVDMVEEVRKQFKEIP
GIMEGKNKPDYKRCVDISTSAALREMILPGLLVLLTPILVGYLFGVKTLAGVLAGALVAGVVLAISAANSGGGWDNAKKY
IEKKAGGKGSDQHKAAVVGDTVGDPFKDTSGPSINILIKLMAITSLVFAEFFVQQGGLIFKIFH

Specific function: Sodium pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for Na(+) movement across the membrane

COG id: COG3808

COG function: function code C; Inorganic pyrophosphatase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the H(+)-translocating pyrophosphatase (TC 3.A.10) family. K(+)-stimulated subfamily

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HPPA_LEPIC (Q72Q29)

Other databases:

- EMBL:   AE016823
- RefSeq:   YP_002219.1
- GeneID:   2770052
- GenomeReviews:   AE016823_GR
- KEGG:   lic:LIC12285
- HOGENOM:   HBG593668
- OMA:   AYLARQY
- ProtClustDB:   PRK00733
- BioCyc:   LINT267671:LIC_12285-MONOMER
- HAMAP:   MF_01129
- InterPro:   IPR004131
- PIRSF:   PIRSF001265
- TIGRFAMs:   TIGR01104

Pfam domain/function: PF03030 H_PPase

EC number: =3.6.1.1

Molecular weight: Translated: 73107; Mature: 73107

Theoretical pI: Translated: 5.56; Mature: 5.56

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x102fa55c)-; HASH(0x1164c050)-; HASH(0x115b1a0c)-; HASH(0x11d69614)-; HASH(0x11525b54)-; HASH(0x119de6b4)-; HASH(0x1041e22c)-; HASH(0x117d40a0)-; HASH(0x10b2cf0c)-; HASH(0x11d6b6c4)-; HASH(0x102f1eb8)-; HASH(0x11d274e4)-; HASH(0x11920fa0)-; HASH(0x9734298)-; HASH(0x118f77b8)-;

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNSVTIIIAMSILAIVTAVVYTLKVTSIKVGTLGGNEKETKKLLEISSAISEGAMAFLVR
CCCEEHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHH
EYKVISLFIAFMAVLIVLLLDNPGSEGFNDGIYTAIAFVSGALISCISGFIGMKIATAGN
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCEEECCCC
VRTAEAAKSSMAKAFRVAFDSGAVMGFGLVGLAILGMIVLFLVFTGMYPGVEKHFLMESL
CCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
AGFGLGGSAVALFGRVGGGIYTKAADVGADLVGKVEKGIPEDDPRNPATIADNVGDNVGD
HCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHCCCCHHH
VAGMGADLFGSCAEATCAALVIGATASALSGSVDALLYPLLISAFGIPASILTSFLARVK
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHH
EDGNVESALKVQLWVSTLLVAGIMYFVTKTFMVDSFEIAGKTITKWDVYISMVVGLFSGM
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCHHHHHHHHHHHHHHHHHH
FIGIVTEYYTSHSYKPVREVAEASNTGAATNIIYGLSLGYHSSVIPVILLVITIVTANLL
HHHHHHHHHHCCCCHHHHHHHHCCCCCCHHHHHEEECCCCCHHHHHHHHHHHHHHHHHHH
AGMYGIAIAALGMISTIAIGLTIDAYGPVSDNAGGIAEMAELGKEVRDRTDTLDAAGNTT
HHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCH
AAIGKGFAIGSAALTSLALFAAFITRTHTTSLEVLNAEVFGGLMFGAMLPFLFTAMTMKS
HHHCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VGKAAVDMVEEVRKQFKEIPGIMEGKNKPDYKRCVDISTSAALREMILPGLLVLLTPILV
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
GYLFGVKTLAGVLAGALVAGVVLAISAANSGGGWDNAKKYIEKKAGGKGSDQHKAAVVGD
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCCCCCCEEEECC
TVGDPFKDTSGPSINILIKLMAITSLVFAEFFVQQGGLIFKIFH
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEH
>Mature Secondary Structure
MNSVTIIIAMSILAIVTAVVYTLKVTSIKVGTLGGNEKETKKLLEISSAISEGAMAFLVR
CCCEEHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHH
EYKVISLFIAFMAVLIVLLLDNPGSEGFNDGIYTAIAFVSGALISCISGFIGMKIATAGN
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCEEECCCC
VRTAEAAKSSMAKAFRVAFDSGAVMGFGLVGLAILGMIVLFLVFTGMYPGVEKHFLMESL
CCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
AGFGLGGSAVALFGRVGGGIYTKAADVGADLVGKVEKGIPEDDPRNPATIADNVGDNVGD
HCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHCCCCHHH
VAGMGADLFGSCAEATCAALVIGATASALSGSVDALLYPLLISAFGIPASILTSFLARVK
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHH
EDGNVESALKVQLWVSTLLVAGIMYFVTKTFMVDSFEIAGKTITKWDVYISMVVGLFSGM
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCHHHHHHHHHHHHHHHHHH
FIGIVTEYYTSHSYKPVREVAEASNTGAATNIIYGLSLGYHSSVIPVILLVITIVTANLL
HHHHHHHHHHCCCCHHHHHHHHCCCCCCHHHHHEEECCCCCHHHHHHHHHHHHHHHHHHH
AGMYGIAIAALGMISTIAIGLTIDAYGPVSDNAGGIAEMAELGKEVRDRTDTLDAAGNTT
HHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCH
AAIGKGFAIGSAALTSLALFAAFITRTHTTSLEVLNAEVFGGLMFGAMLPFLFTAMTMKS
HHHCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VGKAAVDMVEEVRKQFKEIPGIMEGKNKPDYKRCVDISTSAALREMILPGLLVLLTPILV
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
GYLFGVKTLAGVLAGALVAGVVLAISAANSGGGWDNAKKYIEKKAGGKGSDQHKAAVVGD
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCCCCCCEEEECC
TVGDPFKDTSGPSINILIKLMAITSLVFAEFFVQQGGLIFKIFH
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA