Click here to switch to the map view.

The map label for this gene is tktC

Identifier: 45658043

GI number: 45658043

Start: 2646629

End: 2647561

Strand: Reverse

Name: tktC

Synonym: LIC12194

Alternate gene names: 45658043

Gene position: 2647561-2646629 (Counterclockwise)

Preceding gene: 45658044

Following gene: 45658042

Centisome position: 61.9

GC content: 38.16

Gene sequence:

>933_bases
ATGCGTAATACTAGCTTAAAAAGTGTTTATCAATTAGCATTACAAGATCCAAGAGTTGTATATATAGGCTCTGATTTGGG
TGCAGGTGTATTAGATGAAATGAAACAAAATATTCCTGACCGTTTTTATATGGAAGGGGTGAGCGAGCAGCATATCATTG
GTATGTCTGCGGGAATGGCAATGGAAGGTTATATTCCTTATGTGAATACTATTGCTACTTTTCTTACTAGAAGATGTTTC
GAGCAAGTCGCGATTGATTTATGTTTACATGATTTACCCGTTCGTTTAATTGCAAATGGAGGGGGAATTGTTTACGCTCC
TCTTGGGCCTACACATCTTGCTGTTGAGGATATCGCAATTCTGCGTGCTTTACCAAATATGACGATCATCGCTCCTTGCG
ATGCTGAAGAAATGAAAAGGTTAATGCCTTTAACGTTAGATTGGCCTCACCCGATTTATATACGATTGGCAAAAGGTGGA
GATAAGGTAATTAGCAAACCGGAATTCGGATTTGAAATCGGAAAAGCGATTGTAATGCAAGAAGGTAAGGATGGTTTATT
CGTAACCACTGGAGTTATGACTCAACTTGCTTTAGAAGCCATTCAGCAATTGGAATCGGAAGGTGTAAGCTGTGGAGTAA
TCCATATGCATACGATAAAACCTTTAGATGGAGAAATCCTTAAAAAATGGATTCCGAAAGTTTCCGCAATAGTTACCGTA
GAAGAACATACTCGAATTGGTGGATTAGGAAGTGCGATATTAGAATATTGTAATGATTTAATGCCAAGTGAATCCGGAAA
AATCAGGAGAATTGGTCTGCCGGATCGATTTTCAGAAAAGTATGGGAGCCAGGAATCTTTACTAAATTATTTTGGAATCA
ACAAGGATAGTTTAGTTCAAACGATGAGAGATGCGATAAGTATTAAGAAGTGA

Upstream 100 bases:

>100_bases
GGCTGAAGGAAATCCACAGTGGCATCATAAAAATAAAATAACTCCAGAAGAATTCTCTGTAATGTATCAAAGTTTAAACT
AAAAGGTTATATATATTATT

Downstream 100 bases:

>100_bases
TAATGTTCATTTTTGATTTCGAATTTATATTTTTCTAAATTTAAAGTAAGCTTTTGTGTTTAAAATTGTATAAAAGCGTT
TCGTTTATATTTTCGTTTAG

Product: transketolase subunit beta

Products: D-ribose 5-phosphate; D-xylulose 5-phosphate

Alternate protein names: NA

Number of amino acids: Translated: 310; Mature: 310

Protein sequence:

>310_residues
MRNTSLKSVYQLALQDPRVVYIGSDLGAGVLDEMKQNIPDRFYMEGVSEQHIIGMSAGMAMEGYIPYVNTIATFLTRRCF
EQVAIDLCLHDLPVRLIANGGGIVYAPLGPTHLAVEDIAILRALPNMTIIAPCDAEEMKRLMPLTLDWPHPIYIRLAKGG
DKVISKPEFGFEIGKAIVMQEGKDGLFVTTGVMTQLALEAIQQLESEGVSCGVIHMHTIKPLDGEILKKWIPKVSAIVTV
EEHTRIGGLGSAILEYCNDLMPSESGKIRRIGLPDRFSEKYGSQESLLNYFGINKDSLVQTMRDAISIKK

Sequences:

>Translated_310_residues
MRNTSLKSVYQLALQDPRVVYIGSDLGAGVLDEMKQNIPDRFYMEGVSEQHIIGMSAGMAMEGYIPYVNTIATFLTRRCF
EQVAIDLCLHDLPVRLIANGGGIVYAPLGPTHLAVEDIAILRALPNMTIIAPCDAEEMKRLMPLTLDWPHPIYIRLAKGG
DKVISKPEFGFEIGKAIVMQEGKDGLFVTTGVMTQLALEAIQQLESEGVSCGVIHMHTIKPLDGEILKKWIPKVSAIVTV
EEHTRIGGLGSAILEYCNDLMPSESGKIRRIGLPDRFSEKYGSQESLLNYFGINKDSLVQTMRDAISIKK
>Mature_310_residues
MRNTSLKSVYQLALQDPRVVYIGSDLGAGVLDEMKQNIPDRFYMEGVSEQHIIGMSAGMAMEGYIPYVNTIATFLTRRCF
EQVAIDLCLHDLPVRLIANGGGIVYAPLGPTHLAVEDIAILRALPNMTIIAPCDAEEMKRLMPLTLDWPHPIYIRLAKGG
DKVISKPEFGFEIGKAIVMQEGKDGLFVTTGVMTQLALEAIQQLESEGVSCGVIHMHTIKPLDGEILKKWIPKVSAIVTV
EEHTRIGGLGSAILEYCNDLMPSESGKIRRIGLPDRFSEKYGSQESLLNYFGINKDSLVQTMRDAISIKK

Specific function: Catalyzes The Acyloin Condensation Reaction Between C Atoms 2 And 3 Of Pyruvate And Glyceraldehyde 3-Phosphate To Yield 1-Deoxy-D-Xylulose-5-Phosphate (Dxp). [C]

COG id: COG3958

COG function: function code G; Transketolase, C-terminal subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=311, Percent_Identity=27.0096463022508, Blast_Score=113, Evalue=2e-25,
Organism=Homo sapiens, GI4507521, Length=311, Percent_Identity=27.0096463022508, Blast_Score=113, Evalue=2e-25,
Organism=Homo sapiens, GI225637459, Length=298, Percent_Identity=27.5167785234899, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI225637461, Length=298, Percent_Identity=27.5167785234899, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI225637463, Length=298, Percent_Identity=27.5167785234899, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI133778974, Length=296, Percent_Identity=27.027027027027, Blast_Score=102, Evalue=4e-22,
Organism=Escherichia coli, GI1786622, Length=270, Percent_Identity=30, Blast_Score=113, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI17539652, Length=302, Percent_Identity=28.476821192053, Blast_Score=120, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI17538422, Length=227, Percent_Identity=26.8722466960352, Blast_Score=67, Evalue=9e-12,
Organism=Drosophila melanogaster, GI24666278, Length=298, Percent_Identity=27.1812080536913, Blast_Score=108, Evalue=4e-24,
Organism=Drosophila melanogaster, GI24645119, Length=306, Percent_Identity=28.4313725490196, Blast_Score=108, Evalue=5e-24,
Organism=Drosophila melanogaster, GI45551847, Length=306, Percent_Identity=28.4313725490196, Blast_Score=108, Evalue=5e-24,
Organism=Drosophila melanogaster, GI45550715, Length=306, Percent_Identity=28.4313725490196, Blast_Score=108, Evalue=5e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005476 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C [H]

EC number: 2.2.1.1

Molecular weight: Translated: 34220; Mature: 34220

Theoretical pI: Translated: 5.92; Mature: 5.92

Prosite motif: PS01128 SHIKIMATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
6.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRNTSLKSVYQLALQDPRVVYIGSDLGAGVLDEMKQNIPDRFYMEGVSEQHIIGMSAGMA
CCCCHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHCCCHHHHHCCCCCCEEEECCCCCE
MEGYIPYVNTIATFLTRRCFEQVAIDLCLHDLPVRLIANGGGIVYAPLGPTHLAVEDIAI
ECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCEEEECCCCCHHHHHHHHH
LRALPNMTIIAPCDAEEMKRLMPLTLDWPHPIYIRLAKGGDKVISKPEFGFEIGKAIVMQ
HHHCCCCEEEECCCHHHHHHHCCCEECCCCCEEEEEECCCCHHCCCCCCCHHHHHHHEEE
EGKDGLFVTTGVMTQLALEAIQQLESEGVSCGVIHMHTIKPLDGEILKKWIPKVSAIVTV
CCCCCEEEEHHHHHHHHHHHHHHHHHCCCEEEEEEEEECCCCCHHHHHHHCCCHHEEEEE
EEHTRIGGLGSAILEYCNDLMPSESGKIRRIGLPDRFSEKYGSQESLLNYFGINKDSLVQ
HHHCCCCCHHHHHHHHHHHHCCCCCCCEEECCCCHHHHHHCCCHHHHHHHHCCCHHHHHH
TMRDAISIKK
HHHHHHCCCC
>Mature Secondary Structure
MRNTSLKSVYQLALQDPRVVYIGSDLGAGVLDEMKQNIPDRFYMEGVSEQHIIGMSAGMA
CCCCHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHCCCHHHHHCCCCCCEEEECCCCCE
MEGYIPYVNTIATFLTRRCFEQVAIDLCLHDLPVRLIANGGGIVYAPLGPTHLAVEDIAI
ECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCEEEECCCCCHHHHHHHHH
LRALPNMTIIAPCDAEEMKRLMPLTLDWPHPIYIRLAKGGDKVISKPEFGFEIGKAIVMQ
HHHCCCCEEEECCCHHHHHHHCCCEECCCCCEEEEEECCCCHHCCCCCCCHHHHHHHEEE
EGKDGLFVTTGVMTQLALEAIQQLESEGVSCGVIHMHTIKPLDGEILKKWIPKVSAIVTV
CCCCCEEEEHHHHHHHHHHHHHHHHHCCCEEEEEEEEECCCCCHHHHHHHCCCHHEEEEE
EEHTRIGGLGSAILEYCNDLMPSESGKIRRIGLPDRFSEKYGSQESLLNYFGINKDSLVQ
HHHCCCCCHHHHHHHHHHHHCCCCCCCEEECCCCHHHHHHCCCHHHHHHHHCCCHHHHHH
TMRDAISIKK
HHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: sedoheptulose 7-phosphate; D-glyceraldehyde 3-phosphate

Specific reaction: sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-ribose 5-phosphate + D-xylulose 5-phosphate

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9163424 [H]