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The map label for this gene is tktB [C]

Identifier: 45658044

GI number: 45658044

Start: 2647580

End: 2648377

Strand: Reverse

Name: tktB [C]

Synonym: LIC12195

Alternate gene names: 45658044

Gene position: 2648377-2647580 (Counterclockwise)

Preceding gene: 45658045

Following gene: 45658043

Centisome position: 61.92

GC content: 33.58

Gene sequence:

>798_bases
ATGGATGATCGTTCCAAACAATTAAGAAAACTTATAGTTGAAATGATGGAATCGGAAAAAAGAGGACATATTGGTCCAGC
TTTATCATTAATTGAAATATTACGAGTTCTTTATGATGATATATTAAAATATGATTCTAAAAAACTGAATTGGGAAAATC
GAGATCGATTAATTCTTAGTAAGGGTCATGGCTGTTTAGCTTTATATTCTATTCTTGCGGATAAGGGATTTTTTCCACTC
GATGTTTTGAAAACATTTGGCAAACCCGATTCTATACTTGGAGGACACCCCGAAAGAGGGAAAATTCCAGGGGTAGAGGC
CTCGACAGGAGCTTTAGGACATGGATTGTCGATTGGAGTTGGAATAGCGATTGCGGCAAAAATTAAAAAGAAAGATCATA
GAGTTTTTGTAATTACAGGGGATGGAGAGATCAATGAAGGTTCTGTATGGGAAGCTGCTTTATGTGCTTCTAAACATTCC
TTATCAAATTTAGCCGTAATTATTGATTACAATAAATTACAATCTTATGGGCTAACCAAAGACGTTTTGGATCTTGAACC
TTTAATGGATAAATGGAAAAGTTTTGGTTTCGCTATTGAAGAAGTAGATGGTCACAATATTAAAGAATTGAAAAGTTTAT
TTAGTAAATTGCCATTAAATAAAACAAAGCCGACTGCTATTATAGCACATACTATAAAAGGAAAGGGATTTGCTATGGCT
GAAGGAAATCCACAGTGGCATCATAAAAATAAAATAACTCCAGAAGAATTCTCTGTAATGTATCAAAGTTTAAACTAA

Upstream 100 bases:

>100_bases
TAAAGCCGAAATTTTAGAAAAACAATTAAACAAATCAATTCATTTATTCAGATATATTCAGAAAAAATTTTATACGCAGA
TTGAAAAAGGTTAAAAACAC

Downstream 100 bases:

>100_bases
AAGGTTATATATATTATTATGCGTAATACTAGCTTAAAAAGTGTTTATCAATTAGCATTACAAGATCCAAGAGTTGTATA
TATAGGCTCTGATTTGGGTG

Product: transketolase

Products: NA

Alternate protein names: TK [H]

Number of amino acids: Translated: 265; Mature: 265

Protein sequence:

>265_residues
MDDRSKQLRKLIVEMMESEKRGHIGPALSLIEILRVLYDDILKYDSKKLNWENRDRLILSKGHGCLALYSILADKGFFPL
DVLKTFGKPDSILGGHPERGKIPGVEASTGALGHGLSIGVGIAIAAKIKKKDHRVFVITGDGEINEGSVWEAALCASKHS
LSNLAVIIDYNKLQSYGLTKDVLDLEPLMDKWKSFGFAIEEVDGHNIKELKSLFSKLPLNKTKPTAIIAHTIKGKGFAMA
EGNPQWHHKNKITPEEFSVMYQSLN

Sequences:

>Translated_265_residues
MDDRSKQLRKLIVEMMESEKRGHIGPALSLIEILRVLYDDILKYDSKKLNWENRDRLILSKGHGCLALYSILADKGFFPL
DVLKTFGKPDSILGGHPERGKIPGVEASTGALGHGLSIGVGIAIAAKIKKKDHRVFVITGDGEINEGSVWEAALCASKHS
LSNLAVIIDYNKLQSYGLTKDVLDLEPLMDKWKSFGFAIEEVDGHNIKELKSLFSKLPLNKTKPTAIIAHTIKGKGFAMA
EGNPQWHHKNKITPEEFSVMYQSLN
>Mature_265_residues
MDDRSKQLRKLIVEMMESEKRGHIGPALSLIEILRVLYDDILKYDSKKLNWENRDRLILSKGHGCLALYSILADKGFFPL
DVLKTFGKPDSILGGHPERGKIPGVEASTGALGHGLSIGVGIAIAAKIKKKDHRVFVITGDGEINEGSVWEAALCASKHS
LSNLAVIIDYNKLQSYGLTKDVLDLEPLMDKWKSFGFAIEEVDGHNIKELKSLFSKLPLNKTKPTAIIAHTIKGKGFAMA
EGNPQWHHKNKITPEEFSVMYQSLN

Specific function: Unknown

COG id: COG3959

COG function: function code G; Transketolase, N-terminal subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=254, Percent_Identity=36.2204724409449, Blast_Score=144, Evalue=1e-34,
Organism=Homo sapiens, GI4507521, Length=254, Percent_Identity=36.2204724409449, Blast_Score=144, Evalue=1e-34,
Organism=Homo sapiens, GI133778974, Length=250, Percent_Identity=33.6, Blast_Score=135, Evalue=3e-32,
Organism=Homo sapiens, GI225637459, Length=250, Percent_Identity=28.8, Blast_Score=105, Evalue=5e-23,
Organism=Homo sapiens, GI225637463, Length=150, Percent_Identity=36.6666666666667, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI225637461, Length=150, Percent_Identity=36.6666666666667, Blast_Score=100, Evalue=2e-21,
Organism=Escherichia coli, GI1788808, Length=274, Percent_Identity=32.4817518248175, Blast_Score=130, Evalue=6e-32,
Organism=Escherichia coli, GI48994911, Length=244, Percent_Identity=31.1475409836066, Blast_Score=122, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI17539652, Length=250, Percent_Identity=38, Blast_Score=167, Evalue=6e-42,
Organism=Saccharomyces cerevisiae, GI6319593, Length=242, Percent_Identity=33.8842975206612, Blast_Score=117, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6325331, Length=242, Percent_Identity=33.0578512396694, Blast_Score=107, Evalue=2e-24,
Organism=Drosophila melanogaster, GI45551847, Length=250, Percent_Identity=38, Blast_Score=166, Evalue=2e-41,
Organism=Drosophila melanogaster, GI45550715, Length=250, Percent_Identity=38, Blast_Score=166, Evalue=2e-41,
Organism=Drosophila melanogaster, GI24666278, Length=251, Percent_Identity=37.4501992031873, Blast_Score=162, Evalue=3e-40,
Organism=Drosophila melanogaster, GI24645119, Length=217, Percent_Identity=39.63133640553, Blast_Score=150, Evalue=9e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005474 [H]

Pfam domain/function: PF00456 Transketolase_N [H]

EC number: =2.2.1.1 [H]

Molecular weight: Translated: 29400; Mature: 29400

Theoretical pI: Translated: 9.24; Mature: 9.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDDRSKQLRKLIVEMMESEKRGHIGPALSLIEILRVLYDDILKYDSKKLNWENRDRLILS
CCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEE
KGHGCLALYSILADKGFFPLDVLKTFGKPDSILGGHPERGKIPGVEASTGALGHGLSIGV
CCCCHHHHHHHHHCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHH
GIAIAAKIKKKDHRVFVITGDGEINEGSVWEAALCASKHSLSNLAVIIDYNKLQSYGLTK
HHHHHEEEECCCCEEEEEECCCCCCCCCHHHHHHHHHHHCCCCEEEEEEEHHHHHCCCCH
DVLDLEPLMDKWKSFGFAIEEVDGHNIKELKSLFSKLPLNKTKPTAIIAHTIKGKGFAMA
HHHHHHHHHHHHHHHCCEEEECCCCCHHHHHHHHHHCCCCCCCCCEEEEEEECCCEEEEE
EGNPQWHHKNKITPEEFSVMYQSLN
CCCCCCCCCCCCCHHHHHHHHHHCC
>Mature Secondary Structure
MDDRSKQLRKLIVEMMESEKRGHIGPALSLIEILRVLYDDILKYDSKKLNWENRDRLILS
CCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEE
KGHGCLALYSILADKGFFPLDVLKTFGKPDSILGGHPERGKIPGVEASTGALGHGLSIGV
CCCCHHHHHHHHHCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHH
GIAIAAKIKKKDHRVFVITGDGEINEGSVWEAALCASKHSLSNLAVIIDYNKLQSYGLTK
HHHHHEEEECCCCEEEEEECCCCCCCCCHHHHHHHHHHHCCCCEEEEEEEHHHHHCCCCH
DVLDLEPLMDKWKSFGFAIEEVDGHNIKELKSLFSKLPLNKTKPTAIIAHTIKGKGFAMA
HHHHHHHHHHHHHHHCCEEEECCCCCHHHHHHHHHHCCCCCCCCCEEEEEEECCCEEEEE
EGNPQWHHKNKITPEEFSVMYQSLN
CCCCCCCCCCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]