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The map label for this gene is neuA [H]

Identifier: 45658016

GI number: 45658016

Start: 2618427

End: 2619056

Strand: Reverse

Name: neuA [H]

Synonym: LIC12167

Alternate gene names: 45658016

Gene position: 2619056-2618427 (Counterclockwise)

Preceding gene: 45658017

Following gene: 45658015

Centisome position: 61.23

GC content: 36.51

Gene sequence:

>630_bases
ATGAATTTAGCGGTAATTCCGGCCAGGGGCGGTAGTAAGGGACTGCCGGGAAAAAATATAAAAAATCTATGTGGTAAGCC
CCTAATCGCTTGGTCTATTGAAGCGGCAAAAAGAGCCAAAAAAATTGATAGATTTATTGTTTCAACTGATAGCGAAGAAA
TTGCGGCTGTGGCAAGGGAATGGGGTTGTCCGGTTTTAAAAAGACCGGATGAGTTGGCAACTGATGAAACGAAGACGATT
TCCGTGCTTAGCCAAATATCGAAAGAGATTCCAGAAGCCCTAAATTTTATTCTTTTACAACCTACTTCGCCGATTAGGGA
CGTAGGTTTAATTGATGAATGTTTGGATCTATATGAACAAGGGAATTATTCGAATCTTGCTACCGGATATTGGTGCAAAT
ATCAAGAGTTTGGAAAACATAATAACATGCGTCGTCAAGACTATAAAGGTTTTTTTTACGACGATGGGAATGTATATATT
TTATCAAAAAAATTGGTTTCAGAAGGATTATGGTTTGGTGATCATATTTGTCGGCATGTTATTTCAAAACGTCAAAACTT
TGAAATAGATGACGAGATTGATTTTGTAATACTGGAAGCTTTATTAAATAAATACGGAACAATTAACTAA

Upstream 100 bases:

>100_bases
ATGATTTCCTTTCCGTTTCATATTTGGATGAATGAAAATGATTTTGATTATATGATTGCGTCGATAAAACAAGCTCTAAT
AGAATTGCGAAGTTAATTGT

Downstream 100 bases:

>100_bases
TGCTTTGTTCCGGAACTTTAAAATAATCAATAAATCTTAAAATTATATTAGTTGCATAGATAAGGATAATTAAATGACCT
CTCTTAGAATTTTTAAACAA

Product: CMP-N-acetlyneuraminic acid synthetase

Products: NA

Alternate protein names: CMP-N-acetylneuraminic acid synthase; CMP-NeuNAc synthase [H]

Number of amino acids: Translated: 209; Mature: 209

Protein sequence:

>209_residues
MNLAVIPARGGSKGLPGKNIKNLCGKPLIAWSIEAAKRAKKIDRFIVSTDSEEIAAVAREWGCPVLKRPDELATDETKTI
SVLSQISKEIPEALNFILLQPTSPIRDVGLIDECLDLYEQGNYSNLATGYWCKYQEFGKHNNMRRQDYKGFFYDDGNVYI
LSKKLVSEGLWFGDHICRHVISKRQNFEIDDEIDFVILEALLNKYGTIN

Sequences:

>Translated_209_residues
MNLAVIPARGGSKGLPGKNIKNLCGKPLIAWSIEAAKRAKKIDRFIVSTDSEEIAAVAREWGCPVLKRPDELATDETKTI
SVLSQISKEIPEALNFILLQPTSPIRDVGLIDECLDLYEQGNYSNLATGYWCKYQEFGKHNNMRRQDYKGFFYDDGNVYI
LSKKLVSEGLWFGDHICRHVISKRQNFEIDDEIDFVILEALLNKYGTIN
>Mature_209_residues
MNLAVIPARGGSKGLPGKNIKNLCGKPLIAWSIEAAKRAKKIDRFIVSTDSEEIAAVAREWGCPVLKRPDELATDETKTI
SVLSQISKEIPEALNFILLQPTSPIRDVGLIDECLDLYEQGNYSNLATGYWCKYQEFGKHNNMRRQDYKGFFYDDGNVYI
LSKKLVSEGLWFGDHICRHVISKRQNFEIDDEIDFVILEALLNKYGTIN

Specific function: Activates Kdo (A Required 8-Carbon Sugar) For Incorporation Into Bacterial Lipopolysaccharide In Gram-Negative Bacteria (By Similarity). [C]

COG id: COG1083

COG function: function code M; CMP-N-acetylneuraminic acid synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CMP-NeuNAc synthase family [H]

Homologues:

Organism=Homo sapiens, GI8923900, Length=219, Percent_Identity=28.310502283105, Blast_Score=93, Evalue=2e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003329
- InterPro:   IPR013830
- InterPro:   IPR013831 [H]

Pfam domain/function: PF02348 CTP_transf_3 [H]

EC number: =2.7.7.43 [H]

Molecular weight: Translated: 23689; Mature: 23689

Theoretical pI: Translated: 6.28; Mature: 6.28

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLAVIPARGGSKGLPGKNIKNLCGKPLIAWSIEAAKRAKKIDRFIVSTDSEEIAAVARE
CCEEEEECCCCCCCCCCCCHHHHHCCCEEEEEHHHHHHHHHHHHHHHCCCHHHHHHHHHH
WGCPVLKRPDELATDETKTISVLSQISKEIPEALNFILLQPTSPIRDVGLIDECLDLYEQ
HCCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHCEEEECCCCCHHHHHHHHHHHHHHHC
GNYSNLATGYWCKYQEFGKHNNMRRQDYKGFFYDDGNVYILSKKLVSEGLWFGDHICRHV
CCCCCCCCCCEEHHHHHHCCCCCCHHHCCCEEEECCCEEEEEHHHHHCCCCHHHHHHHHH
ISKRQNFEIDDEIDFVILEALLNKYGTIN
HHHCCCCCCCCCHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MNLAVIPARGGSKGLPGKNIKNLCGKPLIAWSIEAAKRAKKIDRFIVSTDSEEIAAVARE
CCEEEEECCCCCCCCCCCCHHHHHCCCEEEEEHHHHHHHHHHHHHHHCCCHHHHHHHHHH
WGCPVLKRPDELATDETKTISVLSQISKEIPEALNFILLQPTSPIRDVGLIDECLDLYEQ
HCCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHCEEEECCCCCHHHHHHHHHHHHHHHC
GNYSNLATGYWCKYQEFGKHNNMRRQDYKGFFYDDGNVYILSKKLVSEGLWFGDHICRHV
CCCCCCCCCCEEHHHHHHCCCCCCHHHCCCEEEECCCEEEEEHHHHHCCCCHHHHHHHHH
ISKRQNFEIDDEIDFVILEALLNKYGTIN
HHHCCCCCCCCCHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2549035 [H]