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The map label for this gene is mdh [H]

Identifier: 45658015

GI number: 45658015

Start: 2617286

End: 2618353

Strand: Reverse

Name: mdh [H]

Synonym: LIC12166

Alternate gene names: 45658015

Gene position: 2618353-2617286 (Counterclockwise)

Preceding gene: 45658016

Following gene: 45658014

Centisome position: 61.22

GC content: 39.04

Gene sequence:

>1068_bases
ATGACCTCTCTTAGAATTTTTAAACAAGTACCACGTTTACTTTTCGGCTTCAATACAATCGATCGAATAAATGAATTATT
GCCTAAAAAAAATAACGGAGATTATTATATTTTTATAATAGACGATGTTCATCAAAAAGGAACTATACATAGTCGATTGA
AACACGCGAGCGAAGATATGGTTGAATGGTTTCCTGCAAGTGTAAAGGAGCCTTCGACGTTGCAGATCGATAATTTAAGG
GATAAGTTTATGCAAACCCGAGATCATAAACTACCGAAAGCGATCGTGGGGATCGGCGGTGGTAGCACTATGGATGTGGC
TAAGGCATTGTCCGTAATGATGTGTAATGAAGGCTCCGCCTCTCAGTACCAAGGATGGGATCTTGTGCCAAATCCTGGAA
TCTATAAGATTGGAATTCCAACCGTAGCGGGTTCTGGGGCAGAGGCTAGTCGTACTGCTGTGCTAATGGGTAAAGAACGT
AAATTCGGGATTAATAGTGATCATAGTATGTTTGATGCAATTATATTAGATAGTTCCTTAATAAAGAATGTCCCAATAGC
TCAAAGATTTTATTCGGGTATGGATTGTTATATTCATTGTGTGGAGAGTTTACAAGGAACAATGATCAATGAATTAGCGA
AAGGTAATGCAAGCAAAGCGTTGGAACTTTGTGAGAAAGTTTTTTTATCGGATGGCGATGACGATATGTTGCTTACGGCT
TCCTATATGGGCGGGGTATCCATTGTGAATTCCGAAGTTGGCGTTTGTCATGCCTTATCCTACGGGCTTAGTCTTGAATT
GGGATACAGGCATGGTTTTGCGAATTGTGTCGCATTCAATGTTTTAGATGAATATTACGGACCTTGGGTGGATCGCTTTC
GGGAAATGTTAAAAATTCATAAAATCGAATTACCAAAAAATGTCTGTAGATCTTTGGATGAAGCTGCGATGCAACGTATG
GTGAATATGACTCTTAAAATGGAAAGACCTCTTACGAATGCACTTGGCGAGAATTGGAAAGATAAGATGACACCGAATAA
AATAGTTAGCTTATACGAGAGAATGTAA

Upstream 100 bases:

>100_bases
TTAAATAAATACGGAACAATTAACTAATGCTTTGTTCCGGAACTTTAAAATAATCAATAAATCTTAAAATTATATTAGTT
GCATAGATAAGGATAATTAA

Downstream 100 bases:

>100_bases
ATGGAAAATTATAAGAAAGAGTCGGATGCGATTAAGATTTTAGCTCGAATTAAAGGCCCCGTATTTGAAGAATATAGGAA
AAGATGGGATTTGGTAAATA

Product: alcohol dehydrogenase

Products: NA

Alternate protein names: MEDH [H]

Number of amino acids: Translated: 355; Mature: 354

Protein sequence:

>355_residues
MTSLRIFKQVPRLLFGFNTIDRINELLPKKNNGDYYIFIIDDVHQKGTIHSRLKHASEDMVEWFPASVKEPSTLQIDNLR
DKFMQTRDHKLPKAIVGIGGGSTMDVAKALSVMMCNEGSASQYQGWDLVPNPGIYKIGIPTVAGSGAEASRTAVLMGKER
KFGINSDHSMFDAIILDSSLIKNVPIAQRFYSGMDCYIHCVESLQGTMINELAKGNASKALELCEKVFLSDGDDDMLLTA
SYMGGVSIVNSEVGVCHALSYGLSLELGYRHGFANCVAFNVLDEYYGPWVDRFREMLKIHKIELPKNVCRSLDEAAMQRM
VNMTLKMERPLTNALGENWKDKMTPNKIVSLYERM

Sequences:

>Translated_355_residues
MTSLRIFKQVPRLLFGFNTIDRINELLPKKNNGDYYIFIIDDVHQKGTIHSRLKHASEDMVEWFPASVKEPSTLQIDNLR
DKFMQTRDHKLPKAIVGIGGGSTMDVAKALSVMMCNEGSASQYQGWDLVPNPGIYKIGIPTVAGSGAEASRTAVLMGKER
KFGINSDHSMFDAIILDSSLIKNVPIAQRFYSGMDCYIHCVESLQGTMINELAKGNASKALELCEKVFLSDGDDDMLLTA
SYMGGVSIVNSEVGVCHALSYGLSLELGYRHGFANCVAFNVLDEYYGPWVDRFREMLKIHKIELPKNVCRSLDEAAMQRM
VNMTLKMERPLTNALGENWKDKMTPNKIVSLYERM
>Mature_354_residues
TSLRIFKQVPRLLFGFNTIDRINELLPKKNNGDYYIFIIDDVHQKGTIHSRLKHASEDMVEWFPASVKEPSTLQIDNLRD
KFMQTRDHKLPKAIVGIGGGSTMDVAKALSVMMCNEGSASQYQGWDLVPNPGIYKIGIPTVAGSGAEASRTAVLMGKERK
FGINSDHSMFDAIILDSSLIKNVPIAQRFYSGMDCYIHCVESLQGTMINELAKGNASKALELCEKVFLSDGDDDMLLTAS
YMGGVSIVNSEVGVCHALSYGLSLELGYRHGFANCVAFNVLDEYYGPWVDRFREMLKIHKIELPKNVCRSLDEAAMQRMV
NMTLKMERPLTNALGENWKDKMTPNKIVSLYERM

Specific function: May Act On The Acetaldehyde Produced From The Degradation Of Ethanolamine. [C]

COG id: COG1454

COG function: function code C; Alcohol dehydrogenase, class IV

Gene ontology:

Cell location: Integral Membrane Protein [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the iron-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI87082107, Length=296, Percent_Identity=25.3378378378378, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI48994951, Length=193, Percent_Identity=25.9067357512953, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1787493, Length=210, Percent_Identity=24.7619047619048, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI1789163, Length=231, Percent_Identity=23.8095238095238, Blast_Score=68, Evalue=9e-13,
Organism=Saccharomyces cerevisiae, GI6321181, Length=192, Percent_Identity=28.6458333333333, Blast_Score=82, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001670
- InterPro:   IPR018211 [H]

Pfam domain/function: PF00465 Fe-ADH [H]

EC number: =1.1.1.244 [H]

Molecular weight: Translated: 39770; Mature: 39638

Theoretical pI: Translated: 6.99; Mature: 6.99

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
5.4 %Met     (Translated Protein)
7.3 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
5.1 %Met     (Mature Protein)
7.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSLRIFKQVPRLLFGFNTIDRINELLPKKNNGDYYIFIIDDVHQKGTIHSRLKHASEDM
CCCHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHH
VEWFPASVKEPSTLQIDNLRDKFMQTRDHKLPKAIVGIGGGSTMDVAKALSVMMCNEGSA
HHHCCCCCCCCCCEEHHHHHHHHHHHHHCCCCHHEEECCCCCHHHHHHHHHHHHCCCCCC
SQYQGWDLVPNPGIYKIGIPTVAGSGAEASRTAVLMGKERKFGINSDHSMFDAIILDSSL
CCCCCCCCCCCCCEEEECCCCCCCCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHH
IKNVPIAQRFYSGMDCYIHCVESLQGTMINELAKGNASKALELCEKVFLSDGDDDMLLTA
HHCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCEEEEE
SYMGGVSIVNSEVGVCHALSYGLSLELGYRHGFANCVAFNVLDEYYGPWVDRFREMLKIH
HHHCCEEEECCCHHHHHHHHHCCEEEECCCCCHHHHHHHHHHHHHHCHHHHHHHHHHHHH
KIELPKNVCRSLDEAAMQRMVNMTLKMERPLTNALGENWKDKMTPNKIVSLYERM
HHCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCCCCHHHHHHHHHCC
>Mature Secondary Structure 
TSLRIFKQVPRLLFGFNTIDRINELLPKKNNGDYYIFIIDDVHQKGTIHSRLKHASEDM
CCHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHH
VEWFPASVKEPSTLQIDNLRDKFMQTRDHKLPKAIVGIGGGSTMDVAKALSVMMCNEGSA
HHHCCCCCCCCCCEEHHHHHHHHHHHHHCCCCHHEEECCCCCHHHHHHHHHHHHCCCCCC
SQYQGWDLVPNPGIYKIGIPTVAGSGAEASRTAVLMGKERKFGINSDHSMFDAIILDSSL
CCCCCCCCCCCCCEEEECCCCCCCCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHH
IKNVPIAQRFYSGMDCYIHCVESLQGTMINELAKGNASKALELCEKVFLSDGDDDMLLTA
HHCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCEEEEE
SYMGGVSIVNSEVGVCHALSYGLSLELGYRHGFANCVAFNVLDEYYGPWVDRFREMLKIH
HHHCCEEEECCCHHHHHHHHHCCEEEECCCCCHHHHHHHHHHHHHHCHHHHHHHHHHHHH
KIELPKNVCRSLDEAAMQRMVNMTLKMERPLTNALGENWKDKMTPNKIVSLYERM
HHCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 1644761; 1995642 [H]