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The map label for this gene is cysM [H]

Identifier: 45657685

GI number: 45657685

Start: 2214489

End: 2215490

Strand: Reverse

Name: cysM [H]

Synonym: LIC11820

Alternate gene names: 45657685

Gene position: 2215490-2214489 (Counterclockwise)

Preceding gene: 45657686

Following gene: 45657684

Centisome position: 51.8

GC content: 39.12

Gene sequence:

>1002_bases
ATGTTTGATGAAATATCCCGTTCTATAGACGAATTCGGAAATAGTTTCCTTAGCGCGCTGAACAACATTCAGAAATCTTT
TGGGCGGGAGTTGAGCGTAGCAAAACCAGTTAAAGAAACGATTTTGCAGATGATCGGAAATACTCCTCTCATCCGTCTGA
ATCAAATTGGTTCTCATATTCCTAATGTAGAATTTTATCTCAAAGCAGAATTCTGTAATCCTACCGGTTCGGTAAAAGAT
AGAACGGCTCTGTCTATGCTTCTTTCTTCTGAAAGAAGAGGAGAATTAAAACCGGCAGGACAAGTGATTCAACCCGGTTA
TAATACTACCGCGATGAGTCTGGCTTGGATTTGTACAATTCGTCAGTATAAATTTCGTTGTTTAGTGGCAGGTGATACTG
ATCCTCTAAAGATCAAAGACTTACAAACTTTTGGGGCGCATGTAGAAATAGTTCCAGGGGCAAAAGGAAATTGGGACGAC
TCTCTTTTAAAAAGAGCTAAGGAAATTAAAGAAAAAGAAAAGAATACTATTATCTTAAACGAGTACAAAGATATGGCGAA
TACAAATGCTCATTATCTTTTTACAGGCCCTGAGATTTGGAGAGATCTTGGTGGTAATGTGGACGCATTTGTTGCAGGTG
GTGGATCTGGTGGAACTCTTTCCGGTGTTGGAAGATTTCTAAAGTCTAAAAAATCTTCTGTTCGGGTGATTATGGGAGTC
AGTCAAAAATCTAGATTCATTCGTAAGATGGTTCAAAATGAAAGTTCGATTTATCTTCCGGAATCCTTCGATCCTAAGAT
CGTAGACGAATATGTAGGCGTGGATCGGGAACAAGCTCTTTTATATCAATCCGATCTCTATCAAAAAGAAGGAATTTTCG
CAGGTCAAACTACAGGTACAACTCTTGCTAGTGCGATTCGATTTGCGGAAGGTCTTTCTATCAAAGAAGATTCAAAATCA
CAGGTCTACAGAATTGTAGTCCTATCCCCTGATCGGTTTTGA

Upstream 100 bases:

>100_bases
AGGTCTAACTCTAAAACAAGAAAGTAAGATTGGAGAGTTTGAAAAAAAGCAGAAAGAAGTTGAACCTTGGTTATACGCCA
TATAATTCTACCGAAAATAT

Downstream 100 bases:

>100_bases
AGGATAGAAATTTTTCTGATTCTATTTCTGAGTTAGAGTTTGTTAAAACCGAACTCGAAAGAGAAAAGAAAGAAGAAGAT
TCTATTTTTTCAAAAGACTG

Product: cysteine synthase

Products: NA

Alternate protein names: CSase B; O-acetylserine (thiol)-lyase B; OAS-TL B; O-acetylserine sulfhydrylase B [H]

Number of amino acids: Translated: 333; Mature: 333

Protein sequence:

>333_residues
MFDEISRSIDEFGNSFLSALNNIQKSFGRELSVAKPVKETILQMIGNTPLIRLNQIGSHIPNVEFYLKAEFCNPTGSVKD
RTALSMLLSSERRGELKPAGQVIQPGYNTTAMSLAWICTIRQYKFRCLVAGDTDPLKIKDLQTFGAHVEIVPGAKGNWDD
SLLKRAKEIKEKEKNTIILNEYKDMANTNAHYLFTGPEIWRDLGGNVDAFVAGGGSGGTLSGVGRFLKSKKSSVRVIMGV
SQKSRFIRKMVQNESSIYLPESFDPKIVDEYVGVDREQALLYQSDLYQKEGIFAGQTTGTTLASAIRFAEGLSIKEDSKS
QVYRIVVLSPDRF

Sequences:

>Translated_333_residues
MFDEISRSIDEFGNSFLSALNNIQKSFGRELSVAKPVKETILQMIGNTPLIRLNQIGSHIPNVEFYLKAEFCNPTGSVKD
RTALSMLLSSERRGELKPAGQVIQPGYNTTAMSLAWICTIRQYKFRCLVAGDTDPLKIKDLQTFGAHVEIVPGAKGNWDD
SLLKRAKEIKEKEKNTIILNEYKDMANTNAHYLFTGPEIWRDLGGNVDAFVAGGGSGGTLSGVGRFLKSKKSSVRVIMGV
SQKSRFIRKMVQNESSIYLPESFDPKIVDEYVGVDREQALLYQSDLYQKEGIFAGQTTGTTLASAIRFAEGLSIKEDSKS
QVYRIVVLSPDRF
>Mature_333_residues
MFDEISRSIDEFGNSFLSALNNIQKSFGRELSVAKPVKETILQMIGNTPLIRLNQIGSHIPNVEFYLKAEFCNPTGSVKD
RTALSMLLSSERRGELKPAGQVIQPGYNTTAMSLAWICTIRQYKFRCLVAGDTDPLKIKDLQTFGAHVEIVPGAKGNWDD
SLLKRAKEIKEKEKNTIILNEYKDMANTNAHYLFTGPEIWRDLGGNVDAFVAGGGSGGTLSGVGRFLKSKKSSVRVIMGV
SQKSRFIRKMVQNESSIYLPESFDPKIVDEYVGVDREQALLYQSDLYQKEGIFAGQTTGTTLASAIRFAEGLSIKEDSKS
QVYRIVVLSPDRF

Specific function: Two cysteine synthase enzymes are found. Both catalyze the same reaction. Cysteine synthase B can also use thiosulfate in place of sulfide to give cysteine thiosulfonate as a product [H]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=305, Percent_Identity=31.8032786885246, Blast_Score=149, Evalue=4e-36,
Organism=Homo sapiens, GI295821200, Length=305, Percent_Identity=31.8032786885246, Blast_Score=149, Evalue=4e-36,
Organism=Homo sapiens, GI4557415, Length=305, Percent_Identity=31.8032786885246, Blast_Score=149, Evalue=4e-36,
Organism=Escherichia coli, GI2367138, Length=296, Percent_Identity=32.4324324324324, Blast_Score=156, Evalue=2e-39,
Organism=Escherichia coli, GI1788754, Length=301, Percent_Identity=32.5581395348837, Blast_Score=134, Evalue=7e-33,
Organism=Caenorhabditis elegans, GI17535051, Length=289, Percent_Identity=33.5640138408304, Blast_Score=149, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI115535073, Length=285, Percent_Identity=31.2280701754386, Blast_Score=125, Evalue=3e-29,
Organism=Caenorhabditis elegans, GI17562970, Length=272, Percent_Identity=29.4117647058824, Blast_Score=124, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI32566674, Length=272, Percent_Identity=29.4117647058824, Blast_Score=123, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI17534315, Length=317, Percent_Identity=28.7066246056782, Blast_Score=98, Evalue=6e-21,
Organism=Caenorhabditis elegans, GI17561720, Length=272, Percent_Identity=29.4117647058824, Blast_Score=97, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI25147552, Length=315, Percent_Identity=26.6666666666667, Blast_Score=95, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI32566672, Length=175, Percent_Identity=27.4285714285714, Blast_Score=81, Evalue=8e-16,
Organism=Saccharomyces cerevisiae, GI6321594, Length=293, Percent_Identity=28.6689419795222, Blast_Score=137, Evalue=3e-33,
Organism=Saccharomyces cerevisiae, GI6321449, Length=310, Percent_Identity=30.3225806451613, Blast_Score=115, Evalue=1e-26,
Organism=Drosophila melanogaster, GI24643623, Length=316, Percent_Identity=30.0632911392405, Blast_Score=131, Evalue=5e-31,
Organism=Drosophila melanogaster, GI20129101, Length=316, Percent_Identity=30.0632911392405, Blast_Score=131, Evalue=5e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001216
- InterPro:   IPR005856
- InterPro:   IPR005858
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =2.5.1.47 [H]

Molecular weight: Translated: 37013; Mature: 37013

Theoretical pI: Translated: 9.19; Mature: 9.19

Prosite motif: PS00901 CYS_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFDEISRSIDEFGNSFLSALNNIQKSFGRELSVAKPVKETILQMIGNTPLIRLNQIGSHI
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCEEEEHHHHCCC
PNVEFYLKAEFCNPTGSVKDRTALSMLLSSERRGELKPAGQVIQPGYNTTAMSLAWICTI
CCEEEEEEEEECCCCCCCCHHHHHHHHHHHHCCCCCCCCCCEECCCCCHHHHHHHHHHHH
RQYKFRCLVAGDTDPLKIKDLQTFGAHVEIVPGAKGNWDDSLLKRAKEIKEKEKNTIILN
HCEEEEEEEECCCCCEEEEEHHHCCCEEEEECCCCCCCCHHHHHHHHHHHHHHCCEEEEE
EYKDMANTNAHYLFTGPEIWRDLGGNVDAFVAGGGSGGTLSGVGRFLKSKKSSVRVIMGV
CHHHHCCCCCEEEEECHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHCCCCCEEEEEEC
SQKSRFIRKMVQNESSIYLPESFDPKIVDEYVGVDREQALLYQSDLYQKEGIFAGQTTGT
CHHHHHHHHHHCCCCCEECCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCHH
TLASAIRFAEGLSIKEDSKSQVYRIVVLSPDRF
HHHHHHHHHHCCCCCCCCCCCEEEEEEECCCCC
>Mature Secondary Structure
MFDEISRSIDEFGNSFLSALNNIQKSFGRELSVAKPVKETILQMIGNTPLIRLNQIGSHI
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCEEEEHHHHCCC
PNVEFYLKAEFCNPTGSVKDRTALSMLLSSERRGELKPAGQVIQPGYNTTAMSLAWICTI
CCEEEEEEEEECCCCCCCCHHHHHHHHHHHHCCCCCCCCCCEECCCCCHHHHHHHHHHHH
RQYKFRCLVAGDTDPLKIKDLQTFGAHVEIVPGAKGNWDDSLLKRAKEIKEKEKNTIILN
HCEEEEEEEECCCCCEEEEEHHHCCCEEEEECCCCCCCCHHHHHHHHHHHHHHCCEEEEE
EYKDMANTNAHYLFTGPEIWRDLGGNVDAFVAGGGSGGTLSGVGRFLKSKKSSVRVIMGV
CHHHHCCCCCEEEEECHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHCCCCCEEEEEEC
SQKSRFIRKMVQNESSIYLPESFDPKIVDEYVGVDREQALLYQSDLYQKEGIFAGQTTGT
CHHHHHHHHHHCCCCCEECCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCHH
TLASAIRFAEGLSIKEDSKSQVYRIVVLSPDRF
HHHHHHHHHHCCCCCCCCCCCEEEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2188958; 9205837; 9278503 [H]