BacMap

Definition	Leptospira interrogans serovar Copenhageni str. Fiocruz L1-130 chromosome chromosome I, complete sequence.
Accession	NC_005823
Length	4,277,185

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The map label for this gene is argD

Identifier: 45657633

GI number: 45657633

Start: 2159272

End: 2160492

Strand: Direct

Name: argD

Synonym: LIC11767

Alternate gene names: 45657633

Gene position: 2159272-2160492 (Clockwise)

Preceding gene: 304570493

Following gene: 45657634

Centisome position: 50.48

GC content: 39.31

Gene sequence:

>1221_bases
ATGAATGACGCAGACATCCACAAAGAACTTTTTCAACACACAAAAGAATTAGCGGATCATTATCTACTCAATACGTATGC
AAGATACGACGTAGCGTTTCGTTATGGAGTTAACGAACTTCTATTCGATTTTGATAATAAACAATATATTGATTTCCATT
GCGGAGTTGCGGTTACAAACCTAGGGCACGCAGATCCTGACATCATAGAAGTAGTCCGTTCCCAAGCGGATAAATTATTT
CACACTTCCAATCTATTTTATTCTGAAGAAGCTTCAAAACTTGCAGAACTTCTCATATTAAACTCTTTTCCTGGAAAAGT
GTTTTTAACCAATTCAGGAACCGAAGCGATCGAAGGAGCGTTTAAACTCGCAAGAAAATACGCATATTCAAAAAGTATCG
TAGATCCTATCATCCTTTCCTTGGAAAAAAGTTTTCACGGAAGATCCGTTTCGGGTATGAGTTTAACCGGACAAGATAAA
ATCAGAAAAGGTTATGGAGAACTTCTAAAAGGAATCGAATTTATAGAACCGAACAACGACGAAGCCCTTGTAGCTGCATT
CGAAAGATACCAGGGAAGAATCGTAGCCTTAATCGAAGAACCCATCTTAGGCGAAAGTGGAATTATACCTTTATCTAGAA
ATTTCCTTACACTTTCCAGAGAACTAACAGAAGAAAACGAAGCGCTTCTAATTTTCGACGAAATCCAAACCGGAATGGGT
AGAACTGGAACGTTATTCGCATTTGAAACGATGGGTTTTAGTCCAGACGCAATGACACTTGCCAAAGGGCTCGGATCTGG
ATTTCCAATCGGCGCTTTGATTGTAGGAGAAAAATATCAGGACCTTTTTACGCAAGGATCTCACGGCTCCACATTTGGAG
GTAATCATTTGGCTGCTGCGGTCGCTTATGAAACGATTCGTATCATTCAAACCAGAGAAATTTTAAACAACGTAAATATT
TGCTCTGACATTGCTTTTACAAGACTGAGAGAAATGCAGGAAAAATATCCAGTGATTTCAGAAGTAAGAGGAAAAGGACT
TCACATCGGACTTGAATTGAAAGTTCCTTCCAAACCAATTGCGGAAGCCTGTTTGTCCGCAGGGCTCGTAGTCAATGCAA
CGGCGGATAACGTAGTTCGGATTATGCCTCCACTTACAATTTCGACAGATTTTTTAAATCAAGGATTAGACATCTTAGAA
TCCGTACTCAAACAAAACTAA

Upstream 100 bases:

>100_bases
AAGCTCCTAAGTCCAAAGAAGAAATTAAAATACTTACCAAAGATCTTCTTTCTGAAATCAAAACTTCCGAAGAAATATTT
TTACAACTGGCGGGGCTCTC

Downstream 100 bases:

>100_bases
AAGGATCTAAAAAAGAATGAAGAATGTAGCAGTACTTTCCGGAGACGGAATCGGACCGGAAGTCATGGAGATAGCCATCT
CCGTTTTGAAAAAGGCTCTC

Product: acetylornithine aminotransferase

Products: NA

Alternate protein names: ACOAT

Number of amino acids: Translated: 406; Mature: 406

Protein sequence:

>406_residues
MNDADIHKELFQHTKELADHYLLNTYARYDVAFRYGVNELLFDFDNKQYIDFHCGVAVTNLGHADPDIIEVVRSQADKLF
HTSNLFYSEEASKLAELLILNSFPGKVFLTNSGTEAIEGAFKLARKYAYSKSIVDPIILSLEKSFHGRSVSGMSLTGQDK
IRKGYGELLKGIEFIEPNNDEALVAAFERYQGRIVALIEEPILGESGIIPLSRNFLTLSRELTEENEALLIFDEIQTGMG
RTGTLFAFETMGFSPDAMTLAKGLGSGFPIGALIVGEKYQDLFTQGSHGSTFGGNHLAAAVAYETIRIIQTREILNNVNI
CSDIAFTRLREMQEKYPVISEVRGKGLHIGLELKVPSKPIAEACLSAGLVVNATADNVVRIMPPLTISTDFLNQGLDILE
SVLKQN

Sequences:

>Translated_406_residues
MNDADIHKELFQHTKELADHYLLNTYARYDVAFRYGVNELLFDFDNKQYIDFHCGVAVTNLGHADPDIIEVVRSQADKLF
HTSNLFYSEEASKLAELLILNSFPGKVFLTNSGTEAIEGAFKLARKYAYSKSIVDPIILSLEKSFHGRSVSGMSLTGQDK
IRKGYGELLKGIEFIEPNNDEALVAAFERYQGRIVALIEEPILGESGIIPLSRNFLTLSRELTEENEALLIFDEIQTGMG
RTGTLFAFETMGFSPDAMTLAKGLGSGFPIGALIVGEKYQDLFTQGSHGSTFGGNHLAAAVAYETIRIIQTREILNNVNI
CSDIAFTRLREMQEKYPVISEVRGKGLHIGLELKVPSKPIAEACLSAGLVVNATADNVVRIMPPLTISTDFLNQGLDILE
SVLKQN
>Mature_406_residues
MNDADIHKELFQHTKELADHYLLNTYARYDVAFRYGVNELLFDFDNKQYIDFHCGVAVTNLGHADPDIIEVVRSQADKLF
HTSNLFYSEEASKLAELLILNSFPGKVFLTNSGTEAIEGAFKLARKYAYSKSIVDPIILSLEKSFHGRSVSGMSLTGQDK
IRKGYGELLKGIEFIEPNNDEALVAAFERYQGRIVALIEEPILGESGIIPLSRNFLTLSRELTEENEALLIFDEIQTGMG
RTGTLFAFETMGFSPDAMTLAKGLGSGFPIGALIVGEKYQDLFTQGSHGSTFGGNHLAAAVAYETIRIIQTREILNNVNI
CSDIAFTRLREMQEKYPVISEVRGKGLHIGLELKVPSKPIAEACLSAGLVVNATADNVVRIMPPLTISTDFLNQGLDILE
SVLKQN

Specific function: Catalyzes The Transmination Of N(2)-Succinylornithine And Alpha-Ketoglutarate Into N(2)-Succinylglutamate Semialdehyde And Glutamate. Can Also Act As A Acetylornithine Aminotransferase. [C]

COG id: COG4992

COG function: function code E; Ornithine/acetylornithine aminotransferase

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily

Homologues:

Organism=Homo sapiens, GI4557809, Length=393, Percent_Identity=31.2977099236641, Blast_Score=178, Evalue=8e-45,
Organism=Homo sapiens, GI13994255, Length=441, Percent_Identity=28.7981859410431, Blast_Score=162, Evalue=4e-40,
Organism=Homo sapiens, GI284507298, Length=303, Percent_Identity=31.6831683168317, Blast_Score=138, Evalue=1e-32,
Organism=Homo sapiens, GI37574042, Length=412, Percent_Identity=25.4854368932039, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI24119277, Length=404, Percent_Identity=24.009900990099, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI226442705, Length=412, Percent_Identity=24.7572815533981, Blast_Score=101, Evalue=2e-21,
Organism=Homo sapiens, GI226442709, Length=390, Percent_Identity=25.1282051282051, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI188536080, Length=297, Percent_Identity=24.9158249158249, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI38679950, Length=297, Percent_Identity=24.9158249158249, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI38679946, Length=297, Percent_Identity=24.9158249158249, Blast_Score=79, Evalue=1e-14,
Organism=Escherichia coli, GI1788044, Length=389, Percent_Identity=39.8457583547558, Blast_Score=265, Evalue=3e-72,
Organism=Escherichia coli, GI1789759, Length=389, Percent_Identity=39.0745501285347, Blast_Score=256, Evalue=1e-69,
Organism=Escherichia coli, GI145693181, Length=410, Percent_Identity=33.1707317073171, Blast_Score=187, Evalue=9e-49,
Organism=Escherichia coli, GI1789016, Length=398, Percent_Identity=31.1557788944724, Blast_Score=178, Evalue=5e-46,
Organism=Escherichia coli, GI1787560, Length=395, Percent_Identity=29.620253164557, Blast_Score=153, Evalue=2e-38,
Organism=Escherichia coli, GI1786349, Length=277, Percent_Identity=29.6028880866426, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1786991, Length=311, Percent_Identity=28.2958199356913, Blast_Score=91, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI25144271, Length=398, Percent_Identity=29.8994974874372, Blast_Score=189, Evalue=2e-48,
Organism=Caenorhabditis elegans, GI32564660, Length=436, Percent_Identity=30.5045871559633, Blast_Score=175, Evalue=3e-44,
Organism=Caenorhabditis elegans, GI25144274, Length=266, Percent_Identity=28.9473684210526, Blast_Score=130, Evalue=9e-31,
Organism=Caenorhabditis elegans, GI71992977, Length=418, Percent_Identity=26.0765550239234, Blast_Score=125, Evalue=3e-29,
Organism=Caenorhabditis elegans, GI71981843, Length=175, Percent_Identity=29.7142857142857, Blast_Score=81, Evalue=8e-16,
Organism=Saccharomyces cerevisiae, GI6324432, Length=397, Percent_Identity=38.0352644836272, Blast_Score=269, Evalue=7e-73,
Organism=Saccharomyces cerevisiae, GI6323470, Length=415, Percent_Identity=31.3253012048193, Blast_Score=186, Evalue=5e-48,
Organism=Saccharomyces cerevisiae, GI6324386, Length=443, Percent_Identity=26.1851015801354, Blast_Score=87, Evalue=4e-18,
Organism=Saccharomyces cerevisiae, GI6321456, Length=435, Percent_Identity=24.367816091954, Blast_Score=80, Evalue=5e-16,
Organism=Drosophila melanogaster, GI21357415, Length=391, Percent_Identity=30.4347826086957, Blast_Score=184, Evalue=8e-47,
Organism=Drosophila melanogaster, GI28574759, Length=440, Percent_Identity=28.4090909090909, Blast_Score=174, Evalue=1e-43,
Organism=Drosophila melanogaster, GI161085790, Length=422, Percent_Identity=28.6729857819905, Blast_Score=174, Evalue=1e-43,
Organism=Drosophila melanogaster, GI21356575, Length=401, Percent_Identity=24.9376558603491, Blast_Score=117, Evalue=1e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ARGD_LEPIC (Q72RH8)

Other databases:

- EMBL:   AE016823
- RefSeq:   YP_001719.1
- ProteinModelPortal:   Q72RH8
- SMR:   Q72RH8
- GeneID:   2771509
- GenomeReviews:   AE016823_GR
- KEGG:   lic:LIC11767
- HOGENOM:   HBG725944
- OMA:   QGELAKW
- ProtClustDB:   PRK02627
- BioCyc:   LINT267671:LIC_11767-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01107
- InterPro:   IPR004636
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- PANTHER:   PTHR11986
- PANTHER:   PTHR11986:SF19

Pfam domain/function: PF00202 Aminotran_3; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.6.1.11

Molecular weight: Translated: 44867; Mature: 44867

Theoretical pI: Translated: 4.91; Mature: 4.91

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: BINDING 145-145 BINDING 148-148 BINDING 290-290 BINDING 291-291

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNDADIHKELFQHTKELADHYLLNTYARYDVAFRYGVNELLFDFDNKQYIDFHCGVAVTN
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHCCCCCEEEEEECCEEEEC
LGHADPDIIEVVRSQADKLFHTSNLFYSEEASKLAELLILNSFPGKVFLTNSGTEAIEGA
CCCCCHHHHHHHHHHHHHHHHHCCCEEHHHHHHHHHHHHEECCCCEEEEECCCCHHHHHH
FKLARKYAYSKSIVDPIILSLEKSFHGRSVSGMSLTGQDKIRKGYGELLKGIEFIEPNND
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEECCHHHHHHHHHHHHHCCEEECCCCC
EALVAAFERYQGRIVALIEEPILGESGIIPLSRNFLTLSRELTEENEALLIFDEIQTGMG
CHHHHHHHHHCCEEEEEEECCCCCCCCCCCCCCCHHHHHHHHCCCCCEEEEEEHHHCCCC
RTGTLFAFETMGFSPDAMTLAKGLGSGFPIGALIVGEKYQDLFTQGSHGSTFGGNHLAAA
CCCEEEEEEECCCCCCHHHHHHHCCCCCCEEEEEECCHHHHHHCCCCCCCCCCCCHHHHH
VAYETIRIIQTREILNNVNICSDIAFTRLREMQEKYPVISEVRGKGLHIGLELKVPSKPI
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCHHHHCCCCEEEEEEEECCCCHH
AEACLSAGLVVNATADNVVRIMPPLTISTDFLNQGLDILESVLKQN
HHHHHHCCEEEEECCCCEEEECCCCEEEHHHHHCCHHHHHHHHHCC
>Mature Secondary Structure
MNDADIHKELFQHTKELADHYLLNTYARYDVAFRYGVNELLFDFDNKQYIDFHCGVAVTN
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHCCCCCEEEEEECCEEEEC
LGHADPDIIEVVRSQADKLFHTSNLFYSEEASKLAELLILNSFPGKVFLTNSGTEAIEGA
CCCCCHHHHHHHHHHHHHHHHHCCCEEHHHHHHHHHHHHEECCCCEEEEECCCCHHHHHH
FKLARKYAYSKSIVDPIILSLEKSFHGRSVSGMSLTGQDKIRKGYGELLKGIEFIEPNND
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEECCHHHHHHHHHHHHHCCEEECCCCC
EALVAAFERYQGRIVALIEEPILGESGIIPLSRNFLTLSRELTEENEALLIFDEIQTGMG
CHHHHHHHHHCCEEEEEEECCCCCCCCCCCCCCCHHHHHHHHCCCCCEEEEEEHHHCCCC
RTGTLFAFETMGFSPDAMTLAKGLGSGFPIGALIVGEKYQDLFTQGSHGSTFGGNHLAAA
CCCEEEEEEECCCCCCHHHHHHHCCCCCCEEEEEECCHHHHHHCCCCCCCCCCCCHHHHH
VAYETIRIIQTREILNNVNICSDIAFTRLREMQEKYPVISEVRGKGLHIGLELKVPSKPI
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCHHHHCCCCEEEEEEEECCCCHH
AEACLSAGLVVNATADNVVRIMPPLTISTDFLNQGLDILESVLKQN
HHHHHHCCEEEEECCCCEEEECCCCEEEHHHHHCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA