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The map label for this gene is manB

Identifier: 304570493

GI number: 304570493

Start: 2157512

End: 2159275

Strand: Direct

Name: manB

Synonym: NA

Alternate gene names: 304570493

Gene position: 2157512-2159275 (Clockwise)

Preceding gene: 45657629

Following gene: 45657633

Centisome position: 50.44

GC content: 36.39

Gene sequence:

>1764_bases
ATGAATCATCTCGAATCTTTTATTCTTCCTTGGACTCAGGAGCCTTTTCCAAATACGGTTCGCAAAGAAGCAAATCTTGC
ACTTGAAAAATTTTCTAGAGGAGAGTCTGGTCCAGAAGTAGAAGCATTTTCAATTCCTCTCGAATTTGGAACCGGAGGAA
TGCGTGGAAAGTTAGGCAACGGAATCGGAAGGATGAACGAATTTACCGTTGGTCGTGCAGCACTTGGATTTATAAGTTAT
CTTTCTAAAAAAAACAAAAAGGCTTCTATCGTAATCGCCTACGATTCTAGAAGAAGATCTAAAGAATTTGCGGAAGTTAC
CGCTGGGATTGCAGCTTACTTAGGAGTCAAAGTTATTCTATTTAAAGAAGTAACTCCCACACCGATTCTTTCTTATGCAA
TTCGTTATTACAAAGCAAGCGGAGGTGTAGTAATTACCGCCTCTCACAATCCTCCAGAGTATAACGGTTTTAAGGCGTAT
CTTTCAGACGGAGGTCAGCTTGTTCCTCCAGACGATCAAAAGATCATTTCTAAAATAGAATCTATCACCGATTGGAAACA
AATTCCAATTCTTTCTACAAAAGATCCAATTTACAAAAAAATGGTAAAATTTGCCGGAAAGGATTGTTTTACTTCTTATA
AGAAAGATCTTTCTAAAGCTGGAATTCTTTCTATTTCCCTAAAACCAAAAGATCGTACTGCTTTGAAAATCGTTTATTCT
CCGTTACATGGAACTGGCGGAAAAAGCATGCAAGAACTCTTAAATAGTTTCGGATATAAAAACGTATTTTTAGTTCCAGA
ACAAAAAGATCCAAATGGAGAATTTCCTACGGTTAAATATCCAAACCCAGAAGAAGCAGAAGCGATGGAACTTTCCAAAA
AATTTGCGATCCAAAAAAACGCCCACGCTTTTATCGCGACCGATCCAGACGCAGATAGACTTGGAATCGGCGTCAAAAAC
GAAAACGGAGAATACGTTTTGTTTAATGGAAATCAGATCGGTTCCATCATGGCCGCTTATTTATGCGAAGCTTATTCCGC
AGGTAAAAAAAAGAAAAAGGCAGTTTTAGTAAAAACGATCGTTACCACAGATTTACAAGAGAACATTGCTAAAAAAAACA
AGGTAAAATATAAAAACGTATTAACCGGATTCAAGTTCATTGCGCAAGTGATGGCAAAAATTGATAAAAGTAAAACCGAT
TTCTTTTTATTCGGAGGAGAAGAATCTTTTGGTTATCTTCCGGTCTCTTTTGTGAGGGATAAGGATTCACTTTCTTCTGC
TTTATTACTTTTAGAAATTCTTACAGAAAAAAAAGATCTTTTCAATTATATGGACGAGATTTATCTTAAATACGGTCTTT
TTCAAGAAAGTCTCAAATCACTTACTTTAGAAGGAAGTGCCGGTAAAGAAAAAATCCGTAAGTCTTTGGAATCTCTACGA
ACCCTAGATTTGTTAGGAAAAAAAATTCATCATAGAAAAATTACCGGAATTCTCGATTATAAAACTCAGATCGCCAAAGG
AAACGCTTCCAAATCCGCGTTTTCTGGTTGTCCTTCATCGGACGTGATTCAAGTCATTTTAGAAGGAAATGCAAAACTCA
CAATCCGACCTTCCGGAACGGAACCTAAAATTAAAATTTATTCTTCCTTTCAAAGCCTAAAAGCTCCTAAGTCCAAAGAA
GAAATTAAAATACTTACCAAAGATCTTCTTTCTGAAATCAAAACTTCCGAAGAAATATTTTTACAACTGGCGGGGCTCTC
ATGA

Upstream 100 bases:
NA

Downstream 100 bases:
NA

Product: phosphomannomutase

Products: NA

Alternate protein names: PGM; Alpha-phosphoglucomutase; Glucose phosphomutase [H]

Number of amino acids: Translated: 587; Mature: 587

Protein sequence:
NA

Sequences:

>Translated_587_residues
MNHLESFILPWTQEPFPNTVRKEANLALEKFSRGESGPEVEAFSIPLEFGTGGMRGKLGNGIGRMNEFTVGRAALGFISY
LSKKNKKASIVIAYDSRRRSKEFAEVTAGIAAYLGVKVILFKEVTPTPILSYAIRYYKASGGVVITASHNPPEYNGFKAY
LSDGGQLVPPDDQKIISKIESITDWKQIPILSTKDPIYKKMVKFAGKDCFTSYKKDLSKAGILSISLKPKDRTALKIVYS
PLHGTGGKSMQELLNSFGYKNVFLVPEQKDPNGEFPTVKYPNPEEAEAMELSKKFAIQKNAHAFIATDPDADRLGIGVKN
ENGEYVLFNGNQIGSIMAAYLCEAYSAGKKKKKAVLVKTIVTTDLQENIAKKNKVKYKNVLTGFKFIAQVMAKIDKSKTD
FFLFGGEESFGYLPVSFVRDKDSLSSALLLLEILTEKKDLFNYMDEIYLKYGLFQESLKSLTLEGSAGKEKIRKSLESLR
TLDLLGKKIHHRKITGILDYKTQIAKGNASKSAFSGCPSSDVIQVILEGNAKLTIRPSGTEPKIKIYSSFQSLKAPKSKE
EIKILTKDLLSEIKTSEEIFLQLAGLS
>Mature_587_residues
MNHLESFILPWTQEPFPNTVRKEANLALEKFSRGESGPEVEAFSIPLEFGTGGMRGKLGNGIGRMNEFTVGRAALGFISY
LSKKNKKASIVIAYDSRRRSKEFAEVTAGIAAYLGVKVILFKEVTPTPILSYAIRYYKASGGVVITASHNPPEYNGFKAY
LSDGGQLVPPDDQKIISKIESITDWKQIPILSTKDPIYKKMVKFAGKDCFTSYKKDLSKAGILSISLKPKDRTALKIVYS
PLHGTGGKSMQELLNSFGYKNVFLVPEQKDPNGEFPTVKYPNPEEAEAMELSKKFAIQKNAHAFIATDPDADRLGIGVKN
ENGEYVLFNGNQIGSIMAAYLCEAYSAGKKKKKAVLVKTIVTTDLQENIAKKNKVKYKNVLTGFKFIAQVMAKIDKSKTD
FFLFGGEESFGYLPVSFVRDKDSLSSALLLLEILTEKKDLFNYMDEIYLKYGLFQESLKSLTLEGSAGKEKIRKSLESLR
TLDLLGKKIHHRKITGILDYKTQIAKGNASKSAFSGCPSSDVIQVILEGNAKLTIRPSGTEPKIKIYSSFQSLKAPKSKE
EIKILTKDLLSEIKTSEEIFLQLAGLS

Specific function: Catalyzes the interconversion between glucose-6- phosphate and alpha-glucose-1-phosphate. This is the first step in the biosynthesis of diglucosyl-diacylglycerol (Glc2-DAG), i.e. the predominant glycolipid found in B.subtilis membrane, which is also used

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the phosphohexose mutase family [H]

Homologues:

Organism=Homo sapiens, GI63055049, Length=570, Percent_Identity=32.6315789473684, Blast_Score=275, Evalue=1e-73,
Organism=Homo sapiens, GI31377548, Length=609, Percent_Identity=30.8702791461412, Blast_Score=243, Evalue=5e-64,
Organism=Homo sapiens, GI21361621, Length=423, Percent_Identity=26.7139479905437, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI290463102, Length=430, Percent_Identity=26.5116279069767, Blast_Score=74, Evalue=6e-13,
Organism=Escherichia coli, GI1786904, Length=565, Percent_Identity=23.8938053097345, Blast_Score=73, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI71993870, Length=526, Percent_Identity=29.0874524714829, Blast_Score=222, Evalue=3e-58,
Organism=Caenorhabditis elegans, GI71993878, Length=288, Percent_Identity=32.6388888888889, Blast_Score=157, Evalue=1e-38,
Organism=Saccharomyces cerevisiae, GI6323934, Length=552, Percent_Identity=30.0724637681159, Blast_Score=225, Evalue=1e-59,
Organism=Drosophila melanogaster, GI20129809, Length=535, Percent_Identity=29.3457943925234, Blast_Score=215, Evalue=8e-56,
Organism=Drosophila melanogaster, GI24651977, Length=461, Percent_Identity=29.7180043383948, Blast_Score=202, Evalue=4e-52,
Organism=Drosophila melanogaster, GI24653722, Length=547, Percent_Identity=28.1535648994516, Blast_Score=201, Evalue=8e-52,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005844
- InterPro:   IPR016055
- InterPro:   IPR005845
- InterPro:   IPR005846
- InterPro:   IPR005843
- InterPro:   IPR016066
- InterPro:   IPR005841 [H]

Pfam domain/function: PF02878 PGM_PMM_I; PF02879 PGM_PMM_II; PF02880 PGM_PMM_III; PF00408 PGM_PMM_IV [H]

EC number: =5.4.2.2 [H]

Molecular weight: Translated: 65039; Mature: 65039

Theoretical pI: Translated: 9.97; Mature: 9.97

Prosite motif: PS00710 PGM_PMM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNHLESFILPWTQEPFPNTVRKEANLALEKFSRGESGPEVEAFSIPLEFGTGGMRGKLGN
CCCHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEEEEEEECCCCCCCCCCC
GIGRMNEFTVGRAALGFISYLSKKNKKASIVIAYDSRRRSKEFAEVTAGIAAYLGVKVIL
CCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHCEEEEE
FKEVTPTPILSYAIRYYKASGGVVITASHNPPEYNGFKAYLSDGGQLVPPDDQKIISKIE
EECCCCCHHHHHHHHHEECCCCEEEEECCCCCCCCCCHHHCCCCCEECCCCHHHHHHHHH
SITDWKQIPILSTKDPIYKKMVKFAGKDCFTSYKKDLSKAGILSISLKPKDRTALKIVYS
HHHHHHHCCCCCCCCHHHHHHHHHHCHHHHHHHHHHHHHCCEEEEEECCCCCCEEEEEEE
PLHGTGGKSMQELLNSFGYKNVFLVPEQKDPNGEFPTVKYPNPEEAEAMELSKKFAIQKN
CCCCCCCHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCC
AHAFIATDPDADRLGIGVKNENGEYVLFNGNQIGSIMAAYLCEAYSAGKKKKKAVLVKTI
CCEEEEECCCCCCEEEEEECCCCCEEEECCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
VTTDLQENIAKKNKVKYKNVLTGFKFIAQVMAKIDKSKTDFFLFGGEESFGYLPVSFVRD
HHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCEEECC
KDSLSSALLLLEILTEKKDLFNYMDEIYLKYGLFQESLKSLTLEGSAGKEKIRKSLESLR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCHHHHHHHHHHHH
TLDLLGKKIHHRKITGILDYKTQIAKGNASKSAFSGCPSSDVIQVILEGNAKLTIRPSGT
HHHHHHHHHHHHHHHEEEHHHHHHHCCCCCCHHHCCCCCHHHEEEEECCCCEEEEECCCC
EPKIKIYSSFQSLKAPKSKEEIKILTKDLLSEIKTSEEIFLQLAGLS
CCCEEEEECHHHHCCCCCHHHHHHHHHHHHHHHCCCHHHHHEECCCC
>Mature Secondary Structure
MNHLESFILPWTQEPFPNTVRKEANLALEKFSRGESGPEVEAFSIPLEFGTGGMRGKLGN
CCCHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEEEEEEECCCCCCCCCCC
GIGRMNEFTVGRAALGFISYLSKKNKKASIVIAYDSRRRSKEFAEVTAGIAAYLGVKVIL
CCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHCEEEEE
FKEVTPTPILSYAIRYYKASGGVVITASHNPPEYNGFKAYLSDGGQLVPPDDQKIISKIE
EECCCCCHHHHHHHHHEECCCCEEEEECCCCCCCCCCHHHCCCCCEECCCCHHHHHHHHH
SITDWKQIPILSTKDPIYKKMVKFAGKDCFTSYKKDLSKAGILSISLKPKDRTALKIVYS
HHHHHHHCCCCCCCCHHHHHHHHHHCHHHHHHHHHHHHHCCEEEEEECCCCCCEEEEEEE
PLHGTGGKSMQELLNSFGYKNVFLVPEQKDPNGEFPTVKYPNPEEAEAMELSKKFAIQKN
CCCCCCCHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCC
AHAFIATDPDADRLGIGVKNENGEYVLFNGNQIGSIMAAYLCEAYSAGKKKKKAVLVKTI
CCEEEEECCCCCCEEEEEECCCCCEEEECCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
VTTDLQENIAKKNKVKYKNVLTGFKFIAQVMAKIDKSKTDFFLFGGEESFGYLPVSFVRD
HHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCEEECC
KDSLSSALLLLEILTEKKDLFNYMDEIYLKYGLFQESLKSLTLEGSAGKEKIRKSLESLR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCHHHHHHHHHHHH
TLDLLGKKIHHRKITGILDYKTQIAKGNASKSAFSGCPSSDVIQVILEGNAKLTIRPSGT
HHHHHHHHHHHHHHHEEEHHHHHHHCCCCCCHHHCCCCCHHHEEEEECCCCEEEEECCCC
EPKIKIYSSFQSLKAPKSKEEIKILTKDLLSEIKTSEEIFLQLAGLS
CCCEEEEECHHHHCCCCCHHHHHHHHHHHHHHHCCCHHHHHEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377; 2127799 [H]