Click here to switch to the map view.

The map label for this gene is sppA [H]

Identifier: 45657584

GI number: 45657584

Start: 2091080

End: 2092819

Strand: Direct

Name: sppA [H]

Synonym: LIC11718

Alternate gene names: 45657584

Gene position: 2091080-2092819 (Clockwise)

Preceding gene: 45657580

Following gene: 45657587

Centisome position: 48.89

GC content: 32.36

Gene sequence:

>1740_bases
ATGTTTCGAAATTTTCTGCAAATTGTATTCATTCCTTTCCGATTGATTTTCCAACTCGTTCGTTGGATTCGATTTCGATT
TTTTTCTGGAGATCATTATTTTTTAGAAATTCCATCCGAATTTTCAAACTATCGAAAATCCTTTTTGATGAAACTTCTCT
CTTCTAAAGAAGAAGAAGTTTTTTTTACAGATTTTCTATTAGAGCTCAAATTACTTTCTCAAGTTCCTAATTTGAAAAAA
GTTTCTATACTCATTCAACAACCTGAGTACGGATTTGGTGAAACTTTAAACATTGCGGAAGGATTACAGATTTTGAAAGA
ACGCGGGATTGTGTTGGAAGGATTTGCACTTACAGGAGGGCTTAAATCCCTGTTTTTATTAGGAGTTTGTAACAAAAGAT
TTAGCAGTGAATCTTCCGAATTTTTTCCAGTTTTACCTTCTGCCGAATCTTTTTTCTTCGGGAACGCAGGCAAAAAATGG
GGAGTCAAGGCAGAAACTTTTCAGAGCGGACCTTATAAATCTTTTGGAGAAACATTTCAAAGAGATAAGTTTTCATCTAA
AGCGAGAGAGAATCTAAATTCTCTTCTCAAACAAATGACGGATGATTTAGAATCGATATTCAAACGTTATACTGGGTTTA
CACTGAAAACTTTTGCTGAACCTTTTTTATCCGCAAAGGTATTACAAGAAAGGAAATTTATCACCGGATTTTTAAATGAA
GAGGATTTTAAAGAGAATTTTATTTATATAAATTATCAAAACGAAAACGAAGATCAAAAACCTTCTTCGAAAGAATTGAA
TCTTTCTTCTTTATATCGTTTTTCTAAATTAAAGAACTTTAAACTAGTCTCTCAAAAGGAATCTGTGGTGGCCGTTCTTC
CTTTAAAGGGAAATATCCATCATGATACAATTGGAAAGGGAGAAGGTAAAACGGACGGTATTTCTTATTATTCAATTAAA
GAAGCACTCAAAGAATTAAAAAAAGAATCCTCGGTTAAGGCGGTGATTTTAGAAGTGGATTCTCCGGGCGGTTCTGCTTT
TGTATCTGAATTGTTATATCAGGAAATTCTAAAGCTACAAAAAAAGAAACCTGTATATGCGTATATACAAAACATTTCTG
CAAGCGGAGGATATTATCTTTCTTGTGGAGCTTCTAAAATTTACGCTTCCCCCTATGGAATTGTAGGAAGTATTGGAAGT
ATATCGATTCGTTTTGATTTAAAAAATCTTTATTCTAAATTAGGAATTACTAAAGACAGAGTGGGATTTTATAAATACAG
GGATCTTCTTTCTGAATATGGGCCAATTCATCCAGAATCTAAGAAACTAATGGAACAGGAGATTAAAGAATCGGAAGGAC
TTTTTTACAAAAGGGTCTCTGATTCTAGAAAAATTCCTATTTCTGATTTAGATAAACGGTTTGGGCAGGGAAAGGTTTTT
ACTTCGAGTCAATTTTTAAAGGAAAGGATGATCGATTCTATCACTGATTTTTTAAGTTTATTAGAAGACATTAAACAAGA
TTTAAAAGTAGAAAAGGTTCAAGTTCGATATTTACCTTCTTTATTTACGTTTCAAAGTTTTCTAAAGTCTTTAAAACCAG
GGTTTTTATCGAACGTTTTTAGTAAGGATTTGACTTCTTATTTTCCTAATGTTTTGGAATCTGAGAATTCGTTGAGAAAA
AAATTTCAATCCATAGAAGCCCAATCTTTATTGGGATCCTCGTTTTGGAATCAAAGTTGA

Upstream 100 bases:

>100_bases
CTCTTGCTTTTTAGGATTTATAGCGTGATTAAATCTGAAAACTCCTTTCCTAAAAGAAATTCTTCTTTTTCAAGAAGAAT
CTGGTTTTCAAACTGACAGC

Downstream 100 bases:

>100_bases
TCAAACCGTTTTTTCTAAATTGTAAGAGTTCCCACATTTTAGGATTTTAAATATGTGTTTTGTAAGTGCGATTAAAAAAT
CTTTTTACATAGTTATATAG

Product: protease IV

Products: NA

Alternate protein names: Endopeptidase IV; Protease IV homolog; Signal peptide peptidase [H]

Number of amino acids: Translated: 579; Mature: 579

Protein sequence:

>579_residues
MFRNFLQIVFIPFRLIFQLVRWIRFRFFSGDHYFLEIPSEFSNYRKSFLMKLLSSKEEEVFFTDFLLELKLLSQVPNLKK
VSILIQQPEYGFGETLNIAEGLQILKERGIVLEGFALTGGLKSLFLLGVCNKRFSSESSEFFPVLPSAESFFFGNAGKKW
GVKAETFQSGPYKSFGETFQRDKFSSKARENLNSLLKQMTDDLESIFKRYTGFTLKTFAEPFLSAKVLQERKFITGFLNE
EDFKENFIYINYQNENEDQKPSSKELNLSSLYRFSKLKNFKLVSQKESVVAVLPLKGNIHHDTIGKGEGKTDGISYYSIK
EALKELKKESSVKAVILEVDSPGGSAFVSELLYQEILKLQKKKPVYAYIQNISASGGYYLSCGASKIYASPYGIVGSIGS
ISIRFDLKNLYSKLGITKDRVGFYKYRDLLSEYGPIHPESKKLMEQEIKESEGLFYKRVSDSRKIPISDLDKRFGQGKVF
TSSQFLKERMIDSITDFLSLLEDIKQDLKVEKVQVRYLPSLFTFQSFLKSLKPGFLSNVFSKDLTSYFPNVLESENSLRK
KFQSIEAQSLLGSSFWNQS

Sequences:

>Translated_579_residues
MFRNFLQIVFIPFRLIFQLVRWIRFRFFSGDHYFLEIPSEFSNYRKSFLMKLLSSKEEEVFFTDFLLELKLLSQVPNLKK
VSILIQQPEYGFGETLNIAEGLQILKERGIVLEGFALTGGLKSLFLLGVCNKRFSSESSEFFPVLPSAESFFFGNAGKKW
GVKAETFQSGPYKSFGETFQRDKFSSKARENLNSLLKQMTDDLESIFKRYTGFTLKTFAEPFLSAKVLQERKFITGFLNE
EDFKENFIYINYQNENEDQKPSSKELNLSSLYRFSKLKNFKLVSQKESVVAVLPLKGNIHHDTIGKGEGKTDGISYYSIK
EALKELKKESSVKAVILEVDSPGGSAFVSELLYQEILKLQKKKPVYAYIQNISASGGYYLSCGASKIYASPYGIVGSIGS
ISIRFDLKNLYSKLGITKDRVGFYKYRDLLSEYGPIHPESKKLMEQEIKESEGLFYKRVSDSRKIPISDLDKRFGQGKVF
TSSQFLKERMIDSITDFLSLLEDIKQDLKVEKVQVRYLPSLFTFQSFLKSLKPGFLSNVFSKDLTSYFPNVLESENSLRK
KFQSIEAQSLLGSSFWNQS
>Mature_579_residues
MFRNFLQIVFIPFRLIFQLVRWIRFRFFSGDHYFLEIPSEFSNYRKSFLMKLLSSKEEEVFFTDFLLELKLLSQVPNLKK
VSILIQQPEYGFGETLNIAEGLQILKERGIVLEGFALTGGLKSLFLLGVCNKRFSSESSEFFPVLPSAESFFFGNAGKKW
GVKAETFQSGPYKSFGETFQRDKFSSKARENLNSLLKQMTDDLESIFKRYTGFTLKTFAEPFLSAKVLQERKFITGFLNE
EDFKENFIYINYQNENEDQKPSSKELNLSSLYRFSKLKNFKLVSQKESVVAVLPLKGNIHHDTIGKGEGKTDGISYYSIK
EALKELKKESSVKAVILEVDSPGGSAFVSELLYQEILKLQKKKPVYAYIQNISASGGYYLSCGASKIYASPYGIVGSIGS
ISIRFDLKNLYSKLGITKDRVGFYKYRDLLSEYGPIHPESKKLMEQEIKESEGLFYKRVSDSRKIPISDLDKRFGQGKVF
TSSQFLKERMIDSITDFLSLLEDIKQDLKVEKVQVRYLPSLFTFQSFLKSLKPGFLSNVFSKDLTSYFPNVLESENSLRK
KFQSIEAQSLLGSSFWNQS

Specific function: Digestion of the cleaved signal peptides. This activity is necessary to maintain proper secretion of mature proteins across the membrane [H]

COG id: COG0616

COG function: function code OU; Periplasmic serine proteases (ClpP class)

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S49 family [H]

Homologues:

Organism=Escherichia coli, GI1788064, Length=366, Percent_Identity=25.4098360655738, Blast_Score=99, Evalue=1e-21,
Organism=Escherichia coli, GI1787527, Length=189, Percent_Identity=27.5132275132275, Blast_Score=69, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004634
- InterPro:   IPR004635
- InterPro:   IPR002142 [H]

Pfam domain/function: PF01343 Peptidase_S49 [H]

EC number: 3.4.21.-

Molecular weight: Translated: 66476; Mature: 66476

Theoretical pI: Translated: 9.74; Mature: 9.74

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFRNFLQIVFIPFRLIFQLVRWIRFRFFSGDHYFLEIPSEFSNYRKSFLMKLLSSKEEEV
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHCCCCCHH
FFTDFLLELKLLSQVPNLKKVSILIQQPEYGFGETLNIAEGLQILKERGIVLEGFALTGG
HHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCHHHHHHHHHHCCCEEEEHHHHHH
LKSLFLLGVCNKRFSSESSEFFPVLPSAESFFFGNAGKKWGVKAETFQSGPYKSFGETFQ
HHHHHHHHHHHHHCCCCCCCCEECCCCCCCEEECCCCCCCCCCHHHCCCCCCHHHHHHHH
RDKFSSKARENLNSLLKQMTDDLESIFKRYTGFTLKTFAEPFLSAKVLQERKFITGFLNE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCC
EDFKENFIYINYQNENEDQKPSSKELNLSSLYRFSKLKNFKLVSQKESVVAVLPLKGNIH
CCCCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHCCCEEECCCCCEEEEEECCCCCC
HDTIGKGEGKTDGISYYSIKEALKELKKESSVKAVILEVDSPGGSAFVSELLYQEILKLQ
CCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHH
KKKPVYAYIQNISASGGYYLSCGASKIYASPYGIVGSIGSISIRFDLKNLYSKLGITKDR
HCCCHHHHHHHCCCCCCEEEEECCCCEECCCCCHHCCCCCEEEEEEHHHHHHHHCCCHHH
VGFYKYRDLLSEYGPIHPESKKLMEQEIKESEGLFYKRVSDSRKIPISDLDKRFGQGKVF
HHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCEEEECCCCCCCCHHHHHHHCCCCCEE
TSSQFLKERMIDSITDFLSLLEDIKQDLKVEKVQVRYLPSLFTFQSFLKSLKPGFLSNVF
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
SKDLTSYFPNVLESENSLRKKFQSIEAQSLLGSSFWNQS
HHHHHHHCHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MFRNFLQIVFIPFRLIFQLVRWIRFRFFSGDHYFLEIPSEFSNYRKSFLMKLLSSKEEEV
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHCCCCCHH
FFTDFLLELKLLSQVPNLKKVSILIQQPEYGFGETLNIAEGLQILKERGIVLEGFALTGG
HHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCHHHHHHHHHHCCCEEEEHHHHHH
LKSLFLLGVCNKRFSSESSEFFPVLPSAESFFFGNAGKKWGVKAETFQSGPYKSFGETFQ
HHHHHHHHHHHHHCCCCCCCCEECCCCCCCEEECCCCCCCCCCHHHCCCCCCHHHHHHHH
RDKFSSKARENLNSLLKQMTDDLESIFKRYTGFTLKTFAEPFLSAKVLQERKFITGFLNE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCC
EDFKENFIYINYQNENEDQKPSSKELNLSSLYRFSKLKNFKLVSQKESVVAVLPLKGNIH
CCCCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHCCCEEECCCCCEEEEEECCCCCC
HDTIGKGEGKTDGISYYSIKEALKELKKESSVKAVILEVDSPGGSAFVSELLYQEILKLQ
CCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHH
KKKPVYAYIQNISASGGYYLSCGASKIYASPYGIVGSIGSISIRFDLKNLYSKLGITKDR
HCCCHHHHHHHCCCCCCEEEEECCCCEECCCCCHHCCCCCEEEEEEHHHHHHHHCCCHHH
VGFYKYRDLLSEYGPIHPESKKLMEQEIKESEGLFYKRVSDSRKIPISDLDKRFGQGKVF
HHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCEEEECCCCCCCCHHHHHHHCCCCCEE
TSSQFLKERMIDSITDFLSLLEDIKQDLKVEKVQVRYLPSLFTFQSFLKSLKPGFLSNVF
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
SKDLTSYFPNVLESENSLRKKFQSIEAQSLLGSSFWNQS
HHHHHHHCHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]