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The map label for this gene is czcD

Identifier: 45657580

GI number: 45657580

Start: 2085715

End: 2086668

Strand: Direct

Name: czcD

Synonym: LIC11714

Alternate gene names: 45657580

Gene position: 2085715-2086668 (Clockwise)

Preceding gene: 304570492

Following gene: 45657584

Centisome position: 48.76

GC content: 30.92

Gene sequence:

>954_bases
TTGATGGATGATTTTTTTCAACTTTATCACGTAAAAAGAAGTCAGGAGAAAGGTCTAAAAAGATCTATTCTCCTTGCGAT
TTTAGTTTCTATTTCCATTTTTTTTGTAGAGTTATTTGGAGGATTTCAAAGCGGTAGTATTGCTCTTCTTGCGGATGCGG
GACATATCATTACAGATACAATTGCTTTGTCCTTGTCCTTGATTGCTGTATTACTTTCTTCTAAAAAACCGAATTATAGA
TTTTCATTTGGCTATTATAGAATTGAAATTCTGACTTCTCTTTTAAATTCTATTTTAATTTTTGGGATTTCGTTTTATAT
CTTTTATGAAAGTATCGAACGATTTCAAAATCAGAAAGAGATTTTGAGTTTTCAGATGATCTTTTACAGTTCTTTCGGAA
TTATTTTTAATCTAATCAGTGCTTGGATTTTATTTCGTTTTAGTGGCGAAAATATTAATATCAAGTCTGCTTACGTTCAC
GTTTTAAGTGATCTTTTATCTACGGTCGGAGTTTTAGTTGGTTCTATTTTAATTTATATTACGAATTGGAACTGGATTGA
TCCTTTGATCAGCGTTTTGATTTCGATTTTAATTTTACGTTCTGCCTGGGGAATTTTTAGGGAAACAATATTCGTTCTTT
TGGAATCCTCTCCAAATACATTCGAAATTACTCATATTCTAGAATACGTTCGTAAGGTGGAAGGAGTAAGTCAAATTTTG
GATTATCACTTTTGGGCAATTACGAGAGGAATTTATGCTTGTACTTTGAGGGTTTCGATTGTGGATTTAAAATTTGCAGA
GGAAGTTGTATTTAAGTTCAATCAAATTTTGAAATCTTCTTTTGGATTTGATTTTGTTACTATTCAATGTGAAGTGCCGA
ATTTAACCGAAAAAATTCAAGAACTACCTCTTGCAAATTATCAGGAAATAAATCAACATCATCACCATCATTAA

Upstream 100 bases:

>100_bases
TTTCACTCGCTGGTTACGGTGAGTTTCAGCCAATCGTTTCTAACGACACTCCCGAAAATAGAGCACTCAACCGAAGAGTG
GATATAGTAGTTGTTCCACG

Downstream 100 bases:

>100_bases
ATTTTCAAGATTCATTTCGTAAAATCCATGATTTGTAATAGTTCCCACATTTTGAAAGTTTGATTGTAAAACTTCGATTT
ATAATAGTTCCCACATTTTG

Product: heavy metal efflux pump

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 317; Mature: 317

Protein sequence:

>317_residues
MMDDFFQLYHVKRSQEKGLKRSILLAILVSISIFFVELFGGFQSGSIALLADAGHIITDTIALSLSLIAVLLSSKKPNYR
FSFGYYRIEILTSLLNSILIFGISFYIFYESIERFQNQKEILSFQMIFYSSFGIIFNLISAWILFRFSGENINIKSAYVH
VLSDLLSTVGVLVGSILIYITNWNWIDPLISVLISILILRSAWGIFRETIFVLLESSPNTFEITHILEYVRKVEGVSQIL
DYHFWAITRGIYACTLRVSIVDLKFAEEVVFKFNQILKSSFGFDFVTIQCEVPNLTEKIQELPLANYQEINQHHHHH

Sequences:

>Translated_317_residues
MMDDFFQLYHVKRSQEKGLKRSILLAILVSISIFFVELFGGFQSGSIALLADAGHIITDTIALSLSLIAVLLSSKKPNYR
FSFGYYRIEILTSLLNSILIFGISFYIFYESIERFQNQKEILSFQMIFYSSFGIIFNLISAWILFRFSGENINIKSAYVH
VLSDLLSTVGVLVGSILIYITNWNWIDPLISVLISILILRSAWGIFRETIFVLLESSPNTFEITHILEYVRKVEGVSQIL
DYHFWAITRGIYACTLRVSIVDLKFAEEVVFKFNQILKSSFGFDFVTIQCEVPNLTEKIQELPLANYQEINQHHHHH
>Mature_317_residues
MMDDFFQLYHVKRSQEKGLKRSILLAILVSISIFFVELFGGFQSGSIALLADAGHIITDTIALSLSLIAVLLSSKKPNYR
FSFGYYRIEILTSLLNSILIFGISFYIFYESIERFQNQKEILSFQMIFYSSFGIIFNLISAWILFRFSGENINIKSAYVH
VLSDLLSTVGVLVGSILIYITNWNWIDPLISVLISILILRSAWGIFRETIFVLLESSPNTFEITHILEYVRKVEGVSQIL
DYHFWAITRGIYACTLRVSIVDLKFAEEVVFKFNQILKSSFGFDFVTIQCEVPNLTEKIQELPLANYQEINQHHHHH

Specific function: Involved in divalent cation and potassium homeostasis in the cell. Catalyzes the active efflux of zinc, cadmium and cobalt, in exchange for potassium and H(+) ions [H]

COG id: COG1230

COG function: function code P; Co/Zn/Cd efflux system component

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily [H]

Homologues:

Organism=Homo sapiens, GI21359890, Length=304, Percent_Identity=27.3026315789474, Blast_Score=135, Evalue=4e-32,
Organism=Homo sapiens, GI52352805, Length=296, Percent_Identity=27.7027027027027, Blast_Score=133, Evalue=2e-31,
Organism=Homo sapiens, GI20070323, Length=322, Percent_Identity=29.5031055900621, Blast_Score=128, Evalue=7e-30,
Organism=Homo sapiens, GI21361112, Length=318, Percent_Identity=26.1006289308176, Blast_Score=119, Evalue=3e-27,
Organism=Homo sapiens, GI289803013, Length=305, Percent_Identity=28.1967213114754, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI289803009, Length=305, Percent_Identity=28.1967213114754, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI289803007, Length=305, Percent_Identity=28.1967213114754, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI289803003, Length=305, Percent_Identity=28.1967213114754, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI64762489, Length=305, Percent_Identity=28.1967213114754, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI14210520, Length=218, Percent_Identity=27.9816513761468, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI52351208, Length=200, Percent_Identity=27, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI222080086, Length=124, Percent_Identity=29.0322580645161, Blast_Score=68, Evalue=1e-11,
Organism=Homo sapiens, GI40255009, Length=124, Percent_Identity=29.0322580645161, Blast_Score=68, Evalue=1e-11,
Organism=Escherichia coli, GI1786966, Length=278, Percent_Identity=34.1726618705036, Blast_Score=153, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI17555794, Length=315, Percent_Identity=26.6666666666667, Blast_Score=153, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI17555796, Length=316, Percent_Identity=26.2658227848101, Blast_Score=150, Evalue=6e-37,
Organism=Caenorhabditis elegans, GI193210990, Length=301, Percent_Identity=26.2458471760797, Blast_Score=137, Evalue=8e-33,
Organism=Caenorhabditis elegans, GI32564488, Length=312, Percent_Identity=26.2820512820513, Blast_Score=111, Evalue=4e-25,
Organism=Saccharomyces cerevisiae, GI6320411, Length=175, Percent_Identity=30.8571428571429, Blast_Score=86, Evalue=6e-18,
Organism=Saccharomyces cerevisiae, GI6324892, Length=148, Percent_Identity=27.027027027027, Blast_Score=70, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6323899, Length=148, Percent_Identity=28.3783783783784, Blast_Score=67, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24656728, Length=316, Percent_Identity=25.3164556962025, Blast_Score=99, Evalue=3e-21,
Organism=Drosophila melanogaster, GI24656724, Length=316, Percent_Identity=25.3164556962025, Blast_Score=99, Evalue=3e-21,
Organism=Drosophila melanogaster, GI24656720, Length=316, Percent_Identity=25.3164556962025, Blast_Score=99, Evalue=3e-21,
Organism=Drosophila melanogaster, GI24656715, Length=316, Percent_Identity=25.3164556962025, Blast_Score=99, Evalue=3e-21,
Organism=Drosophila melanogaster, GI21357035, Length=316, Percent_Identity=25.3164556962025, Blast_Score=99, Evalue=3e-21,
Organism=Drosophila melanogaster, GI24583858, Length=316, Percent_Identity=22.7848101265823, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24585900, Length=134, Percent_Identity=30.5970149253731, Blast_Score=79, Evalue=5e-15,
Organism=Drosophila melanogaster, GI24585898, Length=134, Percent_Identity=30.5970149253731, Blast_Score=79, Evalue=5e-15,
Organism=Drosophila melanogaster, GI24585896, Length=134, Percent_Identity=30.5970149253731, Blast_Score=79, Evalue=5e-15,
Organism=Drosophila melanogaster, GI19921672, Length=134, Percent_Identity=30.5970149253731, Blast_Score=79, Evalue=5e-15,
Organism=Drosophila melanogaster, GI28574430, Length=160, Percent_Identity=24.375, Blast_Score=71, Evalue=8e-13,
Organism=Drosophila melanogaster, GI24584409, Length=160, Percent_Identity=24.375, Blast_Score=71, Evalue=9e-13,
Organism=Drosophila melanogaster, GI24645863, Length=124, Percent_Identity=28.2258064516129, Blast_Score=71, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002524 [H]

Pfam domain/function: PF01545 Cation_efflux [H]

EC number: NA

Molecular weight: Translated: 36527; Mature: 36527

Theoretical pI: Translated: 6.68; Mature: 6.68

Prosite motif: PS00511 CRF

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMDDFFQLYHVKRSQEKGLKRSILLAILVSISIFFVELFGGFQSGSIALLADAGHIITDT
CCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCHHHHHH
IALSLSLIAVLLSSKKPNYRFSFGYYRIEILTSLLNSILIFGISFYIFYESIERFQNQKE
HHHHHHHHHHHHHCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ILSFQMIFYSSFGIIFNLISAWILFRFSGENINIKSAYVHVLSDLLSTVGVLVGSILIYI
HHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHEEE
TNWNWIDPLISVLISILILRSAWGIFRETIFVLLESSPNTFEITHILEYVRKVEGVSQIL
ECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCEEHHHHHHHHHHHHHHHHHH
DYHFWAITRGIYACTLRVSIVDLKFAEEVVFKFNQILKSSFGFDFVTIQCEVPNLTEKIQ
HHHHHHHHHHHHHHEEEEEEEHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCHHHHHH
ELPLANYQEINQHHHHH
HCCCCCHHHHHHCCCCC
>Mature Secondary Structure
MMDDFFQLYHVKRSQEKGLKRSILLAILVSISIFFVELFGGFQSGSIALLADAGHIITDT
CCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCHHHHHH
IALSLSLIAVLLSSKKPNYRFSFGYYRIEILTSLLNSILIFGISFYIFYESIERFQNQKE
HHHHHHHHHHHHHCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ILSFQMIFYSSFGIIFNLISAWILFRFSGENINIKSAYVHVLSDLLSTVGVLVGSILIYI
HHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHEEE
TNWNWIDPLISVLISILILRSAWGIFRETIFVLLESSPNTFEITHILEYVRKVEGVSQIL
ECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCEEHHHHHHHHHHHHHHHHHH
DYHFWAITRGIYACTLRVSIVDLKFAEEVVFKFNQILKSSFGFDFVTIQCEVPNLTEKIQ
HHHHHHHHHHHHHHEEEEEEEHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCHHHHHH
ELPLANYQEINQHHHHH
HCCCCCHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9308178; 9384377; 9099864 [H]