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The map label for this gene is hlyU [H]

Identifier: 45657489

GI number: 45657489

Start: 1979639

End: 1979938

Strand: Reverse

Name: hlyU [H]

Synonym: LIC11617

Alternate gene names: 45657489

Gene position: 1979938-1979639 (Counterclockwise)

Preceding gene: 45657490

Following gene: 45657482

Centisome position: 46.29

GC content: 39.67

Gene sequence:

>300_bases
ATGTCTAAAGAAAAATCAGCATTAAAGAAAAACCAGTTAGAATCGGCAATTCGTGGAATCAAGGGGATCGCTCACCCTGA
TCGTTTGCAGATTCTTTTCTTCTTGTCTCAAAAAGAACACAGTGTAGGCGAACTTGTGGATTTACTGGGAATCAGCCAAT
CGGCGGCTTCTCAGCACCTTAGCAAAATGAAAATCAATGGAATCCTCTCCAGCAGAAAGGAATCCAACCAAGTTTTCTAT
TACCTAAAAGACGGAAAGTATAAGGATCTGATTCGTACGATTGTTAAAATCTACGGTTAA

Upstream 100 bases:

>100_bases
TGAGATTTAGTAGTTTACTAAAATTGAATAAACTTAATTTAGTATTTTTGTCTAAAAAGAGAAAGCATCTTCTTTTAGAA
ATATAAATAAGAGTAAAACA

Downstream 100 bases:

>100_bases
TCTTTAAACGATTACTTTAAAAATTAATTATGTACCCTCTTCTTCATCGAGGAGGGTTACATATTCACTGACTGCGTCCT
TTAATTGAGTAAAACCTTCC

Product: ArsR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 99; Mature: 98

Protein sequence:

>99_residues
MSKEKSALKKNQLESAIRGIKGIAHPDRLQILFFLSQKEHSVGELVDLLGISQSAASQHLSKMKINGILSSRKESNQVFY
YLKDGKYKDLIRTIVKIYG

Sequences:

>Translated_99_residues
MSKEKSALKKNQLESAIRGIKGIAHPDRLQILFFLSQKEHSVGELVDLLGISQSAASQHLSKMKINGILSSRKESNQVFY
YLKDGKYKDLIRTIVKIYG
>Mature_98_residues
SKEKSALKKNQLESAIRGIKGIAHPDRLQILFFLSQKEHSVGELVDLLGISQSAASQHLSKMKINGILSSRKESNQVFYY
LKDGKYKDLIRTIVKIYG

Specific function: Up-regulates the expression of the hemolysin gene, hlyA, and may promote expression of other virulence determinants in vivo. It may have both positive and negative regulator activities [H]

COG id: COG0640

COG function: function code K; Predicted transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH arsR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789021, Length=86, Percent_Identity=36.046511627907, Blast_Score=63, Evalue=3e-12,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001845
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01022 HTH_5 [H]

EC number: NA

Molecular weight: Translated: 11178; Mature: 11047

Theoretical pI: Translated: 10.47; Mature: 10.47

Prosite motif: PS50987 HTH_ARSR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKEKSALKKNQLESAIRGIKGIAHPDRLQILFFLSQKEHSVGELVDLLGISQSAASQHL
CCCHHHHHHHHHHHHHHHHHHCCCCCCHHHEEEEECCCCCCHHHHHHHHCCCHHHHHHHH
SKMKINGILSSRKESNQVFYYLKDGKYKDLIRTIVKIYG
HHHHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHHHHCC
>Mature Secondary Structure 
SKEKSALKKNQLESAIRGIKGIAHPDRLQILFFLSQKEHSVGELVDLLGISQSAASQHL
CCHHHHHHHHHHHHHHHHHHCCCCCCHHHEEEEECCCCCCHHHHHHHHCCCHHHHHHHH
SKMKINGILSSRKESNQVFYYLKDGKYKDLIRTIVKIYG
HHHHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8231807; 9457888; 10952301 [H]