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The map label for this gene is lon

Identifier: 45656506

GI number: 45656506

Start: 743707

End: 746226

Strand: Reverse

Name: lon

Synonym: LIC10608

Alternate gene names: 45656506

Gene position: 746226-743707 (Counterclockwise)

Preceding gene: 45656510

Following gene: 45656505

Centisome position: 17.45

GC content: 38.06

Gene sequence:

>2520_bases
TTGGAAGGAGGTCCTTTGGAACCTTTAGAGGATTTATCTGGAATTGAAGAAAATTCGATCATTCCATTGGATTCAATTTT
GCCACCGGAATTATTTTTAATTCCGATTAAGTCTAGACCAGTATTTCCGGGTATTATCACACCTTTGATCGTTCCTAGCG
GTAAGTTCGCAAAAGCCGTAGAAGAAACCGTCAAAGGAAACTCCTTTTTGGGTCTTGTTCTTTTAAAAGACGAAGAAAAC
GAAAAAGAAACTTCCGAAAACATCTATCAGTACGGAGTTGTCGCTAAAATATTAAAAAAAGTGAATTTACCAGACAACGC
CGTCAACATACTCGTCAACACAATCCGCCGTTTTAAAATCGAATCTTTCGTAAATAAAGATCCTTTGGTCGCAAGAGTTT
CATATCCGGAAGAAGAACCTGGAGCTCCGAAAAACACCACTAAGGCAATGATGAGAACCTTACTCGTCATGACTAGAGAA
CTCGCACAAAACAATCCTCTATTTACAGAAGAAATGAAACTTACCATGCTCAACGTAAATGAGCCTGGAAAGATGGCAGA
CTTTGTATGTTCCATTCTCAATTTAGAAAAAGAAGAATACCAATCCGTAATCGAATCTAATATTCTCAAAACTAGAATTG
AAAAGGTACTTCTCTTTCTAAAGAAAGAAATCGAACTAGTATCCATTCAAAGAGAAATTTCGGATCAGATCCAAGACAAA
ATAGACAAACAACAAAGACAATTTTTTTTAAGAGAACAACTCAAAGCGATTCAAAATGAACTCGGTATTAAGGACGATAA
GTTCGAAAAGAAATACGAAAAATTTTTAGAACGACTTAAAAACCTAAACGCAGACCCAGAAGTAATCGAAGAAGTGACCA
GAGAACTGGATAAGTTTTCTTATGCGGACCCTAATACGGGAGATTATAACGTTATCCGAAATTATTTGGATATTTTAGAA
TCTCTTCCTTGGGAGCCAGCGCCAGTTCGAGAAATCGATTTAGAAAAAGCTAAAAAGACTTTAGATAAAGATCACTATAA
ACTCGAAGACGTTAAAGACAGAATTTTAGAATTCCTAGCAGTTAAAAAACTTAAAAACGATGAAAAAGGCACCATACTAC
TATTAGTCGGACCTCCGGGCGTGGGGAAAACCTCAATCGCGAGATCGATCGCGGAAGCTATGGGAAGAAAATTTTTTCGA
TTTTCAGTCGGAGGTATGAGGGACGAAGCCGAAATCAAAGGACACAGAAGAACTTACATCGGCTCAATGCCAGGCAAAAT
CATTTCAGCACTTCGTATAACGAAAGAAAGAGACTGCGTCATTTTGTTAGACGAAATCGATAAACTTTCGATAGGCATTC
AAGGTGATCCTGCTTCCGCCCTTTTGGAAGTTTTAGACCCGGAACAAAATAAAAATTTCAGAGATCATTATTTAGATCTT
CCATTCGATATTTCTAATGTGTTTTTTATTGCTACTGCAAATACGTTAGATTCCATTTCCAGAATCCTTTTAGACAGAAT
GGAAATCATCAATCTTTCCGGTTATATCACGGATGAGAAGGTTCAAATTTTTCAAAAATACCTTTGGAAAAAAGTCCTCT
ATAAAAACGGAGTTACTCCCTACGGTATCGAGTTTGATAAAAAAGCGATCGTAGCTCTGATTGATTCTTACTCGAGAGAA
TCAGGAGTAAGAGGTCTGGAAAAAGTGACCGATAAATTGGTTCGTAAGATTGCAATTAAAATCGTTCGTAAAGAATCGTT
CCCTAAAATCATCCAAGAAAAAGATCTAGAAACTTTTTTAGGCGTTCCCAAATTTACGGACGAAAGAATGGTTCGCGCTT
CTGTTCCTGGTACCGCCCTCGGTTTAGCCTGGACTTCGGTAGGAGGTGCGACCCTTCTCATAGAAGCACTTTTTGTCAAA
GGGAAAGGTGGAATCCTTCTCACGGGAATGCTCGGTAAAACGATGGAAGAATCTTCTAACATCGCCTTGAGTTATATTAA
AAATTTATTATATAAAGAAGAATTATTCAACAATCGAATGATTCATTTACACGTTCCGGATGGAGCAACTCCCAAGGACG
GCCCTTCTGCCGGAATTACAATGGCCTCCGCGATTCTCTCTCTCGCTCTAAATACAAAAGTAAAGTCTGGTTTTGGAATG
ACCGGAGAGCTCACTCTTACTGGAGAAGTGCTTGCGATCGGCGGTTTACGCGAAAAGATCGTAGCCGCCAAAAGAGTGGG
AATTCATAAAATCATCTACCCAAAAGATAATCTTCAACATCTACAAGAGATTCCGGATTACGTAAAAAAGGGAATGTATT
TTTTTCCGGTGAGTCGTTACGAGGAAGTCGCTTTATTATTGTTTGACGAAAAAGTTATTTCCAAGATCAACCCATCTTTT
CGGGAAAATTTAAAATCAATTGTTAACCCGACCAGAAAACTTTCGCCTAAGAAAAAGACGACCCAAAAACAGAAACTGTC
TCTTTCTAAACAAAAGGGAAACAATCAAAAAAAGAAGTAG

Upstream 100 bases:

>100_bases
AAACCAACCTTTCGAAATTTTTTCGATCGAAAGCGGATCAGATTTGATTTGAGAATCTCTTCCACTGTAAGAACCTGGAC
AAATTAAGAGATGTTTTCAG

Downstream 100 bases:

>100_bases
TATTTTAGAGTATTCTTAAATATAAATTAACTCAGGAGAGCCAAATGGGCGTCCCATTTATAGACATTAAAAGATTTGAA
CCTGGTTTACTGGAAGAATG

Product: ATP-dependent protease La

Products: NA

Alternate protein names: ATP-dependent protease La

Number of amino acids: Translated: 839; Mature: 839

Protein sequence:

>839_residues
MEGGPLEPLEDLSGIEENSIIPLDSILPPELFLIPIKSRPVFPGIITPLIVPSGKFAKAVEETVKGNSFLGLVLLKDEEN
EKETSENIYQYGVVAKILKKVNLPDNAVNILVNTIRRFKIESFVNKDPLVARVSYPEEEPGAPKNTTKAMMRTLLVMTRE
LAQNNPLFTEEMKLTMLNVNEPGKMADFVCSILNLEKEEYQSVIESNILKTRIEKVLLFLKKEIELVSIQREISDQIQDK
IDKQQRQFFLREQLKAIQNELGIKDDKFEKKYEKFLERLKNLNADPEVIEEVTRELDKFSYADPNTGDYNVIRNYLDILE
SLPWEPAPVREIDLEKAKKTLDKDHYKLEDVKDRILEFLAVKKLKNDEKGTILLLVGPPGVGKTSIARSIAEAMGRKFFR
FSVGGMRDEAEIKGHRRTYIGSMPGKIISALRITKERDCVILLDEIDKLSIGIQGDPASALLEVLDPEQNKNFRDHYLDL
PFDISNVFFIATANTLDSISRILLDRMEIINLSGYITDEKVQIFQKYLWKKVLYKNGVTPYGIEFDKKAIVALIDSYSRE
SGVRGLEKVTDKLVRKIAIKIVRKESFPKIIQEKDLETFLGVPKFTDERMVRASVPGTALGLAWTSVGGATLLIEALFVK
GKGGILLTGMLGKTMEESSNIALSYIKNLLYKEELFNNRMIHLHVPDGATPKDGPSAGITMASAILSLALNTKVKSGFGM
TGELTLTGEVLAIGGLREKIVAAKRVGIHKIIYPKDNLQHLQEIPDYVKKGMYFFPVSRYEEVALLLFDEKVISKINPSF
RENLKSIVNPTRKLSPKKKTTQKQKLSLSKQKGNNQKKK

Sequences:

>Translated_839_residues
MEGGPLEPLEDLSGIEENSIIPLDSILPPELFLIPIKSRPVFPGIITPLIVPSGKFAKAVEETVKGNSFLGLVLLKDEEN
EKETSENIYQYGVVAKILKKVNLPDNAVNILVNTIRRFKIESFVNKDPLVARVSYPEEEPGAPKNTTKAMMRTLLVMTRE
LAQNNPLFTEEMKLTMLNVNEPGKMADFVCSILNLEKEEYQSVIESNILKTRIEKVLLFLKKEIELVSIQREISDQIQDK
IDKQQRQFFLREQLKAIQNELGIKDDKFEKKYEKFLERLKNLNADPEVIEEVTRELDKFSYADPNTGDYNVIRNYLDILE
SLPWEPAPVREIDLEKAKKTLDKDHYKLEDVKDRILEFLAVKKLKNDEKGTILLLVGPPGVGKTSIARSIAEAMGRKFFR
FSVGGMRDEAEIKGHRRTYIGSMPGKIISALRITKERDCVILLDEIDKLSIGIQGDPASALLEVLDPEQNKNFRDHYLDL
PFDISNVFFIATANTLDSISRILLDRMEIINLSGYITDEKVQIFQKYLWKKVLYKNGVTPYGIEFDKKAIVALIDSYSRE
SGVRGLEKVTDKLVRKIAIKIVRKESFPKIIQEKDLETFLGVPKFTDERMVRASVPGTALGLAWTSVGGATLLIEALFVK
GKGGILLTGMLGKTMEESSNIALSYIKNLLYKEELFNNRMIHLHVPDGATPKDGPSAGITMASAILSLALNTKVKSGFGM
TGELTLTGEVLAIGGLREKIVAAKRVGIHKIIYPKDNLQHLQEIPDYVKKGMYFFPVSRYEEVALLLFDEKVISKINPSF
RENLKSIVNPTRKLSPKKKTTQKQKLSLSKQKGNNQKKK
>Mature_839_residues
MEGGPLEPLEDLSGIEENSIIPLDSILPPELFLIPIKSRPVFPGIITPLIVPSGKFAKAVEETVKGNSFLGLVLLKDEEN
EKETSENIYQYGVVAKILKKVNLPDNAVNILVNTIRRFKIESFVNKDPLVARVSYPEEEPGAPKNTTKAMMRTLLVMTRE
LAQNNPLFTEEMKLTMLNVNEPGKMADFVCSILNLEKEEYQSVIESNILKTRIEKVLLFLKKEIELVSIQREISDQIQDK
IDKQQRQFFLREQLKAIQNELGIKDDKFEKKYEKFLERLKNLNADPEVIEEVTRELDKFSYADPNTGDYNVIRNYLDILE
SLPWEPAPVREIDLEKAKKTLDKDHYKLEDVKDRILEFLAVKKLKNDEKGTILLLVGPPGVGKTSIARSIAEAMGRKFFR
FSVGGMRDEAEIKGHRRTYIGSMPGKIISALRITKERDCVILLDEIDKLSIGIQGDPASALLEVLDPEQNKNFRDHYLDL
PFDISNVFFIATANTLDSISRILLDRMEIINLSGYITDEKVQIFQKYLWKKVLYKNGVTPYGIEFDKKAIVALIDSYSRE
SGVRGLEKVTDKLVRKIAIKIVRKESFPKIIQEKDLETFLGVPKFTDERMVRASVPGTALGLAWTSVGGATLLIEALFVK
GKGGILLTGMLGKTMEESSNIALSYIKNLLYKEELFNNRMIHLHVPDGATPKDGPSAGITMASAILSLALNTKVKSGFGM
TGELTLTGEVLAIGGLREKIVAAKRVGIHKIIYPKDNLQHLQEIPDYVKKGMYFFPVSRYEEVALLLFDEKVISKINPSF
RENLKSIVNPTRKLSPKKKTTQKQKLSLSKQKGNNQKKK

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG0466

COG function: function code O; ATP-dependent Lon protease, bacterial type

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Lon domain

Homologues:

Organism=Homo sapiens, GI21396489, Length=835, Percent_Identity=40, Blast_Score=575, Evalue=1e-164,
Organism=Homo sapiens, GI31377667, Length=861, Percent_Identity=33.3333333333333, Blast_Score=452, Evalue=1e-127,
Organism=Escherichia coli, GI1786643, Length=763, Percent_Identity=40.1048492791612, Blast_Score=555, Evalue=1e-159,
Organism=Caenorhabditis elegans, GI17505831, Length=702, Percent_Identity=39.031339031339, Blast_Score=503, Evalue=1e-142,
Organism=Caenorhabditis elegans, GI17556486, Length=666, Percent_Identity=35.5855855855856, Blast_Score=420, Evalue=1e-117,
Organism=Saccharomyces cerevisiae, GI6319449, Length=725, Percent_Identity=42.4827586206897, Blast_Score=555, Evalue=1e-159,
Organism=Drosophila melanogaster, GI221513036, Length=665, Percent_Identity=44.2105263157895, Blast_Score=554, Evalue=1e-158,
Organism=Drosophila melanogaster, GI24666867, Length=665, Percent_Identity=44.2105263157895, Blast_Score=554, Evalue=1e-157,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): LON_LEPIC (Q72UP9)

Other databases:

- EMBL:   AE016823
- RefSeq:   YP_000592.1
- ProteinModelPortal:   Q72UP9
- SMR:   Q72UP9
- MEROPS:   S16.002
- GeneID:   2771277
- GenomeReviews:   AE016823_GR
- KEGG:   lic:LIC10608
- NMPDR:   fig|267671.1.peg.592
- HOGENOM:   HBG566281
- OMA:   DYRARIE
- ProtClustDB:   CLSK552898
- BioCyc:   LINT267671:LIC_10608-MONOMER
- GO:   GO:0005737
- GO:   GO:0006508
- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR004815
- InterPro:   IPR003111
- InterPro:   IPR008268
- InterPro:   IPR001984
- InterPro:   IPR015947
- InterPro:   IPR020568
- PRINTS:   PR00830
- SMART:   SM00382
- SMART:   SM00464
- TIGRFAMs:   TIGR00763

Pfam domain/function: PF00004 AAA; PF02190 LON; PF05362 Lon_C; SSF88697 PUA-like; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: =3.4.21.53

Molecular weight: Translated: 94788; Mature: 94788

Theoretical pI: Translated: 9.42; Mature: 9.42

Prosite motif: PS01046 LON_SER

Important sites: ACT_SITE 696-696 ACT_SITE 739-739

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEGGPLEPLEDLSGIEENSIIPLDSILPPELFLIPIKSRPVFPGIITPLIVPSGKFAKAV
CCCCCCCCHHHHCCCCCCCCCCHHCCCCCCEEEEEECCCCCCCHHHHHHCCCCCHHHHHH
EETVKGNSFLGLVLLKDEENEKETSENIYQYGVVAKILKKVNLPDNAVNILVNTIRRFKI
HHHHCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
ESFVNKDPLVARVSYPEEEPGAPKNTTKAMMRTLLVMTRELAQNNPLFTEEMKLTMLNVN
HHHCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEECCEEEEEEECC
EPGKMADFVCSILNLEKEEYQSVIESNILKTRIEKVLLFLKKEIELVSIQREISDQIQDK
CCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IDKQQRQFFLREQLKAIQNELGIKDDKFEKKYEKFLERLKNLNADPEVIEEVTRELDKFS
HHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCC
YADPNTGDYNVIRNYLDILESLPWEPAPVREIDLEKAKKTLDKDHYKLEDVKDRILEFLA
CCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
VKKLKNDEKGTILLLVGPPGVGKTSIARSIAEAMGRKFFRFSVGGMRDEAEIKGHRRTYI
HHHHCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHEEHHHCCCCCCHHHHCCCHHHHC
GSMPGKIISALRITKERDCVILLDEIDKLSIGIQGDPASALLEVLDPEQNKNFRDHYLDL
CCCCHHHHHHHHHCCCCCEEEEEECCCCEEECCCCCCHHHHHHHHCCCCCCCHHHHHCCC
PFDISNVFFIATANTLDSISRILLDRMEIINLSGYITDEKVQIFQKYLWKKVLYKNGVTP
CCCCCCEEEEEECHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCC
YGIEFDKKAIVALIDSYSRESGVRGLEKVTDKLVRKIAIKIVRKESFPKIIQEKDLETFL
CCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
GVPKFTDERMVRASVPGTALGLAWTSVGGATLLIEALFVKGKGGILLTGMLGKTMEESSN
CCCCCCCCCHHEECCCCCHHHHHHHHCCHHHHHHHHHHHCCCCCEEEEEHHCCHHHHCCC
IALSYIKNLLYKEELFNNRMIHLHVPDGATPKDGPSAGITMASAILSLALNTKVKSGFGM
HHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCC
TGELTLTGEVLAIGGLREKIVAAKRVGIHKIIYPKDNLQHLQEIPDYVKKGMYFFPVSRY
CEEEEEECCEEEECCHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHCCEEEEECCCH
EEVALLLFDEKVISKINPSFRENLKSIVNPTRKLSPKKKTTQKQKLSLSKQKGNNQKKK
HHHHHHHCCHHHHHHCCHHHHHHHHHHHCHHHHCCCCHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MEGGPLEPLEDLSGIEENSIIPLDSILPPELFLIPIKSRPVFPGIITPLIVPSGKFAKAV
CCCCCCCCHHHHCCCCCCCCCCHHCCCCCCEEEEEECCCCCCCHHHHHHCCCCCHHHHHH
EETVKGNSFLGLVLLKDEENEKETSENIYQYGVVAKILKKVNLPDNAVNILVNTIRRFKI
HHHHCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
ESFVNKDPLVARVSYPEEEPGAPKNTTKAMMRTLLVMTRELAQNNPLFTEEMKLTMLNVN
HHHCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEECCEEEEEEECC
EPGKMADFVCSILNLEKEEYQSVIESNILKTRIEKVLLFLKKEIELVSIQREISDQIQDK
CCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IDKQQRQFFLREQLKAIQNELGIKDDKFEKKYEKFLERLKNLNADPEVIEEVTRELDKFS
HHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCC
YADPNTGDYNVIRNYLDILESLPWEPAPVREIDLEKAKKTLDKDHYKLEDVKDRILEFLA
CCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
VKKLKNDEKGTILLLVGPPGVGKTSIARSIAEAMGRKFFRFSVGGMRDEAEIKGHRRTYI
HHHHCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHEEHHHCCCCCCHHHHCCCHHHHC
GSMPGKIISALRITKERDCVILLDEIDKLSIGIQGDPASALLEVLDPEQNKNFRDHYLDL
CCCCHHHHHHHHHCCCCCEEEEEECCCCEEECCCCCCHHHHHHHHCCCCCCCHHHHHCCC
PFDISNVFFIATANTLDSISRILLDRMEIINLSGYITDEKVQIFQKYLWKKVLYKNGVTP
CCCCCCEEEEEECHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCC
YGIEFDKKAIVALIDSYSRESGVRGLEKVTDKLVRKIAIKIVRKESFPKIIQEKDLETFL
CCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
GVPKFTDERMVRASVPGTALGLAWTSVGGATLLIEALFVKGKGGILLTGMLGKTMEESSN
CCCCCCCCCHHEECCCCCHHHHHHHHCCHHHHHHHHHHHCCCCCEEEEEHHCCHHHHCCC
IALSYIKNLLYKEELFNNRMIHLHVPDGATPKDGPSAGITMASAILSLALNTKVKSGFGM
HHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCC
TGELTLTGEVLAIGGLREKIVAAKRVGIHKIIYPKDNLQHLQEIPDYVKKGMYFFPVSRY
CEEEEEECCEEEECCHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHCCEEEEECCCH
EEVALLLFDEKVISKINPSFRENLKSIVNPTRKLSPKKKTTQKQKLSLSKQKGNNQKKK
HHHHHHHCCHHHHHHCCHHHHHHHHHHHCHHHHCCCCHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA