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The map label for this gene is nuoI

Identifier: 45656052

GI number: 45656052

Start: 171882

End: 172409

Strand: Direct

Name: nuoI

Synonym: LIC10142

Alternate gene names: 45656052

Gene position: 171882-172409 (Clockwise)

Preceding gene: 45656051

Following gene: 45656054

Centisome position: 4.02

GC content: 39.39

Gene sequence:

>528_bases
TTGGGAACCGTTAACGTAGTAAGAGTAGCAAGTCGTCATAAACTTTCTTGGTATGAAAAGTTTTATTTTTATTCTATTGG
AAAAGGACTTTGGATCACTCTCAAACATTTTATTAAGGCCGCGATTTTAAGAAAAGCGGTAACGATAGAATTCCCTGAAA
AGAAAAGAAAGTATTCCACTCGTTTTCGTGGGATGCATACGATGAAACGTGATGAACAGGGTAGAGAAAGATGTACAAGC
TGTTTCTGTTGTATGTGGATTTGTCCTGCGGATGCAATTTATATAGAAGCAGCAGAAGTAACTCCGGAAATTCAACATCT
TCATCCAGAAGATAAATACGCTAAAAAGTTCGAGATCGACTTACTACGTTGTATTTTTTGTGGAATGTGTGAGGAAGCTT
GTCCAAAAGGGGCGATTTATCTGGATGGTCCGGGCGAGATGGCGACCGATAACCGAGAAGATCTAATCTTAACCAAAGAA
AGAATGATGCAACTTGTGGGTGGACCAATCATCGGAGAAAGGCAATAA

Upstream 100 bases:

>100_bases
TTTCAAAAGGTAATGGAGCCGCCTAAAGGTCTATTAAATTCTGGTTCTGTTTTCCGGAGAATAGCAGAATTGGTCAAAAC
TTCTCCCAAGGAGGCTGAGG

Downstream 100 bases:

>100_bases
AATTTAAAGTTGGTTGAATAGATTTCTAGTTTAAACGTTTATTTCAAAATTTTTTTAAGAGCCTACAAATCGAAGATGGT
ACTTTACGAAAGTTGAAAGT

Product: NADH dehydrogenase II subunit

Products: NA

Alternate protein names: NADH dehydrogenase I subunit I; NDH-1 subunit I [H]

Number of amino acids: Translated: 175; Mature: 174

Protein sequence:

>175_residues
MGTVNVVRVASRHKLSWYEKFYFYSIGKGLWITLKHFIKAAILRKAVTIEFPEKKRKYSTRFRGMHTMKRDEQGRERCTS
CFCCMWICPADAIYIEAAEVTPEIQHLHPEDKYAKKFEIDLLRCIFCGMCEEACPKGAIYLDGPGEMATDNREDLILTKE
RMMQLVGGPIIGERQ

Sequences:

>Translated_175_residues
MGTVNVVRVASRHKLSWYEKFYFYSIGKGLWITLKHFIKAAILRKAVTIEFPEKKRKYSTRFRGMHTMKRDEQGRERCTS
CFCCMWICPADAIYIEAAEVTPEIQHLHPEDKYAKKFEIDLLRCIFCGMCEEACPKGAIYLDGPGEMATDNREDLILTKE
RMMQLVGGPIIGERQ
>Mature_174_residues
GTVNVVRVASRHKLSWYEKFYFYSIGKGLWITLKHFIKAAILRKAVTIEFPEKKRKYSTRFRGMHTMKRDEQGRERCTSC
FCCMWICPADAIYIEAAEVTPEIQHLHPEDKYAKKFEIDLLRCIFCGMCEEACPKGAIYLDGPGEMATDNREDLILTKER
MMQLVGGPIIGERQ

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1143

COG function: function code C; Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I)

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 4Fe-4S ferredoxin-type domains [H]

Homologues:

Organism=Homo sapiens, GI4505371, Length=165, Percent_Identity=36.3636363636364, Blast_Score=99, Evalue=3e-21,
Organism=Escherichia coli, GI1788617, Length=144, Percent_Identity=36.1111111111111, Blast_Score=83, Evalue=1e-17,
Organism=Escherichia coli, GI1789075, Length=120, Percent_Identity=32.5, Blast_Score=64, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17555194, Length=143, Percent_Identity=37.0629370629371, Blast_Score=100, Evalue=4e-22,
Organism=Drosophila melanogaster, GI17864306, Length=143, Percent_Identity=37.7622377622378, Blast_Score=101, Evalue=3e-22,

Paralogues:

None

Copy number: 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001450
- InterPro:   IPR017896
- InterPro:   IPR017900
- InterPro:   IPR012285
- InterPro:   IPR010226 [H]

Pfam domain/function: PF00037 Fer4 [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 20324; Mature: 20193

Theoretical pI: Translated: 8.48; Mature: 8.48

Prosite motif: PS00198 4FE4S_FERREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

5.1 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
9.7 %Cys+Met (Translated Protein)
5.2 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
9.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGTVNVVRVASRHKLSWYEKFYFYSIGKGLWITLKHFIKAAILRKAVTIEFPEKKRKYST
CCCCHHEEHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHEEECCHHHHHHHH
RFRGMHTMKRDEQGRERCTSCFCCMWICPADAIYIEAAEVTPEIQHLHPEDKYAKKFEID
HHHHHHHHHHCHHHHHHHHHHHHHHHCCCCCEEEEEHHHCCCHHHHCCCCHHHHHHHHHH
LLRCIFCGMCEEACPKGAIYLDGPGEMATDNREDLILTKERMMQLVGGPIIGERQ
HHHHHHHHHHHHHCCCCCEEECCCCCCCCCCCCCEEECHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
GTVNVVRVASRHKLSWYEKFYFYSIGKGLWITLKHFIKAAILRKAVTIEFPEKKRKYST
CCCHHEEHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHEEECCHHHHHHHH
RFRGMHTMKRDEQGRERCTSCFCCMWICPADAIYIEAAEVTPEIQHLHPEDKYAKKFEID
HHHHHHHHHHCHHHHHHHHHHHHHHHCCCCCEEEEEHHHCCCHHHHCCCCHHHHHHHHHH
LLRCIFCGMCEEACPKGAIYLDGPGEMATDNREDLILTKERMMQLVGGPIIGERQ
HHHHHHHHHHHHHCCCCCEEECCCCCCCCCCCCCEEECHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA