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The map label for this gene is atpB [H]

Identifier: 45358608

GI number: 45358608

Start: 1038524

End: 1039912

Strand: Direct

Name: atpB [H]

Synonym: MMP1045

Alternate gene names: 45358608

Gene position: 1038524-1039912 (Clockwise)

Preceding gene: 45358607

Following gene: 45358609

Centisome position: 62.52

GC content: 41.18

Gene sequence:

>1389_bases
ATGGACGCTATGCAGAAAACCATAGAATACACATCCGTCTCCAGAATTGCTGGTCCTTTAATGGTTATTGATGGAATCGA
AGGAATTGCTTACGGTGAAATTGTAGATATTACAACTCCAAACGGAGACAAAAGAACCGGGCAAGTTTTAGAAGCTAGAG
AAGAAATTGCTGTTGTTCAGGTATTTGAAGGAACTTCAGAATTAAACACCAGTGAAACAAAAGTAAGATTCACAGGAGAC
ACTGCAAAAATCGGTGTATCATACGATATGCTCGGCAGAATCTTCAACGGTGCAGGAAAACCACTCGATGGCGGACCAGA
AATCATCGCTGAGGAAAAATTAGATATCAACGGTTACCCATTAAACCCAGTTTCAAGAAACCCGCCAAACGCGTTCGTTC
AAACTGGTGTTTCAACAATCGATGGTACAAACACACTCGTTAGAGGACAAAAAATCCCGATCTTTTCCGGATCCGGTTTA
CCACACAACAAGCTTGCTACGCAAATTGCAAGACAAGCTAAGGTAAGGGGAGAAGGTGAACAGTTTGCGGTAGTATTTGC
TGCAATGGGTATCACCGGTGAAGAATCAAACTACTTCATGGATGAATTTAAGAAAACAGGTGCTTTGGAAAAAGCTGTTG
TTTTCATTAACTTAGCAGATGACCCTGCAATTGAAAGAATTCTTACACCAAGAATTGCACTCACAACTGCAGAGTACCTT
GCATACGAAAAAGGAATGCACGTACTTGTTATCTTAACTGACCTTACAAACTACTGTGAGGCATTAAGAGAAATTGCAGC
TGCAAGAAACGAGGTACCTGGAAGAAGAGGTTACCCTGGTTACATGTACACTGACTTAGCTTGCCTTTACGAAAGAGCAG
GAAGAGTTAAAGGTAAAGAAGGAACAGTAACACAGATCCCAATTCTTACAATGCCTGATGACGATATCACGCACCCAATT
CCAGACCTTACAGGTTACATTACCGAAGGACAGATTGTGCTTTCAAGAGAGTTAAACAGAAAAGGGGTTTACCCTCCAGT
TGACATCTTGCCATCACTTTCAAGGCTTGCAGGTAACGGCCAAGGTGAAGGAAAAACAAGAGACGACCACTCAAAAGTTA
TCAGCCAAGCATACGCTGCATACGCTGAAGGTAGAGGTTTAAGAGACCTTGTAGCGGTTGTTGGGGAAGAAGCATTAACC
GAAAGAGACAGATCATTCTTAAAATTCGCTGACGCTTTCGAAAACAGCATTGTTACTCAAGGAGTAGACGAAGACAGAAG
CATTGAAGAAACACTTGATTACGTCTGGGATTTATTAACAATATTGCCTAGAGAAGAACTCAAGAGAGTTTCCGATGAAT
TAATCGAAAAATACTTACCTAAAAAATAA

Upstream 100 bases:

>100_bases
ATAAACACGAAAGTACCTGAAATCATTAACAAAATGGAATCCGAATTAGGTGCTTTAATCAAATAACCTAATTTAATTTT
AAACTGTAAGGAGGGTTATC

Downstream 100 bases:

>100_bases
TTCAGAAGCTGAATTATTCCCATTTTATTAAACTAGGGGGATAGCAATGGCAGACGTAAACCCTACAAGAATGGAACTTC
TAAAGTTGAAAGGAAAAATT

Product: V-type ATP synthase subunit B

Products: ADP; phosphate; H+

Alternate protein names: V-ATPase subunit B [H]

Number of amino acids: Translated: 462; Mature: 462

Protein sequence:

>462_residues
MDAMQKTIEYTSVSRIAGPLMVIDGIEGIAYGEIVDITTPNGDKRTGQVLEAREEIAVVQVFEGTSELNTSETKVRFTGD
TAKIGVSYDMLGRIFNGAGKPLDGGPEIIAEEKLDINGYPLNPVSRNPPNAFVQTGVSTIDGTNTLVRGQKIPIFSGSGL
PHNKLATQIARQAKVRGEGEQFAVVFAAMGITGEESNYFMDEFKKTGALEKAVVFINLADDPAIERILTPRIALTTAEYL
AYEKGMHVLVILTDLTNYCEALREIAAARNEVPGRRGYPGYMYTDLACLYERAGRVKGKEGTVTQIPILTMPDDDITHPI
PDLTGYITEGQIVLSRELNRKGVYPPVDILPSLSRLAGNGQGEGKTRDDHSKVISQAYAAYAEGRGLRDLVAVVGEEALT
ERDRSFLKFADAFENSIVTQGVDEDRSIEETLDYVWDLLTILPREELKRVSDELIEKYLPKK

Sequences:

>Translated_462_residues
MDAMQKTIEYTSVSRIAGPLMVIDGIEGIAYGEIVDITTPNGDKRTGQVLEAREEIAVVQVFEGTSELNTSETKVRFTGD
TAKIGVSYDMLGRIFNGAGKPLDGGPEIIAEEKLDINGYPLNPVSRNPPNAFVQTGVSTIDGTNTLVRGQKIPIFSGSGL
PHNKLATQIARQAKVRGEGEQFAVVFAAMGITGEESNYFMDEFKKTGALEKAVVFINLADDPAIERILTPRIALTTAEYL
AYEKGMHVLVILTDLTNYCEALREIAAARNEVPGRRGYPGYMYTDLACLYERAGRVKGKEGTVTQIPILTMPDDDITHPI
PDLTGYITEGQIVLSRELNRKGVYPPVDILPSLSRLAGNGQGEGKTRDDHSKVISQAYAAYAEGRGLRDLVAVVGEEALT
ERDRSFLKFADAFENSIVTQGVDEDRSIEETLDYVWDLLTILPREELKRVSDELIEKYLPKK
>Mature_462_residues
MDAMQKTIEYTSVSRIAGPLMVIDGIEGIAYGEIVDITTPNGDKRTGQVLEAREEIAVVQVFEGTSELNTSETKVRFTGD
TAKIGVSYDMLGRIFNGAGKPLDGGPEIIAEEKLDINGYPLNPVSRNPPNAFVQTGVSTIDGTNTLVRGQKIPIFSGSGL
PHNKLATQIARQAKVRGEGEQFAVVFAAMGITGEESNYFMDEFKKTGALEKAVVFINLADDPAIERILTPRIALTTAEYL
AYEKGMHVLVILTDLTNYCEALREIAAARNEVPGRRGYPGYMYTDLACLYERAGRVKGKEGTVTQIPILTMPDDDITHPI
PDLTGYITEGQIVLSRELNRKGVYPPVDILPSLSRLAGNGQGEGKTRDDHSKVISQAYAAYAEGRGLRDLVAVVGEEALT
ERDRSFLKFADAFENSIVTQGVDEDRSIEETLDYVWDLLTILPREELKRVSDELIEKYLPKK

Specific function: Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit [H]

COG id: COG1156

COG function: function code C; Archaeal/vacuolar-type H+-ATPase subunit B

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATPase alpha/beta chains family [H]

Homologues:

Organism=Homo sapiens, GI19913428, Length=465, Percent_Identity=54.8387096774194, Blast_Score=540, Evalue=1e-154,
Organism=Homo sapiens, GI19913426, Length=463, Percent_Identity=54.2116630669546, Blast_Score=530, Evalue=1e-150,
Organism=Homo sapiens, GI32189394, Length=338, Percent_Identity=27.2189349112426, Blast_Score=109, Evalue=5e-24,
Organism=Homo sapiens, GI50345984, Length=293, Percent_Identity=24.9146757679181, Blast_Score=92, Evalue=8e-19,
Organism=Homo sapiens, GI4757810, Length=293, Percent_Identity=24.9146757679181, Blast_Score=92, Evalue=8e-19,
Organism=Homo sapiens, GI19913424, Length=316, Percent_Identity=23.7341772151899, Blast_Score=87, Evalue=4e-17,
Organism=Escherichia coli, GI1788251, Length=266, Percent_Identity=34.9624060150376, Blast_Score=132, Evalue=4e-32,
Organism=Escherichia coli, GI1790170, Length=367, Percent_Identity=26.4305177111717, Blast_Score=113, Evalue=3e-26,
Organism=Escherichia coli, GI1790172, Length=330, Percent_Identity=28.4848484848485, Blast_Score=105, Evalue=4e-24,
Organism=Caenorhabditis elegans, GI17570191, Length=458, Percent_Identity=56.5502183406114, Blast_Score=546, Evalue=1e-156,
Organism=Caenorhabditis elegans, GI17510931, Length=461, Percent_Identity=54.880694143167, Blast_Score=537, Evalue=1e-153,
Organism=Caenorhabditis elegans, GI25144756, Length=334, Percent_Identity=27.2455089820359, Blast_Score=111, Evalue=9e-25,
Organism=Caenorhabditis elegans, GI71988080, Length=293, Percent_Identity=25.938566552901, Blast_Score=95, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI71988063, Length=293, Percent_Identity=25.938566552901, Blast_Score=94, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17565854, Length=253, Percent_Identity=25.296442687747, Blast_Score=86, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI71988074, Length=269, Percent_Identity=25.6505576208178, Blast_Score=84, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6319603, Length=459, Percent_Identity=55.5555555555556, Blast_Score=542, Evalue=1e-155,
Organism=Saccharomyces cerevisiae, GI6322581, Length=383, Percent_Identity=29.242819843342, Blast_Score=126, Evalue=8e-30,
Organism=Saccharomyces cerevisiae, GI6319370, Length=307, Percent_Identity=26.3843648208469, Blast_Score=100, Evalue=8e-22,
Organism=Saccharomyces cerevisiae, GI6320016, Length=225, Percent_Identity=24.4444444444444, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI281361666, Length=466, Percent_Identity=54.5064377682403, Blast_Score=530, Evalue=1e-151,
Organism=Drosophila melanogaster, GI24646341, Length=466, Percent_Identity=54.5064377682403, Blast_Score=530, Evalue=1e-151,
Organism=Drosophila melanogaster, GI17136796, Length=466, Percent_Identity=54.5064377682403, Blast_Score=530, Evalue=1e-151,
Organism=Drosophila melanogaster, GI24638766, Length=339, Percent_Identity=27.4336283185841, Blast_Score=111, Evalue=8e-25,
Organism=Drosophila melanogaster, GI28574560, Length=336, Percent_Identity=28.2738095238095, Blast_Score=102, Evalue=5e-22,
Organism=Drosophila melanogaster, GI24658560, Length=343, Percent_Identity=25.9475218658892, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI20129479, Length=309, Percent_Identity=23.3009708737864, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24583992, Length=314, Percent_Identity=22.6114649681529, Blast_Score=81, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24583988, Length=308, Percent_Identity=22.4025974025974, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24583986, Length=308, Percent_Identity=22.4025974025974, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24583984, Length=308, Percent_Identity=22.4025974025974, Blast_Score=80, Evalue=2e-15,

Paralogues:

None

Copy number: 10-20 (rich media) [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020003
- InterPro:   IPR000194
- InterPro:   IPR000793
- InterPro:   IPR004100
- InterPro:   IPR022879 [H]

Pfam domain/function: PF00006 ATP-synt_ab; PF00306 ATP-synt_ab_C; PF02874 ATP-synt_ab_N [H]

EC number: 3.6.3.14

Molecular weight: Translated: 50701; Mature: 50701

Theoretical pI: Translated: 4.59; Mature: 4.59

Prosite motif: PS00152 ATPASE_ALPHA_BETA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDAMQKTIEYTSVSRIAGPLMVIDGIEGIAYGEIVDITTPNGDKRTGQVLEAREEIAVVQ
CCHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCEEEEECCCCCCHHHHHHHHHHHEEEEE
VFEGTSELNTSETKVRFTGDTAKIGVSYDMLGRIFNGAGKPLDGGPEIIAEEKLDINGYP
EECCCCCCCCCCCEEEECCCCEEECCCHHHHHHHHCCCCCCCCCCCCEEECCCCCCCCCC
LNPVSRNPPNAFVQTGVSTIDGTNTLVRGQKIPIFSGSGLPHNKLATQIARQAKVRGEGE
CCCCCCCCCHHHHHCCCCCCCCCCCEECCCCCCEECCCCCCHHHHHHHHHHHHHHCCCCC
QFAVVFAAMGITGEESNYFMDEFKKTGALEKAVVFINLADDPAIERILTPRIALTTAEYL
EEEEEEEEECCCCCCCCHHHHHHHHCCCCEEEEEEEECCCCHHHHHHHCCHHHHHHHHHH
AYEKGMHVLVILTDLTNYCEALREIAAARNEVPGRRGYPGYMYTDLACLYERAGRVKGKE
HHHCCCEEEEEHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCCC
GTVTQIPILTMPDDDITHPIPDLTGYITEGQIVLSRELNRKGVYPPVDILPSLSRLAGNG
CCEEEEEEEECCCCCCCCCCCCHHCEEECCEEEEEECCCCCCCCCCHHHHHHHHHHHCCC
QGEGKTRDDHSKVISQAYAAYAEGRGLRDLVAVVGEEALTERDRSFLKFADAFENSIVTQ
CCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GVDEDRSIEETLDYVWDLLTILPREELKRVSDELIEKYLPKK
CCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MDAMQKTIEYTSVSRIAGPLMVIDGIEGIAYGEIVDITTPNGDKRTGQVLEAREEIAVVQ
CCHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCEEEEECCCCCCHHHHHHHHHHHEEEEE
VFEGTSELNTSETKVRFTGDTAKIGVSYDMLGRIFNGAGKPLDGGPEIIAEEKLDINGYP
EECCCCCCCCCCCEEEECCCCEEECCCHHHHHHHHCCCCCCCCCCCCEEECCCCCCCCCC
LNPVSRNPPNAFVQTGVSTIDGTNTLVRGQKIPIFSGSGLPHNKLATQIARQAKVRGEGE
CCCCCCCCCHHHHHCCCCCCCCCCCEECCCCCCEECCCCCCHHHHHHHHHHHHHHCCCCC
QFAVVFAAMGITGEESNYFMDEFKKTGALEKAVVFINLADDPAIERILTPRIALTTAEYL
EEEEEEEEECCCCCCCCHHHHHHHHCCCCEEEEEEEECCCCHHHHHHHCCHHHHHHHHHH
AYEKGMHVLVILTDLTNYCEALREIAAARNEVPGRRGYPGYMYTDLACLYERAGRVKGKE
HHHCCCEEEEEHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCCC
GTVTQIPILTMPDDDITHPIPDLTGYITEGQIVLSRELNRKGVYPPVDILPSLSRLAGNG
CCEEEEEEEECCCCCCCCCCCCHHCEEECCEEEEEECCCCCCCCCCHHHHHHHHHHHCCC
QGEGKTRDDHSKVISQAYAAYAEGRGLRDLVAVVGEEALTERDRSFLKFADAFENSIVTQ
CCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GVDEDRSIEETLDYVWDLLTILPREELKRVSDELIEKYLPKK
CCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: Borate; Diphosphate; HCO3- [C]

Metal ions: Co2+; Fe2+; Mn2+; Zn2+ [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; H2O; H+

Specific reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out)

General reaction: Phosphorous acid anhydride hydrolysis [C]

Inhibitor: Ca2+; CN-; Efrapeptin; Ethidiumbromide; Guanidines various reactions catalyzed by ATPase, analogs; Oligomycin; Quercetin; Trialkyl tinderivatives; Venturicidin [C]

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA