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The map label for this gene is engA [H]

Identifier: 42523421

GI number: 42523421

Start: 1855842

End: 1857191

Strand: Direct

Name: engA [H]

Synonym: Bd1944

Alternate gene names: 42523421

Gene position: 1855842-1857191 (Clockwise)

Preceding gene: 42523420

Following gene: 42523422

Centisome position: 49.06

GC content: 51.04

Gene sequence:

>1350_bases
ATGTCGTCGACTCTAAAGACTGATTTCTCGCCGAAAGTGGCGATCATCGGTCGCCCGAATGTCGGTAAATCAACACTGTT
TAATATCATCACTGAAACCCGCAAAGCCGTGGTGAAAAACCAGGCGGGGGTTACTCGTGATATCATGATCGAACCTGTCG
ATATCTGGGGCAAACAATTTGACCTGATCGACACGGGCGGTATCACCGAAGCTGGCGACATTTTCTCCAAGCTGATCAAA
GAACAGGTGACTGAGTTCCTGCACTCTGTGGATTTGATCGTGGCGGTGATGGATGGTCGTGTGGGCCTGGTGCCTGAAGA
CCGTGACATCATTCGCGTCGCCAAACAAACCGGCAAACCGTTCCTTCTGGTGATCAACAAGGTCGACAGTGACCAGGATC
AGGACATGGCCAAAGCTGACTTCTATGAATTCGGTGTGGACGTGGTTGCCGCTTCTTTCGAGCAGCGTCGTGGTCTGGCT
GAAATCCTTGAGTGGGTGGTAAAACAGATCCCTGAAAATCCAGGGACTGTGAAAGAGGGCATGAATATCGCCATCGTCGG
TAAACCGAACGTGGGAAAAAGCTCTATCTGTAATGCGATCCTGGGCTACAACCGCATGATCGTTTCTGATATCGCGGGCA
CCACAATTGATTCTGTCGATTCCCCCTTCGTTTATAACGACAAAAAATACACCCTGGTTGATACCGCGGGTCTGCGTCGT
TCGGCAAAGCGTGAAGAGGATCTGGAGATCATTTCCGCCTTCAAATCCCAGGAAGCCATTCGTCGCGCGGACATCGTGCT
GTTGATGGTGGATGGAACTGTCGGCCCGACAGACCAGGATGCGCGCATCATGCAGGCGATTCTGGAGGATCACAAAGGTG
TGATCGTCGTGGCGAATAAATCAGACTTGGGTGGGAAGGAAGTTCCTGAATACCGCAAGACTTTCCGTGAACAGGTGGAG
CGTGTGTTCCACTTCTTCACTGACGTGCACATTGTCTTCACCAGCGCCAAAACCGGTTACGGTCTGGAAGACCTGTTTGA
GATGATTGAAAAAGTCGCTCATCAGATGACCTTCCGTGTTCCAACGGCAGAGCTGAATGACTTCTTCTTCGAAACCATCC
GTAAAGCTCCGGCTCCGGTTTGGGGTACGACGAACGTGAAGTTCTATTATCTGACTCAGACCTATCAGCAGCCTCCGGCA
TTTATCGCGTTTGCGAATCATCCGGATGGTGTGACGAACTCCTATCGCCGCTTCCTGATTAAGCACATTAAAACGAACTG
GGACCTTCACGGGATGCCGATTCGTATCTTCTGTATGAAATCACGCCGTGGTGGATCGGATAATGGCTAG

Upstream 100 bases:

>100_bases
GAAATTGAAAAACTGATGGGAGAGAAAATCTTCCTGGACCTGAACGTGGCATCCAAGCCCGAGTGGTTCTCCAATAAACG
CATGATGAAGGAGCTTGGAT

Downstream 100 bases:

>100_bases
TAAACGCGGCTCATGGAAAACACGCTATGGATTCTATCTTCTGGCCATCGGCTCTGCCTGTGGTTTGGGGAATCTGTGGC
GTTTTCCCTATGTCGTGGGC

Product: GTP-binding protein

Products: NA

Alternate protein names: GTP-binding protein EngA [H]

Number of amino acids: Translated: 449; Mature: 448

Protein sequence:

>449_residues
MSSTLKTDFSPKVAIIGRPNVGKSTLFNIITETRKAVVKNQAGVTRDIMIEPVDIWGKQFDLIDTGGITEAGDIFSKLIK
EQVTEFLHSVDLIVAVMDGRVGLVPEDRDIIRVAKQTGKPFLLVINKVDSDQDQDMAKADFYEFGVDVVAASFEQRRGLA
EILEWVVKQIPENPGTVKEGMNIAIVGKPNVGKSSICNAILGYNRMIVSDIAGTTIDSVDSPFVYNDKKYTLVDTAGLRR
SAKREEDLEIISAFKSQEAIRRADIVLLMVDGTVGPTDQDARIMQAILEDHKGVIVVANKSDLGGKEVPEYRKTFREQVE
RVFHFFTDVHIVFTSAKTGYGLEDLFEMIEKVAHQMTFRVPTAELNDFFFETIRKAPAPVWGTTNVKFYYLTQTYQQPPA
FIAFANHPDGVTNSYRRFLIKHIKTNWDLHGMPIRIFCMKSRRGGSDNG

Sequences:

>Translated_449_residues
MSSTLKTDFSPKVAIIGRPNVGKSTLFNIITETRKAVVKNQAGVTRDIMIEPVDIWGKQFDLIDTGGITEAGDIFSKLIK
EQVTEFLHSVDLIVAVMDGRVGLVPEDRDIIRVAKQTGKPFLLVINKVDSDQDQDMAKADFYEFGVDVVAASFEQRRGLA
EILEWVVKQIPENPGTVKEGMNIAIVGKPNVGKSSICNAILGYNRMIVSDIAGTTIDSVDSPFVYNDKKYTLVDTAGLRR
SAKREEDLEIISAFKSQEAIRRADIVLLMVDGTVGPTDQDARIMQAILEDHKGVIVVANKSDLGGKEVPEYRKTFREQVE
RVFHFFTDVHIVFTSAKTGYGLEDLFEMIEKVAHQMTFRVPTAELNDFFFETIRKAPAPVWGTTNVKFYYLTQTYQQPPA
FIAFANHPDGVTNSYRRFLIKHIKTNWDLHGMPIRIFCMKSRRGGSDNG
>Mature_448_residues
SSTLKTDFSPKVAIIGRPNVGKSTLFNIITETRKAVVKNQAGVTRDIMIEPVDIWGKQFDLIDTGGITEAGDIFSKLIKE
QVTEFLHSVDLIVAVMDGRVGLVPEDRDIIRVAKQTGKPFLLVINKVDSDQDQDMAKADFYEFGVDVVAASFEQRRGLAE
ILEWVVKQIPENPGTVKEGMNIAIVGKPNVGKSSICNAILGYNRMIVSDIAGTTIDSVDSPFVYNDKKYTLVDTAGLRRS
AKREEDLEIISAFKSQEAIRRADIVLLMVDGTVGPTDQDARIMQAILEDHKGVIVVANKSDLGGKEVPEYRKTFREQVER
VFHFFTDVHIVFTSAKTGYGLEDLFEMIEKVAHQMTFRVPTAELNDFFFETIRKAPAPVWGTTNVKFYYLTQTYQQPPAF
IAFANHPDGVTNSYRRFLIKHIKTNWDLHGMPIRIFCMKSRRGGSDNG

Specific function: GTPase that plays an essential role in the late steps of ribosome biogenesis [H]

COG id: COG1160

COG function: function code R; Predicted GTPases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 KH-like domain [H]

Homologues:

Organism=Escherichia coli, GI87082120, Length=465, Percent_Identity=33.1182795698925, Blast_Score=234, Evalue=1e-62,
Organism=Escherichia coli, GI2367268, Length=133, Percent_Identity=38.3458646616541, Blast_Score=79, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI17507259, Length=173, Percent_Identity=32.9479768786127, Blast_Score=71, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6323665, Length=188, Percent_Identity=31.3829787234043, Blast_Score=79, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR016484
- InterPro:   IPR006073
- InterPro:   IPR015946
- InterPro:   IPR002917
- InterPro:   IPR005225 [H]

Pfam domain/function: PF01926 MMR_HSR1 [H]

EC number: NA

Molecular weight: Translated: 50310; Mature: 50179

Theoretical pI: Translated: 6.53; Mature: 6.53

Prosite motif: PS00018 EF_HAND_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSTLKTDFSPKVAIIGRPNVGKSTLFNIITETRKAVVKNQAGVTRDIMIEPVDIWGKQF
CCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCHHEEEEEHHHCCCEE
DLIDTGGITEAGDIFSKLIKEQVTEFLHSVDLIVAVMDGRVGLVPEDRDIIRVAKQTGKP
EEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHEEEECCCEECCCCCHHHHHHHHHCCCC
FLLVINKVDSDQDQDMAKADFYEFGVDVVAASFEQRRGLAEILEWVVKQIPENPGTVKEG
EEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCHHHCC
MNIAIVGKPNVGKSSICNAILGYNRMIVSDIAGTTIDSVDSPFVYNDKKYTLVDTAGLRR
CEEEEEECCCCCHHHHHHHHHCCCHHHHHHHCCCCCCCCCCCEEECCCEEEEEECHHHHH
SAKREEDLEIISAFKSQEAIRRADIVLLMVDGTVGPTDQDARIMQAILEDHKGVIVVANK
HHCCHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCHHHHHHHHHHHCCCCEEEEECC
SDLGGKEVPEYRKTFREQVERVFHFFTDVHIVFTSAKTGYGLEDLFEMIEKVAHQMTFRV
CCCCCCCCHHHHHHHHHHHHHHHHHHHCEEEEEECCCCCCCHHHHHHHHHHHHHHHEECC
PTAELNDFFFETIRKAPAPVWGTTNVKFYYLTQTYQQPPAFIAFANHPDGVTNSYRRFLI
CCHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEECCCCCCCEEEECCCCCCCHHHHHHHHH
KHIKTNWDLHGMPIRIFCMKSRRGGSDNG
HHHHCCCCCCCCCEEEEEEECCCCCCCCC
>Mature Secondary Structure 
SSTLKTDFSPKVAIIGRPNVGKSTLFNIITETRKAVVKNQAGVTRDIMIEPVDIWGKQF
CCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCHHEEEEEHHHCCCEE
DLIDTGGITEAGDIFSKLIKEQVTEFLHSVDLIVAVMDGRVGLVPEDRDIIRVAKQTGKP
EEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHEEEECCCEECCCCCHHHHHHHHHCCCC
FLLVINKVDSDQDQDMAKADFYEFGVDVVAASFEQRRGLAEILEWVVKQIPENPGTVKEG
EEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCHHHCC
MNIAIVGKPNVGKSSICNAILGYNRMIVSDIAGTTIDSVDSPFVYNDKKYTLVDTAGLRR
CEEEEEECCCCCHHHHHHHHHCCCHHHHHHHCCCCCCCCCCCEEECCCEEEEEECHHHHH
SAKREEDLEIISAFKSQEAIRRADIVLLMVDGTVGPTDQDARIMQAILEDHKGVIVVANK
HHCCHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCHHHHHHHHHHHCCCCEEEEECC
SDLGGKEVPEYRKTFREQVERVFHFFTDVHIVFTSAKTGYGLEDLFEMIEKVAHQMTFRV
CCCCCCCCHHHHHHHHHHHHHHHHHHHCEEEEEECCCCCCCHHHHHHHHHHHHHHHEECC
PTAELNDFFFETIRKAPAPVWGTTNVKFYYLTQTYQQPPAFIAFANHPDGVTNSYRRFLI
CCHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEECCCCCCCEEEECCCCCCCHHHHHHHHH
KHIKTNWDLHGMPIRIFCMKSRRGGSDNG
HHHHCCCCCCCCCEEEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11997336 [H]