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The map label for this gene is mvaA [H]

Identifier: 42523130

GI number: 42523130

Start: 1564029

End: 1565345

Strand: Direct

Name: mvaA [H]

Synonym: Bd1627

Alternate gene names: 42523130

Gene position: 1564029-1565345 (Clockwise)

Preceding gene: 42523129

Following gene: 42523131

Centisome position: 41.34

GC content: 50.8

Gene sequence:

>1317_bases
ATGACAAAACAACTTCAGGATATCTTTAAAGGTTTCTCCAAACTGTCTCGTGAAGAACGTCTGAAAGCACTTAAAGAAGT
CGGTGCATTGAACGAAGCCGAAGCTGACTATCTTGCCAAGGGTGGGTTGAAAGACACTTCTTTGGGTGAAAAGTTTATTG
AAAACGTGATTGGGTACTTCCAGCTTCCGCTGGGGGTTGTCACCAACATGCGCGTGGACGGCAAGGACTTTGTCGTTCCT
ATGGCGGTGGAAGAAACCTCTATCGTGGCCGCGTGTTCTAAAACGGCCAAATGGATCCGTGAATCCGGTTCTATCACCAC
CGAAGTGATCGGAAACGAAATCATCGGTCAGATCCAATTGGCAAAAATCCGCAGCTTTGCGGATTTCGAAAAACAAATCC
TGGCTCAGAAAAATTACCTGATCGAAGCGGCCAACCGTGAAGTGGCCTTCGGCTTGGTTCGTCGTGGTGGTGGAGTGCGT
GACCTGCAAGTGCGCCGTGTGCCTCGCGGTGATGGCTCAGATATGGCCGTGATCCACATCCTGATGGACCCGTGCGATGC
CATGGGGGCTAACATCATCAATCAGGTGTGCGAATACCTGAAAGAGCCGATTGAGCAGTTCAGCGGTGAAAAAGTCACCA
TGTGCATCCTGTCCAATCTGGTGGATTCCAAAGTCACTCGCGCTGTTGTGCGCATTGATGACATCGAGCCTGAGTTGGCT
GAAAAAATTGAAGAAGCTTCTTTGTTCGCGCAAATGGACCCGTACCGTGCAGCCACCAACAACAAAGGTGTTCTAAACGG
CATTGATCCGATTCTGATTGCAACCGGCAACGACTGGCGCGCGGTGGAAGCGGGTATTCATGCTTATGCTTGCCGTGATG
GTCAGTACCGTTCGATCACTCGCTGGTACCGTGAAGGCAAAAGCCTGGTGGGCGTGTTTGAAGCACCACTGGTTGTGGGC
ACCGTAGGTGGTGTGACGACTTTGCATCCAACAGCGATGCTTTCCATGAAAATGCTGGACACCAAATCTGCCAATGAATT
GTCCCGTATTGTTGCGGCGGTGGGATTGGTGCAGAACCTGGGTGCTTTGAAGGCTTTGACCACGGTGGGTATCATCGAAG
GTCACATGAAGCTTCACACAAAAAACCTGGCTTTGGGCGCAGGAGCCGAGGAAAAAGAAATTCCTCTGGTTCAGAAGAAG
CTGGAAGAAATTCTGGCGATTCGCAAGCGTATATCCCTGAGCAATGCCATCGACGTTCTGAAAGAACTTCGTGCGGCTCA
GAAAACCCCAGCCTCCACGACTCAACATCATTCCTAG

Upstream 100 bases:

>100_bases
TTGAGAAACTGCTGACCCAGTTGGAAACAGAGTTGAAAGTAACTATGTTCTGCACGGGCAGCCGCAATCTGAAAGACCTC
CAAAGCAAGAAGGTGATTCA

Downstream 100 bases:

>100_bases
GAGCGGACCTTGTCGCTGGTCTTCTCCGTTCCCGGAAAAACATTTATTGCTGGTGAATATCTGGCGCTGGCGGAAGGTCC
GACACTGTTCTTCCTTTCGC

Product: hypothetical protein

Products: NA

Alternate protein names: HMG-CoA reductase [H]

Number of amino acids: Translated: 438; Mature: 437

Protein sequence:

>438_residues
MTKQLQDIFKGFSKLSREERLKALKEVGALNEAEADYLAKGGLKDTSLGEKFIENVIGYFQLPLGVVTNMRVDGKDFVVP
MAVEETSIVAACSKTAKWIRESGSITTEVIGNEIIGQIQLAKIRSFADFEKQILAQKNYLIEAANREVAFGLVRRGGGVR
DLQVRRVPRGDGSDMAVIHILMDPCDAMGANIINQVCEYLKEPIEQFSGEKVTMCILSNLVDSKVTRAVVRIDDIEPELA
EKIEEASLFAQMDPYRAATNNKGVLNGIDPILIATGNDWRAVEAGIHAYACRDGQYRSITRWYREGKSLVGVFEAPLVVG
TVGGVTTLHPTAMLSMKMLDTKSANELSRIVAAVGLVQNLGALKALTTVGIIEGHMKLHTKNLALGAGAEEKEIPLVQKK
LEEILAIRKRISLSNAIDVLKELRAAQKTPASTTQHHS

Sequences:

>Translated_438_residues
MTKQLQDIFKGFSKLSREERLKALKEVGALNEAEADYLAKGGLKDTSLGEKFIENVIGYFQLPLGVVTNMRVDGKDFVVP
MAVEETSIVAACSKTAKWIRESGSITTEVIGNEIIGQIQLAKIRSFADFEKQILAQKNYLIEAANREVAFGLVRRGGGVR
DLQVRRVPRGDGSDMAVIHILMDPCDAMGANIINQVCEYLKEPIEQFSGEKVTMCILSNLVDSKVTRAVVRIDDIEPELA
EKIEEASLFAQMDPYRAATNNKGVLNGIDPILIATGNDWRAVEAGIHAYACRDGQYRSITRWYREGKSLVGVFEAPLVVG
TVGGVTTLHPTAMLSMKMLDTKSANELSRIVAAVGLVQNLGALKALTTVGIIEGHMKLHTKNLALGAGAEEKEIPLVQKK
LEEILAIRKRISLSNAIDVLKELRAAQKTPASTTQHHS
>Mature_437_residues
TKQLQDIFKGFSKLSREERLKALKEVGALNEAEADYLAKGGLKDTSLGEKFIENVIGYFQLPLGVVTNMRVDGKDFVVPM
AVEETSIVAACSKTAKWIRESGSITTEVIGNEIIGQIQLAKIRSFADFEKQILAQKNYLIEAANREVAFGLVRRGGGVRD
LQVRRVPRGDGSDMAVIHILMDPCDAMGANIINQVCEYLKEPIEQFSGEKVTMCILSNLVDSKVTRAVVRIDDIEPELAE
KIEEASLFAQMDPYRAATNNKGVLNGIDPILIATGNDWRAVEAGIHAYACRDGQYRSITRWYREGKSLVGVFEAPLVVGT
VGGVTTLHPTAMLSMKMLDTKSANELSRIVAAVGLVQNLGALKALTTVGIIEGHMKLHTKNLALGAGAEEKEIPLVQKKL
EEILAIRKRISLSNAIDVLKELRAAQKTPASTTQHHS

Specific function: P.mevalonii can use mevalonate as sole carbon source. With this enzyme mevalonate is deacetylated to HMG-CoA [H]

COG id: COG1257

COG function: function code I; Hydroxymethylglutaryl-CoA reductase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMG-CoA reductase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002202
- InterPro:   IPR004553
- InterPro:   IPR023074
- InterPro:   IPR023076
- InterPro:   IPR009023
- InterPro:   IPR009029 [H]

Pfam domain/function: PF00368 HMG-CoA_red [H]

EC number: =1.1.1.88 [H]

Molecular weight: Translated: 47897; Mature: 47766

Theoretical pI: Translated: 7.53; Mature: 7.53

Prosite motif: PS00066 HMG_COA_REDUCTASE_1 ; PS50065 HMG_COA_REDUCTASE_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKQLQDIFKGFSKLSREERLKALKEVGALNEAEADYLAKGGLKDTSLGEKFIENVIGYF
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHH
QLPLGVVTNMRVDGKDFVVPMAVEETSIVAACSKTAKWIRESGSITTEVIGNEIIGQIQL
HHHHHHHHCCEECCCCEEEEEEECHHHHHHHHHHHHHHHHHCCCEEHHHHHHHHHHHHHH
AKIRSFADFEKQILAQKNYLIEAANREVAFGLVRRGGGVRDLQVRRVPRGDGSDMAVIHI
HHHHHHHHHHHHHHHHHHHHEEECCCHHHHHHHHCCCCCCEEEEEECCCCCCCCEEEEEE
LMDPCDAMGANIINQVCEYLKEPIEQFSGEKVTMCILSNLVDSKVTRAVVRIDDIEPELA
ECCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEHHHHHHHHHHHHHHHHHHHCCCCCHHHH
EKIEEASLFAQMDPYRAATNNKGVLNGIDPILIATGNDWRAVEAGIHAYACRDGQYRSIT
HHHHHHHHHHHCCCCHHCCCCCCCCCCCCCEEEEECCCCHHHHHCCHHEEECCCCHHHHH
RWYREGKSLVGVFEAPLVVGTVGGVTTLHPTAMLSMKMLDTKSANELSRIVAAVGLVQNL
HHHHCCCCEEEHHHCCEEEECCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
GALKALTTVGIIEGHMKLHTKNLALGAGAEEKEIPLVQKKLEEILAIRKRISLSNAIDVL
HHHHHHHHHHHHHHHHEEEECCEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
KELRAAQKTPASTTQHHS
HHHHHHHCCCCCCCCCCC
>Mature Secondary Structure 
TKQLQDIFKGFSKLSREERLKALKEVGALNEAEADYLAKGGLKDTSLGEKFIENVIGYF
CHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHH
QLPLGVVTNMRVDGKDFVVPMAVEETSIVAACSKTAKWIRESGSITTEVIGNEIIGQIQL
HHHHHHHHCCEECCCCEEEEEEECHHHHHHHHHHHHHHHHHCCCEEHHHHHHHHHHHHHH
AKIRSFADFEKQILAQKNYLIEAANREVAFGLVRRGGGVRDLQVRRVPRGDGSDMAVIHI
HHHHHHHHHHHHHHHHHHHHEEECCCHHHHHHHHCCCCCCEEEEEECCCCCCCCEEEEEE
LMDPCDAMGANIINQVCEYLKEPIEQFSGEKVTMCILSNLVDSKVTRAVVRIDDIEPELA
ECCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEHHHHHHHHHHHHHHHHHHHCCCCCHHHH
EKIEEASLFAQMDPYRAATNNKGVLNGIDPILIATGNDWRAVEAGIHAYACRDGQYRSIT
HHHHHHHHHHHCCCCHHCCCCCCCCCCCCCEEEEECCCCHHHHHCCHHEEECCCCHHHHH
RWYREGKSLVGVFEAPLVVGTVGGVTTLHPTAMLSMKMLDTKSANELSRIVAAVGLVQNL
HHHHCCCCEEEHHHCCEEEECCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
GALKALTTVGIIEGHMKLHTKNLALGAGAEEKEIPLVQKKLEEILAIRKRISLSNAIDVL
HHHHHHHHHHHHHHHHEEEECCEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
KELRAAQKTPASTTQHHS
HHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2656635; 2477360; 2123872; 1634543; 10377386 [H]