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The map label for this gene is relA [H]

Identifier: 42523075

GI number: 42523075

Start: 1494446

End: 1496662

Strand: Direct

Name: relA [H]

Synonym: Bd1570

Alternate gene names: 42523075

Gene position: 1494446-1496662 (Clockwise)

Preceding gene: 42523074

Following gene: 42523076

Centisome position: 39.5

GC content: 51.83

Gene sequence:

>2217_bases
ATGTTTAATTTCCTGAAAGAGGATGGCTTAACCAACAAGCCGGTCAAAACAGTCGACGATCTGCTGGCGCGCATTCGAGT
CTATTATCCGAATGCAGATCTCAAAATTATTGAGAAGGCCTATTCATTCTCTGAGAAAATGCACGAAGGCCAAATCCGCC
GCAGCGGTGAACCTTACATTTCTCATCCTCTTTCGGTTGCCGCAATCTTGGCGGACTTCCATTTGGATCTGGACACCATT
GCCACCGGTCTTCTGCATGACACCGTTGAAGACACCGCGGCCACGCTGGAAGACATTCGCCGCGAGTTCGGTGATGTGAT
CGCGCACCTGGTGGACGGGGTGACCAAGATCGGTCAGATGAAGTTCAAGAACAGCCACGAAAAGCAGGGTGAAAACATCC
GCAAAATGATCGTGGCCATGGGTAAAGACGTGCGCGTCGTTCTGGTGAAGCTGGCTGATCGCCTTCACAACATGCGAACT
TTGAATTTCATGCCGTTTGAAAAACAAGAGCGCATCGCTCTTGAAACATTGGAAATCTATTGTCCGCTGGCAGGGCGCAT
GGGTATCAGTGCGCTGAAGATTGAGCTGGAAGACCTGTGCTTCCGTTACTATCGCCCGGACATGTACTATGAACTTGTCC
AGCAGATTAAAAAGACCGAAGCCGAGCAGAATAGATATATCGAGGAAGTGAAGCATCTGATCGGAAAAGAACTGACCAAA
GCCGGCTTCCGTTATGAAGTCTATGGGCGTTCCAAACACTTGTGGTCCATCTACCGAAAAATGCAATCCCGTAACATCGA
CTACGATCAGGTATACGATGTTCTGGCATTCCGTGTGCTGGTTGAATCCGTGGCGGAATGTTATGCCGCTCTGGGGCTGG
TCCACTCGCTGTGGAAGCCGATCCCGGGTCGTTTTAAAGACTTCATCGCGATGCCCAAGGCCAATAACTATCAGTCCCTG
CACACGACCGTCATGGGCCCGGGCGGGGAGCGCATCGAGATTCAAATCCGTACCAGTGAAATGCATCTGGTTGCGGAAAA
AGGTATCGCCGCTCACTGGAAGTACAAAGAGCGCGGCAAGATGATGGACGACGGTGATTTGCAGCAGGCCAACTGGCTGC
GTGATCTGGTGTCGTGGCATCAGAACGTGCGCAATCCTGACGAATTCCTGGACACCGTCAAAACGGATTTGTTCGAAACT
GAAATTTACGTTTTCACTCCGACCGGAGATGTTCGTGAATTCCCTGAAGGGGCCACCCCGGTGGACTTTGCCTTCGCGGT
TCACACGGAGCTTGGCAACCGCATTGTCGGGGCCCGCGTGAACGGCAAAATGGTGCCGCTGAAATATCAGCTGCAAAACG
GGGACACAGTCGAAGTTGTCACTTCCAAAACCCAGGTGCCTTCCAAGGACTGGTTGAAATTTGTCGTTACCAATAAAGCC
AAATCCAAAATCCGCGCCTTCGTCAAAGAAGAGCAGCGCCGTCGTGCGATCATGCTGGGTAAAGAACTGGTGGAAAAAGA
ATTCCGCAAGTTCGGCATGGCTGCCGTGAAGTATCTGAAAGGCCCGGCCTTTGAAGCCTATCTGAAGGACCACGGCCTGG
CGGATCTGGATGAGTTGTACGTGACCGTGGGTTACGGAAAACTTGAAACGCGCATTCTGGTGGAAAGACTTTCCCCGGAA
AATATCGCCAAAGAAGCGGCCAAAACCGAAGACACGACCTTTATGGAAAGAGTCATGCGTGCCGCGACTCAAAAAACACG
CAAGACCAATTCCCTTATCAGTGTGGACGGCATGGATGACGTGCTGGTGCACTATGCAAAATGCTGTCATCCGATCCCGG
GGGATCCGATCGTGGGCTTTATCAGCCGTGGCCGTGGTATCTCCATTCACCGCAGCGACTGCCGCAAGGCTTTTGAATTC
GATCAGCTTCGCAAAGTCGATGTGACCTGGAATGTGAAACAAGCCGGAGAAGGCCAGGAGCGCATTGTGCGCCTGAAGAT
CATCTCCCAGGACGTGCCGGGATTGCTAAAACTGATGTCAGAAGCCTTTGCCCAGCAGGGGATCAATATTCAGTCAGCCC
AGATCCGCACGACCAAGGATAAAAAAGCCGTGTGTAACTTCGAGGTCAGCGTTCAGAATGCGAGCCAGTTGAACCAGGCG
GTGTTTGAAATCCAGAAGATCAAGGGGATCATTGGGGTCACCCGTGTTATTCACTAA

Upstream 100 bases:

>100_bases
AACCCAATGAAGGGAGGCGGAAGTCTCCCTTTTTGCGTTTTCTGGACGCCTGTAATTCTTCGTTGGACACCCCTCTGGGG
TCAGGTAAGCTATAGGGAAT

Downstream 100 bases:

>100_bases
CATCAGGAAGAATCTGCATTTCCTGATGGCTCTGTCCGTGCTGGGCATCGCCTCCATCGTGATTTTCGGATGGATTCTGC
GGGACCCGGCTCTGATTCAA

Product: GTP pyrophosphokinase

Products: NA

Alternate protein names: (p)ppGpp synthase; ATP:GTP 3'-pyrophosphotransferase; ppGpp synthase I [H]

Number of amino acids: Translated: 738; Mature: 738

Protein sequence:

>738_residues
MFNFLKEDGLTNKPVKTVDDLLARIRVYYPNADLKIIEKAYSFSEKMHEGQIRRSGEPYISHPLSVAAILADFHLDLDTI
ATGLLHDTVEDTAATLEDIRREFGDVIAHLVDGVTKIGQMKFKNSHEKQGENIRKMIVAMGKDVRVVLVKLADRLHNMRT
LNFMPFEKQERIALETLEIYCPLAGRMGISALKIELEDLCFRYYRPDMYYELVQQIKKTEAEQNRYIEEVKHLIGKELTK
AGFRYEVYGRSKHLWSIYRKMQSRNIDYDQVYDVLAFRVLVESVAECYAALGLVHSLWKPIPGRFKDFIAMPKANNYQSL
HTTVMGPGGERIEIQIRTSEMHLVAEKGIAAHWKYKERGKMMDDGDLQQANWLRDLVSWHQNVRNPDEFLDTVKTDLFET
EIYVFTPTGDVREFPEGATPVDFAFAVHTELGNRIVGARVNGKMVPLKYQLQNGDTVEVVTSKTQVPSKDWLKFVVTNKA
KSKIRAFVKEEQRRRAIMLGKELVEKEFRKFGMAAVKYLKGPAFEAYLKDHGLADLDELYVTVGYGKLETRILVERLSPE
NIAKEAAKTEDTTFMERVMRAATQKTRKTNSLISVDGMDDVLVHYAKCCHPIPGDPIVGFISRGRGISIHRSDCRKAFEF
DQLRKVDVTWNVKQAGEGQERIVRLKIISQDVPGLLKLMSEAFAQQGINIQSAQIRTTKDKKAVCNFEVSVQNASQLNQA
VFEIQKIKGIIGVTRVIH

Sequences:

>Translated_738_residues
MFNFLKEDGLTNKPVKTVDDLLARIRVYYPNADLKIIEKAYSFSEKMHEGQIRRSGEPYISHPLSVAAILADFHLDLDTI
ATGLLHDTVEDTAATLEDIRREFGDVIAHLVDGVTKIGQMKFKNSHEKQGENIRKMIVAMGKDVRVVLVKLADRLHNMRT
LNFMPFEKQERIALETLEIYCPLAGRMGISALKIELEDLCFRYYRPDMYYELVQQIKKTEAEQNRYIEEVKHLIGKELTK
AGFRYEVYGRSKHLWSIYRKMQSRNIDYDQVYDVLAFRVLVESVAECYAALGLVHSLWKPIPGRFKDFIAMPKANNYQSL
HTTVMGPGGERIEIQIRTSEMHLVAEKGIAAHWKYKERGKMMDDGDLQQANWLRDLVSWHQNVRNPDEFLDTVKTDLFET
EIYVFTPTGDVREFPEGATPVDFAFAVHTELGNRIVGARVNGKMVPLKYQLQNGDTVEVVTSKTQVPSKDWLKFVVTNKA
KSKIRAFVKEEQRRRAIMLGKELVEKEFRKFGMAAVKYLKGPAFEAYLKDHGLADLDELYVTVGYGKLETRILVERLSPE
NIAKEAAKTEDTTFMERVMRAATQKTRKTNSLISVDGMDDVLVHYAKCCHPIPGDPIVGFISRGRGISIHRSDCRKAFEF
DQLRKVDVTWNVKQAGEGQERIVRLKIISQDVPGLLKLMSEAFAQQGINIQSAQIRTTKDKKAVCNFEVSVQNASQLNQA
VFEIQKIKGIIGVTRVIH
>Mature_738_residues
MFNFLKEDGLTNKPVKTVDDLLARIRVYYPNADLKIIEKAYSFSEKMHEGQIRRSGEPYISHPLSVAAILADFHLDLDTI
ATGLLHDTVEDTAATLEDIRREFGDVIAHLVDGVTKIGQMKFKNSHEKQGENIRKMIVAMGKDVRVVLVKLADRLHNMRT
LNFMPFEKQERIALETLEIYCPLAGRMGISALKIELEDLCFRYYRPDMYYELVQQIKKTEAEQNRYIEEVKHLIGKELTK
AGFRYEVYGRSKHLWSIYRKMQSRNIDYDQVYDVLAFRVLVESVAECYAALGLVHSLWKPIPGRFKDFIAMPKANNYQSL
HTTVMGPGGERIEIQIRTSEMHLVAEKGIAAHWKYKERGKMMDDGDLQQANWLRDLVSWHQNVRNPDEFLDTVKTDLFET
EIYVFTPTGDVREFPEGATPVDFAFAVHTELGNRIVGARVNGKMVPLKYQLQNGDTVEVVTSKTQVPSKDWLKFVVTNKA
KSKIRAFVKEEQRRRAIMLGKELVEKEFRKFGMAAVKYLKGPAFEAYLKDHGLADLDELYVTVGYGKLETRILVERLSPE
NIAKEAAKTEDTTFMERVMRAATQKTRKTNSLISVDGMDDVLVHYAKCCHPIPGDPIVGFISRGRGISIHRSDCRKAFEF
DQLRKVDVTWNVKQAGEGQERIVRLKIISQDVPGLLKLMSEAFAQQGINIQSAQIRTTKDKKAVCNFEVSVQNASQLNQA
VFEIQKIKGIIGVTRVIH

Specific function: In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes the formation of pppGpp which i

COG id: COG0317

COG function: function code TK; Guanosine polyphosphate pyrophosphohydrolases/synthetases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HD domain [H]

Homologues:

Organism=Escherichia coli, GI1790082, Length=714, Percent_Identity=39.6358543417367, Blast_Score=534, Evalue=1e-153,
Organism=Escherichia coli, GI1789147, Length=686, Percent_Identity=35.7142857142857, Blast_Score=483, Evalue=1e-137,
Organism=Caenorhabditis elegans, GI25143118, Length=133, Percent_Identity=35.3383458646617, Blast_Score=69, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR012675
- InterPro:   IPR003607
- InterPro:   IPR007685
- InterPro:   IPR004811
- InterPro:   IPR004095
- InterPro:   IPR012676 [H]

Pfam domain/function: PF01842 ACT; PF04607 RelA_SpoT; PF02824 TGS [H]

EC number: =2.7.6.5 [H]

Molecular weight: Translated: 84393; Mature: 84393

Theoretical pI: Translated: 9.02; Mature: 9.02

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFNFLKEDGLTNKPVKTVDDLLARIRVYYPNADLKIIEKAYSFSEKMHEGQIRRSGEPYI
CCCCCCCCCCCCCCHHHHHHHHHHEEEECCCCCHHHHHHHHHHHHHHHHCCHHCCCCCCC
SHPLSVAAILADFHLDLDTIATGLLHDTVEDTAATLEDIRREFGDVIAHLVDGVTKIGQM
CCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KFKNSHEKQGENIRKMIVAMGKDVRVVLVKLADRLHNMRTLNFMPFEKQERIALETLEIY
HHCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCEECCCCCCCHHHHHHHHHHHHH
CPLAGRMGISALKIELEDLCFRYYRPDMYYELVQQIKKTEAEQNRYIEEVKHLIGKELTK
CCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AGFRYEVYGRSKHLWSIYRKMQSRNIDYDQVYDVLAFRVLVESVAECYAALGLVHSLWKP
CCCEEEEECCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
IPGRFKDFIAMPKANNYQSLHTTVMGPGGERIEIQIRTSEMHLVAEKGIAAHWKYKERGK
CCCHHHHHHCCCCCCCCCHHEEEEECCCCCEEEEEEEECCEEEHHHCCCHHCCCCHHCCC
MMDDGDLQQANWLRDLVSWHQNVRNPDEFLDTVKTDLFETEIYVFTPTGDVREFPEGATP
CCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHEECEEEEECCCCCHHHCCCCCCC
VDFAFAVHTELGNRIVGARVNGKMVPLKYQLQNGDTVEVVTSKTQVPSKDWLKFVVTNKA
CHHHHEEHHHHCCEEEEEEECCEEEEEEEEECCCCEEEEEECCCCCCCHHHHHHHHHHHH
KSKIRAFVKEEQRRRAIMLGKELVEKEFRKFGMAAVKYLKGPAFEAYLKDHGLADLDELY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCHHHEE
VTVGYGKLETRILVERLSPENIAKEAAKTEDTTFMERVMRAATQKTRKTNSLISVDGMDD
EEECCCHHHHHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCEEEECCHHH
VLVHYAKCCHPIPGDPIVGFISRGRGISIHRSDCRKAFEFDQLRKVDVTWNVKQAGEGQE
HHHHHHHHCCCCCCCCHHHHHHCCCCCEEEHHHHHHHHHHHHHEEEEEEEEHHHCCCCHH
RIVRLKIISQDVPGLLKLMSEAFAQQGINIQSAQIRTTKDKKAVCNFEVSVQNASQLNQA
HEEEEEEECCCCHHHHHHHHHHHHHCCCCEECCEEEECCCCCCEEEEEEEECCHHHHHHH
VFEIQKIKGIIGVTRVIH
HHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MFNFLKEDGLTNKPVKTVDDLLARIRVYYPNADLKIIEKAYSFSEKMHEGQIRRSGEPYI
CCCCCCCCCCCCCCHHHHHHHHHHEEEECCCCCHHHHHHHHHHHHHHHHCCHHCCCCCCC
SHPLSVAAILADFHLDLDTIATGLLHDTVEDTAATLEDIRREFGDVIAHLVDGVTKIGQM
CCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KFKNSHEKQGENIRKMIVAMGKDVRVVLVKLADRLHNMRTLNFMPFEKQERIALETLEIY
HHCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCEECCCCCCCHHHHHHHHHHHHH
CPLAGRMGISALKIELEDLCFRYYRPDMYYELVQQIKKTEAEQNRYIEEVKHLIGKELTK
CCCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AGFRYEVYGRSKHLWSIYRKMQSRNIDYDQVYDVLAFRVLVESVAECYAALGLVHSLWKP
CCCEEEEECCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
IPGRFKDFIAMPKANNYQSLHTTVMGPGGERIEIQIRTSEMHLVAEKGIAAHWKYKERGK
CCCHHHHHHCCCCCCCCCHHEEEEECCCCCEEEEEEEECCEEEHHHCCCHHCCCCHHCCC
MMDDGDLQQANWLRDLVSWHQNVRNPDEFLDTVKTDLFETEIYVFTPTGDVREFPEGATP
CCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHEECEEEEECCCCCHHHCCCCCCC
VDFAFAVHTELGNRIVGARVNGKMVPLKYQLQNGDTVEVVTSKTQVPSKDWLKFVVTNKA
CHHHHEEHHHHCCEEEEEEECCEEEEEEEEECCCCEEEEEECCCCCCCHHHHHHHHHHHH
KSKIRAFVKEEQRRRAIMLGKELVEKEFRKFGMAAVKYLKGPAFEAYLKDHGLADLDELY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCHHHEE
VTVGYGKLETRILVERLSPENIAKEAAKTEDTTFMERVMRAATQKTRKTNSLISVDGMDD
EEECCCHHHHHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCEEEECCHHH
VLVHYAKCCHPIPGDPIVGFISRGRGISIHRSDCRKAFEFDQLRKVDVTWNVKQAGEGQE
HHHHHHHHCCCCCCCCHHHHHHCCCCCEEEHHHHHHHHHHHHHEEEEEEEEHHHCCCCHH
RIVRLKIISQDVPGLLKLMSEAFAQQGINIQSAQIRTTKDKKAVCNFEVSVQNASQLNQA
HEEEEEEECCCCHHHHHHHHHHHHHCCCCEECCEEEECCCCCCEEEEEEEECCHHHHHHH
VFEIQKIKGIIGVTRVIH
HHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA