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The map label for this gene is mutL [H]

Identifier: 42523070

GI number: 42523070

Start: 1489758

End: 1491638

Strand: Direct

Name: mutL [H]

Synonym: Bd1564

Alternate gene names: 42523070

Gene position: 1489758-1491638 (Clockwise)

Preceding gene: 42523069

Following gene: 42523071

Centisome position: 39.38

GC content: 53.43

Gene sequence:

>1881_bases
ATGCAAATTCCCCCTATGTCGATCCAGATTTTATCCCCTGAAGTTGTTGACCAAATCGCCGCGGGCGAGGTGGTGGAGCG
TCCTGCTCATCTCGTCAAAGAACTTGTGGAAAACAGCATCGATGCCGGCGCCACCCGCGTGCACGTGGAATTCTACGACG
GCGGCCGCATCGTCAAGGTGATCGACAACGGCAAGGGGATGTCCCCGGAAGATTTGCCCAAATCCCTGGAACGATTCGCA
ACCAGCAAAATCTCAAAAACCGATGACCTGTGGTCTTTGCGCACTTTCGGTTTCCGCGGCGAAGCTTTGGCCAGTATCGC
CTCTGTCAGCAAGCTGACACTGACTTCGCGTCGTGCCGGGGATGAACAGGCCCATCAGCTGATCAGTGAATACGGAAAAA
GAAAAGAGATCGACAAAGTCGGCGGCTCGCAAGGCACGACCATCCTGATTGAAAACCTTTTCGACAACACTCCGGCGCGT
TTGAAATTCCTGAAGTCTGATTCGGCTGAAAACTCGGCGATCAAGACGACCTTGAAGGCGATGGCCTTGTCTCATTACGA
TGTCGAGTTCCGCATTCAGGAAAACGGCAAGCTTGTGGCGTTCTGGCCGGCGTGTAAATCCCGCAAGGACCGTGTTGAAC
AAATTCTTGAAATCAAACCTCTGTTCGAAGGCGAAGCTTCCCGCGAAAACGTGAAGGCCTATGCGGTGTTTGCCGATCCT
CATAACGTCGCCAAGACTTCAAAAAATATCTGGCTGTTTGCGCAAAATCGCTGGATCCAGGATCGCAGTCTGCAGGCGGC
CGTGAACGAAGCCTATCGCAGTCTTCTGATGCACGGAGAATATCCGATTGCCGCCGTGTGGGTGGAAGTGGATCCGGACT
GTGTGGATGTGAACATTCACCCGACAAAATCCCAGGTGAAATTCCAGGATCCGTCCCTGGCATTCCGTGCTGTGGCGGCG
GCTTTGCGTGGCACGCTGGAGCAGGCACCCTGGATCAAACGCTCGGATGTGGCAACGCAGAATGTGACCATGCCGCTTAC
GCAGAACTCTTCTGAGGAGTTTAAATCCACTGACGGGCTTCCGAACTTTGCTTCGCAACCCATGCCTCAGCAGAATCTGC
GCTTCCAGGACAATTCTTTGGAAGTGACTCAGTTCCAGAAAAAAGAATTCAGCTTCCCGGCGTCCAGTTTTCCGGTCTCA
TCATTGCAGCAGCCGCAGACCACTTATCAGGCCCTGGCTGAGTCGGCGGCTCAGCGTGAATCCTTTGCTCCGAAAGCGGA
GGAGGCTTCACTGGGTTACTGGTCTTCTTTGGAGGTTCTGGGGCAGGCGAATTTGACTTACATCGTGACTCAGTCCAGAG
ACAAGCTGGTGTTCGTGGATCAGCACGCCGCTCACGAGCGTGTGGTGTTTGAAAAACTGATGAATGCCTGGAAGGGTGGG
AAGGTTGATATTCAAGACTTCCTGTTCCCCCTGGCGATTGATATGTCTCCGGAAAAAGTCGAAGGTCTTTTGACCATGGC
CAAAGAAATGGAACGCCTGGGTGTTTTCATTGAAGCTTTGGGTCCGGGCACGGTTGGTGTTAAAGCCGCCCCGTTGATGA
TCAAAGAATCCAGCCTCAGCGGTGTTTTGGACAAGATGGCGACCGAGATCGTGGATCAGGGCGGCAGTTATTCTTTGGAA
AGAACTGTGGGCGACATTTGTGCCACGATGGCGTGCCATTCCGTGGTGCGGGCAGGGCAGTCTTTAAGTCCGGATCAGAT
GCGCAGTCTGCTTCGTGACATGGACATGTTCCCGCTTTCAAGCTTCTGTCCTCACGGTCGCCCGGTCAGTGTGGAGTACC
CGTACTACAAGCTGGAAAAAGATTTCGGACGAATAGTTTAA

Upstream 100 bases:

>100_bases
CTTGACCGAGGTCAAACAACTGCGCTCCAAACTGCTGAAATGTCAGGCTTGGGGCGAGTGTCTGCGCCCACAATAGTCCT
TTGACTTGAGGGGGGAGCTC

Downstream 100 bases:

>100_bases
TGGCGAAAAGGCATGTGATTTTTGTTGTCGGCTCCACGGCCACCGGGAAATCCGAGTGGGCGCTGAAGCTTGCGCAAGAA
TTCAACGGCGTCATCGTCAA

Product: DNA mismatch repair protein MutL

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 626; Mature: 626

Protein sequence:

>626_residues
MQIPPMSIQILSPEVVDQIAAGEVVERPAHLVKELVENSIDAGATRVHVEFYDGGRIVKVIDNGKGMSPEDLPKSLERFA
TSKISKTDDLWSLRTFGFRGEALASIASVSKLTLTSRRAGDEQAHQLISEYGKRKEIDKVGGSQGTTILIENLFDNTPAR
LKFLKSDSAENSAIKTTLKAMALSHYDVEFRIQENGKLVAFWPACKSRKDRVEQILEIKPLFEGEASRENVKAYAVFADP
HNVAKTSKNIWLFAQNRWIQDRSLQAAVNEAYRSLLMHGEYPIAAVWVEVDPDCVDVNIHPTKSQVKFQDPSLAFRAVAA
ALRGTLEQAPWIKRSDVATQNVTMPLTQNSSEEFKSTDGLPNFASQPMPQQNLRFQDNSLEVTQFQKKEFSFPASSFPVS
SLQQPQTTYQALAESAAQRESFAPKAEEASLGYWSSLEVLGQANLTYIVTQSRDKLVFVDQHAAHERVVFEKLMNAWKGG
KVDIQDFLFPLAIDMSPEKVEGLLTMAKEMERLGVFIEALGPGTVGVKAAPLMIKESSLSGVLDKMATEIVDQGGSYSLE
RTVGDICATMACHSVVRAGQSLSPDQMRSLLRDMDMFPLSSFCPHGRPVSVEYPYYKLEKDFGRIV

Sequences:

>Translated_626_residues
MQIPPMSIQILSPEVVDQIAAGEVVERPAHLVKELVENSIDAGATRVHVEFYDGGRIVKVIDNGKGMSPEDLPKSLERFA
TSKISKTDDLWSLRTFGFRGEALASIASVSKLTLTSRRAGDEQAHQLISEYGKRKEIDKVGGSQGTTILIENLFDNTPAR
LKFLKSDSAENSAIKTTLKAMALSHYDVEFRIQENGKLVAFWPACKSRKDRVEQILEIKPLFEGEASRENVKAYAVFADP
HNVAKTSKNIWLFAQNRWIQDRSLQAAVNEAYRSLLMHGEYPIAAVWVEVDPDCVDVNIHPTKSQVKFQDPSLAFRAVAA
ALRGTLEQAPWIKRSDVATQNVTMPLTQNSSEEFKSTDGLPNFASQPMPQQNLRFQDNSLEVTQFQKKEFSFPASSFPVS
SLQQPQTTYQALAESAAQRESFAPKAEEASLGYWSSLEVLGQANLTYIVTQSRDKLVFVDQHAAHERVVFEKLMNAWKGG
KVDIQDFLFPLAIDMSPEKVEGLLTMAKEMERLGVFIEALGPGTVGVKAAPLMIKESSLSGVLDKMATEIVDQGGSYSLE
RTVGDICATMACHSVVRAGQSLSPDQMRSLLRDMDMFPLSSFCPHGRPVSVEYPYYKLEKDFGRIV
>Mature_626_residues
MQIPPMSIQILSPEVVDQIAAGEVVERPAHLVKELVENSIDAGATRVHVEFYDGGRIVKVIDNGKGMSPEDLPKSLERFA
TSKISKTDDLWSLRTFGFRGEALASIASVSKLTLTSRRAGDEQAHQLISEYGKRKEIDKVGGSQGTTILIENLFDNTPAR
LKFLKSDSAENSAIKTTLKAMALSHYDVEFRIQENGKLVAFWPACKSRKDRVEQILEIKPLFEGEASRENVKAYAVFADP
HNVAKTSKNIWLFAQNRWIQDRSLQAAVNEAYRSLLMHGEYPIAAVWVEVDPDCVDVNIHPTKSQVKFQDPSLAFRAVAA
ALRGTLEQAPWIKRSDVATQNVTMPLTQNSSEEFKSTDGLPNFASQPMPQQNLRFQDNSLEVTQFQKKEFSFPASSFPVS
SLQQPQTTYQALAESAAQRESFAPKAEEASLGYWSSLEVLGQANLTYIVTQSRDKLVFVDQHAAHERVVFEKLMNAWKGG
KVDIQDFLFPLAIDMSPEKVEGLLTMAKEMERLGVFIEALGPGTVGVKAAPLMIKESSLSGVLDKMATEIVDQGGSYSLE
RTVGDICATMACHSVVRAGQSLSPDQMRSLLRDMDMFPLSSFCPHGRPVSVEYPYYKLEKDFGRIV

Specific function: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-bindi

COG id: COG0323

COG function: function code L; DNA mismatch repair enzyme (predicted ATPase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA mismatch repair mutL/hexB family [H]

Homologues:

Organism=Homo sapiens, GI4557757, Length=313, Percent_Identity=34.5047923322684, Blast_Score=175, Evalue=1e-43,
Organism=Homo sapiens, GI4505913, Length=373, Percent_Identity=27.8820375335121, Blast_Score=122, Evalue=1e-27,
Organism=Homo sapiens, GI310128478, Length=373, Percent_Identity=27.8820375335121, Blast_Score=122, Evalue=1e-27,
Organism=Homo sapiens, GI189458896, Length=398, Percent_Identity=25.3768844221106, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI189458898, Length=464, Percent_Identity=24.1379310344828, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI4505911, Length=415, Percent_Identity=25.0602409638554, Blast_Score=107, Evalue=4e-23,
Organism=Homo sapiens, GI91992160, Length=358, Percent_Identity=27.3743016759777, Blast_Score=99, Evalue=2e-20,
Organism=Homo sapiens, GI91992162, Length=358, Percent_Identity=27.3743016759777, Blast_Score=99, Evalue=2e-20,
Organism=Homo sapiens, GI263191589, Length=219, Percent_Identity=29.2237442922374, Blast_Score=87, Evalue=7e-17,
Organism=Escherichia coli, GI1790612, Length=342, Percent_Identity=38.3040935672515, Blast_Score=215, Evalue=7e-57,
Organism=Caenorhabditis elegans, GI71991825, Length=390, Percent_Identity=32.5641025641026, Blast_Score=169, Evalue=4e-42,
Organism=Caenorhabditis elegans, GI17562796, Length=357, Percent_Identity=24.0896358543417, Blast_Score=105, Evalue=7e-23,
Organism=Saccharomyces cerevisiae, GI6323819, Length=333, Percent_Identity=34.8348348348348, Blast_Score=181, Evalue=4e-46,
Organism=Saccharomyces cerevisiae, GI6324247, Length=362, Percent_Identity=25.414364640884, Blast_Score=100, Evalue=6e-22,
Organism=Saccharomyces cerevisiae, GI6325093, Length=208, Percent_Identity=28.3653846153846, Blast_Score=74, Evalue=9e-14,
Organism=Saccharomyces cerevisiae, GI6323063, Length=168, Percent_Identity=30.952380952381, Blast_Score=71, Evalue=6e-13,
Organism=Drosophila melanogaster, GI17136968, Length=314, Percent_Identity=34.3949044585987, Blast_Score=172, Evalue=4e-43,
Organism=Drosophila melanogaster, GI17136970, Length=179, Percent_Identity=36.8715083798883, Blast_Score=103, Evalue=5e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR002099
- InterPro:   IPR013507
- InterPro:   IPR014762
- InterPro:   IPR020667
- InterPro:   IPR014763
- InterPro:   IPR014790
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF01119 DNA_mis_repair; PF02518 HATPase_c; PF08676 MutL_C [H]

EC number: NA

Molecular weight: Translated: 69523; Mature: 69523

Theoretical pI: Translated: 5.88; Mature: 5.88

Prosite motif: PS00058 DNA_MISMATCH_REPAIR_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQIPPMSIQILSPEVVDQIAAGEVVERPAHLVKELVENSIDAGATRVHVEFYDGGRIVKV
CCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCEEEEE
IDNGKGMSPEDLPKSLERFATSKISKTDDLWSLRTFGFRGEALASIASVSKLTLTSRRAG
EECCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCC
DEQAHQLISEYGKRKEIDKVGGSQGTTILIENLFDNTPARLKFLKSDSAENSAIKTTLKA
HHHHHHHHHHHCCHHHHHHCCCCCCCEEEEECHHCCCCHHEEEEECCCCCCHHHHHHHHH
MALSHYDVEFRIQENGKLVAFWPACKSRKDRVEQILEIKPLFEGEASRENVKAYAVFADP
HHHHCCCEEEEECCCCCEEEECCCCCCHHHHHHHHHHHCCCCCCCCCCCCEEEEEEEECC
HNVAKTSKNIWLFAQNRWIQDRSLQAAVNEAYRSLLMHGEYPIAAVWVEVDPDCVDVNIH
HHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCEEEEEEC
PTKSQVKFQDPSLAFRAVAAALRGTLEQAPWIKRSDVATQNVTMPLTQNSSEEFKSTDGL
CCCCCEEECCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEECCCCHHHHHHCCCC
PNFASQPMPQQNLRFQDNSLEVTQFQKKEFSFPASSFPVSSLQQPQTTYQALAESAAQRE
CCCCCCCCCCCCCCCCCCCEEHHHHHHHHCCCCCCCCCHHHCCCCHHHHHHHHHHHHHHH
SFAPKAEEASLGYWSSLEVLGQANLTYIVTQSRDKLVFVDQHAAHERVVFEKLMNAWKGG
HCCCCCCCCCCCCCHHHHHHCCCCEEEEEECCCCCEEEEECCCHHHHHHHHHHHHHHCCC
KVDIQDFLFPLAIDMSPEKVEGLLTMAKEMERLGVFIEALGPGTVGVKAAPLMIKESSLS
CEEHHHHHHHHEECCCHHHHHHHHHHHHHHHHHCEEEEECCCCCCCCEECCEEEECCHHH
GVLDKMATEIVDQGGSYSLERTVGDICATMACHSVVRAGQSLSPDQMRSLLRDMDMFPLS
HHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCH
SFCPHGRPVSVEYPYYKLEKDFGRIV
HHCCCCCEEEEECCHHHHHHHHCCCC
>Mature Secondary Structure
MQIPPMSIQILSPEVVDQIAAGEVVERPAHLVKELVENSIDAGATRVHVEFYDGGRIVKV
CCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCEEEEE
IDNGKGMSPEDLPKSLERFATSKISKTDDLWSLRTFGFRGEALASIASVSKLTLTSRRAG
EECCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCC
DEQAHQLISEYGKRKEIDKVGGSQGTTILIENLFDNTPARLKFLKSDSAENSAIKTTLKA
HHHHHHHHHHHCCHHHHHHCCCCCCCEEEEECHHCCCCHHEEEEECCCCCCHHHHHHHHH
MALSHYDVEFRIQENGKLVAFWPACKSRKDRVEQILEIKPLFEGEASRENVKAYAVFADP
HHHHCCCEEEEECCCCCEEEECCCCCCHHHHHHHHHHHCCCCCCCCCCCCEEEEEEEECC
HNVAKTSKNIWLFAQNRWIQDRSLQAAVNEAYRSLLMHGEYPIAAVWVEVDPDCVDVNIH
HHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCEEEEEEC
PTKSQVKFQDPSLAFRAVAAALRGTLEQAPWIKRSDVATQNVTMPLTQNSSEEFKSTDGL
CCCCCEEECCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEECCCCHHHHHHCCCC
PNFASQPMPQQNLRFQDNSLEVTQFQKKEFSFPASSFPVSSLQQPQTTYQALAESAAQRE
CCCCCCCCCCCCCCCCCCCEEHHHHHHHHCCCCCCCCCHHHCCCCHHHHHHHHHHHHHHH
SFAPKAEEASLGYWSSLEVLGQANLTYIVTQSRDKLVFVDQHAAHERVVFEKLMNAWKGG
HCCCCCCCCCCCCCHHHHHHCCCCEEEEEECCCCCEEEEECCCHHHHHHHHHHHHHHCCC
KVDIQDFLFPLAIDMSPEKVEGLLTMAKEMERLGVFIEALGPGTVGVKAAPLMIKESSLS
CEEHHHHHHHHEECCCHHHHHHHHHHHHHHHHHCEEEEECCCCCCCCEECCEEEECCHHH
GVLDKMATEIVDQGGSYSLERTVGDICATMACHSVVRAGQSLSPDQMRSLLRDMDMFPLS
HHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCH
SFCPHGRPVSVEYPYYKLEKDFGRIV
HHCCCCCEEEEECCHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA