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The map label for this gene is guaD [H]

Identifier: 42521730

GI number: 42521730

Start: 80485

End: 80952

Strand: Direct

Name: guaD [H]

Synonym: Bd0085

Alternate gene names: 42521730

Gene position: 80485-80952 (Clockwise)

Preceding gene: 42521729

Following gene: 42521731

Centisome position: 2.13

GC content: 48.72

Gene sequence:

>468_bases
ATGAACAAAGAATTTATGTTAAGAGCCATCGAGCTTTCCAGAAACAACATGCGTGCCGGCGCAGGCGGTCCTTTTGGGGC
AGTCATTGTTAAAGACGGCAAAATCATCGGTGAAGGTTGGAACAAAGTGACTTCCTCCAACGACCCTACCGCGCATGCTG
AAGTTTCTGCTATCCGCGACGCTTGCTCCAAAATCAGTAATTTTGAACTGGCTGGTGCGGAAATCTACACAAGCTGCGAA
CCGTGCCCAATGTGCCTGTCGGCGATCTACTGGGCCCGCATTGAAAAGATCTATTACGGCAACACCCGTAAAGACGCCGC
TGAAATCAACTTCGACGACGACTTCCTTTATCAGGAAATTCCAAAAGACCTCAAAGACCGCAAAGTACCCATGGTTCAAT
GCGCTCACACAGAGGCATTGGAAGTTTTCAAAGAGTGGGACAGTAAGACCGACAAGGTTCCGTACTAA

Upstream 100 bases:

>100_bases
GACCTACGCTTTAAACTGGTTGCAGCCTCGCAGCTAAACTTAAAATACAAGGGAAGCTCAACTTGACTAACTCCATGAGT
CCCCATAAATTCGTCGGCCT

Downstream 100 bases:

>100_bases
AGCCCAGTAAATAGTTTTGGGACTGCAGTCCCATTCACAAGTCAGAGAGAATAAAGGAATGAAAGCACTTTCATTCCTTT
TTCTTTTTTTGAGCGTTGTT

Product: cytidine/deoxycytidylate deaminase family protein

Products: NA

Alternate protein names: GDEase; Guanase; Guanine aminase; Guanine aminohydrolase; GAH [H]

Number of amino acids: Translated: 155; Mature: 155

Protein sequence:

>155_residues
MNKEFMLRAIELSRNNMRAGAGGPFGAVIVKDGKIIGEGWNKVTSSNDPTAHAEVSAIRDACSKISNFELAGAEIYTSCE
PCPMCLSAIYWARIEKIYYGNTRKDAAEINFDDDFLYQEIPKDLKDRKVPMVQCAHTEALEVFKEWDSKTDKVPY

Sequences:

>Translated_155_residues
MNKEFMLRAIELSRNNMRAGAGGPFGAVIVKDGKIIGEGWNKVTSSNDPTAHAEVSAIRDACSKISNFELAGAEIYTSCE
PCPMCLSAIYWARIEKIYYGNTRKDAAEINFDDDFLYQEIPKDLKDRKVPMVQCAHTEALEVFKEWDSKTDKVPY
>Mature_155_residues
MNKEFMLRAIELSRNNMRAGAGGPFGAVIVKDGKIIGEGWNKVTSSNDPTAHAEVSAIRDACSKISNFELAGAEIYTSCE
PCPMCLSAIYWARIEKIYYGNTRKDAAEINFDDDFLYQEIPKDLKDRKVPMVQCAHTEALEVFKEWDSKTDKVPY

Specific function: Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia [H]

COG id: COG0590

COG function: function code FJ; Cytosine/adenosine deaminases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cytidine and deoxycytidylate deaminase family [H]

Homologues:

Organism=Escherichia coli, GI145693172, Length=77, Percent_Identity=42.8571428571429, Blast_Score=83, Evalue=7e-18,
Organism=Caenorhabditis elegans, GI17554608, Length=152, Percent_Identity=49.3421052631579, Blast_Score=157, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI17555996, Length=155, Percent_Identity=40.6451612903226, Blast_Score=129, Evalue=4e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016192
- InterPro:   IPR002125
- InterPro:   IPR016193 [H]

Pfam domain/function: PF00383 dCMP_cyt_deam_1 [H]

EC number: =3.5.4.3 [H]

Molecular weight: Translated: 17422; Mature: 17422

Theoretical pI: Translated: 5.05; Mature: 5.05

Prosite motif: PS00903 CYT_DCMP_DEAMINASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.2 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
6.5 %Cys+Met (Translated Protein)
3.2 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
6.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKEFMLRAIELSRNNMRAGAGGPFGAVIVKDGKIIGEGWNKVTSSNDPTAHAEVSAIRD
CCHHHHHHHHHHCCCCCCCCCCCCEEEEEEECCEEEECCCCCCCCCCCCCCHHHHHHHHH
ACSKISNFELAGAEIYTSCEPCPMCLSAIYWARIEKIYYGNTRKDAAEINFDDDFLYQEI
HHHHHCCCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCCCEECCCCHHHHHHHH
PKDLKDRKVPMVQCAHTEALEVFKEWDSKTDKVPY
HHHHHHCCCCEEEHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MNKEFMLRAIELSRNNMRAGAGGPFGAVIVKDGKIIGEGWNKVTSSNDPTAHAEVSAIRD
CCHHHHHHHHHHCCCCCCCCCCCCEEEEEEECCEEEECCCCCCCCCCCCCCHHHHHHHHH
ACSKISNFELAGAEIYTSCEPCPMCLSAIYWARIEKIYYGNTRKDAAEINFDDDFLYQEI
HHHHHCCCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCCCEECCCCHHHHHHHH
PKDLKDRKVPMVQCAHTEALEVFKEWDSKTDKVPY
HHHHHHCCCCEEEHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377; 11101664 [H]