Click here to switch to the map view.

The map label for this gene is sdhA [H]

Identifier: 42521673

GI number: 42521673

Start: 22422

End: 24338

Strand: Direct

Name: sdhA [H]

Synonym: Bd0025

Alternate gene names: 42521673

Gene position: 22422-24338 (Clockwise)

Preceding gene: 42521672

Following gene: 42521674

Centisome position: 0.59

GC content: 53.0

Gene sequence:

>1917_bases
ATGGCTCACAATTTAGACAGCAAAATTCCAAGTGGCCCGATTGAATCCAAATGGACCAAAACCAAGTTCGACTACAAGCT
GGTGAACCCGGCGAATAAAAGAAAGCACTCCATCATCGTGGTGGGAACCGGTCTTGCCGGCGCCTCTGCAGCGGCTTCTT
TGGGTGAACTGGGATACAAAGTAAAAGCTTTCTGCGTGCATGAATCCCCTCGCCGTGCCCACTCTGTGGCGGCTCAAGGT
GGTATCAATGCTGCGAAAAACTACCAGAACGACGGCGATTCCACGTACCGTCTTTTCTACGACACCGTTAAGGGTGGTGA
CTTCCGTGCACGTGAGGCCAACGTTTACCGTCTGGCGGAAGTGTCTGCGAACATCATCGATCAGATGGTGGCTCAGGGGG
TTCCATTTGCCCGTGAATACGGCGGAACTCTGGCCAACCGTTCTTTTGGTGGCGCCCAAGTGTCCCGCACTTTCTATGCC
CGCGGTCAGACAGGTCAGCAGCTTCTTCTGGGTGCTTACTCAGAGATGATGAGACAGGTTGATATTGGCAACGTTGAATT
GCGCAGCCGCCGCGAAATGCTGGATGTTGTGGTGATCGACGGCAAAGCCCGCGGCATCGTGGTACGTAACCTTTTGACCG
GCGAAATTGAATCTCACGAAGCTGATGCGGTGGTGATTGCTTCCGGCGGTTATTCCAACGTGTTCTTCCTTTCCACCAAT
GCGATGAACTGTGCGGTGACGGCAGCGTGGAAAGCCCACAAACGTGGCGCTTACTTCGCGAACCCTTGTTACACTCAGAT
TCACCCGACTTGTATTCCGGTTCACGGCGAAAACCAGTCCAAACTGACTTTGATGTCTGAATCCCTGCGCAACGACGGTC
GCGTTTGGGTGCCAAAAGCTGTCGGTGACAAACGTCATCCAAATGACATCCCGGAAAACGAACGCGATTATTATCTGGAG
CGTGTGTACCCGTCCTTCGGGAACCTGGCTCCTCGTGACGTGGCTTCCCGTCAGGCGAAATACCGCTGTGACGAAGGCCG
TGGCGTGAATGAAACCGGCAAAGCTGTGTATCTTGATTTCGCGGACGCGATCAAGCGTCTGGGTGAAGACAAGATCTCCG
AGCGTTACGGAAATCTGTTTGAAATGTACGACAAAATCACCGGCCAGAATCCGTACAAACAGCCGATGATGATTTACCCG
GCTCCTCACTACACCATGGGTGGTCTGTGGGTGGACTACAATCTGGAATCTACGATTCCAGGTCTGTTCGTTGCGGGTGA
AGCGAACTTCTCTGACCACGGTGCCAACCGCTTGGGTGCGTCTGCACTGATGCAGGGTCTGGCGGATGGTTACTTCGTAC
TGCCGTTCACTTTGGGGAACTACCTGGGTGGAACCAAACTTGAAAAAGTGGCGACCACGAATGAAGCCTTCAAAGCGGCT
GAACACGGCGTGAAGGAAGAAATCAAAAAAATGATGAACATCAAAGGGGCCCGCACAGTGGACAGCTTCCACAAAGAGCT
GGGCAACGTGATGTGGGAATACTGCGGTATGGGTCGTAACGAAGCCGGCTTGAAGAAGGCCCTTCAGGAAATCCCAAAAA
TCCGCGAAGAGTTCTGGAACAACGTGCGTATTCCGGGTGATGCAAATTACCTCAACGTCGAGCTTGAAAAAGCAGGACGT
GTGGCGGACTTCCTGGAGCTGGGTGAGTTGATGTGCCGTGATGCCCTGGAGCGCCAGGAATCCTGCGGCGGTCATTACCG
TGAAGAGTATCAGGTGGATGGCGAAGCCAAACGTGATGACGAGAAGTTCTGTCACGTGGCTGCTTGGGAATACACTGGCG
AAAACAAACCGTCCGTGCGTCACCAGGAAGAGCTGAAATTCGAAAACGTACACCTAGCAACTCGTAGCTATAAATAA

Upstream 100 bases:

>100_bases
CGTGGAAAAAACTCAGCTACGGTTATGCCGTGGTTGTGGCTGCGGGTTTCATCGCTCAACCTGTTTACATTTTCCTTGTC
GGTAACTAAGGGGACAACAC

Downstream 100 bases:

>100_bases
GAGGCGTAGCATGTCTGGAAAAAATATTAATCTGACTTTGAAAGTTTGGAGACAAAAAGGCCCGAAAGACCAGGGGGCCT
TTGCAGAGTATCAGGCCAAG

Product: succinate dehydrogenase flavoprotein subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 638; Mature: 637

Protein sequence:

>638_residues
MAHNLDSKIPSGPIESKWTKTKFDYKLVNPANKRKHSIIVVGTGLAGASAAASLGELGYKVKAFCVHESPRRAHSVAAQG
GINAAKNYQNDGDSTYRLFYDTVKGGDFRAREANVYRLAEVSANIIDQMVAQGVPFAREYGGTLANRSFGGAQVSRTFYA
RGQTGQQLLLGAYSEMMRQVDIGNVELRSRREMLDVVVIDGKARGIVVRNLLTGEIESHEADAVVIASGGYSNVFFLSTN
AMNCAVTAAWKAHKRGAYFANPCYTQIHPTCIPVHGENQSKLTLMSESLRNDGRVWVPKAVGDKRHPNDIPENERDYYLE
RVYPSFGNLAPRDVASRQAKYRCDEGRGVNETGKAVYLDFADAIKRLGEDKISERYGNLFEMYDKITGQNPYKQPMMIYP
APHYTMGGLWVDYNLESTIPGLFVAGEANFSDHGANRLGASALMQGLADGYFVLPFTLGNYLGGTKLEKVATTNEAFKAA
EHGVKEEIKKMMNIKGARTVDSFHKELGNVMWEYCGMGRNEAGLKKALQEIPKIREEFWNNVRIPGDANYLNVELEKAGR
VADFLELGELMCRDALERQESCGGHYREEYQVDGEAKRDDEKFCHVAAWEYTGENKPSVRHQEELKFENVHLATRSYK

Sequences:

>Translated_638_residues
MAHNLDSKIPSGPIESKWTKTKFDYKLVNPANKRKHSIIVVGTGLAGASAAASLGELGYKVKAFCVHESPRRAHSVAAQG
GINAAKNYQNDGDSTYRLFYDTVKGGDFRAREANVYRLAEVSANIIDQMVAQGVPFAREYGGTLANRSFGGAQVSRTFYA
RGQTGQQLLLGAYSEMMRQVDIGNVELRSRREMLDVVVIDGKARGIVVRNLLTGEIESHEADAVVIASGGYSNVFFLSTN
AMNCAVTAAWKAHKRGAYFANPCYTQIHPTCIPVHGENQSKLTLMSESLRNDGRVWVPKAVGDKRHPNDIPENERDYYLE
RVYPSFGNLAPRDVASRQAKYRCDEGRGVNETGKAVYLDFADAIKRLGEDKISERYGNLFEMYDKITGQNPYKQPMMIYP
APHYTMGGLWVDYNLESTIPGLFVAGEANFSDHGANRLGASALMQGLADGYFVLPFTLGNYLGGTKLEKVATTNEAFKAA
EHGVKEEIKKMMNIKGARTVDSFHKELGNVMWEYCGMGRNEAGLKKALQEIPKIREEFWNNVRIPGDANYLNVELEKAGR
VADFLELGELMCRDALERQESCGGHYREEYQVDGEAKRDDEKFCHVAAWEYTGENKPSVRHQEELKFENVHLATRSYK
>Mature_637_residues
AHNLDSKIPSGPIESKWTKTKFDYKLVNPANKRKHSIIVVGTGLAGASAAASLGELGYKVKAFCVHESPRRAHSVAAQGG
INAAKNYQNDGDSTYRLFYDTVKGGDFRAREANVYRLAEVSANIIDQMVAQGVPFAREYGGTLANRSFGGAQVSRTFYAR
GQTGQQLLLGAYSEMMRQVDIGNVELRSRREMLDVVVIDGKARGIVVRNLLTGEIESHEADAVVIASGGYSNVFFLSTNA
MNCAVTAAWKAHKRGAYFANPCYTQIHPTCIPVHGENQSKLTLMSESLRNDGRVWVPKAVGDKRHPNDIPENERDYYLER
VYPSFGNLAPRDVASRQAKYRCDEGRGVNETGKAVYLDFADAIKRLGEDKISERYGNLFEMYDKITGQNPYKQPMMIYPA
PHYTMGGLWVDYNLESTIPGLFVAGEANFSDHGANRLGASALMQGLADGYFVLPFTLGNYLGGTKLEKVATTNEAFKAAE
HGVKEEIKKMMNIKGARTVDSFHKELGNVMWEYCGMGRNEAGLKKALQEIPKIREEFWNNVRIPGDANYLNVELEKAGRV
ADFLELGELMCRDALERQESCGGHYREEYQVDGEAKRDDEKFCHVAAWEYTGENKPSVRHQEELKFENVHLATRSYK

Specific function: Two Distinct, Membrane-Bound, FAD-Containing Enzymes Are Responsible For The Catalysis Of Fumarate And Succinate Interconversion; The Fumarate Reductase Is Used In Anaerobic Growth, And The Succinate Dehydrogenase Is Used In Aerobic Growth. [C]

COG id: COG1053

COG function: function code C; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily [H]

Homologues:

Organism=Homo sapiens, GI156416003, Length=558, Percent_Identity=25.8064516129032, Blast_Score=155, Evalue=1e-37,
Organism=Escherichia coli, GI1790597, Length=545, Percent_Identity=30.2752293577982, Blast_Score=216, Evalue=3e-57,
Organism=Escherichia coli, GI1786942, Length=557, Percent_Identity=26.7504488330341, Blast_Score=138, Evalue=1e-33,
Organism=Escherichia coli, GI1788928, Length=594, Percent_Identity=23.7373737373737, Blast_Score=120, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI17505833, Length=541, Percent_Identity=27.1719038817006, Blast_Score=171, Evalue=8e-43,
Organism=Caenorhabditis elegans, GI17550100, Length=565, Percent_Identity=27.0796460176991, Blast_Score=160, Evalue=1e-39,
Organism=Saccharomyces cerevisiae, GI6322701, Length=598, Percent_Identity=27.9264214046823, Blast_Score=190, Evalue=6e-49,
Organism=Saccharomyces cerevisiae, GI6322416, Length=618, Percent_Identity=26.8608414239482, Blast_Score=174, Evalue=5e-44,
Organism=Drosophila melanogaster, GI17137288, Length=553, Percent_Identity=26.5822784810127, Blast_Score=171, Evalue=1e-42,
Organism=Drosophila melanogaster, GI24655642, Length=553, Percent_Identity=26.5822784810127, Blast_Score=171, Evalue=1e-42,
Organism=Drosophila melanogaster, GI24655647, Length=553, Percent_Identity=26.5822784810127, Blast_Score=171, Evalue=1e-42,
Organism=Drosophila melanogaster, GI24663005, Length=591, Percent_Identity=24.7038917089679, Blast_Score=145, Evalue=7e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003953
- InterPro:   IPR013027
- InterPro:   IPR003952
- InterPro:   IPR015939
- InterPro:   IPR004112
- InterPro:   IPR011280 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF02910 Succ_DH_flav_C [H]

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 71113; Mature: 70982

Theoretical pI: Translated: 7.61; Mature: 7.61

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAHNLDSKIPSGPIESKWTKTKFDYKLVNPANKRKHSIIVVGTGLAGASAAASLGELGYK
CCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCEEEEEECCCCCHHHHHHHHHCCCE
VKAFCVHESPRRAHSVAAQGGINAAKNYQNDGDSTYRLFYDTVKGGDFRAREANVYRLAE
EEEEEECCCCHHHHHHHHHCCCCHHHCCCCCCCCEEEEEEEECCCCCCCCCCCCEEEHHH
VSANIIDQMVAQGVPFAREYGGTLANRSFGGAQVSRTFYARGQTGQQLLLGAYSEMMRQV
HHHHHHHHHHHCCCCCHHHHCCCCCCCCCCCHHHHHEEEECCCCCHHHHHHHHHHHHHHC
DIGNVELRSRREMLDVVVIDGKARGIVVRNLLTGEIESHEADAVVIASGGYSNVFFLSTN
CCCCEEHHHHHCEEEEEEECCCCCCEEEEHHHHCCCCCCCCCEEEEECCCCCEEEEEECC
AMNCAVTAAWKAHKRGAYFANPCYTQIHPTCIPVHGENQSKLTLMSESLRNDGRVWVPKA
CCCEEEEEHHHHHCCCCEECCCCCCCCCCEEEEECCCCCCHHHHHHHHHCCCCCEEEECC
VGDKRHPNDIPENERDYYLERVYPSFGNLAPRDVASRQAKYRCDEGRGVNETGKAVYLDF
CCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCEEEEEH
ADAIKRLGEDKISERYGNLFEMYDKITGQNPYKQPMMIYPAPHYTMGGLWVDYNLESTIP
HHHHHHHCHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCEECCEEEEECCCCCCC
GLFVAGEANFSDHGANRLGASALMQGLADGYFVLPFTLGNYLGGTKLEKVATTNEAFKAA
CEEEECCCCCCCCCCHHHHHHHHHHHHCCCEEEEEEHHCCCCCCCHHHHHHHHHHHHHHH
EHGVKEEIKKMMNIKGARTVDSFHKELGNVMWEYCGMGRNEAGLKKALQEIPKIREEFWN
HCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHC
NVRIPGDANYLNVELEKAGRVADFLELGELMCRDALERQESCGGHYREEYQVDGEAKRDD
CEECCCCCCEEEEEHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHEECCCCCCCCC
EKFCHVAAWEYTGENKPSVRHQEELKFENVHLATRSYK
HHEEEEEEEEECCCCCCCCCHHHHCCCCEEEEEECCCC
>Mature Secondary Structure 
AHNLDSKIPSGPIESKWTKTKFDYKLVNPANKRKHSIIVVGTGLAGASAAASLGELGYK
CCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCEEEEEECCCCCHHHHHHHHHCCCE
VKAFCVHESPRRAHSVAAQGGINAAKNYQNDGDSTYRLFYDTVKGGDFRAREANVYRLAE
EEEEEECCCCHHHHHHHHHCCCCHHHCCCCCCCCEEEEEEEECCCCCCCCCCCCEEEHHH
VSANIIDQMVAQGVPFAREYGGTLANRSFGGAQVSRTFYARGQTGQQLLLGAYSEMMRQV
HHHHHHHHHHHCCCCCHHHHCCCCCCCCCCCHHHHHEEEECCCCCHHHHHHHHHHHHHHC
DIGNVELRSRREMLDVVVIDGKARGIVVRNLLTGEIESHEADAVVIASGGYSNVFFLSTN
CCCCEEHHHHHCEEEEEEECCCCCCEEEEHHHHCCCCCCCCCEEEEECCCCCEEEEEECC
AMNCAVTAAWKAHKRGAYFANPCYTQIHPTCIPVHGENQSKLTLMSESLRNDGRVWVPKA
CCCEEEEEHHHHHCCCCEECCCCCCCCCCEEEEECCCCCCHHHHHHHHHCCCCCEEEECC
VGDKRHPNDIPENERDYYLERVYPSFGNLAPRDVASRQAKYRCDEGRGVNETGKAVYLDF
CCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCEEEEEH
ADAIKRLGEDKISERYGNLFEMYDKITGQNPYKQPMMIYPAPHYTMGGLWVDYNLESTIP
HHHHHHHCHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCEECCEEEEECCCCCCC
GLFVAGEANFSDHGANRLGASALMQGLADGYFVLPFTLGNYLGGTKLEKVATTNEAFKAA
CEEEECCCCCCCCCCHHHHHHHHHHHHCCCEEEEEEHHCCCCCCCHHHHHHHHHHHHHHH
EHGVKEEIKKMMNIKGARTVDSFHKELGNVMWEYCGMGRNEAGLKKALQEIPKIREEFWN
HCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHC
NVRIPGDANYLNVELEKAGRVADFLELGELMCRDALERQESCGGHYREEYQVDGEAKRDD
CEECCCCCCEEEEEHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHEECCCCCCCCC
EKFCHVAAWEYTGENKPSVRHQEELKFENVHLATRSYK
HHEEEEEEEEECCCCCCCCCHHHHCCCCEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3027051; 8969504; 9384377; 3086287; 3021212 [H]