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The map label for this gene is upp

Identifier: 41409529

GI number: 41409529

Start: 3810624

End: 3811397

Strand: Reverse

Name: upp

Synonym: MAP3431c

Alternate gene names: 41409529

Gene position: 3811397-3810624 (Counterclockwise)

Preceding gene: 41409533

Following gene: 41409526

Centisome position: 78.91

GC content: 72.09

Gene sequence:

>774_bases
ATGGACGTGTGCGTGATCGACCACCCGTTGGCCGCGGCCCGGCTGACGGTGCTGCGCGACGAACGCACCGACACCGCCGG
ATTTCGGGCCGCGCTGCGCGATCTGACGCTGATGCTGGTCTACGAGGCCAGCCGCGACGCGCCGCGCAAGTCGGTCCGGA
TCCGCACCCCGGTGGCCGCGGCCGCCGGGACCCGACTGGTCAATCCGCCGCTGCTGGTTCCGGTGCTGCGCGCCGGGCTG
GGCATGGTCGACCCGGCGCAGGCCGCGCTGCCCGAGGCCGAGGTGGGCTTCGTCGGCGTCGCCCGCGACGAGCAAACCCA
CCGGCCGGTCCCGTATTTGGCGGCGCTGCCCGACAAGCTGGCCGGCAGGCCGGTGATGGTGCTGGACCCGATGCTGGCCA
CCGGCGGCTCGATGGCGCACACCCTGGGGCTGTTGCAGCGTCGCGGCGCCACCGACATTACCGTGCTGTGTGTGGTGGCC
GCGCCGGAAGGTCTTGCGGCGGTTGGGGAAACGGCGCCCGACGCGCGAGTGTTCACTGCCGCGGTAGACAAGGGACTCAA
CAAGGCGGCCTACATCGTGCCCGGCCTCGGCGATGCCGGGGATCGCCAATTCGGGCCGAACCTGTTCACCAGCTCCGCAC
CGTCGCGACCAGAAGCTCCCGCAGGGCGCGGGCGCGCCGCCGCGAAGACGCCAGGTCGTCGCTCGGCGCGCAGCGAATCT
CCAAGTAGCACTTCACCTTCGGCTCGGTCCCGGAAGGCCGCACCACCAGCCTGA

Upstream 100 bases:

>100_bases
CGCGACACGCCCGGAGTATACGAACGGCGGTAAGGCGTTTGCGGCCGGCGGGCAAGCGTGTCAGCGGGGCTTTGCCCGAT
CGTTATATACGCTCGACCAG

Downstream 100 bases:

>100_bases
CCGACGTGTCGTCGTCGCCGCCGGTGAAGATCAGCGCGTCGGTGATGTCGGTGAGCGCCACCCCGAACCCGGCCAGCGTC
TCCGGCGGGCTGGTGCGCAG

Product: uracil phosphoribosyltransferase

Products: NA

Alternate protein names: UMP pyrophosphorylase; UPRTase

Number of amino acids: Translated: 257; Mature: 257

Protein sequence:

>257_residues
MDVCVIDHPLAAARLTVLRDERTDTAGFRAALRDLTLMLVYEASRDAPRKSVRIRTPVAAAAGTRLVNPPLLVPVLRAGL
GMVDPAQAALPEAEVGFVGVARDEQTHRPVPYLAALPDKLAGRPVMVLDPMLATGGSMAHTLGLLQRRGATDITVLCVVA
APEGLAAVGETAPDARVFTAAVDKGLNKAAYIVPGLGDAGDRQFGPNLFTSSAPSRPEAPAGRGRAAAKTPGRRSARSES
PSSTSPSARSRKAAPPA

Sequences:

>Translated_257_residues
MDVCVIDHPLAAARLTVLRDERTDTAGFRAALRDLTLMLVYEASRDAPRKSVRIRTPVAAAAGTRLVNPPLLVPVLRAGL
GMVDPAQAALPEAEVGFVGVARDEQTHRPVPYLAALPDKLAGRPVMVLDPMLATGGSMAHTLGLLQRRGATDITVLCVVA
APEGLAAVGETAPDARVFTAAVDKGLNKAAYIVPGLGDAGDRQFGPNLFTSSAPSRPEAPAGRGRAAAKTPGRRSARSES
PSSTSPSARSRKAAPPA
>Mature_257_residues
MDVCVIDHPLAAARLTVLRDERTDTAGFRAALRDLTLMLVYEASRDAPRKSVRIRTPVAAAAGTRLVNPPLLVPVLRAGL
GMVDPAQAALPEAEVGFVGVARDEQTHRPVPYLAALPDKLAGRPVMVLDPMLATGGSMAHTLGLLQRRGATDITVLCVVA
APEGLAAVGETAPDARVFTAAVDKGLNKAAYIVPGLGDAGDRQFGPNLFTSSAPSRPEAPAGRGRAAAKTPGRRSARSES
PSSTSPSARSRKAAPPA

Specific function: Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate

COG id: COG0035

COG function: function code F; Uracil phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPRTase family

Homologues:

Organism=Homo sapiens, GI57863312, Length=200, Percent_Identity=27, Blast_Score=72, Evalue=4e-13,
Organism=Homo sapiens, GI301129207, Length=200, Percent_Identity=27, Blast_Score=72, Evalue=4e-13,
Organism=Escherichia coli, GI87082118, Length=210, Percent_Identity=40, Blast_Score=168, Evalue=3e-43,
Organism=Caenorhabditis elegans, GI17539894, Length=203, Percent_Identity=24.6305418719212, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17539892, Length=203, Percent_Identity=24.6305418719212, Blast_Score=69, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6321920, Length=192, Percent_Identity=30.7291666666667, Blast_Score=97, Evalue=2e-21,
Organism=Drosophila melanogaster, GI28573516, Length=194, Percent_Identity=24.2268041237113, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI28573514, Length=194, Percent_Identity=24.2268041237113, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI28573512, Length=194, Percent_Identity=24.2268041237113, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI45550449, Length=194, Percent_Identity=25.2577319587629, Blast_Score=66, Evalue=2e-11,

Paralogues:

None

Copy number: 2580 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): UPP_MYCPA (Q73UD7)

Other databases:

- EMBL:   AE016958
- RefSeq:   NP_962365.1
- ProteinModelPortal:   Q73UD7
- SMR:   Q73UD7
- EnsemblBacteria:   EBMYCT00000040440
- GeneID:   2721163
- GenomeReviews:   AE016958_GR
- KEGG:   mpa:MAP3431c
- NMPDR:   fig|262316.1.peg.3431
- GeneTree:   EBGT00050000016428
- HOGENOM:   HBG326432
- OMA:   VYVLDPM
- BRENDA:   2.4.2.9
- HAMAP:   MF_01218_B
- InterPro:   IPR000836
- InterPro:   IPR005765
- TIGRFAMs:   TIGR01091

Pfam domain/function: PF00156 Pribosyltran

EC number: =2.4.2.9

Molecular weight: Translated: 26629; Mature: 26629

Theoretical pI: Translated: 10.62; Mature: 10.62

Prosite motif: NA

Important sites: BINDING 77-77 BINDING 102-102 BINDING 192-192 BINDING 198-198

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDVCVIDHPLAAARLTVLRDERTDTAGFRAALRDLTLMLVYEASRDAPRKSVRIRTPVAA
CCEEEECCCHHHHHHHHHHCCCCCHHHHHHHHHHHEEEEEEECCCCCCCCCEEEECCHHH
AAGTRLVNPPLLVPVLRAGLGMVDPAQAALPEAEVGFVGVARDEQTHRPVPYLAALPDKL
HCCCCCCCCHHHHHHHHHCCCCCCCHHHHCCCCCCCEEEEECCCCCCCCCCHHHHCCHHH
AGRPVMVLDPMLATGGSMAHTLGLLQRRGATDITVLCVVAAPEGLAAVGETAPDARVFTA
CCCCEEEECCHHHCCCHHHHHHHHHHHCCCCCEEEEEEEECCCCHHHHCCCCCCHHHHHH
AVDKGLNKAAYIVPGLGDAGDRQFGPNLFTSSAPSRPEAPAGRGRAAAKTPGRRSARSES
HHHCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
PSSTSPSARSRKAAPPA
CCCCCCCHHCCCCCCCC
>Mature Secondary Structure
MDVCVIDHPLAAARLTVLRDERTDTAGFRAALRDLTLMLVYEASRDAPRKSVRIRTPVAA
CCEEEECCCHHHHHHHHHHCCCCCHHHHHHHHHHHEEEEEEECCCCCCCCCEEEECCHHH
AAGTRLVNPPLLVPVLRAGLGMVDPAQAALPEAEVGFVGVARDEQTHRPVPYLAALPDKL
HCCCCCCCCHHHHHHHHHCCCCCCCHHHHCCCCCCCEEEEECCCCCCCCCCHHHHCCHHH
AGRPVMVLDPMLATGGSMAHTLGLLQRRGATDITVLCVVAAPEGLAAVGETAPDARVFTA
CCCCEEEECCHHHCCCHHHHHHHHHHHCCCCCEEEEEEEECCCCHHHHCCCCCCHHHHHH
AVDKGLNKAAYIVPGLGDAGDRQFGPNLFTSSAPSRPEAPAGRGRAAAKTPGRRSARSES
HHHCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
PSSTSPSARSRKAAPPA
CCCCCCCHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA