Click here to switch to the map view.

The map label for this gene is sahH

Identifier: 41409460

GI number: 41409460

Start: 3734443

End: 3735933

Strand: Reverse

Name: sahH

Synonym: MAP3362c

Alternate gene names: 41409460

Gene position: 3735933-3734443 (Counterclockwise)

Preceding gene: 41409461

Following gene: 41409459

Centisome position: 77.35

GC content: 66.73

Gene sequence:

>1491_bases
ATGACGACGACCGAAAACGCGCTCACCCCCGACGTTCGCAACGGCATCGAGTTCAAGGTCGCCGATCTGTCGCTGGCCGA
CTACGGGCGCCGCGACATCGAGCTCTCGGAGCAGGAGATGCCCGGTCTGATGTCGCTGCGCCGGGAGTACCACGACGTGC
AGCCGCTCAAGGGCGCGCGCATCTCCGGCTCGCTGCACATGACCGTGCAGACCGCGGTGCTGATCGAGACGCTGGTGGCG
CTGGGCGCCGAGGTGCGCTGGGCGTCCTGCAACATCTTCTCCACCCAGGACCACGCCGCCGCGGCGGTCGTCGTCGGCCC
GCACGGCACCCCCGAGGAGCCCCGGGGCGTGCCGGTGTTCGCGTGGAAGGGCGAGACGCTCGAGGAGTACTGGTGGGCCG
CCGAGCAGGCGCTGACCTGGCCTCCGCTCGCGGACGGGACAGAGGCGCCGGCCAACATGATCCTCGACGACGGCGGCGAC
GCCACCATGCTGGTGCTGCGCGGCGCCCAGTACGAGAAGGCCGGCGTGGTGCCGCCCGACGACGAGGACGACTCCGCCGA
GCACCGGGTGTTCCTCAACCTGCTGCGCGCGCGCTTCGAGACCGACAAGACCAAGTGGACCAAGATCTCCGAGTCGATCA
AGGGCGTCACCGAGGAGACCACCACCGGGGTGCTGCGGCTGTACCAGTTCGCCGCGGCCGGTGATCTGGCGTTCCCGGCG
ATCAACGTCAACGACTCGGTCACCAAGAGCAAGTTCGACAACAAGTACGGCTGCCGGCACTCGCTGATCGACGGCATCAA
CCGCGGCACCGACGTGCTGATCGGCGGCAAGAACGTGCTGGTCTGCGGCTACGGCGACGTCGGCAAGGGCAGCGTGGAGT
CGCTGGCCGGTCAGGGCGCCCGGGTGACCGTCACCGAGATCGACCCGATCAACGCGCTGCAGGCGCTGATGGAGGGCTAC
AACGTCAAGCGGGTGGAGGACGTCATCGGCGAGGCCGACATCGTCATCACCGCTACCGGCAACAAGGACATCATCACCCT
CGAGCACATGAAGGCGATGAAGGACAAGGCCATCCTGGGCAATATCGGCCACTTCGACAACGAGATCCAGATCGCCCGGC
TGGAGAAGTCCGGCGCCATCAAGACCAACATCCGCCCGCAGGTGGACCTGTGGACCTTCCCGGACACCGGCAAGTCGATC
ATCGTGCTCTCCGAGGGCCGGCTGCTGAACCTGGGCAACGCCACCGGGCACCCGTCGTTCGTGATGAGCAACAGCTTCTC
CAACCAGGTGATCGCCCAGATCGAGCTGTGGACCAAGAACGACGAATACGACAACGAGGTCTACCGGCTGCCCAAGCACC
TCGACGAGAAGGTGGCCCGCATCCACGTGGAGGCCCTGGGCGGCGAGCTGACCAAGCTCACCAAGGAGCAGGCCGAGTAC
ATCGGCGTCGACGTCGACGGCCCGTACAAGGCCGACCACTACCGCTACTGA

Upstream 100 bases:

>100_bases
TGGCCGCGGCGGGGCGCCGACCCGCGACTACAGTGGCGCAAGAACATACCTAAGCTAATTACCCAGTGATCCCCGGACGG
CAGGAACAGGAAGAGAACCC

Downstream 100 bases:

>100_bases
GCGCGCTGCCGGGCGCCGGCGGCCACAGCGCCGGCGGCCCGGGCGTGAACTTAGATTCACGTTCGGCGCCGAGCGTGAAG
ATAACTTCACGCTCGGCGGC

Product: S-adenosyl-L-homocysteine hydrolase

Products: NA

Alternate protein names: S-adenosyl-L-homocysteine hydrolase; AdoHcyase

Number of amino acids: Translated: 496; Mature: 495

Protein sequence:

>496_residues
MTTTENALTPDVRNGIEFKVADLSLADYGRRDIELSEQEMPGLMSLRREYHDVQPLKGARISGSLHMTVQTAVLIETLVA
LGAEVRWASCNIFSTQDHAAAAVVVGPHGTPEEPRGVPVFAWKGETLEEYWWAAEQALTWPPLADGTEAPANMILDDGGD
ATMLVLRGAQYEKAGVVPPDDEDDSAEHRVFLNLLRARFETDKTKWTKISESIKGVTEETTTGVLRLYQFAAAGDLAFPA
INVNDSVTKSKFDNKYGCRHSLIDGINRGTDVLIGGKNVLVCGYGDVGKGSVESLAGQGARVTVTEIDPINALQALMEGY
NVKRVEDVIGEADIVITATGNKDIITLEHMKAMKDKAILGNIGHFDNEIQIARLEKSGAIKTNIRPQVDLWTFPDTGKSI
IVLSEGRLLNLGNATGHPSFVMSNSFSNQVIAQIELWTKNDEYDNEVYRLPKHLDEKVARIHVEALGGELTKLTKEQAEY
IGVDVDGPYKADHYRY

Sequences:

>Translated_496_residues
MTTTENALTPDVRNGIEFKVADLSLADYGRRDIELSEQEMPGLMSLRREYHDVQPLKGARISGSLHMTVQTAVLIETLVA
LGAEVRWASCNIFSTQDHAAAAVVVGPHGTPEEPRGVPVFAWKGETLEEYWWAAEQALTWPPLADGTEAPANMILDDGGD
ATMLVLRGAQYEKAGVVPPDDEDDSAEHRVFLNLLRARFETDKTKWTKISESIKGVTEETTTGVLRLYQFAAAGDLAFPA
INVNDSVTKSKFDNKYGCRHSLIDGINRGTDVLIGGKNVLVCGYGDVGKGSVESLAGQGARVTVTEIDPINALQALMEGY
NVKRVEDVIGEADIVITATGNKDIITLEHMKAMKDKAILGNIGHFDNEIQIARLEKSGAIKTNIRPQVDLWTFPDTGKSI
IVLSEGRLLNLGNATGHPSFVMSNSFSNQVIAQIELWTKNDEYDNEVYRLPKHLDEKVARIHVEALGGELTKLTKEQAEY
IGVDVDGPYKADHYRY
>Mature_495_residues
TTTENALTPDVRNGIEFKVADLSLADYGRRDIELSEQEMPGLMSLRREYHDVQPLKGARISGSLHMTVQTAVLIETLVAL
GAEVRWASCNIFSTQDHAAAAVVVGPHGTPEEPRGVPVFAWKGETLEEYWWAAEQALTWPPLADGTEAPANMILDDGGDA
TMLVLRGAQYEKAGVVPPDDEDDSAEHRVFLNLLRARFETDKTKWTKISESIKGVTEETTTGVLRLYQFAAAGDLAFPAI
NVNDSVTKSKFDNKYGCRHSLIDGINRGTDVLIGGKNVLVCGYGDVGKGSVESLAGQGARVTVTEIDPINALQALMEGYN
VKRVEDVIGEADIVITATGNKDIITLEHMKAMKDKAILGNIGHFDNEIQIARLEKSGAIKTNIRPQVDLWTFPDTGKSII
VLSEGRLLNLGNATGHPSFVMSNSFSNQVIAQIELWTKNDEYDNEVYRLPKHLDEKVARIHVEALGGELTKLTKEQAEYI
GVDVDGPYKADHYRY

Specific function: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine

COG id: COG0499

COG function: function code H; S-adenosylhomocysteine hydrolase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenosylhomocysteinase family

Homologues:

Organism=Homo sapiens, GI9951915, Length=481, Percent_Identity=54.2619542619543, Blast_Score=494, Evalue=1e-140,
Organism=Homo sapiens, GI239937451, Length=457, Percent_Identity=54.9234135667396, Blast_Score=472, Evalue=1e-133,
Organism=Homo sapiens, GI195539337, Length=484, Percent_Identity=44.6280991735537, Blast_Score=420, Evalue=1e-117,
Organism=Homo sapiens, GI24308043, Length=484, Percent_Identity=44.6280991735537, Blast_Score=420, Evalue=1e-117,
Organism=Homo sapiens, GI298286489, Length=484, Percent_Identity=44.6280991735537, Blast_Score=420, Evalue=1e-117,
Organism=Homo sapiens, GI195539349, Length=484, Percent_Identity=44.6280991735537, Blast_Score=419, Evalue=1e-117,
Organism=Homo sapiens, GI21361647, Length=480, Percent_Identity=43.9583333333333, Blast_Score=404, Evalue=1e-113,
Organism=Caenorhabditis elegans, GI17506425, Length=482, Percent_Identity=55.1867219917012, Blast_Score=503, Evalue=1e-143,
Organism=Saccharomyces cerevisiae, GI6320882, Length=493, Percent_Identity=52.9411764705882, Blast_Score=478, Evalue=1e-136,
Organism=Drosophila melanogaster, GI24642172, Length=479, Percent_Identity=56.9937369519833, Blast_Score=508, Evalue=1e-144,
Organism=Drosophila melanogaster, GI24656245, Length=473, Percent_Identity=45.0317124735729, Blast_Score=413, Evalue=1e-115,
Organism=Drosophila melanogaster, GI45553387, Length=485, Percent_Identity=45.1546391752577, Blast_Score=410, Evalue=1e-115,
Organism=Drosophila melanogaster, GI45553385, Length=484, Percent_Identity=45.0413223140496, Blast_Score=407, Evalue=1e-114,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SAHH_MYCPA (Q73UK6)

Other databases:

- EMBL:   AE016958
- RefSeq:   NP_962296.1
- ProteinModelPortal:   Q73UK6
- SMR:   Q73UK6
- EnsemblBacteria:   EBMYCT00000039059
- GeneID:   2719309
- GenomeReviews:   AE016958_GR
- KEGG:   mpa:MAP3362c
- NMPDR:   fig|262316.1.peg.3362
- GeneTree:   EBGT00050000016060
- HOGENOM:   HBG352029
- OMA:   VITHDHM
- ProtClustDB:   PRK05476
- BRENDA:   3.3.1.1
- GO:   GO:0005737
- GO:   GO:0005488
- HAMAP:   MF_00563
- InterPro:   IPR000043
- InterPro:   IPR015878
- InterPro:   IPR020082
- PANTHER:   PTHR23420
- PIRSF:   PIRSF001109
- TIGRFAMs:   TIGR00936

Pfam domain/function: PF05221 AdoHcyase; PF00670 AdoHcyase_NAD

EC number: =3.3.1.1

Molecular weight: Translated: 54436; Mature: 54305

Theoretical pI: Translated: 4.72; Mature: 4.72

Prosite motif: PS00738 ADOHCYASE_1; PS00739 ADOHCYASE_2

Important sites: BINDING 68-68 BINDING 157-157 BINDING 219-219 BINDING 249-249 BINDING 253-253 BINDING 254-254 BINDING 306-306 BINDING 341-341 BINDING 410-410

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTTENALTPDVRNGIEFKVADLSLADYGRRDIELSEQEMPGLMSLRREYHDVQPLKGAR
CCCCCCCCCCHHHCCCEEEEEEEEHHHCCCCCCCCCHHCCCHHHHHHHHHHCCCCCCCCE
ISGSLHMTVQTAVLIETLVALGAEVRWASCNIFSTQDHAAAAVVVGPHGTPEEPRGVPVF
ECCEEEEEHHHHHHHHHHHHCCCCEEEEEEEEECCCCCCEEEEEECCCCCCCCCCCCEEE
AWKGETLEEYWWAAEQALTWPPLADGTEAPANMILDDGGDATMLVLRGAQYEKAGVVPPD
EECCCCHHHHHHHHHHCCCCCCCCCCCCCCCCEEEECCCCEEEEEEECCCCCCCCCCCCC
DEDDSAEHRVFLNLLRARFETDKTKWTKISESIKGVTEETTTGVLRLYQFAAAGDLAFPA
CCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCE
INVNDSVTKSKFDNKYGCRHSLIDGINRGTDVLIGGKNVLVCGYGDVGKGSVESLAGQGA
ECCCCCHHHHHCCCCCCCHHHHHHHCCCCCEEEECCCEEEEECCCCCCCCHHHHHCCCCC
RVTVTEIDPINALQALMEGYNVKRVEDVIGEADIVITATGNKDIITLEHMKAMKDKAILG
EEEEEECCCHHHHHHHHCCCCHHHHHHHHCCCCEEEEECCCCCEEEHHHHHHHHHHHHCC
NIGHFDNEIQIARLEKSGAIKTNIRPQVDLWTFPDTGKSIIVLSEGRLLNLGNATGHPSF
CCCCCCCCEEEEEEECCCCEEECCCCCEEEEECCCCCCEEEEEECCCEEECCCCCCCCCE
VMSNSFSNQVIAQIELWTKNDEYDNEVYRLPKHLDEKVARIHVEALGGELTKLTKEQAEY
EEECCCCCCEEEEEEEEECCCCCCHHHHHHHHHHHHHHHEEEHHHHCCHHHHHHHHHHHE
IGVDVDGPYKADHYRY
EEEECCCCCCCCCCCC
>Mature Secondary Structure 
TTTENALTPDVRNGIEFKVADLSLADYGRRDIELSEQEMPGLMSLRREYHDVQPLKGAR
CCCCCCCCCHHHCCCEEEEEEEEHHHCCCCCCCCCHHCCCHHHHHHHHHHCCCCCCCCE
ISGSLHMTVQTAVLIETLVALGAEVRWASCNIFSTQDHAAAAVVVGPHGTPEEPRGVPVF
ECCEEEEEHHHHHHHHHHHHCCCCEEEEEEEEECCCCCCEEEEEECCCCCCCCCCCCEEE
AWKGETLEEYWWAAEQALTWPPLADGTEAPANMILDDGGDATMLVLRGAQYEKAGVVPPD
EECCCCHHHHHHHHHHCCCCCCCCCCCCCCCCEEEECCCCEEEEEEECCCCCCCCCCCCC
DEDDSAEHRVFLNLLRARFETDKTKWTKISESIKGVTEETTTGVLRLYQFAAAGDLAFPA
CCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCE
INVNDSVTKSKFDNKYGCRHSLIDGINRGTDVLIGGKNVLVCGYGDVGKGSVESLAGQGA
ECCCCCHHHHHCCCCCCCHHHHHHHCCCCCEEEECCCEEEEECCCCCCCCHHHHHCCCCC
RVTVTEIDPINALQALMEGYNVKRVEDVIGEADIVITATGNKDIITLEHMKAMKDKAILG
EEEEEECCCHHHHHHHHCCCCHHHHHHHHCCCCEEEEECCCCCEEEHHHHHHHHHHHHCC
NIGHFDNEIQIARLEKSGAIKTNIRPQVDLWTFPDTGKSIIVLSEGRLLNLGNATGHPSF
CCCCCCCCEEEEEEECCCCEEECCCCCEEEEECCCCCCEEEEEECCCEEECCCCCCCCCE
VMSNSFSNQVIAQIELWTKNDEYDNEVYRLPKHLDEKVARIHVEALGGELTKLTKEQAEY
EEECCCCCCEEEEEEEEECCCCCCHHHHHHHHHHHHHHHEEEHHHHCCHHHHHHHHHHHE
IGVDVDGPYKADHYRY
EEEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA