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The map label for this gene is tmk

Identifier: 41409459

GI number: 41409459

Start: 3733694

End: 3734326

Strand: Reverse

Name: tmk

Synonym: MAP3361c

Alternate gene names: 41409459

Gene position: 3734326-3733694 (Counterclockwise)

Preceding gene: 41409460

Following gene: 41409458

Centisome position: 77.32

GC content: 75.51

Gene sequence:

>633_bases
GTGCTGATCGCGATCGAGGGCGTCGACGGCGCCGGCAAGCGGACACTGGCCGAGGGTCTGCGCAAGGCCTTCGAGGCGGC
GGGACAGTCGGTGGCCACGCTGGCCTTCCCGCGTTACGGGCGCTCCGTGACCGCCGACATCGCGGCCGAGGCGCTGCACG
GCGAGCACGGCGACCTGGCGTCGTCGGTGTACGCGATGGCGATGCTCTTCGCGCTGGACCGGGCCGCGGCCGTCGGCGAC
ATCGAGGGCCTGCGCCGCGACCACGACGTGGTGATCATGGACCGCTACGTCGCCTCCAACGCGGCCTACACCGCCGCGCG
CCTGCACCAGGACGCCGACGGGCCCGCGGTCGCCTGGGTGCACACCCTGGAGTACGGGCGGCTGAAACTGCCCGCACCCG
ACCGGCAGGTGCTGCTGGCGGTCTCGGCCGAGCTGGCCGCCGAGCGCGCCCGCAGCCGGGCCGAGTCCGATCCGGGCCGC
GCGCGGGACAGCTACGAACGCGACGACGGGCTGCAGCAACGCACCGGCGCGGTGTACGCGCAGCTGGCCGCCGCGGGCTG
GGGCGGTGCCTGGCGGGTCGTCGACGCGGACGTCGACCCGGCCCGGCTGGCCGCCGATTTGGCGGCCGGATAG

Upstream 100 bases:

>100_bases
CGGCGGCCACAGCGCCGGCGGCCCGGGCGTGAACTTAGATTCACGTTCGGCGCCGAGCGTGAAGATAACTTCACGCTCGG
CGGCCCGATAGGCTCGCGCC

Downstream 100 bases:

>100_bases
CACAGATTTGTCACGATTCGGCCGTATCCGAGAAGAAACGCCCGTGTGGCGCCCCAATTTTGTCCCGATCTGGTGACACC
ATGGACTCCATGAGGCAAAG

Product: thymidylate kinase

Products: NA

Alternate protein names: Thymidine monophosphate kinase; dTMP kinase; TMPK [H]

Number of amino acids: Translated: 210; Mature: 210

Protein sequence:

>210_residues
MLIAIEGVDGAGKRTLAEGLRKAFEAAGQSVATLAFPRYGRSVTADIAAEALHGEHGDLASSVYAMAMLFALDRAAAVGD
IEGLRRDHDVVIMDRYVASNAAYTAARLHQDADGPAVAWVHTLEYGRLKLPAPDRQVLLAVSAELAAERARSRAESDPGR
ARDSYERDDGLQQRTGAVYAQLAAAGWGGAWRVVDADVDPARLAADLAAG

Sequences:

>Translated_210_residues
MLIAIEGVDGAGKRTLAEGLRKAFEAAGQSVATLAFPRYGRSVTADIAAEALHGEHGDLASSVYAMAMLFALDRAAAVGD
IEGLRRDHDVVIMDRYVASNAAYTAARLHQDADGPAVAWVHTLEYGRLKLPAPDRQVLLAVSAELAAERARSRAESDPGR
ARDSYERDDGLQQRTGAVYAQLAAAGWGGAWRVVDADVDPARLAADLAAG
>Mature_210_residues
MLIAIEGVDGAGKRTLAEGLRKAFEAAGQSVATLAFPRYGRSVTADIAAEALHGEHGDLASSVYAMAMLFALDRAAAVGD
IEGLRRDHDVVIMDRYVASNAAYTAARLHQDADGPAVAWVHTLEYGRLKLPAPDRQVLLAVSAELAAERARSRAESDPGR
ARDSYERDDGLQQRTGAVYAQLAAAGWGGAWRVVDADVDPARLAADLAAG

Specific function: Catalyzes the reversible phosphorylation of deoxythymidine monophosphate (dTMP) to deoxythymidine diphosphate (dTDP), using ATP as its preferred phosphoryl donor. Situated at the junction of both de novo and salvage pathways of deoxythymidine triphosphate

COG id: COG0125

COG function: function code F; Thymidylate kinase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidylate kinase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018095
- InterPro:   IPR018094 [H]

Pfam domain/function: PF02223 Thymidylate_kin [H]

EC number: =2.7.4.9 [H]

Molecular weight: Translated: 22182; Mature: 22182

Theoretical pI: Translated: 5.09; Mature: 5.09

Prosite motif: PS01331 THYMIDYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLIAIEGVDGAGKRTLAEGLRKAFEAAGQSVATLAFPRYGRSVTADIAAEALHGEHGDLA
CEEEEECCCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHCCCCCHHH
SSVYAMAMLFALDRAAAVGDIEGLRRDHDVVIMDRYVASNAAYTAARLHQDADGPAVAWV
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHCCCHHHHHHHHCCCCCCEEEEE
HTLEYGRLKLPAPDRQVLLAVSAELAAERARSRAESDPGRARDSYERDDGLQQRTGAVYA
EECCCCEEECCCCCHHEEHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHCCHHHHHHHHHH
QLAAAGWGGAWRVVDADVDPARLAADLAAG
HHHHCCCCCEEEEEECCCCHHHHHHHHCCC
>Mature Secondary Structure
MLIAIEGVDGAGKRTLAEGLRKAFEAAGQSVATLAFPRYGRSVTADIAAEALHGEHGDLA
CEEEEECCCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHCCCCCHHH
SSVYAMAMLFALDRAAAVGDIEGLRRDHDVVIMDRYVASNAAYTAARLHQDADGPAVAWV
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHCCCHHHHHHHHCCCCCCEEEEE
HTLEYGRLKLPAPDRQVLLAVSAELAAERARSRAESDPGRARDSYERDDGLQQRTGAVYA
EECCCCEEECCCCCHHEEHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHCCHHHHHHHHHH
QLAAAGWGGAWRVVDADVDPARLAADLAAG
HHHHCCCCCEEEEEECCCCHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036; 11369858; 10666613; 11469859; 11914484; 12454011; 12662932 [H]