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The map label for this gene is fadE23

Identifier: 41409287

GI number: 41409287

Start: 3539560

End: 3540765

Strand: Direct

Name: fadE23

Synonym: MAP3189

Alternate gene names: 41409287

Gene position: 3539560-3540765 (Clockwise)

Preceding gene: 41409286

Following gene: 41409288

Centisome position: 73.29

GC content: 66.0

Gene sequence:

>1206_bases
ATGGCAATCAATCTGGAACTTCCCCGCAAGATGCAGGCGGTGACCACGAAGACGCATCAGGGCGCCGCGGAGTTGATGCG
CCCGATCGCGCGCAAGTACGACCTGAAGGAACACGCCTACCCGGTCGAGCTGGACACGCTGATCAGCCTGTTCGAAGGGG
CTTCGGAGTCAATCGAATTCGCCGGGGCGAACGCGCTGGGCGGCGAGGACGAAGAACGGGACAAGAACCACAACGGCGCC
AACATGGCCGCGCTGCTGCAGACGCTGGAAGCCAGCTGGGGCGACCTCGCGATGATGCTCTCGGTGCCCTACCAGGGGTT
GGGCAACGCGGCCATCTCCGCGGTCGCCAACGACGAGCAGCTGCAGCGGCTGGGCAAGGTGTGGGCGGCGATGGCCATCA
CCGAGCCCGGCTTCGGATCGGACTCGGCGGCGGTGTCGACGACCGCCACCCTGGACGGCGACGAGTACGTGATCAACGGC
GAGAAGATCTTCGTCACCGCCGGCTCGCGGGCCACCCACATCGTGGTGTGGGCGACGCTGGACAAGTCGAAGGGCCGCCC
GGCGATCAAGTCATTCATCGTGCCGCGCGACCATCCCGGCGTCACCGTCGAGCGGCTCGAGAAAAAGCTCGGCATCAAGG
GCTCCGACACCGCGGCCGTCCGGTTCGACAACGTCCGCATCCCCAAGGAAAACCTGCTCGGCAACCCGGAAATCGAAGAG
GGCAAAGGCTTTTCGGGGGTGATGGAGACCTTCGACAACACCCGGCCCATCGTTGCCGCCATGGCCGTCGGGGTGGCCCG
CGCCGCGCTGGAGGAGATCCGCAAGATCCTCACCGACGCCGGCGTGGAGATCTCCTACGACAAACCCGCGCACGTCCAGA
GCGCGGCCGCGGCCGAGTTCCTGCGGATGGAAGCCGACTGGGAGTCGGCCTATCTGCTGTCGCTGCGAGCGGCGTGGCAG
GCCGACAACGAGATCCCCAACTCCAAAGAAGCGTCCATGAGCAAGGCCAAGGCGGGCCGGATGGCCACCGACGTCACCCT
CAAGACCGTCGAATTGGCGGGCACCGCAGGCTATTCCGAGCAGTCACTGCTGGAGAAGTGGGCGCGTGACTCCAAGATCC
TGGACATCTTCGAGGGCACCCAGCAGATCCAGCAGCTGGTGGTGGCGCGCCGCCTGCTGGGCCTGTCGTCGGCCGAACTC
AAGTAG

Upstream 100 bases:

>100_bases
CGGTCGAACGCTGGTACCGCGACCTGCGGGCCATCGGCGTCGCCGAGGGCGTCGTGGTCATCTGAGTCGTTAATGCAAGA
ACCGAGCTGAAAGTTCAATC

Downstream 100 bases:

>100_bases
CGGCCGGGCTATCGGCGTTGCGCGCCGAGCGTGCAACCACCGCGAGACATCGGCCGTTTTCTCGCCGCGAGTACACGTTC
GGCGACAGTCAAGCGCGCCG

Product: FadE23

Products: 2,3-dehydroacyl-CoA; reduced acceptor

Alternate protein names: NA

Number of amino acids: Translated: 401; Mature: 400

Protein sequence:

>401_residues
MAINLELPRKMQAVTTKTHQGAAELMRPIARKYDLKEHAYPVELDTLISLFEGASESIEFAGANALGGEDEERDKNHNGA
NMAALLQTLEASWGDLAMMLSVPYQGLGNAAISAVANDEQLQRLGKVWAAMAITEPGFGSDSAAVSTTATLDGDEYVING
EKIFVTAGSRATHIVVWATLDKSKGRPAIKSFIVPRDHPGVTVERLEKKLGIKGSDTAAVRFDNVRIPKENLLGNPEIEE
GKGFSGVMETFDNTRPIVAAMAVGVARAALEEIRKILTDAGVEISYDKPAHVQSAAAAEFLRMEADWESAYLLSLRAAWQ
ADNEIPNSKEASMSKAKAGRMATDVTLKTVELAGTAGYSEQSLLEKWARDSKILDIFEGTQQIQQLVVARRLLGLSSAEL
K

Sequences:

>Translated_401_residues
MAINLELPRKMQAVTTKTHQGAAELMRPIARKYDLKEHAYPVELDTLISLFEGASESIEFAGANALGGEDEERDKNHNGA
NMAALLQTLEASWGDLAMMLSVPYQGLGNAAISAVANDEQLQRLGKVWAAMAITEPGFGSDSAAVSTTATLDGDEYVING
EKIFVTAGSRATHIVVWATLDKSKGRPAIKSFIVPRDHPGVTVERLEKKLGIKGSDTAAVRFDNVRIPKENLLGNPEIEE
GKGFSGVMETFDNTRPIVAAMAVGVARAALEEIRKILTDAGVEISYDKPAHVQSAAAAEFLRMEADWESAYLLSLRAAWQ
ADNEIPNSKEASMSKAKAGRMATDVTLKTVELAGTAGYSEQSLLEKWARDSKILDIFEGTQQIQQLVVARRLLGLSSAEL
K
>Mature_400_residues
AINLELPRKMQAVTTKTHQGAAELMRPIARKYDLKEHAYPVELDTLISLFEGASESIEFAGANALGGEDEERDKNHNGAN
MAALLQTLEASWGDLAMMLSVPYQGLGNAAISAVANDEQLQRLGKVWAAMAITEPGFGSDSAAVSTTATLDGDEYVINGE
KIFVTAGSRATHIVVWATLDKSKGRPAIKSFIVPRDHPGVTVERLEKKLGIKGSDTAAVRFDNVRIPKENLLGNPEIEEG
KGFSGVMETFDNTRPIVAAMAVGVARAALEEIRKILTDAGVEISYDKPAHVQSAAAAEFLRMEADWESAYLLSLRAAWQA
DNEIPNSKEASMSKAKAGRMATDVTLKTVELAGTAGYSEQSLLEKWARDSKILDIFEGTQQIQQLVVARRLLGLSSAELK

Specific function: Catalyzes the reduction of crotonobetainyl-CoA to gamma-butyrobetainyl-CoA. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI187960098, Length=402, Percent_Identity=33.3333333333333, Blast_Score=187, Evalue=1e-47,
Organism=Homo sapiens, GI4557231, Length=402, Percent_Identity=33.3333333333333, Blast_Score=187, Evalue=1e-47,
Organism=Homo sapiens, GI4557233, Length=394, Percent_Identity=31.4720812182741, Blast_Score=174, Evalue=1e-43,
Organism=Homo sapiens, GI4501859, Length=264, Percent_Identity=31.8181818181818, Blast_Score=141, Evalue=9e-34,
Organism=Homo sapiens, GI21361497, Length=312, Percent_Identity=32.0512820512821, Blast_Score=121, Evalue=1e-27,
Organism=Homo sapiens, GI76496475, Length=402, Percent_Identity=29.6019900497512, Blast_Score=118, Evalue=8e-27,
Organism=Homo sapiens, GI4557235, Length=402, Percent_Identity=29.6019900497512, Blast_Score=118, Evalue=8e-27,
Organism=Homo sapiens, GI4501857, Length=304, Percent_Identity=29.2763157894737, Blast_Score=115, Evalue=6e-26,
Organism=Homo sapiens, GI226958412, Length=274, Percent_Identity=28.4671532846715, Blast_Score=110, Evalue=3e-24,
Organism=Homo sapiens, GI226958414, Length=274, Percent_Identity=28.4671532846715, Blast_Score=110, Evalue=3e-24,
Organism=Homo sapiens, GI7656849, Length=290, Percent_Identity=26.551724137931, Blast_Score=106, Evalue=3e-23,
Organism=Homo sapiens, GI4503943, Length=299, Percent_Identity=23.0769230769231, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI48976061, Length=276, Percent_Identity=26.8115942028986, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI211971008, Length=276, Percent_Identity=26.8115942028986, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI7669494, Length=284, Percent_Identity=22.1830985915493, Blast_Score=69, Evalue=7e-12,
Organism=Homo sapiens, GI38505218, Length=276, Percent_Identity=25.7246376811594, Blast_Score=66, Evalue=7e-11,
Organism=Escherichia coli, GI1786223, Length=268, Percent_Identity=28.7313432835821, Blast_Score=115, Evalue=4e-27,
Organism=Escherichia coli, GI87081958, Length=265, Percent_Identity=29.4339622641509, Blast_Score=113, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI17569725, Length=383, Percent_Identity=33.9425587467363, Blast_Score=177, Evalue=1e-44,
Organism=Caenorhabditis elegans, GI17534899, Length=377, Percent_Identity=33.42175066313, Blast_Score=170, Evalue=9e-43,
Organism=Caenorhabditis elegans, GI17570075, Length=293, Percent_Identity=36.8600682593857, Blast_Score=168, Evalue=4e-42,
Organism=Caenorhabditis elegans, GI17508101, Length=266, Percent_Identity=36.4661654135338, Blast_Score=155, Evalue=4e-38,
Organism=Caenorhabditis elegans, GI17506239, Length=266, Percent_Identity=34.2105263157895, Blast_Score=142, Evalue=4e-34,
Organism=Caenorhabditis elegans, GI71985184, Length=300, Percent_Identity=32.3333333333333, Blast_Score=128, Evalue=5e-30,
Organism=Caenorhabditis elegans, GI17531909, Length=248, Percent_Identity=27.4193548387097, Blast_Score=110, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI71990804, Length=211, Percent_Identity=32.2274881516588, Blast_Score=109, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI17538396, Length=275, Percent_Identity=27.6363636363636, Blast_Score=107, Evalue=8e-24,
Organism=Caenorhabditis elegans, GI71985192, Length=224, Percent_Identity=33.9285714285714, Blast_Score=107, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI32563615, Length=144, Percent_Identity=38.8888888888889, Blast_Score=106, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17533517, Length=276, Percent_Identity=25.3623188405797, Blast_Score=100, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17505929, Length=274, Percent_Identity=26.6423357664234, Blast_Score=98, Evalue=9e-21,
Organism=Caenorhabditis elegans, GI17551932, Length=273, Percent_Identity=27.1062271062271, Blast_Score=96, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI71982178, Length=156, Percent_Identity=32.6923076923077, Blast_Score=92, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI17534353, Length=274, Percent_Identity=25.5474452554745, Blast_Score=92, Evalue=5e-19,
Organism=Drosophila melanogaster, GI24660351, Length=339, Percent_Identity=36.5781710914454, Blast_Score=184, Evalue=8e-47,
Organism=Drosophila melanogaster, GI21356377, Length=270, Percent_Identity=37.7777777777778, Blast_Score=173, Evalue=2e-43,
Organism=Drosophila melanogaster, GI24646207, Length=315, Percent_Identity=32.6984126984127, Blast_Score=167, Evalue=9e-42,
Organism=Drosophila melanogaster, GI24666513, Length=384, Percent_Identity=31.25, Blast_Score=147, Evalue=2e-35,
Organism=Drosophila melanogaster, GI281363737, Length=326, Percent_Identity=30.6748466257669, Blast_Score=120, Evalue=2e-27,
Organism=Drosophila melanogaster, GI21355753, Length=276, Percent_Identity=28.9855072463768, Blast_Score=106, Evalue=3e-23,
Organism=Drosophila melanogaster, GI19920834, Length=334, Percent_Identity=27.5449101796407, Blast_Score=102, Evalue=3e-22,
Organism=Drosophila melanogaster, GI281365206, Length=183, Percent_Identity=32.2404371584699, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24585193, Length=183, Percent_Identity=32.2404371584699, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24585195, Length=183, Percent_Identity=32.2404371584699, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24585191, Length=183, Percent_Identity=32.2404371584699, Blast_Score=71, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.3

Molecular weight: Translated: 43328; Mature: 43196

Theoretical pI: Translated: 4.94; Mature: 4.94

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAINLELPRKMQAVTTKTHQGAAELMRPIARKYDLKEHAYPVELDTLISLFEGASESIEF
CEECCCCCHHHHHHHHHHHCCHHHHHHHHHHHCCHHHCCCCCCHHHHHHHHHCCCCCEEE
AGANALGGEDEERDKNHNGANMAALLQTLEASWGDLAMMLSVPYQGLGNAAISAVANDEQ
CCCCCCCCCCHHHCCCCCCHHHHHHHHHHHCCCCCEEEEECCCCCCCCHHHHHHHCCHHH
LQRLGKVWAAMAITEPGFGSDSAAVSTTATLDGDEYVINGEKIFVTAGSRATHIVVWATL
HHHHHHHHHHHHCCCCCCCCCCCCEEEEEEECCCEEEECCCEEEEEECCCCEEEEEEEEE
DKSKGRPAIKSFIVPRDHPGVTVERLEKKLGIKGSDTAAVRFDNVRIPKENLLGNPEIEE
CCCCCCHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCCEEEEECCEECCHHHCCCCCCCCC
GKGFSGVMETFDNTRPIVAAMAVGVARAALEEIRKILTDAGVEISYDKPAHVQSAAAAEF
CCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCHHHHHHHHHH
LRMEADWESAYLLSLRAAWQADNEIPNSKEASMSKAKAGRMATDVTLKTVELAGTAGYSE
HHHHCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCCEEEEEEEEECCCCCCH
QSLLEKWARDSKILDIFEGTQQIQQLVVARRLLGLSSAELK
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
AINLELPRKMQAVTTKTHQGAAELMRPIARKYDLKEHAYPVELDTLISLFEGASESIEF
EECCCCCHHHHHHHHHHHCCHHHHHHHHHHHCCHHHCCCCCCHHHHHHHHHCCCCCEEE
AGANALGGEDEERDKNHNGANMAALLQTLEASWGDLAMMLSVPYQGLGNAAISAVANDEQ
CCCCCCCCCCHHHCCCCCCHHHHHHHHHHHCCCCCEEEEECCCCCCCCHHHHHHHCCHHH
LQRLGKVWAAMAITEPGFGSDSAAVSTTATLDGDEYVINGEKIFVTAGSRATHIVVWATL
HHHHHHHHHHHHCCCCCCCCCCCCEEEEEEECCCEEEECCCEEEEEECCCCEEEEEEEEE
DKSKGRPAIKSFIVPRDHPGVTVERLEKKLGIKGSDTAAVRFDNVRIPKENLLGNPEIEE
CCCCCCHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCCEEEEECCEECCHHHCCCCCCCCC
GKGFSGVMETFDNTRPIVAAMAVGVARAALEEIRKILTDAGVEISYDKPAHVQSAAAAEF
CCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCHHHHHHHHHH
LRMEADWESAYLLSLRAAWQADNEIPNSKEASMSKAKAGRMATDVTLKTVELAGTAGYSE
HHHHCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCCEEEEEEEEECCCCCCH
QSLLEKWARDSKILDIFEGTQQIQQLVVARRLLGLSSAELK
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: acyl-CoA; acceptor

Specific reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9387222; 9384377 [H]