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The map label for this gene is gorA

Identifier: 41409021

GI number: 41409021

Start: 3256478

End: 3257857

Strand: Direct

Name: gorA

Synonym: MAP2923

Alternate gene names: 41409021

Gene position: 3256478-3257857 (Clockwise)

Preceding gene: 41409020

Following gene: 41409022

Centisome position: 67.42

GC content: 67.68

Gene sequence:

>1380_bases
ATGGAAACCTACGACCTCGCGATCATCGGAACCGGTTCGGGCAACAGCCTTCTCGATGCCCGCTTCGCCGGCAAGCGGAC
CGCCATCTGCGAGCACGGCACCTTCGGCGGAACCTGCCTCAACGTCGGGTGCATCCCCACCAAGATGTTCGTCTACGCCG
CCGACGTCGCCACGACGATCCGGGAGGCGGCCCGCTACGGCGTCGACACGCACCTCGACGGGGTGCGCTGGCCCGACATC
GTCTCCCGCGTCTTCGGCCGCATCGACCCGATCGCGCTCAGCGGCGAAGAGTATCGGCGCTCCTCGGTCAATATCGACCT
GTACCGCAGCCACACCCGGTTCGGGCCGGTGCAATTCGACGGCCGTTACCTGTTGCGCACCGACGCCGGCGAACAGTTCA
CCGCCGAGCAGGTGGTGATCGCCGCCGGGTCGCGGCCGGTGATTCCCCCCGCGATCCTCGAGAGCGGCGTCACCTACCAC
ACCAGCGACACCATCATGCGCATCCCCGCGCTGCCCGAGCATCTGGTGATCGTCGGAAGTGGCTTCGTGGCAGCCGAATT
CGCCCACATCTTCTCCGCGCTGGGGGTGCACGTGACCGTGGTGATCCGCAGCGGCCGCATGCTGCGCCAGTACGACGACA
TGATCTGCGAGCGGTTCACCCGGCTGGCCGCGGCCAAATGGGAACTGCGCACCCAGCGCAACGTGGTGGGCGGCAGCAAC
CGCGGCTCCGGCGTCACGCTGCGCCTGGACGACGGATCCACGCTGGACGCCGACGTGCTGCTGGTGGCCACCGGCCGGAT
ATCCAACGCCGATCTGCTCGACGCCGGGCAGGCCGGCGTCGACGTGGAGAACGGTCGCGTGGTGGTCGACGAGTACCAAC
GCACTTCGGCCCGAGGGGTTTTCGCGCTCGGTGACGTATCGTCGCCGTATCAGCTCAAGCACGTCGCCAACCACGAGGCC
CGGGTGGTGCGGCACAACCTGCTCTGCGACTGGGACGACACCGAGTCGATGGCCGTCACCGACCACCGCTATGTTCCGTC
GGCGGTGTTCACCGATCCCCAGCTGGCCACCGTGGGGCTGACCGAAAACCAGGCGATAGCACGGGGATTCGACATCTCGG
TGGCGATCCAGAACTACGGCGACGTCGCCTACGGGTGGGCGATGGAAGACACCACCGGGGTGGTCAAGCTGATCGCCGAG
CGCACCAGCGGTCGGCTGCTGGGCGCGCACATCATGGGCCCTCAGGCGTCCTCGATCATCCAGCCGCTGATCCAGGCGAT
GAGCTTCGGGCTGACCGCCGCGCAGATGGCCCGCGGCCAGTACTGGATTCACCCGGCGCTGCCCGAGGTCGTCGAGAACG
CGCTGCTGGGCCTGTACTGA

Upstream 100 bases:

>100_bases
TATCGTCAACTGGATCTGTGGCTGGACGGCTACCTGCGCGACCGGAGCACCGATAGCACCCGGGCCCCGGCGTCCCGGGA
CGAAGGGTGAGGCGCCGAAC

Downstream 100 bases:

>100_bases
TTTCGCGGGCACGGGCCGTGTGCCCGCCTTGCGTCCGGCAAGACGCGGAACTTACAGTCGTGCCCGTTGCCCTGTGCCCG
ACACCGCCCGCGCCGGAAGG

Product: mycothione reductase

Products: NA

Alternate protein names: Mycothiol-disulfide reductase; NADPH-dependent mycothione reductase [H]

Number of amino acids: Translated: 459; Mature: 459

Protein sequence:

>459_residues
METYDLAIIGTGSGNSLLDARFAGKRTAICEHGTFGGTCLNVGCIPTKMFVYAADVATTIREAARYGVDTHLDGVRWPDI
VSRVFGRIDPIALSGEEYRRSSVNIDLYRSHTRFGPVQFDGRYLLRTDAGEQFTAEQVVIAAGSRPVIPPAILESGVTYH
TSDTIMRIPALPEHLVIVGSGFVAAEFAHIFSALGVHVTVVIRSGRMLRQYDDMICERFTRLAAAKWELRTQRNVVGGSN
RGSGVTLRLDDGSTLDADVLLVATGRISNADLLDAGQAGVDVENGRVVVDEYQRTSARGVFALGDVSSPYQLKHVANHEA
RVVRHNLLCDWDDTESMAVTDHRYVPSAVFTDPQLATVGLTENQAIARGFDISVAIQNYGDVAYGWAMEDTTGVVKLIAE
RTSGRLLGAHIMGPQASSIIQPLIQAMSFGLTAAQMARGQYWIHPALPEVVENALLGLY

Sequences:

>Translated_459_residues
METYDLAIIGTGSGNSLLDARFAGKRTAICEHGTFGGTCLNVGCIPTKMFVYAADVATTIREAARYGVDTHLDGVRWPDI
VSRVFGRIDPIALSGEEYRRSSVNIDLYRSHTRFGPVQFDGRYLLRTDAGEQFTAEQVVIAAGSRPVIPPAILESGVTYH
TSDTIMRIPALPEHLVIVGSGFVAAEFAHIFSALGVHVTVVIRSGRMLRQYDDMICERFTRLAAAKWELRTQRNVVGGSN
RGSGVTLRLDDGSTLDADVLLVATGRISNADLLDAGQAGVDVENGRVVVDEYQRTSARGVFALGDVSSPYQLKHVANHEA
RVVRHNLLCDWDDTESMAVTDHRYVPSAVFTDPQLATVGLTENQAIARGFDISVAIQNYGDVAYGWAMEDTTGVVKLIAE
RTSGRLLGAHIMGPQASSIIQPLIQAMSFGLTAAQMARGQYWIHPALPEVVENALLGLY
>Mature_459_residues
METYDLAIIGTGSGNSLLDARFAGKRTAICEHGTFGGTCLNVGCIPTKMFVYAADVATTIREAARYGVDTHLDGVRWPDI
VSRVFGRIDPIALSGEEYRRSSVNIDLYRSHTRFGPVQFDGRYLLRTDAGEQFTAEQVVIAAGSRPVIPPAILESGVTYH
TSDTIMRIPALPEHLVIVGSGFVAAEFAHIFSALGVHVTVVIRSGRMLRQYDDMICERFTRLAAAKWELRTQRNVVGGSN
RGSGVTLRLDDGSTLDADVLLVATGRISNADLLDAGQAGVDVENGRVVVDEYQRTSARGVFALGDVSSPYQLKHVANHEA
RVVRHNLLCDWDDTESMAVTDHRYVPSAVFTDPQLATVGLTENQAIARGFDISVAIQNYGDVAYGWAMEDTTGVVKLIAE
RTSGRLLGAHIMGPQASSIIQPLIQAMSFGLTAAQMARGQYWIHPALPEVVENALLGLY

Specific function: Catalyzes the NAD(P)H-dependent reduction of mycothione (the oxidized disulfide form of mycothiol) to mycothiol [H]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI50301238, Length=467, Percent_Identity=29.1220556745182, Blast_Score=162, Evalue=6e-40,
Organism=Homo sapiens, GI91199540, Length=477, Percent_Identity=26.4150943396226, Blast_Score=138, Evalue=1e-32,
Organism=Homo sapiens, GI22035672, Length=454, Percent_Identity=27.7533039647577, Blast_Score=122, Evalue=8e-28,
Organism=Homo sapiens, GI291045266, Length=440, Percent_Identity=26.8181818181818, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI148277065, Length=445, Percent_Identity=24.2696629213483, Blast_Score=110, Evalue=4e-24,
Organism=Homo sapiens, GI33519430, Length=445, Percent_Identity=24.2696629213483, Blast_Score=110, Evalue=4e-24,
Organism=Homo sapiens, GI33519428, Length=445, Percent_Identity=24.2696629213483, Blast_Score=110, Evalue=4e-24,
Organism=Homo sapiens, GI33519426, Length=445, Percent_Identity=24.2696629213483, Blast_Score=110, Evalue=4e-24,
Organism=Homo sapiens, GI148277071, Length=445, Percent_Identity=24.2696629213483, Blast_Score=109, Evalue=5e-24,
Organism=Homo sapiens, GI291045268, Length=441, Percent_Identity=24.0362811791383, Blast_Score=88, Evalue=1e-17,
Organism=Escherichia coli, GI1789915, Length=439, Percent_Identity=30.9794988610478, Blast_Score=175, Evalue=6e-45,
Organism=Escherichia coli, GI1786307, Length=446, Percent_Identity=28.0269058295964, Blast_Score=158, Evalue=9e-40,
Organism=Escherichia coli, GI87081717, Length=471, Percent_Identity=29.0870488322718, Blast_Score=144, Evalue=9e-36,
Organism=Escherichia coli, GI87082354, Length=433, Percent_Identity=26.0969976905312, Blast_Score=128, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI32565766, Length=470, Percent_Identity=28.2978723404255, Blast_Score=151, Evalue=5e-37,
Organism=Caenorhabditis elegans, GI17557007, Length=481, Percent_Identity=29.7297297297297, Blast_Score=140, Evalue=1e-33,
Organism=Caenorhabditis elegans, GI71983419, Length=446, Percent_Identity=27.5784753363229, Blast_Score=137, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI71983429, Length=446, Percent_Identity=27.5784753363229, Blast_Score=137, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI71982272, Length=493, Percent_Identity=27.1805273833671, Blast_Score=102, Evalue=5e-22,
Organism=Saccharomyces cerevisiae, GI6325166, Length=455, Percent_Identity=26.1538461538462, Blast_Score=151, Evalue=2e-37,
Organism=Saccharomyces cerevisiae, GI6321091, Length=485, Percent_Identity=25.979381443299, Blast_Score=123, Evalue=8e-29,
Organism=Saccharomyces cerevisiae, GI6325240, Length=478, Percent_Identity=23.6401673640167, Blast_Score=75, Evalue=2e-14,
Organism=Drosophila melanogaster, GI21358499, Length=472, Percent_Identity=24.5762711864407, Blast_Score=127, Evalue=2e-29,
Organism=Drosophila melanogaster, GI24640553, Length=490, Percent_Identity=30, Blast_Score=121, Evalue=9e-28,
Organism=Drosophila melanogaster, GI24640549, Length=492, Percent_Identity=29.6747967479675, Blast_Score=121, Evalue=1e-27,
Organism=Drosophila melanogaster, GI24640551, Length=492, Percent_Identity=29.6747967479675, Blast_Score=121, Evalue=1e-27,
Organism=Drosophila melanogaster, GI17737741, Length=477, Percent_Identity=28.3018867924528, Blast_Score=120, Evalue=2e-27,

Paralogues:

None

Copy number: 650 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR017817
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.8.1.15 [H]

Molecular weight: Translated: 49811; Mature: 49811

Theoretical pI: Translated: 5.90; Mature: 5.90

Prosite motif: PS00076 PYRIDINE_REDOX_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
METYDLAIIGTGSGNSLLDARFAGKRTAICEHGTFGGTCLNVGCIPTKMFVYAADVATTI
CCCEEEEEEECCCCCCEEEHHHCCCCCEEECCCCCCCEEEECCCCCHHHEEEEHHHHHHH
REAARYGVDTHLDGVRWPDIVSRVFGRIDPIALSGEEYRRSSVNIDLYRSHTRFGPVQFD
HHHHHCCCCCCCCCCCCHHHHHHHHCCCCCEEECCHHHHHCCCCEEEEECCCCCCCEEEC
GRYLLRTDAGEQFTAEQVVIAAGSRPVIPPAILESGVTYHTSDTIMRIPALPEHLVIVGS
CEEEEEECCCCCCCCCEEEEEECCCCCCCHHHHHCCCEEECCCCEEECCCCCCEEEEEEC
GFVAAEFAHIFSALGVHVTVVIRSGRMLRQYDDMICERFTRLAAAKWELRTQRNVVGGSN
CHHHHHHHHHHHHHCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
RGSGVTLRLDDGSTLDADVLLVATGRISNADLLDAGQAGVDVENGRVVVDEYQRTSARGV
CCCEEEEEECCCCCCCCEEEEEEECCCCCCCEECCCCCCCEECCCEEEEECCCCCCCCCE
FALGDVSSPYQLKHVANHEARVVRHNLLCDWDDTESMAVTDHRYVPSAVFTDPQLATVGL
EEECCCCCCCHHHHHCCCHHHEEHHHEEECCCCCCCEEEECCCCCCCCEECCCCEEEEEC
TENQAIARGFDISVAIQNYGDVAYGWAMEDTTGVVKLIAERTSGRLLGAHIMGPQASSII
CCCCHHHCCCEEEEEEECCCCEEEEEEECCCHHHHHHHHHHCCCCEEEEEECCCCHHHHH
QPLIQAMSFGLTAAQMARGQYWIHPALPEVVENALLGLY
HHHHHHHHCCCHHHHHHCCCEEECCCHHHHHHHHHHCCC
>Mature Secondary Structure
METYDLAIIGTGSGNSLLDARFAGKRTAICEHGTFGGTCLNVGCIPTKMFVYAADVATTI
CCCEEEEEEECCCCCCEEEHHHCCCCCEEECCCCCCCEEEECCCCCHHHEEEEHHHHHHH
REAARYGVDTHLDGVRWPDIVSRVFGRIDPIALSGEEYRRSSVNIDLYRSHTRFGPVQFD
HHHHHCCCCCCCCCCCCHHHHHHHHCCCCCEEECCHHHHHCCCCEEEEECCCCCCCEEEC
GRYLLRTDAGEQFTAEQVVIAAGSRPVIPPAILESGVTYHTSDTIMRIPALPEHLVIVGS
CEEEEEECCCCCCCCCEEEEEECCCCCCCHHHHHCCCEEECCCCEEECCCCCCEEEEEEC
GFVAAEFAHIFSALGVHVTVVIRSGRMLRQYDDMICERFTRLAAAKWELRTQRNVVGGSN
CHHHHHHHHHHHHHCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
RGSGVTLRLDDGSTLDADVLLVATGRISNADLLDAGQAGVDVENGRVVVDEYQRTSARGV
CCCEEEEEECCCCCCCCEEEEEEECCCCCCCEECCCCCCCEECCCEEEEECCCCCCCCCE
FALGDVSSPYQLKHVANHEARVVRHNLLCDWDDTESMAVTDHRYVPSAVFTDPQLATVGL
EEECCCCCCCHHHHHCCCHHHEEHHHEEECCCCCCCEEEECCCCCCCCEECCCCEEEEEC
TENQAIARGFDISVAIQNYGDVAYGWAMEDTTGVVKLIAERTSGRLLGAHIMGPQASSII
CCCCHHHCCCEEEEEEECCCCEEEEEEECCCHHHHHHHHHHCCCCEEEEEECCCCHHHHH
QPLIQAMSFGLTAAQMARGQYWIHPALPEVVENALLGLY
HHHHHHHHCCCHHHHHHCCCEEECCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]