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The map label for this gene is acdA [H]

Identifier: 41408326

GI number: 41408326

Start: 2478109

End: 2479215

Strand: Direct

Name: acdA [H]

Synonym: MAP2228

Alternate gene names: 41408326

Gene position: 2478109-2479215 (Clockwise)

Preceding gene: 41408325

Following gene: 41408327

Centisome position: 51.31

GC content: 69.56

Gene sequence:

>1107_bases
ATGGACTTTCAGTTGAGCGACGAGCAGGCCCTGCTGCGCGACACCACCCGCGATCTGCTGTCGCGCAGTTACGACCCGGA
GAGCCGCAACAAGGTCATCGGCTCCGAGCTGGGCTGGAGCCGCGAGGTGTGGAGCCAGCTCGCCGACACCGGGATCCTGG
GCCTGGGCTTCGACCCCGACGAGTCGGGACAGATCGAGATCATGGTGGTGCTCACCGAGATCGGGCGCCGGCTGGCCCCC
GAGCCGGTGCTGCACGCCGCGCTGGGGCCCGGCGCGCTGATCGCCGAGCTGGGCAGCGCGGCCCAGAAGGAACTGCTGGA
CGAGGTCGCGGCCGGCCAGCGGCTGCTGGCGTTCGCCCACCTGGAGCCGGGGCAGCGCAAACCGACCGCCGAGGTGGGCA
CCAAGGCTGCGCGGCAAGGTGATTCGTGGACGCTGAGCGGTCAGAAGAACCCGGTGCTGGCCGGCGACTGCGCCGACACC
CTGGTGGTCAGCGCCGCGTTGCCGGACGGCGGCACCGGGCTGTTCCTGGTCGACGCGGGCGCCGTCACCCGGCACCCGTA
CCGCACCTTCGACGGGCAGCGGGGCGCCCAAATCGATCTGGACGCCACCCCGGCCGAACCGCTGGGCGAGGCGACCGACG
CGTCGGGCGGCATCGAGGCGGCCATCATCCGCATCCAGTCCGCGTTGTGCTCCGAAGCGCTTGGGGCGATGGAGGAATCG
CTGCGCCTGACCACCGACTACCTCAAGACCCGCAAGCAGTTCGGGGTCACCCTGAACAAATTCCAGGCGCTCACCCAGCG
CGCCGCCGACATGTACGTCTCGCTGGAATTGGCCCGCAGCATGAGCCTGTATGCGGCGATGTCGATCGCCGACGGCAATA
TCGACCCGGTGATCGCCTCGCGGGCCAAGCTGCAGATCGGCCGCTCCGGCCGGCACATTGCGCAGGAGTCCATCCAGATG
CACGGCGGGATCGGGGTGACCGCGGAGTACCCGATCAGCCACTACGCCGCCCGGCTCACCGCGATCGAGCACACCCTGGG
CACCTCGGGTGAGCATCTGCACAACCTGATCGACCACCTCGGCGACTACGACCTGGTCCGCCTCTAA

Upstream 100 bases:

>100_bases
CCGCACTACCTGAACTATCGCAAGACGTCGATCTACGGCGGCAGCAGCGAAGTACAGCGCAACATCATCGCGTCCACCAT
TCTGGGATTGTGAGGCAGCC

Downstream 100 bases:

>100_bases
CCCCATGGCCGCGCTGTCCGCCGAGGTCGTCGAGTTCCTGTCCGCCGGCACCCGCACCGGGATGCTCGGCTATGTCGCCG
CCGACGGCCGGCCGCTGGTC

Product: hypothetical protein

Products: gamma-butyrobetaine; Acceptor; gamma-butyrobetainyl-CoA [C]

Alternate protein names: NA

Number of amino acids: Translated: 368; Mature: 368

Protein sequence:

>368_residues
MDFQLSDEQALLRDTTRDLLSRSYDPESRNKVIGSELGWSREVWSQLADTGILGLGFDPDESGQIEIMVVLTEIGRRLAP
EPVLHAALGPGALIAELGSAAQKELLDEVAAGQRLLAFAHLEPGQRKPTAEVGTKAARQGDSWTLSGQKNPVLAGDCADT
LVVSAALPDGGTGLFLVDAGAVTRHPYRTFDGQRGAQIDLDATPAEPLGEATDASGGIEAAIIRIQSALCSEALGAMEES
LRLTTDYLKTRKQFGVTLNKFQALTQRAADMYVSLELARSMSLYAAMSIADGNIDPVIASRAKLQIGRSGRHIAQESIQM
HGGIGVTAEYPISHYAARLTAIEHTLGTSGEHLHNLIDHLGDYDLVRL

Sequences:

>Translated_368_residues
MDFQLSDEQALLRDTTRDLLSRSYDPESRNKVIGSELGWSREVWSQLADTGILGLGFDPDESGQIEIMVVLTEIGRRLAP
EPVLHAALGPGALIAELGSAAQKELLDEVAAGQRLLAFAHLEPGQRKPTAEVGTKAARQGDSWTLSGQKNPVLAGDCADT
LVVSAALPDGGTGLFLVDAGAVTRHPYRTFDGQRGAQIDLDATPAEPLGEATDASGGIEAAIIRIQSALCSEALGAMEES
LRLTTDYLKTRKQFGVTLNKFQALTQRAADMYVSLELARSMSLYAAMSIADGNIDPVIASRAKLQIGRSGRHIAQESIQM
HGGIGVTAEYPISHYAARLTAIEHTLGTSGEHLHNLIDHLGDYDLVRL
>Mature_368_residues
MDFQLSDEQALLRDTTRDLLSRSYDPESRNKVIGSELGWSREVWSQLADTGILGLGFDPDESGQIEIMVVLTEIGRRLAP
EPVLHAALGPGALIAELGSAAQKELLDEVAAGQRLLAFAHLEPGQRKPTAEVGTKAARQGDSWTLSGQKNPVLAGDCADT
LVVSAALPDGGTGLFLVDAGAVTRHPYRTFDGQRGAQIDLDATPAEPLGEATDASGGIEAAIIRIQSALCSEALGAMEES
LRLTTDYLKTRKQFGVTLNKFQALTQRAADMYVSLELARSMSLYAAMSIADGNIDPVIASRAKLQIGRSGRHIAQESIQM
HGGIGVTAEYPISHYAARLTAIEHTLGTSGEHLHNLIDHLGDYDLVRL

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI226958412, Length=366, Percent_Identity=25.4098360655738, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI226958414, Length=330, Percent_Identity=24.8484848484848, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI4501857, Length=356, Percent_Identity=24.1573033707865, Blast_Score=83, Evalue=4e-16,
Organism=Homo sapiens, GI4557233, Length=373, Percent_Identity=28.4182305630027, Blast_Score=82, Evalue=8e-16,
Organism=Homo sapiens, GI7656849, Length=287, Percent_Identity=28.9198606271777, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI4503943, Length=379, Percent_Identity=25.065963060686, Blast_Score=73, Evalue=5e-13,
Organism=Homo sapiens, GI7669494, Length=365, Percent_Identity=24.6575342465753, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI4501859, Length=383, Percent_Identity=23.4986945169713, Blast_Score=68, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17538396, Length=353, Percent_Identity=24.929178470255, Blast_Score=87, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17570075, Length=353, Percent_Identity=24.6458923512748, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17569725, Length=264, Percent_Identity=27.6515151515151, Blast_Score=65, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI17534899, Length=250, Percent_Identity=28, Blast_Score=64, Evalue=1e-10,
Organism=Drosophila melanogaster, GI21355753, Length=351, Percent_Identity=25.3561253561254, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI21356377, Length=369, Percent_Identity=25.7452574525745, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24666513, Length=359, Percent_Identity=23.9554317548747, Blast_Score=67, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24660351, Length=262, Percent_Identity=25.1908396946565, Blast_Score=66, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24646207, Length=365, Percent_Identity=25.2054794520548, Blast_Score=65, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.- [C]

Molecular weight: Translated: 39359; Mature: 39359

Theoretical pI: Translated: 4.78; Mature: 4.78

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDFQLSDEQALLRDTTRDLLSRSYDPESRNKVIGSELGWSREVWSQLADTGILGLGFDPD
CCCCCCCHHHHHHHHHHHHHHCCCCCCHHCCHHCHHCCCCHHHHHHHHHCCEEECCCCCC
ESGQIEIMVVLTEIGRRLAPEPVLHAALGPGALIAELGSAAQKELLDEVAAGQRLLAFAH
CCCCEEEEEEHHHHHHHCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEE
LEPGQRKPTAEVGTKAARQGDSWTLSGQKNPVLAGDCADTLVVSAALPDGGTGLFLVDAG
CCCCCCCCCHHHHHHHHHCCCCEEECCCCCCEEECCCHHHHEEEEECCCCCCEEEEEECC
AVTRHPYRTFDGQRGAQIDLDATPAEPLGEATDASGGIEAAIIRIQSALCSEALGAMEES
CCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
LRLTTDYLKTRKQFGVTLNKFQALTQRAADMYVSLELARSMSLYAAMSIADGNIDPVIAS
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCHHHHC
RAKLQIGRSGRHIAQESIQMHGGIGVTAEYPISHYAARLTAIEHTLGTSGEHLHNLIDHL
CHHEEECCCCHHHHHHHHHHCCCCCCEECCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
GDYDLVRL
CCCCCCCC
>Mature Secondary Structure
MDFQLSDEQALLRDTTRDLLSRSYDPESRNKVIGSELGWSREVWSQLADTGILGLGFDPD
CCCCCCCHHHHHHHHHHHHHHCCCCCCHHCCHHCHHCCCCHHHHHHHHHCCEEECCCCCC
ESGQIEIMVVLTEIGRRLAPEPVLHAALGPGALIAELGSAAQKELLDEVAAGQRLLAFAH
CCCCEEEEEEHHHHHHHCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEE
LEPGQRKPTAEVGTKAARQGDSWTLSGQKNPVLAGDCADTLVVSAALPDGGTGLFLVDAG
CCCCCCCCCHHHHHHHHHCCCCEEECCCCCCEEECCCHHHHEEEEECCCCCCEEEEEECC
AVTRHPYRTFDGQRGAQIDLDATPAEPLGEATDASGGIEAAIIRIQSALCSEALGAMEES
CCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
LRLTTDYLKTRKQFGVTLNKFQALTQRAADMYVSLELARSMSLYAAMSIADGNIDPVIAS
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCHHHHC
RAKLQIGRSGRHIAQESIQMHGGIGVTAEYPISHYAARLTAIEHTLGTSGEHLHNLIDHL
CHHEEECCCCHHHHHHHHHHCCCCCCEECCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
GDYDLVRL
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: crotono-betaine; reduced acceptor; crotonobetainyl-CoA [C]

Specific reaction: reduced acceptor + crotono-betaine = Acceptor + gamma-butyrobetaine reduced acceptor + crotonobetainyl-CoA = Acceptor + gamma-butyrobetainyl-CoA [C]

General reaction: Oxidoreductases; Acting on the CH-CH group of donors; With other acceptors [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]