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The map label for this gene is cysH_2

Identifier: 41408307

GI number: 41408307

Start: 2456558

End: 2457301

Strand: Direct

Name: cysH_2

Synonym: MAP2209

Alternate gene names: 41408307

Gene position: 2456558-2457301 (Clockwise)

Preceding gene: 41408306

Following gene: 41408313

Centisome position: 50.86

GC content: 67.61

Gene sequence:

>744_bases
ATGACCGAACGAACGACCAAACTTCCAGAGGCCGAACTGCGTGAACTAGCCGCCCGCGGCGCCGCCGAGCTCGAAGGCGC
CAGCGCCAGCGACGTGTTGCGTTGGACCGACGAGACATTCGGCGGCGTCAACGGGCCACGCGGATGGGCCACCTGCAACT
ACGTGGTGGCCTCGAGCATGCAGGAAGCGGTGTTGATCGACCTGGCCGCCAAGGTCCGCCCCGGTGTGCCGGTGGTCTTC
CTGGACACCGGCTACCACTTCGCCGAGACCATCGGGACCCGGGATGCGATCGAATCCGTCTACGACATCCGGGTGCTCAA
CGTCACTCCCGAGCACAGCGTCGCCGAGCAGGACAAACTGCTGGGCAAGGACCTGTTCGCGCGCGACCCCGGCGAATGCT
GCCGGCTGCGCAAGGTCGCCCCGCTGGGCAAGACGCTGCGCGGATACTCGGCCTGGGTGACCGGCCTGCGCCGCTCGGAG
GCCGCGACACGGGCCAACGCGCCGGTGATCGGCTTCGACGAGGGCTTCAAGCTGGTCAAGGTCAACCCCATGGCCACCTG
GACCGACGAGGACGTGCAGAACTACATCGACGAGCACAACGTGCTGGTCAATCCGCTTATCTACGAAGGCTATTCGTCGA
TCGGCTGCGCCCCCTGCACGGCCAAGCCGCTGGCCGGCGCCGACCCGCGCAGCGGGCGCTGGCAGGGCCTGGCCAAGACG
GAATGCGGGCTGCACGCCTCGTAA

Upstream 100 bases:

>100_bases
GCGACTACATCGAGCGGGTGGCACGCAACTTCGTGAAATATCGCGGCGAAGGTGAACGTTTCGCCCAGTGGGCCATGAGG
GCAGACGAGGACGATTTGCG

Downstream 100 bases:

>100_bases
AGCCTTCGGCGCCAACCTGTTTGGCTGTCGCGCTGAAGAGCGTTCCTTACGCCGACGTCAGGGTGGCCTCGTCGGCGCCG
TCGCGGGAGAGCGCGGGCAC

Product: phosphoadenosine phosphosulfate reductase

Products: NA

Alternate protein names: 3'-phosphoadenylylsulfate reductase; PAPS reductase, thioredoxin dependent; PAPS sulfotransferase; PAdoPS reductase [H]

Number of amino acids: Translated: 247; Mature: 246

Protein sequence:

>247_residues
MTERTTKLPEAELRELAARGAAELEGASASDVLRWTDETFGGVNGPRGWATCNYVVASSMQEAVLIDLAAKVRPGVPVVF
LDTGYHFAETIGTRDAIESVYDIRVLNVTPEHSVAEQDKLLGKDLFARDPGECCRLRKVAPLGKTLRGYSAWVTGLRRSE
AATRANAPVIGFDEGFKLVKVNPMATWTDEDVQNYIDEHNVLVNPLIYEGYSSIGCAPCTAKPLAGADPRSGRWQGLAKT
ECGLHAS

Sequences:

>Translated_247_residues
MTERTTKLPEAELRELAARGAAELEGASASDVLRWTDETFGGVNGPRGWATCNYVVASSMQEAVLIDLAAKVRPGVPVVF
LDTGYHFAETIGTRDAIESVYDIRVLNVTPEHSVAEQDKLLGKDLFARDPGECCRLRKVAPLGKTLRGYSAWVTGLRRSE
AATRANAPVIGFDEGFKLVKVNPMATWTDEDVQNYIDEHNVLVNPLIYEGYSSIGCAPCTAKPLAGADPRSGRWQGLAKT
ECGLHAS
>Mature_246_residues
TERTTKLPEAELRELAARGAAELEGASASDVLRWTDETFGGVNGPRGWATCNYVVASSMQEAVLIDLAAKVRPGVPVVFL
DTGYHFAETIGTRDAIESVYDIRVLNVTPEHSVAEQDKLLGKDLFARDPGECCRLRKVAPLGKTLRGYSAWVTGLRRSEA
ATRANAPVIGFDEGFKLVKVNPMATWTDEDVQNYIDEHNVLVNPLIYEGYSSIGCAPCTAKPLAGADPRSGRWQGLAKTE
CGLHAS

Specific function: Reduction of activated sulfate into sulfite [H]

COG id: COG0175

COG function: function code EH; 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PAPS reductase family. CysH subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789121, Length=246, Percent_Identity=31.3008130081301, Blast_Score=103, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6325425, Length=195, Percent_Identity=35.3846153846154, Blast_Score=108, Evalue=9e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011798
- InterPro:   IPR004511
- InterPro:   IPR002500
- InterPro:   IPR014729 [H]

Pfam domain/function: PF01507 PAPS_reduct [H]

EC number: =1.8.4.8 [H]

Molecular weight: Translated: 26781; Mature: 26650

Theoretical pI: Translated: 5.18; Mature: 5.18

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTERTTKLPEAELRELAARGAAELEGASASDVLRWTDETFGGVNGPRGWATCNYVVASSM
CCCCCCCCCHHHHHHHHHCCCHHCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHH
QEAVLIDLAAKVRPGVPVVFLDTGYHFAETIGTRDAIESVYDIRVLNVTPEHSVAEQDKL
HHHHHHHHHHHCCCCCCEEEEECCCHHHHHHCCHHHHHHHHEEEEEEECCCCHHHHHHHH
LGKDLFARDPGECCRLRKVAPLGKTLRGYSAWVTGLRRSEAATRANAPVIGFDEGFKLVK
HHHHHHCCCHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCEEEEE
VNPMATWTDEDVQNYIDEHNVLVNPLIYEGYSSIGCAPCTAKPLAGADPRSGRWQGLAKT
ECCCCCCCHHHHHHHHHHCCEEECHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
ECGLHAS
CCCCCCC
>Mature Secondary Structure 
TERTTKLPEAELRELAARGAAELEGASASDVLRWTDETFGGVNGPRGWATCNYVVASSM
CCCCCCCCHHHHHHHHHCCCHHCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHH
QEAVLIDLAAKVRPGVPVVFLDTGYHFAETIGTRDAIESVYDIRVLNVTPEHSVAEQDKL
HHHHHHHHHHHCCCCCCEEEEECCCHHHHHHCCHHHHHHHHEEEEEEECCCCHHHHHHHH
LGKDLFARDPGECCRLRKVAPLGKTLRGYSAWVTGLRRSEAATRANAPVIGFDEGFKLVK
HHHHHHCCCHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCEEEEE
VNPMATWTDEDVQNYIDEHNVLVNPLIYEGYSSIGCAPCTAKPLAGADPRSGRWQGLAKT
ECCCCCCCHHHHHHHHHHCCEEECHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
ECGLHAS
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]