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The map label for this gene is fadK [H]

Identifier: 41408286

GI number: 41408286

Start: 2429625

End: 2431169

Strand: Reverse

Name: fadK [H]

Synonym: MAP2188c

Alternate gene names: 41408286

Gene position: 2431169-2429625 (Counterclockwise)

Preceding gene: 41408300

Following gene: 41408285

Centisome position: 50.34

GC content: 68.03

Gene sequence:

>1545_bases
GTGACCGGTATCCGTGTCGTCGCGCCCGAGTTGGCGCGCCGCTACGAGGAGCAGGGCTGGTGGACCCCGGACACGCTCGG
GGATCTGCTGGCCCGCGGCCTCAAAGACAACCAGCACAACACGTTTCGCGTGCACTCCGCGGTGCGGCCATTCGCGGGCA
CGTTCGGCGATGTCGAGCTGCTGGCCCGCAGGCTCGCGGCAGGGCTGCGCGCCCGGGGCGTCGGCCCGGGTGACGTGGTC
GCCTTCCAGCTACCGAACTGGGTGGAAGCGGCGGTCACCTTCTGGGCCTCGGCACTCCTTTCCGCGGTGGTCGTGCCGAT
CGTCCACTTCTACGGGCCGAAGGAATTGCGCTACATCCTGTCGAGCGTCAGGCCGCGGGTCTTCATCACCGCCGAGGGAT
TCGGGCGCATGACCTACGTGCCGGAGGTCTGTGCGGGCGTACCGACCGTCGCGCTGGTGGGCGAGAGCTTTGACGCGCTG
CTCGAGGACGAACCGATGGACGCCACGGTGGCGACCGATCCCGCCAACCCGGCGGTGATCGCGTTCACGTCGGGCACCAC
CAGCGACCCCAAGGGCGTGATCCACAGCCATCAGACACTGGGCTTCGAAACGCGCCAGCTGTTGGCGAATTACCCGCAGG
GGCTCGGGCGGCAGCTCACCGCGCTGCCCGTCGGGCATTTCATCGGCATGCTCGGCGCGTTCCTGATGCTGGTTCTCGAC
GGCGCGCCGATCGACCTCACCGATGTCTGGGACCCGGACAAGGCGATCGACCTGATGGACGCCGACGGCGTGGCACTCGG
CGGGGGACCGCCGTACTTCGTCACCAGCCTGCTAGACCACCCCCGCTTCACCCCGGATCACCTGCGCTACATCAAACACA
TCGGACTGGGTGGATCCACCGTCCCGGCGGCGGTCACCCGGCGCCTGGCCGACCTCGGGATCGTCGTCACCCGCTCCTAC
GGCAGCTCCGAGCATCCGTCGATCACCGGTTCGCAGCACACCGCACCGGAGGCCAAGCGGCTGTTCACCGACGGCAAGGC
GCGCGCGGGCGTCGAGGTGCGGTTGGCCGACGACGGCGAAATACTTTCGCGCGGACCGGATCTGTTCGTCGGCTACACCG
ATCCCGTGTTGACAGCCCGAGCGTTCGACGAGGACGGCTGGTATCACACCGGCGACATCGGGGTGATGGATGACGACGGC
TACCTGACCATCACCGACCGCAAGTCCGACATCATCATCCGCGGCGGCGAGAACATCAGCGCCCTGGAAGTCGAGGAAGT
TCTGCTCGCCATGCCGGCGGTCGCCGAGGCGGTCGTGGTTTCCGCGCCCGATGCGCGGCTCGGCGAGCACGCCGCGGCCG
TGCTGCGTCTTAAGCCCGGGTATGGCATGCCGACCATGGCCGAGGTCCGCGAGCACTTCGAGCGCGCCGGGGTGGCCAAG
CAGAAGTGGCCCGAGGAGCTGCACGAAGTGGCCGACTTTCCCCGCACCGCCAGCGGCAAGGTGCAGAAATACGTTGTGCG
CCAGAGTATTCGGGAGAAAGCGTAG

Upstream 100 bases:

>100_bases
CGAGCAGAACGATACATCCGCATTACGAGAACTTCAATACTGTTCAACACGAGAGTATCGTTCTACGCTGGCCACGGCTG
AAGCCCACCGGAGGAGCAAT

Downstream 100 bases:

>100_bases
CGGTCGGCGGGCGGGTCAGCGGCTCGACCGGCCGAAAATTGAGAGTTGAACTTCTGGTCAAAATAGAATACGGTTCTACC
GTTACCTGGTATTTAGGAGT

Product: hypothetical protein

Products: NA

Alternate protein names: Acyl-CoA synthetase [H]

Number of amino acids: Translated: 514; Mature: 513

Protein sequence:

>514_residues
MTGIRVVAPELARRYEEQGWWTPDTLGDLLARGLKDNQHNTFRVHSAVRPFAGTFGDVELLARRLAAGLRARGVGPGDVV
AFQLPNWVEAAVTFWASALLSAVVVPIVHFYGPKELRYILSSVRPRVFITAEGFGRMTYVPEVCAGVPTVALVGESFDAL
LEDEPMDATVATDPANPAVIAFTSGTTSDPKGVIHSHQTLGFETRQLLANYPQGLGRQLTALPVGHFIGMLGAFLMLVLD
GAPIDLTDVWDPDKAIDLMDADGVALGGGPPYFVTSLLDHPRFTPDHLRYIKHIGLGGSTVPAAVTRRLADLGIVVTRSY
GSSEHPSITGSQHTAPEAKRLFTDGKARAGVEVRLADDGEILSRGPDLFVGYTDPVLTARAFDEDGWYHTGDIGVMDDDG
YLTITDRKSDIIIRGGENISALEVEEVLLAMPAVAEAVVVSAPDARLGEHAAAVLRLKPGYGMPTMAEVREHFERAGVAK
QKWPEELHEVADFPRTASGKVQKYVVRQSIREKA

Sequences:

>Translated_514_residues
MTGIRVVAPELARRYEEQGWWTPDTLGDLLARGLKDNQHNTFRVHSAVRPFAGTFGDVELLARRLAAGLRARGVGPGDVV
AFQLPNWVEAAVTFWASALLSAVVVPIVHFYGPKELRYILSSVRPRVFITAEGFGRMTYVPEVCAGVPTVALVGESFDAL
LEDEPMDATVATDPANPAVIAFTSGTTSDPKGVIHSHQTLGFETRQLLANYPQGLGRQLTALPVGHFIGMLGAFLMLVLD
GAPIDLTDVWDPDKAIDLMDADGVALGGGPPYFVTSLLDHPRFTPDHLRYIKHIGLGGSTVPAAVTRRLADLGIVVTRSY
GSSEHPSITGSQHTAPEAKRLFTDGKARAGVEVRLADDGEILSRGPDLFVGYTDPVLTARAFDEDGWYHTGDIGVMDDDG
YLTITDRKSDIIIRGGENISALEVEEVLLAMPAVAEAVVVSAPDARLGEHAAAVLRLKPGYGMPTMAEVREHFERAGVAK
QKWPEELHEVADFPRTASGKVQKYVVRQSIREKA
>Mature_513_residues
TGIRVVAPELARRYEEQGWWTPDTLGDLLARGLKDNQHNTFRVHSAVRPFAGTFGDVELLARRLAAGLRARGVGPGDVVA
FQLPNWVEAAVTFWASALLSAVVVPIVHFYGPKELRYILSSVRPRVFITAEGFGRMTYVPEVCAGVPTVALVGESFDALL
EDEPMDATVATDPANPAVIAFTSGTTSDPKGVIHSHQTLGFETRQLLANYPQGLGRQLTALPVGHFIGMLGAFLMLVLDG
APIDLTDVWDPDKAIDLMDADGVALGGGPPYFVTSLLDHPRFTPDHLRYIKHIGLGGSTVPAAVTRRLADLGIVVTRSYG
SSEHPSITGSQHTAPEAKRLFTDGKARAGVEVRLADDGEILSRGPDLFVGYTDPVLTARAFDEDGWYHTGDIGVMDDDGY
LTITDRKSDIIIRGGENISALEVEEVLLAMPAVAEAVVVSAPDARLGEHAAAVLRLKPGYGMPTMAEVREHFERAGVAKQ
KWPEELHEVADFPRTASGKVQKYVVRQSIREKA

Specific function: Catalyzes the esterification, concomitant with transport, of exogenous fatty acids into metabolically active CoA thioesters for subsequent degradation or incorporation into phospholipids. It has a low activity on medium or long chain fatty acids and is ma

COG id: COG0318

COG function: function code IQ; Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II

Gene ontology:

Cell location: Membrane; Peripheral membrane protein. Note=Partially membrane-associated [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI156151445, Length=518, Percent_Identity=27.7992277992278, Blast_Score=166, Evalue=4e-41,
Organism=Homo sapiens, GI187761345, Length=502, Percent_Identity=26.2948207171315, Blast_Score=121, Evalue=1e-27,
Organism=Homo sapiens, GI187761343, Length=502, Percent_Identity=26.2948207171315, Blast_Score=121, Evalue=1e-27,
Organism=Homo sapiens, GI38505220, Length=480, Percent_Identity=27.5, Blast_Score=119, Evalue=6e-27,
Organism=Homo sapiens, GI42544132, Length=495, Percent_Identity=24.6464646464646, Blast_Score=102, Evalue=6e-22,
Organism=Homo sapiens, GI115511026, Length=510, Percent_Identity=25.6862745098039, Blast_Score=102, Evalue=9e-22,
Organism=Homo sapiens, GI58082049, Length=479, Percent_Identity=25.8872651356994, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI157311624, Length=479, Percent_Identity=25.8872651356994, Blast_Score=100, Evalue=5e-21,
Organism=Homo sapiens, GI157311622, Length=479, Percent_Identity=25.8872651356994, Blast_Score=100, Evalue=5e-21,
Organism=Homo sapiens, GI122937307, Length=490, Percent_Identity=25.5102040816327, Blast_Score=98, Evalue=2e-20,
Organism=Homo sapiens, GI27477105, Length=154, Percent_Identity=35.0649350649351, Blast_Score=79, Evalue=7e-15,
Organism=Homo sapiens, GI40807491, Length=84, Percent_Identity=42.8571428571429, Blast_Score=68, Evalue=2e-11,
Organism=Escherichia coli, GI145693145, Length=531, Percent_Identity=33.7099811676083, Blast_Score=266, Evalue=2e-72,
Organism=Escherichia coli, GI1786810, Length=551, Percent_Identity=28.8566243194192, Blast_Score=156, Evalue=3e-39,
Organism=Escherichia coli, GI221142682, Length=487, Percent_Identity=27.1047227926078, Blast_Score=125, Evalue=7e-30,
Organism=Escherichia coli, GI1788107, Length=517, Percent_Identity=25.9187620889749, Blast_Score=113, Evalue=3e-26,
Organism=Escherichia coli, GI1789201, Length=462, Percent_Identity=25.5411255411255, Blast_Score=87, Evalue=3e-18,
Organism=Escherichia coli, GI1788595, Length=284, Percent_Identity=27.4647887323944, Blast_Score=87, Evalue=3e-18,
Organism=Escherichia coli, GI1790505, Length=123, Percent_Identity=34.1463414634146, Blast_Score=63, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI71994703, Length=519, Percent_Identity=27.7456647398844, Blast_Score=160, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI71994694, Length=519, Percent_Identity=27.7456647398844, Blast_Score=160, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI71994690, Length=519, Percent_Identity=27.7456647398844, Blast_Score=159, Evalue=3e-39,
Organism=Caenorhabditis elegans, GI17558820, Length=485, Percent_Identity=28.0412371134021, Blast_Score=155, Evalue=4e-38,
Organism=Caenorhabditis elegans, GI17560308, Length=556, Percent_Identity=26.2589928057554, Blast_Score=143, Evalue=3e-34,
Organism=Caenorhabditis elegans, GI32563687, Length=469, Percent_Identity=25.3731343283582, Blast_Score=139, Evalue=4e-33,
Organism=Caenorhabditis elegans, GI71996755, Length=474, Percent_Identity=24.0506329113924, Blast_Score=103, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI17538037, Length=502, Percent_Identity=24.9003984063745, Blast_Score=101, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17557194, Length=536, Percent_Identity=24.6268656716418, Blast_Score=95, Evalue=9e-20,
Organism=Caenorhabditis elegans, GI17531443, Length=363, Percent_Identity=23.4159779614325, Blast_Score=94, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17559526, Length=480, Percent_Identity=25.8333333333333, Blast_Score=92, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI71985884, Length=354, Percent_Identity=26.5536723163842, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI71983001, Length=559, Percent_Identity=23.613595706619, Blast_Score=68, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI71982997, Length=553, Percent_Identity=23.6889692585895, Blast_Score=67, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6319699, Length=481, Percent_Identity=24.7401247401247, Blast_Score=129, Evalue=2e-30,
Organism=Saccharomyces cerevisiae, GI6319264, Length=517, Percent_Identity=24.1779497098646, Blast_Score=67, Evalue=5e-12,
Organism=Drosophila melanogaster, GI24581924, Length=532, Percent_Identity=25.187969924812, Blast_Score=132, Evalue=4e-31,
Organism=Drosophila melanogaster, GI24648260, Length=522, Percent_Identity=25.8620689655172, Blast_Score=119, Evalue=6e-27,
Organism=Drosophila melanogaster, GI21356947, Length=514, Percent_Identity=24.7081712062257, Blast_Score=115, Evalue=8e-26,
Organism=Drosophila melanogaster, GI18859661, Length=474, Percent_Identity=24.4725738396624, Blast_Score=105, Evalue=7e-23,
Organism=Drosophila melanogaster, GI24653035, Length=343, Percent_Identity=26.8221574344023, Blast_Score=100, Evalue=4e-21,
Organism=Drosophila melanogaster, GI19922652, Length=521, Percent_Identity=24.3761996161228, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI21355181, Length=485, Percent_Identity=23.0927835051546, Blast_Score=96, Evalue=7e-20,
Organism=Drosophila melanogaster, GI24648257, Length=346, Percent_Identity=25.7225433526012, Blast_Score=95, Evalue=1e-19,
Organism=Drosophila melanogaster, GI161076582, Length=359, Percent_Identity=25.3481894150418, Blast_Score=94, Evalue=3e-19,
Organism=Drosophila melanogaster, GI24648253, Length=515, Percent_Identity=23.3009708737864, Blast_Score=86, Evalue=5e-17,
Organism=Drosophila melanogaster, GI20130357, Length=478, Percent_Identity=22.5941422594142, Blast_Score=86, Evalue=6e-17,
Organism=Drosophila melanogaster, GI24648255, Length=515, Percent_Identity=23.495145631068, Blast_Score=85, Evalue=1e-16,
Organism=Drosophila melanogaster, GI21358303, Length=314, Percent_Identity=25.4777070063694, Blast_Score=81, Evalue=2e-15,
Organism=Drosophila melanogaster, GI21356441, Length=346, Percent_Identity=25.4335260115607, Blast_Score=79, Evalue=6e-15,
Organism=Drosophila melanogaster, GI281365686, Length=223, Percent_Identity=28.6995515695067, Blast_Score=77, Evalue=3e-14,
Organism=Drosophila melanogaster, GI19921316, Length=152, Percent_Identity=32.2368421052632, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI17933690, Length=139, Percent_Identity=34.5323741007194, Blast_Score=73, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: NA

Molecular weight: Translated: 55569; Mature: 55438

Theoretical pI: Translated: 5.33; Mature: 5.33

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTGIRVVAPELARRYEEQGWWTPDTLGDLLARGLKDNQHNTFRVHSAVRPFAGTFGDVEL
CCCCEEECHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCEEEEHHHHCHHCCCCCCHHH
LARRLAAGLRARGVGPGDVVAFQLPNWVEAAVTFWASALLSAVVVPIVHFYGPKELRYIL
HHHHHHHHHHHCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
SSVRPRVFITAEGFGRMTYVPEVCAGVPTVALVGESFDALLEDEPMDATVATDPANPAVI
HHCCCEEEEEECCCCCEEECHHHHCCCCEEEEECCCHHHHHCCCCCCCEEEECCCCCEEE
AFTSGTTSDPKGVIHSHQTLGFETRQLLANYPQGLGRQLTALPVGHFIGMLGAFLMLVLD
EEECCCCCCCCCHHCCCHHCCHHHHHHHHHCCHHHCCEEHHHHHHHHHHHHHHHHHHHHC
GAPIDLTDVWDPDKAIDLMDADGVALGGGPPYFVTSLLDHPRFTPDHLRYIKHIGLGGST
CCCCCCCCCCCCCCCEEEECCCCEEECCCCHHHHHHHHCCCCCCHHHHHHHHHHCCCCCH
VPAAVTRRLADLGIVVTRSYGSSEHPSITGSQHTAPEAKRLFTDGKARAGVEVRLADDGE
HHHHHHHHHHHCCEEEEECCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCCEEEEECCCCH
ILSRGPDLFVGYTDPVLTARAFDEDGWYHTGDIGVMDDDGYLTITDRKSDIIIRGGENIS
HHHCCCCEEEECCCCHHEEEEECCCCCEECCCEEEEECCCEEEEECCCCCEEEECCCCCC
ALEVEEVLLAMPAVAEAVVVSAPDARLGEHAAAVLRLKPGYGMPTMAEVREHFERAGVAK
HHHHHHHHHHHHHHHHEEEEECCCCHHCCHHEEEEEECCCCCCCCHHHHHHHHHHCCCCH
QKWPEELHEVADFPRTASGKVQKYVVRQSIREKA
HCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TGIRVVAPELARRYEEQGWWTPDTLGDLLARGLKDNQHNTFRVHSAVRPFAGTFGDVEL
CCCEEECHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCEEEEHHHHCHHCCCCCCHHH
LARRLAAGLRARGVGPGDVVAFQLPNWVEAAVTFWASALLSAVVVPIVHFYGPKELRYIL
HHHHHHHHHHHCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
SSVRPRVFITAEGFGRMTYVPEVCAGVPTVALVGESFDALLEDEPMDATVATDPANPAVI
HHCCCEEEEEECCCCCEEECHHHHCCCCEEEEECCCHHHHHCCCCCCCEEEECCCCCEEE
AFTSGTTSDPKGVIHSHQTLGFETRQLLANYPQGLGRQLTALPVGHFIGMLGAFLMLVLD
EEECCCCCCCCCHHCCCHHCCHHHHHHHHHCCHHHCCEEHHHHHHHHHHHHHHHHHHHHC
GAPIDLTDVWDPDKAIDLMDADGVALGGGPPYFVTSLLDHPRFTPDHLRYIKHIGLGGST
CCCCCCCCCCCCCCCEEEECCCCEEECCCCHHHHHHHHCCCCCCHHHHHHHHHHCCCCCH
VPAAVTRRLADLGIVVTRSYGSSEHPSITGSQHTAPEAKRLFTDGKARAGVEVRLADDGE
HHHHHHHHHHHCCEEEEECCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCCEEEEECCCCH
ILSRGPDLFVGYTDPVLTARAFDEDGWYHTGDIGVMDDDGYLTITDRKSDIIIRGGENIS
HHHCCCCEEEECCCCHHEEEEECCCCCEECCCEEEEECCCEEEEECCCCCEEEECCCCCC
ALEVEEVLLAMPAVAEAVVVSAPDARLGEHAAAVLRLKPGYGMPTMAEVREHFERAGVAK
HHHHHHHHHHHHHHHHEEEEECCCCHHCCHHEEEEEECCCCCCCCHHHHHHHHHHCCCCH
QKWPEELHEVADFPRTASGKVQKYVVRQSIREKA
HCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9097039; 9278503; 7984428; 12535077 [H]