BacMap

Definition	Mycobacterium avium subsp. paratuberculosis K-10, complete genome.
Accession	NC_002944
Length	4,829,781

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The map label for this gene is dhaS [H]

Identifier: 41408285

GI number: 41408285

Start: 2428504

End: 2429586

Strand: Reverse

Name: dhaS [H]

Synonym: MAP2187c

Alternate gene names: 41408285

Gene position: 2429586-2428504 (Counterclockwise)

Preceding gene: 41408286

Following gene: 41408284

Centisome position: 50.3

GC content: 66.85

Gene sequence:

>1083_bases
TTGAGAGTTGAACTTCTGGTCAAAATAGAATACGGTTCTACCGTTACCTGGTATTTAGGAGTTGTCGTGACGATCGTCGC
GGAACAACGCACGTATGTCGCGGGCCGTTGGGTCACCGGTGACGAAGTGGTCAGCGTCGAAAATCCCGCCGACGAGAGTC
ACGTCGCCGACATCACCGTCACTCCGTTGCCCGAGGTGCAGCGCGCGATCGCCGAGGCGCGCCGCAGCTTCGACGACGGG
GTGTGGGCCGACATGCCGCCCGTCGAGCGGGCGCAAATACTGCACGCCTTTATCGACCACATCGAGTCCGAGCGCGCCAC
ACTGGTTCCCACCCTCGTCGCCGAGGCCGGCCAATCGGCGCGCTTCGCCGAGATGACGCAGCTGGGTGCCGGGGCGGCCA
TCGCGCGCCAGACGATCGACCTGTACCTGTCGATGTCGCACGAGGAAGCCAGCCCGGTTCCGGTCGATGACCTGGTGCGT
GGCCGGGTCGCGCTGAGCGTGCGGCGGCACGAACCCGTCGGCGTCGTCACCGCCATCACGCCGTACAACGCGGCGCTGAT
CATGGGCTTTCAGAAGCTGATTCCCGCGTTGATGGCGGGCAATTCGGTGATCTTGCGGCCCAGCCCGCTGACCCCGATCT
CGTCGCTGATCTTCGGCGCGGCCGCCGACGCGGCCGGCCTGCCGCCGGGAGTCCTGAGCGTCGTCGTCGAGTCGGGCATC
GCCGGGGCCGAGTTGCTCACCAGCGATCCGAGCGTGGACATGGTGTCGTTCACGGGCTCGACGCTGGCGGGGCGCAAAAT
CCTGGCCCAGGCGGCGCCGACCGTCAAACGGGTGTCGCTGGAACTCGGCGGAAAGTCGGCGCAGATCTACCTGCCCGATG
CGGTGCACCGCGCCGTCGGCGGCGCCTTCGTCGCGGTCGCCAGCACCGCCGGACAGGCCTGCGTAGCGGCCACCAGATTG
CTTGTGCCACAAGACAAGAAAGCCGAAGTGCTGGACGCGGTCAGCGCGATGTACCAGCAGATCAAGGTCGGGCCGCCCAG
CGACGAAACGGCGATGATGGGCCCGGTCATCAGCGCGGCCTAG

Upstream 100 bases:

>100_bases
GCACCGCCAGCGGCAAGGTGCAGAAATACGTTGTGCGCCAGAGTATTCGGGAGAAAGCGTAGCGGTCGGCGGGCGGGTCA
GCGGCTCGACCGGCCGAAAA

Downstream 100 bases:

>100_bases
CGCGACAAATGCGAGCAGTACGTGAAGTTGGCCGAAGAACACGGCGGCAAGGTGTTCTGCGGTGGCGGACGCCCGGCGGG
TCTTGACCGCGGCTACTACT

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 360; Mature: 360

Protein sequence:

>360_residues
MRVELLVKIEYGSTVTWYLGVVVTIVAEQRTYVAGRWVTGDEVVSVENPADESHVADITVTPLPEVQRAIAEARRSFDDG
VWADMPPVERAQILHAFIDHIESERATLVPTLVAEAGQSARFAEMTQLGAGAAIARQTIDLYLSMSHEEASPVPVDDLVR
GRVALSVRRHEPVGVVTAITPYNAALIMGFQKLIPALMAGNSVILRPSPLTPISSLIFGAAADAAGLPPGVLSVVVESGI
AGAELLTSDPSVDMVSFTGSTLAGRKILAQAAPTVKRVSLELGGKSAQIYLPDAVHRAVGGAFVAVASTAGQACVAATRL
LVPQDKKAEVLDAVSAMYQQIKVGPPSDETAMMGPVISAA

Sequences:

>Translated_360_residues
MRVELLVKIEYGSTVTWYLGVVVTIVAEQRTYVAGRWVTGDEVVSVENPADESHVADITVTPLPEVQRAIAEARRSFDDG
VWADMPPVERAQILHAFIDHIESERATLVPTLVAEAGQSARFAEMTQLGAGAAIARQTIDLYLSMSHEEASPVPVDDLVR
GRVALSVRRHEPVGVVTAITPYNAALIMGFQKLIPALMAGNSVILRPSPLTPISSLIFGAAADAAGLPPGVLSVVVESGI
AGAELLTSDPSVDMVSFTGSTLAGRKILAQAAPTVKRVSLELGGKSAQIYLPDAVHRAVGGAFVAVASTAGQACVAATRL
LVPQDKKAEVLDAVSAMYQQIKVGPPSDETAMMGPVISAA
>Mature_360_residues
MRVELLVKIEYGSTVTWYLGVVVTIVAEQRTYVAGRWVTGDEVVSVENPADESHVADITVTPLPEVQRAIAEARRSFDDG
VWADMPPVERAQILHAFIDHIESERATLVPTLVAEAGQSARFAEMTQLGAGAAIARQTIDLYLSMSHEEASPVPVDDLVR
GRVALSVRRHEPVGVVTAITPYNAALIMGFQKLIPALMAGNSVILRPSPLTPISSLIFGAAADAAGLPPGVLSVVVESGI
AGAELLTSDPSVDMVSFTGSTLAGRKILAQAAPTVKRVSLELGGKSAQIYLPDAVHRAVGGAFVAVASTAGQACVAATRL
LVPQDKKAEVLDAVSAMYQQIKVGPPSDETAMMGPVISAA

Specific function: Weak But Measurable Aldh Enzyme Activity That Prefers Nadp Over NAD As Coenzyme. [C]

COG id: COG1012

COG function: function code C; NAD-dependent aldehyde dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aldehyde dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI153266822, Length=337, Percent_Identity=30.8605341246291, Blast_Score=157, Evalue=1e-38,
Organism=Homo sapiens, GI25777724, Length=335, Percent_Identity=31.6417910447761, Blast_Score=150, Evalue=1e-36,
Organism=Homo sapiens, GI238814322, Length=331, Percent_Identity=29.607250755287, Blast_Score=150, Evalue=2e-36,
Organism=Homo sapiens, GI21614513, Length=337, Percent_Identity=30.5637982195846, Blast_Score=147, Evalue=1e-35,
Organism=Homo sapiens, GI115387104, Length=316, Percent_Identity=31.9620253164557, Blast_Score=144, Evalue=2e-34,
Organism=Homo sapiens, GI21361176, Length=335, Percent_Identity=30.7462686567164, Blast_Score=142, Evalue=4e-34,
Organism=Homo sapiens, GI25777732, Length=315, Percent_Identity=31.4285714285714, Blast_Score=138, Evalue=6e-33,
Organism=Homo sapiens, GI12007648, Length=340, Percent_Identity=29.4117647058824, Blast_Score=138, Evalue=9e-33,
Organism=Homo sapiens, GI25777730, Length=316, Percent_Identity=31.6455696202532, Blast_Score=137, Evalue=1e-32,
Organism=Homo sapiens, GI25777728, Length=277, Percent_Identity=33.2129963898917, Blast_Score=131, Evalue=1e-30,
Organism=Homo sapiens, GI4507229, Length=336, Percent_Identity=30.3571428571429, Blast_Score=125, Evalue=7e-29,
Organism=Homo sapiens, GI25952152, Length=273, Percent_Identity=30.7692307692308, Blast_Score=117, Evalue=1e-26,
Organism=Homo sapiens, GI25777721, Length=349, Percent_Identity=29.2263610315186, Blast_Score=116, Evalue=3e-26,
Organism=Homo sapiens, GI25777726, Length=335, Percent_Identity=27.4626865671642, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI188035924, Length=342, Percent_Identity=27.1929824561404, Blast_Score=107, Evalue=1e-23,
Organism=Homo sapiens, GI310128103, Length=342, Percent_Identity=27.1929824561404, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI310128093, Length=342, Percent_Identity=26.9005847953216, Blast_Score=106, Evalue=4e-23,
Organism=Homo sapiens, GI11095441, Length=364, Percent_Identity=24.7252747252747, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI310128091, Length=338, Percent_Identity=25.7396449704142, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI310128087, Length=308, Percent_Identity=26.6233766233766, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI25777736, Length=348, Percent_Identity=26.7241379310345, Blast_Score=76, Evalue=5e-14,
Organism=Homo sapiens, GI25777734, Length=348, Percent_Identity=26.7241379310345, Blast_Score=76, Evalue=5e-14,
Organism=Homo sapiens, GI238859541, Length=198, Percent_Identity=30.3030303030303, Blast_Score=76, Evalue=5e-14,
Organism=Homo sapiens, GI310128089, Length=129, Percent_Identity=34.1085271317829, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI310128095, Length=167, Percent_Identity=29.940119760479, Blast_Score=73, Evalue=4e-13,
Organism=Homo sapiens, GI310128097, Length=112, Percent_Identity=36.6071428571429, Blast_Score=73, Evalue=4e-13,
Organism=Homo sapiens, GI206597441, Length=308, Percent_Identity=26.6233766233766, Blast_Score=72, Evalue=7e-13,
Organism=Homo sapiens, GI206597439, Length=308, Percent_Identity=26.6233766233766, Blast_Score=72, Evalue=7e-13,
Organism=Homo sapiens, GI22907049, Length=308, Percent_Identity=26.6233766233766, Blast_Score=72, Evalue=7e-13,
Organism=Homo sapiens, GI301500698, Length=129, Percent_Identity=32.5581395348837, Blast_Score=69, Evalue=5e-12,
Organism=Escherichia coli, GI1787558, Length=351, Percent_Identity=31.3390313390313, Blast_Score=155, Evalue=4e-39,
Organism=Escherichia coli, GI87081896, Length=332, Percent_Identity=32.2289156626506, Blast_Score=150, Evalue=8e-38,
Organism=Escherichia coli, GI1787684, Length=333, Percent_Identity=30.6306306306306, Blast_Score=145, Evalue=5e-36,
Organism=Escherichia coli, GI1786504, Length=337, Percent_Identity=29.673590504451, Blast_Score=141, Evalue=7e-35,
Organism=Escherichia coli, GI1789015, Length=339, Percent_Identity=32.7433628318584, Blast_Score=139, Evalue=4e-34,
Organism=Escherichia coli, GI1787715, Length=196, Percent_Identity=37.2448979591837, Blast_Score=123, Evalue=2e-29,
Organism=Escherichia coli, GI87082295, Length=354, Percent_Identity=28.2485875706215, Blast_Score=118, Evalue=5e-28,
Organism=Escherichia coli, GI1788042, Length=336, Percent_Identity=30.0595238095238, Blast_Score=112, Evalue=5e-26,
Organism=Escherichia coli, GI1787250, Length=331, Percent_Identity=30.2114803625378, Blast_Score=95, Evalue=9e-21,
Organism=Escherichia coli, GI87081926, Length=192, Percent_Identity=30.2083333333333, Blast_Score=75, Evalue=7e-15,
Organism=Escherichia coli, GI1787653, Length=294, Percent_Identity=26.8707482993197, Blast_Score=69, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI133930964, Length=330, Percent_Identity=30.3030303030303, Blast_Score=155, Evalue=3e-38,
Organism=Caenorhabditis elegans, GI17562198, Length=313, Percent_Identity=31.629392971246, Blast_Score=135, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI25144435, Length=322, Percent_Identity=30.4347826086957, Blast_Score=132, Evalue=4e-31,
Organism=Caenorhabditis elegans, GI17534119, Length=344, Percent_Identity=31.6860465116279, Blast_Score=123, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI32564736, Length=284, Percent_Identity=30.9859154929577, Blast_Score=122, Evalue=3e-28,
Organism=Caenorhabditis elegans, GI25143874, Length=302, Percent_Identity=32.1192052980132, Blast_Score=121, Evalue=7e-28,
Organism=Caenorhabditis elegans, GI25143876, Length=302, Percent_Identity=32.1192052980132, Blast_Score=120, Evalue=9e-28,
Organism=Caenorhabditis elegans, GI115534176, Length=335, Percent_Identity=28.3582089552239, Blast_Score=114, Evalue=8e-26,
Organism=Caenorhabditis elegans, GI17551164, Length=183, Percent_Identity=33.879781420765, Blast_Score=109, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI71995606, Length=286, Percent_Identity=32.5174825174825, Blast_Score=107, Evalue=9e-24,
Organism=Caenorhabditis elegans, GI71995613, Length=282, Percent_Identity=31.9148936170213, Blast_Score=107, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI32564151, Length=334, Percent_Identity=27.2455089820359, Blast_Score=97, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17534447, Length=334, Percent_Identity=27.2455089820359, Blast_Score=97, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI71990744, Length=321, Percent_Identity=27.4143302180685, Blast_Score=95, Evalue=7e-20,
Organism=Caenorhabditis elegans, GI115532534, Length=256, Percent_Identity=28.125, Blast_Score=90, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI71986308, Length=337, Percent_Identity=24.3323442136499, Blast_Score=87, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI25146391, Length=278, Percent_Identity=25.8992805755396, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI25146394, Length=278, Percent_Identity=25.8992805755396, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI32566756, Length=278, Percent_Identity=25.8992805755396, Blast_Score=70, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6324950, Length=320, Percent_Identity=31.875, Blast_Score=168, Evalue=1e-42,
Organism=Saccharomyces cerevisiae, GI6320917, Length=326, Percent_Identity=31.2883435582822, Blast_Score=156, Evalue=5e-39,
Organism=Saccharomyces cerevisiae, GI6325196, Length=322, Percent_Identity=30.4347826086957, Blast_Score=149, Evalue=5e-37,
Organism=Saccharomyces cerevisiae, GI6323822, Length=327, Percent_Identity=30.2752293577982, Blast_Score=125, Evalue=1e-29,
Organism=Saccharomyces cerevisiae, GI6323821, Length=327, Percent_Identity=30.2752293577982, Blast_Score=122, Evalue=8e-29,
Organism=Saccharomyces cerevisiae, GI6319478, Length=339, Percent_Identity=28.9085545722714, Blast_Score=115, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6321826, Length=300, Percent_Identity=25, Blast_Score=75, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6323757, Length=180, Percent_Identity=30, Blast_Score=67, Evalue=4e-12,
Organism=Drosophila melanogaster, GI20129399, Length=314, Percent_Identity=31.2101910828025, Blast_Score=135, Evalue=5e-32,
Organism=Drosophila melanogaster, GI24585660, Length=330, Percent_Identity=27.8787878787879, Blast_Score=132, Evalue=3e-31,
Organism=Drosophila melanogaster, GI24650465, Length=315, Percent_Identity=30.4761904761905, Blast_Score=128, Evalue=5e-30,
Organism=Drosophila melanogaster, GI281362580, Length=341, Percent_Identity=26.9794721407625, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI62472918, Length=341, Percent_Identity=26.9794721407625, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI62472926, Length=341, Percent_Identity=26.9794721407625, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI62472936, Length=341, Percent_Identity=26.9794721407625, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI21356737, Length=341, Percent_Identity=26.9794721407625, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI24638878, Length=341, Percent_Identity=25.2199413489736, Blast_Score=88, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24638876, Length=341, Percent_Identity=25.2199413489736, Blast_Score=88, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24666674, Length=338, Percent_Identity=25.1479289940828, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24668425, Length=199, Percent_Identity=26.6331658291457, Blast_Score=76, Evalue=4e-14,
Organism=Drosophila melanogaster, GI24668417, Length=199, Percent_Identity=26.6331658291457, Blast_Score=76, Evalue=4e-14,
Organism=Drosophila melanogaster, GI24668413, Length=199, Percent_Identity=26.6331658291457, Blast_Score=76, Evalue=4e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016161
- InterPro:   IPR016163
- InterPro:   IPR016160
- InterPro:   IPR016162
- InterPro:   IPR015590 [H]

Pfam domain/function: PF00171 Aldedh [H]

EC number: =1.2.1.3 [H]

Molecular weight: Translated: 37746; Mature: 37746

Theoretical pI: Translated: 4.83; Mature: 4.83

Prosite motif: PS00687 ALDEHYDE_DEHYDR_GLU ; PS00070 ALDEHYDE_DEHYDR_CYS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVELLVKIEYGSTVTWYLGVVVTIVAEQRTYVAGRWVTGDEVVSVENPADESHVADITV
CCEEEEEEEECCCCHHHHHHHHHHHHHCCCEEEEEEEECCCEEEEECCCCCCCCEEEEEE
TPLPEVQRAIAEARRSFDDGVWADMPPVERAQILHAFIDHIESERATLVPTLVAEAGQSA
CCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCC
RFAEMTQLGAGAAIARQTIDLYLSMSHEEASPVPVDDLVRGRVALSVRRHEPVGVVTAIT
HHHHHHHHCCCHHHHHHHEEEEEEECCCCCCCCCHHHHHCCCEEEEEECCCCCEEEEEEC
PYNAALIMGFQKLIPALMAGNSVILRPSPLTPISSLIFGAAADAAGLPPGVLSVVVESGI
CCCHHHHHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHCCC
AGAELLTSDPSVDMVSFTGSTLAGRKILAQAAPTVKRVSLELGGKSAQIYLPDAVHRAVG
CCCHHCCCCCCCEEEEECCCCHHHHHHHHHHCCCCEEEEEEECCCEEEEECCHHHHHHHC
GAFVAVASTAGQACVAATRLLVPQDKKAEVLDAVSAMYQQIKVGPPSDETAMMGPVISAA
CCEEEEECCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHCCHHCCC
>Mature Secondary Structure
MRVELLVKIEYGSTVTWYLGVVVTIVAEQRTYVAGRWVTGDEVVSVENPADESHVADITV
CCEEEEEEEECCCCHHHHHHHHHHHHHCCCEEEEEEEECCCEEEEECCCCCCCCEEEEEE
TPLPEVQRAIAEARRSFDDGVWADMPPVERAQILHAFIDHIESERATLVPTLVAEAGQSA
CCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCC
RFAEMTQLGAGAAIARQTIDLYLSMSHEEASPVPVDDLVRGRVALSVRRHEPVGVVTAIT
HHHHHHHHCCCHHHHHHHEEEEEEECCCCCCCCCHHHHHCCCEEEEEECCCCCEEEEEEC
PYNAALIMGFQKLIPALMAGNSVILRPSPLTPISSLIFGAAADAAGLPPGVLSVVVESGI
CCCHHHHHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHCCC
AGAELLTSDPSVDMVSFTGSTLAGRKILAQAAPTVKRVSLELGGKSAQIYLPDAVHRAVG
CCCHHCCCCCCCEEEEECCCCHHHHHHHHHHCCCCEEEEEEECCCEEEEECCHHHHHHHC
GAFVAVASTAGQACVAATRLLVPQDKKAEVLDAVSAMYQQIKVGPPSDETAMMGPVISAA
CCEEEEECCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]