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The map label for this gene is furB

Identifier: 41408237

GI number: 41408237

Start: 2369630

End: 2370037

Strand: Direct

Name: furB

Synonym: MAP2139

Alternate gene names: 41408237

Gene position: 2369630-2370037 (Clockwise)

Preceding gene: 41408236

Following gene: 41408241

Centisome position: 49.06

GC content: 67.89

Gene sequence:

>408_bases
ATGACGCCGTCCGGCGACGGGGCAGGAGTGAGTGTCCGCTCCACCCGGCAGCGCGCCGCGATCTCCACTCTGCTGGAGAC
CCTCGACGACTTCCGCTCCGCCCAGGAGTTGCACGACGAGCTGCGCCGCCGTGGCGAGAACATCGGGCTGACCACCGTCT
ACCGCACGCTGCAGTCGATGGCCGCCGCGGGCCTGATCGACACGCTGCGCACCGACACCGGCGAGTCGGTGTACCGCCGA
TGTTCCGAGCATCATCACCACCACCTGGTGTGCCGCAGTTGCGGGTCCACCATCGAGGTGGGCGATCACGAGGTCGAGGA
GTGGGCCACCGCGGTGGCCGCCAAGCACGGTTTCTCCGACGTCAGCCACACCATCGAAATCTTCGGCACCTGCTCGGAGT
GCCGGTAA

Upstream 100 bases:

>100_bases
GGGAGCGGTCCGGACGCGAGGTGCTCTACCGGCTCGCCGATCATCACCTCGCGCACATCGTGGTCGACGCCGTCGCCCAC
GCCGGCGAAGAGCCGCGCCC

Downstream 100 bases:

>100_bases
ACCGCGCCGAACGTGAAGCTAGTTTCACGTTCGCGGTCGAGCGTGAAACTAGCTTCACGCTCGGCAGGCGGGGAAGGACT
CAATCGGTCAGGGTGTGACG

Product: FurB

Products: NA

Alternate protein names: Ferric uptake regulator [H]

Number of amino acids: Translated: 135; Mature: 134

Protein sequence:

>135_residues
MTPSGDGAGVSVRSTRQRAAISTLLETLDDFRSAQELHDELRRRGENIGLTTVYRTLQSMAAAGLIDTLRTDTGESVYRR
CSEHHHHHLVCRSCGSTIEVGDHEVEEWATAVAAKHGFSDVSHTIEIFGTCSECR

Sequences:

>Translated_135_residues
MTPSGDGAGVSVRSTRQRAAISTLLETLDDFRSAQELHDELRRRGENIGLTTVYRTLQSMAAAGLIDTLRTDTGESVYRR
CSEHHHHHLVCRSCGSTIEVGDHEVEEWATAVAAKHGFSDVSHTIEIFGTCSECR
>Mature_134_residues
TPSGDGAGVSVRSTRQRAAISTLLETLDDFRSAQELHDELRRRGENIGLTTVYRTLQSMAAAGLIDTLRTDTGESVYRRC
SEHHHHHLVCRSCGSTIEVGDHEVEEWATAVAAKHGFSDVSHTIEIFGTCSECR

Specific function: Acts as a global negative controlling element, employing Fe(2+) as a cofactor to bind the operator of the repressed genes. Regulates the expression of several outer-membrane proteins including the iron transport operon [H]

COG id: COG0735

COG function: function code P; Fe2+/Zn2+ uptake regulation proteins

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Fur family [H]

Homologues:

Organism=Escherichia coli, GI1786899, Length=131, Percent_Identity=38.1679389312977, Blast_Score=88, Evalue=2e-19,

Paralogues:

None

Copy number: 3432 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002481
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01475 FUR [H]

EC number: NA

Molecular weight: Translated: 14869; Mature: 14737

Theoretical pI: Translated: 6.22; Mature: 6.22

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.7 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
3.7 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPSGDGAGVSVRSTRQRAAISTLLETLDDFRSAQELHDELRRRGENIGLTTVYRTLQSM
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
AAAGLIDTLRTDTGESVYRRCSEHHHHHLVCRSCGSTIEVGDHEVEEWATAVAAKHGFSD
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCHHH
VSHTIEIFGTCSECR
HHHHHHHHHHHHCCC
>Mature Secondary Structure 
TPSGDGAGVSVRSTRQRAAISTLLETLDDFRSAQELHDELRRRGENIGLTTVYRTLQSM
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
AAAGLIDTLRTDTGESVYRRCSEHHHHHLVCRSCGSTIEVGDHEVEEWATAVAAKHGFSD
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCHHH
VSHTIEIFGTCSECR
HHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9055816 [H]