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The map label for this gene is fadA_2

Identifier: 41407812

GI number: 41407812

Start: 1872259

End: 1873470

Strand: Direct

Name: fadA_2

Synonym: MAP1714

Alternate gene names: 41407812

Gene position: 1872259-1873470 (Clockwise)

Preceding gene: 41407811

Following gene: 41407813

Centisome position: 38.76

GC content: 67.82

Gene sequence:

>1212_bases
TTGACTGAGGCATACATTTACGAGGGAATCCGCACCCCGCGGGGCAAGGGCAGAGCCAGCGGTGCGCTGCATTCCGTGAA
GCCGATCTCGTTGGTGGTCGGGCTGATCGACGAGCTGCGCCGCCGCTTTCCGGACCTCGACGAGGACCGCATCTCCGACG
TCGTGCTCGGCGTCGTCACCCCGGTGGGCGATCAGGGCATGGACATCGCGCGCACGGCGGTCACCGTGGCCGGGCTGCCC
GACACCGTGGACGGGGTGCAGCTCAACCGGTTCTGCGGGTCGGGCCTGGACGCGGTCAACGTCGCGGCGAAGGCGGTGCG
CTCGGGTTTCGACGAGTTGGTGATCGCCGGTGGGGTGGAGTCGATGTCGCGGGTCGAGATGGGCAGCGACCGTGGGGCGA
TGGCTTACGACGCGGCGACCGCCTACGACAACTACTTCATCCCGCAGGGGGTGGCCGCCGACCTGCTGGCCACCATCGAG
GGGTACACCCGCGAGGACGTCGACGCCTACGCGGTGCGTTCGCAGCGGCGCGCCGCCGAGGCGTGGTCGGGCGGCTACTT
CGCGAAATCGGTTGTGCCGGTGCGGGATATCAACGGGTTGACCATCCTGGATCACGACGAGCACATGCGGCCGGACGGCA
CGGTGGAGGACCTGGCCAAGTTGACGCCCGCGTTCGCGGGCATCGGCGAATTCGGTGGCTTCGACGCCGTCGCGATGCAG
CGCTACCACTGGGTCGAAGCGATCAACCACGTGCACACCGGCGGCAACAGCTCGGGCATTGTGGACGGCGCCTCGCTGGT
GCTGGTCGGTAGCGAGCAGGCCGGCGCGGCATCCGGTCTGACCCCGCGGGCGCGCATCGTGTCCGCGGCCACCAGCGGCG
CCGACCCGGTGCTGATGTTCGGCGGCCCAATCCCGGCCGTGCGCAAAGCACTTGACCTTGCCGGCCTGACCATCGACGAC
ATCGACCTGTTCGAGATGAACGAGGCCTTCGCGGCCATCGCCATCAAGATCCAACAGTATTTCGGCATCCCGGACCAGAA
GTACAACGTCAACGGCGGTGCTATCGCGATGGGTCATCCCCTCGGCGCCACCGGCGCCATGTTGTTGGGCACCGTTTTCG
ACGAGCTGGAGCGGCGGGGTGGACGCTACGGCCTGATCACGCTGTGCGTCGCCGGCGGCATGGGCGTGGCGACCATCATC
GAAAGGGTTTGA

Upstream 100 bases:

>100_bases
ATCGCCAACATGTACACCGCGTCGCGGGTCAACCGGATCTATGGCGGTACCAGCGAAATCATGAAGGAAATCATCAGCCG
CTCGCTGTAAGGACGTTGAA

Downstream 100 bases:

>100_bases
GTTCAATTGAGTGACAGCATTATTGGCTGGGACAAGGACGCCGACGGGATCGTCACGCTGACGATCGACGACCCCGACAA
CAGCGCCAACATGCTCACCG

Product: acetyl-CoA acetyltransferase

Products: CoA; 3-oxoacyl-CoA

Alternate protein names: NA

Number of amino acids: Translated: 403; Mature: 402

Protein sequence:

>403_residues
MTEAYIYEGIRTPRGKGRASGALHSVKPISLVVGLIDELRRRFPDLDEDRISDVVLGVVTPVGDQGMDIARTAVTVAGLP
DTVDGVQLNRFCGSGLDAVNVAAKAVRSGFDELVIAGGVESMSRVEMGSDRGAMAYDAATAYDNYFIPQGVAADLLATIE
GYTREDVDAYAVRSQRRAAEAWSGGYFAKSVVPVRDINGLTILDHDEHMRPDGTVEDLAKLTPAFAGIGEFGGFDAVAMQ
RYHWVEAINHVHTGGNSSGIVDGASLVLVGSEQAGAASGLTPRARIVSAATSGADPVLMFGGPIPAVRKALDLAGLTIDD
IDLFEMNEAFAAIAIKIQQYFGIPDQKYNVNGGAIAMGHPLGATGAMLLGTVFDELERRGGRYGLITLCVAGGMGVATII
ERV

Sequences:

>Translated_403_residues
MTEAYIYEGIRTPRGKGRASGALHSVKPISLVVGLIDELRRRFPDLDEDRISDVVLGVVTPVGDQGMDIARTAVTVAGLP
DTVDGVQLNRFCGSGLDAVNVAAKAVRSGFDELVIAGGVESMSRVEMGSDRGAMAYDAATAYDNYFIPQGVAADLLATIE
GYTREDVDAYAVRSQRRAAEAWSGGYFAKSVVPVRDINGLTILDHDEHMRPDGTVEDLAKLTPAFAGIGEFGGFDAVAMQ
RYHWVEAINHVHTGGNSSGIVDGASLVLVGSEQAGAASGLTPRARIVSAATSGADPVLMFGGPIPAVRKALDLAGLTIDD
IDLFEMNEAFAAIAIKIQQYFGIPDQKYNVNGGAIAMGHPLGATGAMLLGTVFDELERRGGRYGLITLCVAGGMGVATII
ERV
>Mature_402_residues
TEAYIYEGIRTPRGKGRASGALHSVKPISLVVGLIDELRRRFPDLDEDRISDVVLGVVTPVGDQGMDIARTAVTVAGLPD
TVDGVQLNRFCGSGLDAVNVAAKAVRSGFDELVIAGGVESMSRVEMGSDRGAMAYDAATAYDNYFIPQGVAADLLATIEG
YTREDVDAYAVRSQRRAAEAWSGGYFAKSVVPVRDINGLTILDHDEHMRPDGTVEDLAKLTPAFAGIGEFGGFDAVAMQR
YHWVEAINHVHTGGNSSGIVDGASLVLVGSEQAGAASGLTPRARIVSAATSGADPVLMFGGPIPAVRKALDLAGLTIDDI
DLFEMNEAFAAIAIKIQQYFGIPDQKYNVNGGAIAMGHPLGATGAMLLGTVFDELERRGGRYGLITLCVAGGMGVATIIE
RV

Specific function: Thiolytic Cleavage Of Beta-Ketoadipyl-CoA To Succinate And Acetyl-CoA (By Similarity). [C]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI148539872, Length=401, Percent_Identity=35.9102244389027, Blast_Score=213, Evalue=2e-55,
Organism=Homo sapiens, GI167614485, Length=367, Percent_Identity=34.6049046321526, Blast_Score=213, Evalue=3e-55,
Organism=Homo sapiens, GI4501853, Length=367, Percent_Identity=36.5122615803815, Blast_Score=197, Evalue=2e-50,
Organism=Homo sapiens, GI4557237, Length=373, Percent_Identity=29.4906166219839, Blast_Score=157, Evalue=2e-38,
Organism=Homo sapiens, GI4504327, Length=380, Percent_Identity=30.5263157894737, Blast_Score=140, Evalue=3e-33,
Organism=Homo sapiens, GI194353979, Length=99, Percent_Identity=47.4747474747475, Blast_Score=97, Evalue=2e-20,
Organism=Escherichia coli, GI1787663, Length=424, Percent_Identity=43.6320754716981, Blast_Score=311, Evalue=5e-86,
Organism=Escherichia coli, GI48994986, Length=412, Percent_Identity=38.1067961165049, Blast_Score=249, Evalue=2e-67,
Organism=Escherichia coli, GI87082165, Length=419, Percent_Identity=37.4701670644391, Blast_Score=226, Evalue=2e-60,
Organism=Escherichia coli, GI1788554, Length=420, Percent_Identity=37.6190476190476, Blast_Score=223, Evalue=2e-59,
Organism=Escherichia coli, GI1788683, Length=442, Percent_Identity=30.5429864253394, Blast_Score=141, Evalue=7e-35,
Organism=Caenorhabditis elegans, GI133906874, Length=378, Percent_Identity=35.978835978836, Blast_Score=213, Evalue=2e-55,
Organism=Caenorhabditis elegans, GI25147385, Length=415, Percent_Identity=29.8795180722892, Blast_Score=156, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI17535921, Length=416, Percent_Identity=29.3269230769231, Blast_Score=154, Evalue=8e-38,
Organism=Caenorhabditis elegans, GI17551802, Length=417, Percent_Identity=28.537170263789, Blast_Score=126, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI17535917, Length=416, Percent_Identity=26.6826923076923, Blast_Score=94, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6322031, Length=397, Percent_Identity=33.2493702770781, Blast_Score=178, Evalue=1e-45,
Organism=Saccharomyces cerevisiae, GI6325229, Length=415, Percent_Identity=28.433734939759, Blast_Score=141, Evalue=2e-34,
Organism=Drosophila melanogaster, GI24655093, Length=418, Percent_Identity=39.4736842105263, Blast_Score=244, Evalue=9e-65,
Organism=Drosophila melanogaster, GI17648125, Length=374, Percent_Identity=33.4224598930481, Blast_Score=191, Evalue=9e-49,
Organism=Drosophila melanogaster, GI24640423, Length=365, Percent_Identity=30.1369863013699, Blast_Score=155, Evalue=5e-38,
Organism=Drosophila melanogaster, GI17137578, Length=448, Percent_Identity=29.0178571428571, Blast_Score=136, Evalue=2e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: 2.3.1.16

Molecular weight: Translated: 42362; Mature: 42230

Theoretical pI: Translated: 4.60; Mature: 4.60

Prosite motif: PS00098 THIOLASE_1 ; PS00737 THIOLASE_2 ; PS00099 THIOLASE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEAYIYEGIRTPRGKGRASGALHSVKPISLVVGLIDELRRRFPDLDEDRISDVVLGVVT
CCCCEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCC
PVGDQGMDIARTAVTVAGLPDTVDGVQLNRFCGSGLDAVNVAAKAVRSGFDELVIAGGVE
CCCCCCCHHHHHHEEECCCCCCCCCEEHHHHHCCCCHHHHHHHHHHHCCHHHEEEECCHH
SMSRVEMGSDRGAMAYDAATAYDNYFIPQGVAADLLATIEGYTREDVDAYAVRSQRRAAE
HHHHHHCCCCCCCEEEHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHH
AWSGGYFAKSVVPVRDINGLTILDHDEHMRPDGTVEDLAKLTPAFAGIGEFGGFDAVAMQ
HHCCCCHHHCCCCEECCCCCEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHH
RYHWVEAINHVHTGGNSSGIVDGASLVLVGSEQAGAASGLTPRARIVSAATSGADPVLMF
HHHHHHHHHHHCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCHHHHEEHHCCCCCEEEEE
GGPIPAVRKALDLAGLTIDDIDLFEMNEAFAAIAIKIQQYFGIPDQKYNVNGGAIAMGHP
CCCCHHHHHHHHHCCCEECCCCHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCEEEECCC
LGATGAMLLGTVFDELERRGGRYGLITLCVAGGMGVATIIERV
CCCHHHHHHHHHHHHHHHCCCCEEEEEEEHHCCCHHHHHHHCC
>Mature Secondary Structure 
TEAYIYEGIRTPRGKGRASGALHSVKPISLVVGLIDELRRRFPDLDEDRISDVVLGVVT
CCCEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCC
PVGDQGMDIARTAVTVAGLPDTVDGVQLNRFCGSGLDAVNVAAKAVRSGFDELVIAGGVE
CCCCCCCHHHHHHEEECCCCCCCCCEEHHHHHCCCCHHHHHHHHHHHCCHHHEEEECCHH
SMSRVEMGSDRGAMAYDAATAYDNYFIPQGVAADLLATIEGYTREDVDAYAVRSQRRAAE
HHHHHHCCCCCCCEEEHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHH
AWSGGYFAKSVVPVRDINGLTILDHDEHMRPDGTVEDLAKLTPAFAGIGEFGGFDAVAMQ
HHCCCCHHHCCCCEECCCCCEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHH
RYHWVEAINHVHTGGNSSGIVDGASLVLVGSEQAGAASGLTPRARIVSAATSGADPVLMF
HHHHHHHHHHHCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCHHHHEEHHCCCCCEEEEE
GGPIPAVRKALDLAGLTIDDIDLFEMNEAFAAIAIKIQQYFGIPDQKYNVNGGAIAMGHP
CCCCHHHHHHHHHCCCEECCCCHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCEEEECCC
LGATGAMLLGTVFDELERRGGRYGLITLCVAGGMGVATIIERV
CCCHHHHHHHHHHHHHHHCCCCEEEEEEEHHCCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: acyl-CoA; acetyl-CoA

Specific reaction: acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230 [H]