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The map label for this gene is fadB_2

Identifier: 41407813

GI number: 41407813

Start: 1873477

End: 1875609

Strand: Direct

Name: fadB_2

Synonym: MAP1715

Alternate gene names: 41407813

Gene position: 1873477-1875609 (Clockwise)

Preceding gene: 41407812

Following gene: 41407814

Centisome position: 38.79

GC content: 65.78

Gene sequence:

>2133_bases
TTGAGTGACAGCATTATTGGCTGGGACAAGGACGCCGACGGGATCGTCACGCTGACGATCGACGACCCCGACAACAGCGC
CAACATGCTCACCGATGCCTACGTCGAGCAGATGGGCGCGATGATCGACCGGCTCGAGGCCGAGGTCGACGAGACCACCG
GTGTGGTGATCACCTCGGGTAAGTCCACGTTTTTCGCCGGCGCCGATCTGACCCAGATCCGCAGCGCCGGACCCGAGCAC
GCGCAGCAACTGTTCGACGGCTCCACGGCGATCAAACGTGATCTGCGTCGGCTGGAGACGCTGGGCAAACCGGTCGTCGC
CGCGATCAACGGCGCCGCGTTGGGCGGCGGGCTGGAGCTGGCGCTGGCCACCCATCACCGCATCGCGGCCAACGTGGCGG
GCAGCGTGATCGGTCTGCCCGAAGTGATGCTGGGTGTGCTACCCGGCGCCGGCGGCGTGGCGCGCAGCGTGCGGCTGCTC
GGCATCCAAAACGCGCTGATGCAGGTGTTGTTGACCGGCAACCGATTCAAGCCCGCCAAGGCCCAACAGGTCGGCCTCGT
CGACGAACTGGTCGAGTCCGTCGACGAATTGGTGCCGGCCGCCAAGGCGTGGATCCTGGCCAACCCGGGCAAGCATGTGC
AGCCGTGGGACGTTCCGGGTTTCGAGATTCCCGGGGGCAGCCCGTCCACACCGGCGTTTGCGGCCAACCTGCCGGCGTTC
CCGGCCAACTTGCGCAAGCAGCTCAAGGGCTCGCCGATGCCGGCGCCGCGAGCAATCATGGCGGCCGCACTCGAAGGGGC
CCAGGTCGACTTCGACACCGCCCAGCTCATCGAGACGCGCTACTTCGTCAACCTGGTCACCGGCCCGATCGCCAAGAACA
TGATTCAGGCGTTCTTCTTCGATCTGCAGGCCGTGCAGAGCGGGACGTCGCGCCCCGCCGATGCGCCCGAGCGCACAATC
CACAAGGTCGGCATCCTGGGCGCGGGCATGATGGGCGCCGGGATCGCATATGTCACAGCGAAAGCCGGCATCGACGTCGT
CCTCAAAGACGTCACGCTGCAGGCGGCCCGCAAGGGCAAGGCGTATTCGGAAAACCTCGAGCAGAAGGCATTGGCGAAAG
GCCGTACCACCGAGGCGAAGTCGCGGGCGCTGCTGGACCGCATCACCCCGACCGCCGACGCCGCCGACTTCACCGGCGTG
GATTTCGTGATCGAGGCGGTGTTCGAAAACACCGAGCTGAAGAACAAGGTGTTCGCCGAGATCGAGAACATCGTCGAACC
CGGCGCCGTGCTGGGCTCCAACACCTCGTCGCTGCCGATCACCGAGCTGGCCGCCGGGGTGAGTCGCCCGGAGAACTTCG
TCGGCATCCACTTCTTCTCACCGGTGGAAAAGATGGACCCGATCGAGATCATCCGCGGCGCAAAGACATCCGACGAGACC
CTGGCCCGGGTCATCGACTACACGCTGGCCATCAACAAGTACCCCATCGTGGTCAACGACGGCCGCGGGTTCTTCACCAC
CCGGGTGTTCTCCACCTACCTGCTCGAGGCCTTCAACATGCTCGCCGAAGGCATCGACCCGGCCACCATCGAACAGGCGG
CGCTTCAGGCCGGCTACCCGGCCGGGCCGCTGCAAGTGGCCGACGAGCTCAGCTTCGGCACCATCCGCAAGATCATGGAT
GAGACGGTGCAGGCGGCCAAGGCCGACGGCGTGGCGCTCGACGAGTCGGTGCGCGTGGCCGCCGAGGTGGTCACCACGCT
GATGGACACGTTCGACCGCACCGGCAAAAGGGGCGGCGCGGGTTTCTACGACTACGTCGACGGCACCCGCGCCGGGTTGT
GGGACGATCTGCGAAAGGCATTCAACACCACACGCGCACTGTCGGTTCCGTTCGACGACCTGCAGGACCGCTACCTGTTC
ATCCAGGCGATCGAAACGCAAAAGGCTTACGACGACGGCGTCATCAGCTCCGACCCGGACGCCAACATCGGCTCGATCTT
CAGCATCGGCTACCCGCCGTGGACCGGCGGAGTGCGCCAGTTCGTCACCGGCTATCCGGGCGGGATCGATGCGTTCCGCC
GGCGCGCCGATGAACTCGCCGCAAGGTATGGAGGGCGATTCCGATGGATCTGA

Upstream 100 bases:

>100_bases
CGACGAGCTGGAGCGGCGGGGTGGACGCTACGGCCTGATCACGCTGTGCGTCGCCGGCGGCATGGGCGTGGCGACCATCA
TCGAAAGGGTTTGAGTTCAA

Downstream 100 bases:

>100_bases
CAGACAAGGTCGTCGCGATCACCGGCGGCGCACGCGGCATCGGGCTGGCGACGGCGAAAGCGTTCCTGGCAGCCGGCGCA
AAGGTCGCCCTCGGTGACCT

Product: FadB_2

Products: NA

Alternate protein names: Enoyl-CoA hydratase/3-hydroxybutyryl-CoA epimerase; 3-hydroxyacyl-CoA dehydrogenase [H]

Number of amino acids: Translated: 710; Mature: 709

Protein sequence:

>710_residues
MSDSIIGWDKDADGIVTLTIDDPDNSANMLTDAYVEQMGAMIDRLEAEVDETTGVVITSGKSTFFAGADLTQIRSAGPEH
AQQLFDGSTAIKRDLRRLETLGKPVVAAINGAALGGGLELALATHHRIAANVAGSVIGLPEVMLGVLPGAGGVARSVRLL
GIQNALMQVLLTGNRFKPAKAQQVGLVDELVESVDELVPAAKAWILANPGKHVQPWDVPGFEIPGGSPSTPAFAANLPAF
PANLRKQLKGSPMPAPRAIMAAALEGAQVDFDTAQLIETRYFVNLVTGPIAKNMIQAFFFDLQAVQSGTSRPADAPERTI
HKVGILGAGMMGAGIAYVTAKAGIDVVLKDVTLQAARKGKAYSENLEQKALAKGRTTEAKSRALLDRITPTADAADFTGV
DFVIEAVFENTELKNKVFAEIENIVEPGAVLGSNTSSLPITELAAGVSRPENFVGIHFFSPVEKMDPIEIIRGAKTSDET
LARVIDYTLAINKYPIVVNDGRGFFTTRVFSTYLLEAFNMLAEGIDPATIEQAALQAGYPAGPLQVADELSFGTIRKIMD
ETVQAAKADGVALDESVRVAAEVVTTLMDTFDRTGKRGGAGFYDYVDGTRAGLWDDLRKAFNTTRALSVPFDDLQDRYLF
IQAIETQKAYDDGVISSDPDANIGSIFSIGYPPWTGGVRQFVTGYPGGIDAFRRRADELAARYGGRFRWI

Sequences:

>Translated_710_residues
MSDSIIGWDKDADGIVTLTIDDPDNSANMLTDAYVEQMGAMIDRLEAEVDETTGVVITSGKSTFFAGADLTQIRSAGPEH
AQQLFDGSTAIKRDLRRLETLGKPVVAAINGAALGGGLELALATHHRIAANVAGSVIGLPEVMLGVLPGAGGVARSVRLL
GIQNALMQVLLTGNRFKPAKAQQVGLVDELVESVDELVPAAKAWILANPGKHVQPWDVPGFEIPGGSPSTPAFAANLPAF
PANLRKQLKGSPMPAPRAIMAAALEGAQVDFDTAQLIETRYFVNLVTGPIAKNMIQAFFFDLQAVQSGTSRPADAPERTI
HKVGILGAGMMGAGIAYVTAKAGIDVVLKDVTLQAARKGKAYSENLEQKALAKGRTTEAKSRALLDRITPTADAADFTGV
DFVIEAVFENTELKNKVFAEIENIVEPGAVLGSNTSSLPITELAAGVSRPENFVGIHFFSPVEKMDPIEIIRGAKTSDET
LARVIDYTLAINKYPIVVNDGRGFFTTRVFSTYLLEAFNMLAEGIDPATIEQAALQAGYPAGPLQVADELSFGTIRKIMD
ETVQAAKADGVALDESVRVAAEVVTTLMDTFDRTGKRGGAGFYDYVDGTRAGLWDDLRKAFNTTRALSVPFDDLQDRYLF
IQAIETQKAYDDGVISSDPDANIGSIFSIGYPPWTGGVRQFVTGYPGGIDAFRRRADELAARYGGRFRWI
>Mature_709_residues
SDSIIGWDKDADGIVTLTIDDPDNSANMLTDAYVEQMGAMIDRLEAEVDETTGVVITSGKSTFFAGADLTQIRSAGPEHA
QQLFDGSTAIKRDLRRLETLGKPVVAAINGAALGGGLELALATHHRIAANVAGSVIGLPEVMLGVLPGAGGVARSVRLLG
IQNALMQVLLTGNRFKPAKAQQVGLVDELVESVDELVPAAKAWILANPGKHVQPWDVPGFEIPGGSPSTPAFAANLPAFP
ANLRKQLKGSPMPAPRAIMAAALEGAQVDFDTAQLIETRYFVNLVTGPIAKNMIQAFFFDLQAVQSGTSRPADAPERTIH
KVGILGAGMMGAGIAYVTAKAGIDVVLKDVTLQAARKGKAYSENLEQKALAKGRTTEAKSRALLDRITPTADAADFTGVD
FVIEAVFENTELKNKVFAEIENIVEPGAVLGSNTSSLPITELAAGVSRPENFVGIHFFSPVEKMDPIEIIRGAKTSDETL
ARVIDYTLAINKYPIVVNDGRGFFTTRVFSTYLLEAFNMLAEGIDPATIEQAALQAGYPAGPLQVADELSFGTIRKIMDE
TVQAAKADGVALDESVRVAAEVVTTLMDTFDRTGKRGGAGFYDYVDGTRAGLWDDLRKAFNTTRALSVPFDDLQDRYLFI
QAIETQKAYDDGVISSDPDANIGSIFSIGYPPWTGGVRQFVTGYPGGIDAFRRRADELAARYGGRFRWI

Specific function: Catalyzes the formation of an hydroxyacyl-CoA by addition of water on enoyl-CoA. Also exhibits 3-hydroxyacyl-CoA epimerase and 3-hydroxyacyl-CoA dehydrogenase activities [H]

COG id: COG1250

COG function: function code I; 3-hydroxyacyl-CoA dehydrogenase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: In the central section; belongs to the 3-hydroxyacyl- CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI20127408, Length=726, Percent_Identity=30.7162534435262, Blast_Score=323, Evalue=3e-88,
Organism=Homo sapiens, GI68989263, Length=658, Percent_Identity=29.6352583586626, Blast_Score=212, Evalue=1e-54,
Organism=Homo sapiens, GI261878539, Length=590, Percent_Identity=28.9830508474576, Blast_Score=195, Evalue=1e-49,
Organism=Homo sapiens, GI296179429, Length=300, Percent_Identity=32.3333333333333, Blast_Score=144, Evalue=4e-34,
Organism=Homo sapiens, GI296179427, Length=317, Percent_Identity=30.5993690851735, Blast_Score=136, Evalue=7e-32,
Organism=Homo sapiens, GI194097323, Length=199, Percent_Identity=30.1507537688442, Blast_Score=84, Evalue=3e-16,
Organism=Homo sapiens, GI115430219, Length=208, Percent_Identity=26.9230769230769, Blast_Score=73, Evalue=1e-12,
Organism=Homo sapiens, GI157694516, Length=200, Percent_Identity=29, Blast_Score=70, Evalue=6e-12,
Organism=Homo sapiens, GI213417737, Length=200, Percent_Identity=29, Blast_Score=70, Evalue=7e-12,
Organism=Escherichia coli, GI1788682, Length=703, Percent_Identity=35.2773826458037, Blast_Score=307, Evalue=2e-84,
Organism=Escherichia coli, GI1790281, Length=691, Percent_Identity=32.9956584659913, Blast_Score=286, Evalue=3e-78,
Organism=Escherichia coli, GI1787661, Length=292, Percent_Identity=30.1369863013699, Blast_Score=147, Evalue=3e-36,
Organism=Escherichia coli, GI1787659, Length=195, Percent_Identity=34.8717948717949, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI221142681, Length=183, Percent_Identity=31.1475409836066, Blast_Score=68, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17508953, Length=725, Percent_Identity=32.4137931034483, Blast_Score=308, Evalue=5e-84,
Organism=Caenorhabditis elegans, GI17508951, Length=725, Percent_Identity=32.4137931034483, Blast_Score=308, Evalue=8e-84,
Organism=Caenorhabditis elegans, GI17558304, Length=710, Percent_Identity=30.9859154929577, Blast_Score=306, Evalue=2e-83,
Organism=Caenorhabditis elegans, GI25144276, Length=625, Percent_Identity=33.28, Blast_Score=279, Evalue=4e-75,
Organism=Caenorhabditis elegans, GI17549919, Length=296, Percent_Identity=32.4324324324324, Blast_Score=155, Evalue=8e-38,
Organism=Caenorhabditis elegans, GI17553560, Length=300, Percent_Identity=34.6666666666667, Blast_Score=154, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI71985930, Length=410, Percent_Identity=26.0975609756098, Blast_Score=150, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI71985923, Length=379, Percent_Identity=27.7044854881267, Blast_Score=149, Evalue=7e-36,
Organism=Caenorhabditis elegans, GI17563036, Length=327, Percent_Identity=30.5810397553517, Blast_Score=114, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI17540714, Length=183, Percent_Identity=34.4262295081967, Blast_Score=91, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI25145438, Length=191, Percent_Identity=32.4607329842932, Blast_Score=74, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17554946, Length=168, Percent_Identity=35.1190476190476, Blast_Score=74, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24583077, Length=726, Percent_Identity=32.2314049586777, Blast_Score=295, Evalue=1e-79,
Organism=Drosophila melanogaster, GI24583079, Length=726, Percent_Identity=32.2314049586777, Blast_Score=295, Evalue=1e-79,
Organism=Drosophila melanogaster, GI19921000, Length=726, Percent_Identity=32.2314049586777, Blast_Score=294, Evalue=1e-79,
Organism=Drosophila melanogaster, GI20129971, Length=185, Percent_Identity=31.8918918918919, Blast_Score=81, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24653477, Length=185, Percent_Identity=31.8918918918919, Blast_Score=81, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24653139, Length=189, Percent_Identity=32.8042328042328, Blast_Score=80, Evalue=4e-15,
Organism=Drosophila melanogaster, GI45549573, Length=211, Percent_Identity=26.0663507109005, Blast_Score=68, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24650670, Length=185, Percent_Identity=30.8108108108108, Blast_Score=67, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006180
- InterPro:   IPR006176
- InterPro:   IPR006108
- InterPro:   IPR008927
- InterPro:   IPR001753
- InterPro:   IPR013328
- InterPro:   IPR012802
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00725 3HCDH; PF02737 3HCDH_N; PF00378 ECH [H]

EC number: =4.2.1.17; =5.1.2.3; =1.1.1.35 [H]

Molecular weight: Translated: 75859; Mature: 75728

Theoretical pI: Translated: 4.68; Mature: 4.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDSIIGWDKDADGIVTLTIDDPDNSANMLTDAYVEQMGAMIDRLEAEVDETTGVVITSG
CCCCCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECC
KSTFFAGADLTQIRSAGPEHAQQLFDGSTAIKRDLRRLETLGKPVVAAINGAALGGGLEL
CCEEEECCCHHHHHCCCHHHHHHHHCCHHHHHHHHHHHHHHCCCCEEHCCCCCCCCCEEE
ALATHHRIAANVAGSVIGLPEVMLGVLPGAGGVARSVRLLGIQNALMQVLLTGNRFKPAK
EEHHHHHHHHHHCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCH
AQQVGLVDELVESVDELVPAAKAWILANPGKHVQPWDVPGFEIPGGSPSTPAFAANLPAF
HHHHCHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCCCCCEECCCCCCCCCCEECCCCCC
PANLRKQLKGSPMPAPRAIMAAALEGAQVDFDTAQLIETRYFVNLVTGPIAKNMIQAFFF
CHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DLQAVQSGTSRPADAPERTIHKVGILGAGMMGAGIAYVTAKAGIDVVLKDVTLQAARKGK
HHHHHHCCCCCCCCCHHHHHHHHHHHCCCHHHCCHHEEEECCCCEEEHHHHHHHHHHCCC
AYSENLEQKALAKGRTTEAKSRALLDRITPTADAADFTGVDFVIEAVFENTELKNKVFAE
HHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHH
IENIVEPGAVLGSNTSSLPITELAAGVSRPENFVGIHFFSPVEKMDPIEIIRGAKTSDET
HHHHHCCCCEECCCCCCCCHHHHHHHCCCCCCEEEEEEECCHHHCCHHHHHCCCCCCHHH
LARVIDYTLAINKYPIVVNDGRGFFTTRVFSTYLLEAFNMLAEGIDPATIEQAALQAGYP
HHHHHHHHHEECCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCC
AGPLQVADELSFGTIRKIMDETVQAAKADGVALDESVRVAAEVVTTLMDTFDRTGKRGGA
CCCHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCC
GFYDYVDGTRAGLWDDLRKAFNTTRALSVPFDDLQDRYLFIQAIETQKAYDDGVISSDPD
CCHHCCCCCCCCHHHHHHHHHCCCCEEECCHHHHCCCEEEEEEHHHHHHHCCCCCCCCCC
ANIGSIFSIGYPPWTGGVRQFVTGYPGGIDAFRRRADELAARYGGRFRWI
CCCCCEEECCCCCCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
SDSIIGWDKDADGIVTLTIDDPDNSANMLTDAYVEQMGAMIDRLEAEVDETTGVVITSG
CCCCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECC
KSTFFAGADLTQIRSAGPEHAQQLFDGSTAIKRDLRRLETLGKPVVAAINGAALGGGLEL
CCEEEECCCHHHHHCCCHHHHHHHHCCHHHHHHHHHHHHHHCCCCEEHCCCCCCCCCEEE
ALATHHRIAANVAGSVIGLPEVMLGVLPGAGGVARSVRLLGIQNALMQVLLTGNRFKPAK
EEHHHHHHHHHHCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCH
AQQVGLVDELVESVDELVPAAKAWILANPGKHVQPWDVPGFEIPGGSPSTPAFAANLPAF
HHHHCHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCCCCCEECCCCCCCCCCEECCCCCC
PANLRKQLKGSPMPAPRAIMAAALEGAQVDFDTAQLIETRYFVNLVTGPIAKNMIQAFFF
CHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DLQAVQSGTSRPADAPERTIHKVGILGAGMMGAGIAYVTAKAGIDVVLKDVTLQAARKGK
HHHHHHCCCCCCCCCHHHHHHHHHHHCCCHHHCCHHEEEECCCCEEEHHHHHHHHHHCCC
AYSENLEQKALAKGRTTEAKSRALLDRITPTADAADFTGVDFVIEAVFENTELKNKVFAE
HHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHH
IENIVEPGAVLGSNTSSLPITELAAGVSRPENFVGIHFFSPVEKMDPIEIIRGAKTSDET
HHHHHCCCCEECCCCCCCCHHHHHHHCCCCCCEEEEEEECCHHHCCHHHHHCCCCCCHHH
LARVIDYTLAINKYPIVVNDGRGFFTTRVFSTYLLEAFNMLAEGIDPATIEQAALQAGYP
HHHHHHHHHEECCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCC
AGPLQVADELSFGTIRKIMDETVQAAKADGVALDESVRVAAEVVTTLMDTFDRTGKRGGA
CCCHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCC
GFYDYVDGTRAGLWDDLRKAFNTTRALSVPFDDLQDRYLFIQAIETQKAYDDGVISSDPD
CCHHCCCCCCCCHHHHHHHHHCCCCEEECCHHHHCCCEEEEEEHHHHHHHCCCCCCCCCC
ANIGSIFSIGYPPWTGGVRQFVTGYPGGIDAFRRRADELAARYGGRFRWI
CCCCCEEECCCCCCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA