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The map label for this gene is ribA2

Identifier: 41407238

GI number: 41407238

Start: 1194633

End: 1195910

Strand: Direct

Name: ribA2

Synonym: MAP1140

Alternate gene names: 41407238

Gene position: 1194633-1195910 (Clockwise)

Preceding gene: 41407237

Following gene: 41407239

Centisome position: 24.73

GC content: 66.98

Gene sequence:

>1278_bases
ATGACGAGGTTGGACTCCGTCGAAAGGGCGGTTGCCGACATTGCGGCCGGCAAGGCCGTCATCGTCATCGACGACGAAGA
CCGGGAGAACGAGGGCGATCTGATCTTCGCCGCCGAGAAGGCGACGCCGGAGATGGTGGCGTTCATGGTGCGCTACACCT
CGGGCTACCTGTGTGTGCCGCTGGACGGGGCGATCTGCGACCGCCTGGGCCTGCTGCCGATGTATGCGGTCAACCAGGAC
AAGCACGGGACCGCTTACACGGTCACGGTCGACGCGAGAAACGGTGTGGGCACCGGGATTTCGGCCTCGGACCGGGCCAC
CACCATGCGCCTGCTGGCCGATCCCACCAGCATCGCCGAGGATTTCACCCGGCCCGGTCATGTGGTTCCGTTGCGCGCCA
AGGACGGTGGCGTGCTGCGCCGGCCCGGTCACACCGAGGCCGCCGTGGACCTGGCCCGGATGGCCGGCCTGCAGCCGGCC
GGCGCCATCTGCGAGATCGTCAGCCAGAAGGACGAGGGCTCGATGGCGCAGACCGACGAGCTGCGGGTGTTCGCCGACGA
ACACGACCTCGCCATGATCACCATCGCCGACCTGATCGAGTGGCGCCGCAAGCACGAGAAGCACATCGAGCGCATCGCGG
AGGCCCGGATCCCGACTCGGCACGGCGAGTTTCGCGCCATCGGTTACACCAGCATCTACGAGGAGGTCGAACACGTCGCG
CTGGTTCGCGGCGAGATCGCCGGCCCCAACTCCGACGGCGACGACGTGCTGGTGCGGGTGCACTCGGAGTGCCTGACCGG
TGACGTGTTCGGTTCGCGCCGTTGCGATTGCGGACCCCAGCTCGACGCCGCCATGGCCATGGTGGCCCGTGAGGGGCGCG
GCATCGTGCTGTACATGCGCGGGCACGAGGGCCGCGGCATCGGGCTGATGCACAAGCTGCAGGCCTACCAGCTGCAGGAC
GCCGGCGAGGACACCGTCGACGCCAACCTCAAACTCGGATTGCCTGCTGACGCAAGGGATTACGGAATCGGCGCGCAGAT
CCTGGTCGATCTGGGGGTGCGTTCGATGCGGCTGCTGACCAACAACCCCGCCAAGCGGGTGGGGCTGGACGGCTACGGTC
TGCACATCATCGAGCGGGTGCCGCTGCCGGTGCGCACCAACGCCGAGAACATTCGTTACCTGATGACCAAGCGCGATAAG
ATGGGCCACGATCTGGCCGGCCTGGACGATTTTCACGAATCGGTCCATCTGCCAGGCGAATTCGGCGGCGCCCTGTGA

Upstream 100 bases:

>100_bases
GGCGCCGCCGTGGTTCATACTGAATGCAACACGTGGGCTTCTCGTGTGAGCCGTTTCTACAGTGTTCCCGCGGCCAAGCG
GGGACGGCGAGGTAGCAGAG

Downstream 100 bases:

>100_bases
GTCGCGCCGGCGACGATGCAGAGCGAAGCGATGAGGAGGAGTGGCGCCCATGAGTCCAGCCGCCGGCGTGCCGGAGATGC
CGGCGCTCGACGCGTCCGGC

Product: bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein

Products: NA

Alternate protein names: 3,4-dihydroxy-2-butanone 4-phosphate synthase; DHBP synthase; GTP cyclohydrolase-2; GTP cyclohydrolase II [H]

Number of amino acids: Translated: 425; Mature: 424

Protein sequence:

>425_residues
MTRLDSVERAVADIAAGKAVIVIDDEDRENEGDLIFAAEKATPEMVAFMVRYTSGYLCVPLDGAICDRLGLLPMYAVNQD
KHGTAYTVTVDARNGVGTGISASDRATTMRLLADPTSIAEDFTRPGHVVPLRAKDGGVLRRPGHTEAAVDLARMAGLQPA
GAICEIVSQKDEGSMAQTDELRVFADEHDLAMITIADLIEWRRKHEKHIERIAEARIPTRHGEFRAIGYTSIYEEVEHVA
LVRGEIAGPNSDGDDVLVRVHSECLTGDVFGSRRCDCGPQLDAAMAMVAREGRGIVLYMRGHEGRGIGLMHKLQAYQLQD
AGEDTVDANLKLGLPADARDYGIGAQILVDLGVRSMRLLTNNPAKRVGLDGYGLHIIERVPLPVRTNAENIRYLMTKRDK
MGHDLAGLDDFHESVHLPGEFGGAL

Sequences:

>Translated_425_residues
MTRLDSVERAVADIAAGKAVIVIDDEDRENEGDLIFAAEKATPEMVAFMVRYTSGYLCVPLDGAICDRLGLLPMYAVNQD
KHGTAYTVTVDARNGVGTGISASDRATTMRLLADPTSIAEDFTRPGHVVPLRAKDGGVLRRPGHTEAAVDLARMAGLQPA
GAICEIVSQKDEGSMAQTDELRVFADEHDLAMITIADLIEWRRKHEKHIERIAEARIPTRHGEFRAIGYTSIYEEVEHVA
LVRGEIAGPNSDGDDVLVRVHSECLTGDVFGSRRCDCGPQLDAAMAMVAREGRGIVLYMRGHEGRGIGLMHKLQAYQLQD
AGEDTVDANLKLGLPADARDYGIGAQILVDLGVRSMRLLTNNPAKRVGLDGYGLHIIERVPLPVRTNAENIRYLMTKRDK
MGHDLAGLDDFHESVHLPGEFGGAL
>Mature_424_residues
TRLDSVERAVADIAAGKAVIVIDDEDRENEGDLIFAAEKATPEMVAFMVRYTSGYLCVPLDGAICDRLGLLPMYAVNQDK
HGTAYTVTVDARNGVGTGISASDRATTMRLLADPTSIAEDFTRPGHVVPLRAKDGGVLRRPGHTEAAVDLARMAGLQPAG
AICEIVSQKDEGSMAQTDELRVFADEHDLAMITIADLIEWRRKHEKHIERIAEARIPTRHGEFRAIGYTSIYEEVEHVAL
VRGEIAGPNSDGDDVLVRVHSECLTGDVFGSRRCDCGPQLDAAMAMVAREGRGIVLYMRGHEGRGIGLMHKLQAYQLQDA
GEDTVDANLKLGLPADARDYGIGAQILVDLGVRSMRLLTNNPAKRVGLDGYGLHIIERVPLPVRTNAENIRYLMTKRDKM
GHDLAGLDDFHESVHLPGEFGGAL

Specific function: Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate [H]

COG id: COG0807

COG function: function code H; GTP cyclohydrolase II

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the GTP cyclohydrolase II family [H]

Homologues:

Organism=Escherichia coli, GI1787533, Length=198, Percent_Identity=52.5252525252525, Blast_Score=194, Evalue=1e-50,
Organism=Escherichia coli, GI1789420, Length=206, Percent_Identity=46.1165048543689, Blast_Score=187, Evalue=1e-48,
Organism=Saccharomyces cerevisiae, GI6320695, Length=204, Percent_Identity=45.5882352941176, Blast_Score=196, Evalue=8e-51,
Organism=Saccharomyces cerevisiae, GI6319438, Length=174, Percent_Identity=47.1264367816092, Blast_Score=137, Evalue=4e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017945
- InterPro:   IPR000422
- InterPro:   IPR000926
- InterPro:   IPR016299 [H]

Pfam domain/function: PF00926 DHBP_synthase; PF00925 GTP_cyclohydro2 [H]

EC number: =4.1.99.12; =3.5.4.25 [H]

Molecular weight: Translated: 46281; Mature: 46150

Theoretical pI: Translated: 5.22; Mature: 5.22

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRLDSVERAVADIAAGKAVIVIDDEDRENEGDLIFAAEKATPEMVAFMVRYTSGYLCVP
CCCHHHHHHHHHHHHCCCEEEEECCCCCCCCCCEEEEECCCCHHHHHHHHHHCCCEEEEE
LDGAICDRLGLLPMYAVNQDKHGTAYTVTVDARNGVGTGISASDRATTMRLLADPTSIAE
CCHHHHHHHCCCEEEEECCCCCCEEEEEEEECCCCCCCCCCCCCCHHEEEEECCCHHHHH
DFTRPGHVVPLRAKDGGVLRRPGHTEAAVDLARMAGLQPAGAICEIVSQKDEGSMAQTDE
HHCCCCCEEEEEECCCCEEECCCCCHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCCCC
LRVFADEHDLAMITIADLIEWRRKHEKHIERIAEARIPTRHGEFRAIGYTSIYEEVEHVA
EEEEECCCCEEEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEHHHHHHHHHHHH
LVRGEIAGPNSDGDDVLVRVHSECLTGDVFGSRRCDCGPQLDAAMAMVAREGRGIVLYMR
HHHCCCCCCCCCCCCEEEEEEHHHHCCCCCCCCCCCCCCCHHHHHHHHHHCCCEEEEEEE
GHEGRGIGLMHKLQAYQLQDAGEDTVDANLKLGLPADARDYGIGAQILVDLGVRSMRLLT
CCCCCCCHHHHHHHHHHHCCCCCCCCCCCEEECCCCCCHHCCCCHHHHHHHCCHHEEHHC
NNPAKRVGLDGYGLHIIERVPLPVRTNAENIRYLMTKRDKMGHDLAGLDDFHESVHLPGE
CCCHHHCCCCCCCEEEEEECCCCCCCCCCHHEEEEECCHHCCCCCCCCHHHHHHCCCCHH
FGGAL
CCCCC
>Mature Secondary Structure 
TRLDSVERAVADIAAGKAVIVIDDEDRENEGDLIFAAEKATPEMVAFMVRYTSGYLCVP
CCHHHHHHHHHHHHCCCEEEEECCCCCCCCCCEEEEECCCCHHHHHHHHHHCCCEEEEE
LDGAICDRLGLLPMYAVNQDKHGTAYTVTVDARNGVGTGISASDRATTMRLLADPTSIAE
CCHHHHHHHCCCEEEEECCCCCCEEEEEEEECCCCCCCCCCCCCCHHEEEEECCCHHHHH
DFTRPGHVVPLRAKDGGVLRRPGHTEAAVDLARMAGLQPAGAICEIVSQKDEGSMAQTDE
HHCCCCCEEEEEECCCCEEECCCCCHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCCCC
LRVFADEHDLAMITIADLIEWRRKHEKHIERIAEARIPTRHGEFRAIGYTSIYEEVEHVA
EEEEECCCCEEEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEHHHHHHHHHHHH
LVRGEIAGPNSDGDDVLVRVHSECLTGDVFGSRRCDCGPQLDAAMAMVAREGRGIVLYMR
HHHCCCCCCCCCCCCEEEEEEHHHHCCCCCCCCCCCCCCCHHHHHHHHHHCCCEEEEEEE
GHEGRGIGLMHKLQAYQLQDAGEDTVDANLKLGLPADARDYGIGAQILVDLGVRSMRLLT
CCCCCCCHHHHHHHHHHHCCCCCCCCCCCEEECCCCCCHHCCCCHHHHHHHCCHHEEHHC
NNPAKRVGLDGYGLHIIERVPLPVRTNAENIRYLMTKRDKMGHDLAGLDDFHESVHLPGE
CCCHHHCCCCCCCEEEEEECCCCCCCCCCHHEEEEECCHHCCCCCCCCHHHHHHCCCCHH
FGGAL
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA